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Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… . – Apply emollients with 10% urea, use topical exfoliants, and protect areas prone to pressure. – Refrain from using hot water. – Minimize friction and pressure on the hands and feet. – Limit exposure to direct sunlight and avoid unprotected exposure to cold. – Avoid scented, foaming cleansers and alcohol-based … Preventative measures should be continued Use emollients containing 20–40% urea Use salicylic acid, ammonium lactate or alpha hydroxyl acid, tazarotene 0.1% cream, and fluorouracil 5% cream to soften and exfoliate hyperkeratotic and callused areas Use a solution of recombinant human basic endothelial …

Более широкое использование медицинских услуг до начала педиатрического склероза: общенациональное когортное исследование.

Доказательства более широкого использования медицинских услуг до появления многочисленных склерозов у детей говорят о продромальной фазе. Однако мало что известно о его продолжительности или особенностях, и лишь немногие исследования получили доступ к клинической когорте для изучения периода до возникновения симптомов. Мы сравнили годовые показатели использования медицинских услуг до того, как педиатрический множественный склероз наступает в клинических и административных когортах, с соответствующими немногообразными когортами склероза. Мы идентифицировали лиц с педиатрическим множественным ск

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… In the year pre-index, eight therapeutic drug classes were identified as being dispensed more frequently in the PoMS cohort: drugs for acid-related disorders, diabetes, vitamins, emollients and protectives, corticosteroids for dermatological use, systemic corticosteroids, antibacterials and anti-inflammatory … drug class by Anatomical Therapeutic Chemical (ATC) 2nd level | Events (PoMS cohort) | Events (matched cohort) | Rate ratio (95% CI) 1 | A02 | Acid-related disorders | 17 | 22 | 3.76 (1.31–10.79) 1 | A10 | Diabetes | 8 | 6 | 6.49 (1.39–30.25) 1 | A11 | Vitamins | 8 | 7 | 5.56 (1.52–20.30) 1 | D02 | Emollients …

Grover's Disease in a Kidney Transplant Recipient.

Dear Editor, It is not unusual for patients with renal insufficiency to develop skin pathologies. There are reports in the literature of inc … atively by avoiding risk factors such as UV light and sweating as well as and applying moisturizing emollients which may cause the lesion to resolve spontaneously. Medical therapy consists of topic corticosteroids, topical vitamin D analogues, oral retinoids, and oral corticosteroids, PUVA, and methotrexate for resistant cases (6,12). When a patient exhibits …

Pharmacovigilance in oncology.

Background Side effects of cancer therapy are one of the most important issues faced by cancer patients during their illness. Pharmacovigilance, namely the science and activities aimed at monitoring the safety of drugs, is particularly important in oncology, due to the intrinsic biologic toxicity of antineoplastic agents, their narrow therapeutic windows, and the high doses and rigid timing of treatment regimens. Aim of the review To identify the main issues in carrying out an effective pharmacovigilance activity in oncology. Method We searched PubMed for articles about pharmacovigilance in re

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… reaction) Anthracyclines, antimetabolites, immunomodulatory therapies and targeted therapies Monitor the patient’s symptoms and behavioral modifications: avoid skin, hand and feet pressure, sun exposure, hot water, friction Administer oral pyridoxine (up to 150 mg/day); use skin creams (keratolytics or emollients … | Anthracyclines, antimetabolites, immunomodulatory therapies and targeted therapies | Monitor the patient’s symptoms and behavioral modifications: avoid skin, hand and feet pressure, sun exposure, hot water, friction | Administer oral pyridoxine (up to 150 mg/day); use skin creams (keratolytics or emollients …

Pruritus in Systemic Diseases: A Review of Etiological Factors and New Treatment Modalities.

Pruritus is the most frequently described symptom in dermatology and can significantly impair the patient's quality of life. In 10-50% of adults with persistent pruritus, it can be an important dermatologic clue for the presence of a significant underlying systemic disease such as renal insufficiency, cholestasis, hematologic disorder, or malignancy (Etter and Myers, 2002; Zirwas and Seraly, 2001). This review describes the presence of pruritus in different systemic diseases. It is quite important to discover the cause of pruritus for providing relief for the patients experiencing substantial

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… For therapy general measures include a cool environment, loose clothes, and the frequent use of emollients such as aqueous cream [ 21 ]. … This itching responds to emollients and thyroid hormone replacement [ 79 ]. Abnormal parathyroid gland activity usually occurs in the context of chronic renal failure that may also cause pruritus [ 80 ]. …

Capecitabine-Induced Hand-Foot Syndrome With Genital Involvement.

