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A cohort electron blood self-dose fraction and its propagated uncertainty for ¹²⁴I PET pre-therapy dosimetry in radioiodine therapy of differentiated thyroid cancer.

OBJECTIVE: Pre-therapy blood-marrow dosimetry for ¹³¹I treatment of differentiated thyroid cancer (DTC) requires serial imaging and blood sampling, limiting clinical adoption. When blood data are unavailable, operators fall back to fixed or imaging-only prescribing, usually without an explicit uncertainty bound. We characterise the cohort electron blood self-dose fraction (βfrac) in a single-centre ¹²⁴I PET cohort and quantify the uncertainty incurred by substituting that reference for patient-specific blood data. METHODS: Retrospective single-centre analysis of 18 pre-therapy ¹²⁴I PET course