Результаты поиска

Q Fever (Coxiella Burnetii).

Q fever is a zoonotic infectious disease caused by the Coxiella burnetii bacterium. It is an obligate intracellular pathogen with a high infection capacity that proliferates exclusively in an acidified medium, forming a lysosome-like vacuole. It presents a peculiar phenomenon called "antigenic phase variation," produced by a modification in the complexity of the membrane lipopolysaccharides. Q fever can be found worldwide and presents variable clinical features and geographical distribution. It mostly affects people in rural areas who are in contact with animals. The most common type of transm…

Q fever--selected issues.

Q fever is an infectious disease of humans and animals caused by Gram-negative coccobacillus Coxiella burnetii, belonging to the Legionellales order, Coxiellaceae family. The presented study compares selected features of the bacteria genome, including chromosome and plasmids QpH1, QpRS, QpDG and QpDV. The pathomechanism of infection--starting from internalization of the bacteria to its release from infected cell are thoroughly described. The drugs of choice for the treatment of acute Q fever are tetracyclines, macrolides and quinolones. Some other antimicrobials are also active against C. burn…

Q fever in Greenland.

We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection.

Q fever in children.

Q fever is a zoonosis caused by Coxiella burnetii. Farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. This illness is associated with a wide clinical spectrum, from asymptomatic or mildly symptomatic seroconversion to fatal disease. Q fever in children has been rarely reported. We reviewed published work on this topic. Seroepidemiological studies show that children are frequently exposed to C burnetii. However, children are less frequently symptomatic than adults following infection, a…

Q fever endocarditis revisited.

A diagnosis of Q fever endocarditis was made in 7 patients, 6 with predisposing factors and 3 with occupational risk factors. Prompt recognition of Coxiella burnettii endocarditis is required when clinical signs of endocarditis such as fever, anaemia, elevated liver transaminases, congestive cardiac failure are accompanied by negative blood cultures. Serological evidence of elevated antibody titres to Phase I and Phase II antigens of Coxiella burnettii are diagnostic. Prolonged antimicrobial therapy combined with surgery has resulted in the marked reduction of mortality from 50 per cent of 17 …

Q лихорадка на Тайване.

Несмотря на то, что Q лихорадка, рикетсиальная болезнь, вызванная Coxiella signetii, должна происходить спорадически во всем мире, на Тайване имеется лишь один случай заболевания этой болезнью. Мы изучили антитела Q лихорадки, чтобы оценить состояние Q лихорадки на Тайване. В 1991 и 1992 годах 579 парных образцов сыворотки предполагаемых пациентов-фербрилов, направленных в этот институт несколькими больницами и санитарными станциями, были проверены в соответствии с методом косвенного флуоресцентного антитела (ИФА). Результаты: В общей сложности было выявлено 48 случаев серологической острой Q

Совпадение в аннотации оригинала
BACKGROUND: Although Q fever, a rickettsial disease caused by Coxiella burnetii, is supposed to occur sporadically worldwide, there is only one case report of this disease in Taiwan. We examined the antibody of Q fever to evaluate the status of Q fever in Taiwan. METHODS: In total, 579 paired serum specimens of suspected febrile patients sent by several hos…

Q fever in Israel.

BACKGROUND: Q fever was first described over fifty years ago. While in a proportion of cases there is a clear etiologic link to farm animals, their products, and fomites, in the majority of cases no such association is apparent, and the mode of infection is a mystery. METHODS: In this paper, we examine the reported incidence of Q fever in Israel since it was made notifiable in 1951, and in particular for the period 1981-1985, when special surveillance at national reference laboratories was carried out. RESULTS: Age and sex as well as urban-rural distributions suggest the influence of occupat…

Q fever in octogenarians.

Two of the 186 persons (1%) with acute Q fever examined in this study were 80 years of age or older. Both were males and both had Coxiella burnetti pneumonia. Q fever was not suspected during their hospital stay and would not have been diagnosed if these patients had not been part of a prospective study of community-acquired pneumonia.

Q fever - a review.

Q or "query" fever is a zoonosis caused by the organism Coxiella burnetii. Cattle, sheep and goats are the most common reservoirs of this organism. The placenta of infected animals contains high numbers (up to 10(9)/g) of C. burnetii. Aerosols occur at the time of parturition and man becomes infected following inhalation of the microorganism. The spectrum of illness in man is wide and consists of acute and chronic forms. Acute Q fever is most often a self-limited flu-like illness but may include pneumonia, hepatitis, or meningoencephalitis. Chronic Q fever almost always means endocarditis and …

Immunity in Q fever.

Post-infection and post-vaccination immune mechanisms in Q fever are summarized. Whereas cell-mediated immunity has been found to play a crucial role in developing resistance to Coxiella burnetii infection, data on the role of specific antibodies in Q fever immunity are controversial. The functional state of immunocompetent cells and professional phagocytes seems to be decisive for the persistence of C. burnetii within phagocytic cells and for the control of Q fever at the host level. Defects of cellular immunity, immune complex formation, and immune response modulation by C. burnetii isolates…