Palmar-plantar erythrodysesthesia, also known as hand-foot syndrome (HFS), is a common dermatologic toxicity of capecitabine. In this report, the case of a 59-year-old man with metastatic pancreatic ductal adenocarcinoma who developed grade 2 HFS with rare genital involvement is described. This case underscores the importance of recognizing atypical genital involvement in HFS to support timely management.

Darier Disease Presenting with Recurrent Kaposi Varicelliform Eruption in a 10-year-old Boy with Seborrheic Dermatitis.

We present a case of a 10-year-old boy with a longstanding history of seborrheic dermatitis (SD) referred to the Allergy and Immunology Depa … , irritation, pruritus, and malodor), and prevention or treatment of secondary infections. Topical (emollients, corticosteroids, retinoids, 5-fluorouracil, tacrolimus, pimecrolimus), physical (excision, electrodessication, dermabrasion, ablative laser, photodynamic therapy), and systemic (oral antibiotics, antiviral drugs, antimicrobial prophylaxis, vitamin …

A Case Report of Sebaceous Filaments.

This report details a case of a 16-year-old African American girl who presented with a two-year history of white spicules on her face without associated symptoms, including pruritus or pain. On physical examination, there were many 1-2 mm discreet white to yellow filamentous spicules on the mid and lower face. Histopathology scrapings showed cornified cells and calcification consistent with sebaceous filaments. Sebaceous filaments are a rare condition that presents as white-to-yellow spicules distributed in highly sebaceous areas on the face. It is caused by sebum accumulation and cornified ke

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… These include topical keratolytics, emollients, tretinoin, and laser treatments [ 7 ]. Pityriasis folliculorum results from infestation of the Demodex folliculorum mite and presents similarly to sebaceous filaments with plugged sebaceous hair follicles. …

Lenalidomide and Dexamethasone in Scleromyxedema: A Case Report of Long-Term Efficacy and Challenges in a 54-Year-Old Patient.

Lichen myxedematosus (LM) is characterized by dermal mucin buildup, fibroblast proliferation, and variable presentation. The diffuse variant, known as scleromyxedema, is identified by monoclonal paraprotein presence and lack of thyroid issues, with considerations for infections and underlying conditions. Despite lacking FDA-approved treatment, intravenous immunoglobulin stands as effective, although resource-intensive, while targeting the clonal source of pathogenic immunoglobulin offers an alternate therapeutic route. Our case explores the efficacy of an oral plasma cell-focused lenalidomide

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… Topical treatments, such as steroids or emollients, offer localized symptom relief but do not target systemic involvement. Immunomodulatory agents like lenalidomide (Ld) and rituximab show varying efficacy in modulating immune responses and have been explored in limited studies. …

Diabetes mellitus and the skin.

Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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… Topical treatment using emollients with basis of urea and oral metformin can be used (due to insulin resistance), but the only effective measures are weight loss and physical exercises, which reverses the metabolic disturbances that causes cutaneous manifestations. … When the lesions are flat, use of emollients is indicated. …

Успешное лечение трифаротена типичной болезни Кирла с обзором тематической терапии.

Болезнь Кирла - это редкое кожное расстройство, связанное с диагностикой трансэпидермального кератина, обычно связанного с системными заболеваниями. Мы сообщаем об уникальном случае, когда здоровый 26-летний человек сопротивляется стандартной терапии. В течение восьми недель была достигнута ремиссия с ежедневным тематическим трифаротеном 0,005%. Это первый, о котором сообщалось, случай КД, успешно обработанный трифаротином, избирательным RAR-__ retinoid, ориентированным на дифференциацию кератиноцитов и воспаление. Его эффективность и безопасность дают возможность пациентам, не пригодным для с

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… 2015) [ 7 ] 64‐year‐old man Limbs, back, hands, face and scalp Hyperpigmented hyperkeratotic papules with central crusted keratotic plugs N/A  Irregular epithelial hyperplasia with follicular cornified plug and focal parakeratosis Diabetes and hypertension, chronic renal failure Topical retinoids and emollients …

Hand hygiene for the prevention of infections in neonates.

