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Seroepidemiological survey on dengue and Japanese encephalitis virus infections in Asian monkeys.

To investigate the ecology of dengue and Japanese encephalitis (JE) viruses in the forest in Asia, a seroepidemiological survey was carried out on 358 Southeast Asian cynomolgus (Macaca iris), 33 Indian bonnet (Macaca radiata) and 37 Japanese (Macaca fuscata) monkey sera by a plaque reduction neutralization test. The results indicated that Southeast Asian monkeys were naturally infected with these viruses but the frequency of antibody to them varied considerably according to the geographical origin of the monkeys. The frequency of antibody to one or more types of dengue virus were 87.2, 49.5, …

Стойкость к ДДТ в Западной Африке и Азии (Aedes aegypti (L.).

В регионе Карибского бассейна и в Юго-Восточной Азии, но не в Западной Африке, наблюдается резистентность к ДДТ у комаров желтой лихорадки Aedes aegypti. В связи с этим штаммы в Западной Африке были сопоставлены с штаммами в Юго-Восточной Азии с точки зрения их реакции на отбор лабораторий с использованием ДДТ. Было установлено, что на начальном этапе штаммы в Западной Африке были гораздо медленнее, но в конечном итоге они могли бы повысить степень устойчивости к ДДТ. При переходе и обратном пересечении с чувствительным штаммом маркера-гена было установлено, что это сопротивление было вызвано

Совпадение в аннотации оригинала
The yellow fever mosquito Aedes aegypti has developed resistance to DDT in the Caribbean region and in South-East Asia, but not in West Africa. Therefore West African strains were compared with South-East Asian strains for their response to laboratory selection with DDT. It was found that West African strains were much slower to respond initially, but eventu…

Differential cardiovascular impact of ω-3 fatty acid in patients at high cardiovascular risk in Asians versus non-Asians: Sub-analysis of the strength randomized clinical trial.

BACKGROUND/AIMS: Racial differences in lipid and cardiovascular risk profiles are well-established, including for Asians. We compared cardiovascular treatment effects of ω-3 carboxylic acid (CA) between Asians and non-Asians in this post-hoc analysis of the STRENGTH trial. METHODS: The STRENGTH trial was a double-blinded randomized controlled trial of 13,078 high cardiovascular risk patients enrolled at 675 global centers. Efficacy and interactions of ω-3 CA for Asians (n = 1355) and non-Asians (n = 11,723) were assessed. The primary endpoint is a 5-point composite of cardiovascular death, no…

Investigation of the current situation regarding diagnosis and treatment of Alport syndrome in Asian countries: results of survey of the Asian Paediatric Nephrology association (AsPNA) tubular and inherited working group.

BACKGROUND: Alport syndrome is one of the most common inherited kidney diseases worldwide. A genetic test or kidney biopsy is necessary for a definite diagnosis of this disease, and an accurate diagnosis system for this disease is highly desired in each country. However, the current situation in Asian countries is not clear. Therefore, the tubular and inherited disease working group of the Asian Pediatric Nephrology Association (AsPNA) aimed to assess the current situation of diagnosis and treatment for Alport syndrome in Asia. METHODS: The group conducted an online survey among the members o…

Comparative efficacy and safety of Glucagon-like pepetide-1 receptor agonists with metformin in Asian versus non-Asian patients with type 2 diabetes: A systematic review and meta-analysis.

AIMS: In type 2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1RAs) in combination with metformin show better efficacy than metformin alone. Nevertheless, the reactions of different ethnic groups, especially Asian and non-Asian populations, are still controversial. To give clinical medication usage an evidence-based foundation, this meta-analysis examined GLP-1RAs' safety and efficacy when combined with metformin in the treatment of type 2 diabetes mellitus. MATERIALS AND METHODS: Up to January 2025, systematic searches for randomised controlled trials were carried out in PubMed, E…

High Prevalence of Late-Onset Fabry Cardiomyopathy in a Cohort of 499 Non-Selective Patients with Left Ventricular Hypertrophy: The Asian Fabry Cardiomyopathy High-Risk Screening Study (ASIAN-FAME).

Left ventricular hypertrophy (LVH) caused by cardiac variant Fabry disease (FD) is typically late-onset and may mimic LVH caused by abnormal loading conditions. We aimed to determine the prevalence of FD in a non-selective patient population of everyday practice presenting with LVH, including those with hypertension and valve disease. We measured plasma alpha-galactosidase A activity using dried blood spot tests in 499 (age = 66 ± 13 years; 336 men) Hong Kong Chinese patients with LVH defined as maximal LV septal/posterior wall thickness ≥13 mm on echocardiography. Patients with low enzyme act

Lipoprotein(a) in Disaggregated South Asian Groups: An Analysis of MASALA and the UK Biobank.

BACKGROUND: South Asian individuals have a high prevalence of elevated lipoprotein(a) [Lp(a)], but little is known about the variation between disaggregated South Asian subgroups. OBJECTIVES: The authors aimed to evaluate Lp(a) levels, nongenetic influences, and the association with incident atherosclerotic cardiovascular disease (ASCVD) in South Asian populations using data from the Meditators of Atherosclerosis in South Asians Living in America (MASALA) and the UK Biobank (UKB) studies. METHODS: Lp(a) levels were assessed by South Asian country of origin and by state among Indian-origin pa…

Statin Exposure and Survival Outcomes in Amyotrophic Lateral Sclerosis in an Asian Cohort.

INTRODUCTION: Data from Asian cohorts on whether statin therapy affects amyotrophic lateral sclerosis (ALS) progression are limited. We examined whether statin exposure was associated with ALS disease duration or tracheostomy-free survival in a multiethnic Asian ALS cohort. METHODS: Data from patients diagnosed with ALS between 2012 and 2025 were retrospectively reviewed. Patients were categorized as "ever" or "never" statin users for primary analyses, and as "never," "former," or "current" users at diagnosis for additional analyses. Disease duration was defined as time from symptom onset to …

Prevalence of periodontal diseases in children and adolescents in Asian countries: A scoping review.

OBJECTIVES: Extensive research has explored the prevalence of periodontal diseases in adult populations, however there is a paucity of synthesised data focusing on its prevalence among children and adolescents particularly in Asian countries. The objective of this scoping review was to analyse the available literature to evaluate the prevalence of periodontal diseases among children and adolescents in Asian countries. METHODS: A scoping review was conducted in accordance with the PRISMA-ScR guidelines and registered with Open Science Framework. Electronic searches of PubMed, Embase, Scopus, a…

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans.

Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential evolutionary forces shaping these differences. Our analyses revealed that EAS populations generally harbor a lower frequency of pharmacogenomic variants previously associated with reduced drug response compared with EUR populations, indicating po…

Health of South Asian migrants and refugees in Australia: an evidence gap map.

OBJECTIVE: The objective of this gap map is to provide an overview of existing evidence on the health of South Asian migrants and refugees in Australia and highlight research gaps. METHOD: We searched four databases until June 2025 to include quantitative, qualitative and mixed methods studies conducted in Australia and published from the year 2000 onwards on health of migrants and refugees from South Asian countries. Two reviewers screened titles/abstracts and full texts using Covidence to establish eligibility. The included studies were then coded in Evidence for Policy & Practice Informati…

Telehealth Use in Asian Americans: Closing or Widening the Gap in Health Access?

Telehealth use rapidly expands and provides critical access to health care services. However, evidence is scarce regarding telehealth use in Asian Americans. We conducted a cross-sectional study in 265 Asian American adults and examined personal, interpersonal, clinical, access, and geographic factors that interplay in telehealth use, using data from the 2022 Health Information National Trends Survey. Data analysis used descriptive statistics and logistic regressions. Telehealth was used by 42.4% of Asian Americans during the last year. Asian American males and those with low income were less …

Lorazepam and Survival in Asian Patients with Pancreatic Cancer: A Retrospective Cohort Study.

PURPOSE: Lorazepam is frequently used in pancreatic cancer patients receiving chemotherapy for its antiemetic properties and to mitigate psy … SION: Higher cumulative lorazepam exposure was associated with shorter progression-free survival in Asian patients with pancreatic cancer treated with palliative chemotherapy.

Comparison of ABBV-552 Safety and Pharmacokinetics in Healthy Asian and Western Adults.

ABBV-552, a positive modulator of synaptic vesicle glycoprotein 2A (SV2A), was under investigation as a treatment for cognitive impairment related to Alzheimer's disease. This Phase 1, multicenter, open-label, parallel cohort study (NCT05686980) was conducted to examine the pharmacokinetics (PK), safety, and tolerability of ABBV-552 in healthy adult Japanese and Han Chinese participants and to compare PK and safety findings with healthy adult Western participants from previous studies. Japanese participants in Cohort 1 (N = 10) received three ascending single oral doses (5, 15, and 40 mg) of A

Coronary computed tomography angiography for cardiovascular risk assessment in South Asians.

BACKGROUND: South Asians represent one of the world's largest and fastest-growing ethnic groups and experience a disproportionately high burden of premature atherosclerotic cardiovascular disease (ASCVD). OBJECTIVE: Conventional risk calculators consistently underestimate true risk, largely because of unique metabolic, genetic, and inflammatory factors that accelerate atherosclerosis at younger ages. Coronary computed tomography angiography (CCTA) provides a comprehensive assessment of coronary atherosclerosis and offers an accurate method of detecting subclinical disease in this population. …

Expert Consensus on the Use of Lurasidone for Bipolar I Depression in Asian Patients.

​​Eight psychiatrists from Malaysia, Singapore, Taiwan, Hong Kong, and Thailand participated in three meetings using the RAND Corporation/University of California Los Angeles (RAND/UCLA) appropriateness method to establish expert consensus on the use of lurasidone for bipolar I depression in Asian patients. The first meeting generated clinical questions and statements for voting, the second refined these statements, and the third addressed disagreements or areas of uncertainty. Consensus was defined as ≥66% agreement that a statement was appropriate or extremely appropriate. Nearly all propose…

Patterns of Presentation and Histopathology of Retroperitoneal Sarcoma in a South Asian Tertiary Center.

BACKGROUND: Retroperitoneal sarcoma (RPS) is a rare and heterogeneous malignancy that often presents late due to its deep anatomical location and nonspecific symptoms. Data from South Asian settings remain limited. OBJECTIVE: This study aimed to describe the patterns of clinical presentation, diagnostic evaluation, and histopathological characteristics of surgically managed retroperitoneal sarcoma in a tertiary center in Bangladesh. METHODS: This descriptive observational case series was conducted in the Department of General Surgery (Surgical Oncology Unit) at the Bangladesh Medical Univers…