BACKGROUND: Annually, infections contribute to approximately 25% of the 2.8 million neonatal deaths worldwide. Over 95% of sepsis-related ne … lass of agent: 2% chlorhexidine gluconate (CHG) compared to alcohol hand sanitiser (61% alcohol and emollients) For this comparison, no study assessed the effect of the intervention on the incidence of suspected infection within the first 28 days of life. Two percent chlorhexidine gluconate (CHG) probably reduces the risk of all infection in neonates compare …

Dermatologic Emergencies

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… Emollients can improve barrier function. Analgesia may be needed for pain control. Fresh frozen plasma (FFP) may be used in systemically unwell children as FFP contains antibodies against endotoxin A. … Clinical stage IV acute cutaneous GVHD results in widespread skin desquamation (Fig. 22.15 ) that in addition to systemic steroids requires restoration of the epidermal barrier via emollients and occlusive dressings, electrolyte monitoring/replacement, and cooling measures for patients that develop fever …

Успешное лечение гуселкумаба у пациента с коморбидом псориазом и амиотропическим латеральным склерозом: тематическое исследование и обзор литературы.

Псориаз имеет генетические последствия и может быть вызван такими факторами, как инфекция, стресс и образ жизни. Хроническая доска psoriasis, наиболее распространенная форма, включает в себя ключевые роли для IL-17 и IL-23 в его патогенезе. Амиотропический боковой склероз (ALS) — нейродегенеративное расстройство, характеризующееся дегенерацией моторных нейронов, что приводит к слабости мышц и атрофии. В настоящее время нет лекарства от БАС, а лечение является симптоматическим и направлено на повышение качества жизни. Сочетание псориаза и БАС является относительно редким. Хотя биологические аге

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… These limitations hindered his ability to use systemic medications, apply emollients, engage in topical therapies, and perform basic self-care, leading to intractable pruritus and persistent skin lesions. …

Interventions for chronic pruritus of unknown origin.

BACKGROUND: Pruritus is a sensation that leads to the desire to scratch; its origin is unknown in 8% to 15% of affected patients. The prevalence of chronic pruritus of unknown origin (CPUO) in individuals with generalised pruritus ranges from 3.6% to 44.5%, with highest prevalence among the elderly. When the origin of pruritus is known, its management may be straightforward if an effective treatment for the causal disease is available. Treatment of CPUO is particularly difficult due to its unknown pathophysiology. OBJECTIVES: To assess the effects of interventions for CPUO in adults and child

Over-the-counter and compounded mouthwashes for radiotherapy-induced xerostomia: a randomized controlled trial.

Head and neck radiotherapy quantitatively and qualitatively compromises salivary flow, and salivary substitutes have the potential to alleviate the symptoms. This study aims to assess the effectiveness of two salivary substitutes in relieving symptoms of radiotherapy-induced xerostomia through a double-blind randomized controlled trial. Twenty-four patients were selected from a dental oncology clinic and randomly assigned to the over-the-counter or compounded mouthwash group. Each patient was instructed to rinse their oral cavity with the assigned solution three times a day for 30 days. Both p

Efficacy and safety of dupilumab in a patient with metastatic clear cell renal cell carcinoma.

This case report evaluated the efficacy and safety of dupilumab, a monoclonal antibody targeting interleukin-4 and interleukin-13, in a patient with atopic dermatitis (AD) and a history of metastatic renal cancer. Over 20 months of follow-up, the patient experienced significant improvement in AD symptoms without any recurrence of cancer. In addition to not stimulating carcinogenesis, dupilumab might synergistically inhibit tumor-induced immunosuppression, thereby potentially preventing tumor progression. This case suggests that dupilumab could be a viable treatment option for patients with AD

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… patients with severe AD. 8 Despite its efficacy, there is a paucity of literature on the use of dupilumab in patients with a history of malignancies or those with currently active malignancies. 4 , 9 Case report This case involved a 61-year-old man with a history of mild AD that was controlled with emollients …

Clinical curative effect and quality of life evaluation of dupilumab in treating children with atopic dermatitis and its effect on IgE levels, eosinophil count, Th2 cytokines (IL-4 and IL-13), and thymus and activation-regulated chemokine.

INTRODUCTION: Atopic dermatitis (AD) is a common chronic skin inflammatory disease. The traditional treatment shows limited effect and side effects. Dupilumab is a monoclonal antibody immunotherapy targeting IL-4 and IL-13, which may become a new direction for treating AD. AIM: This study was to explore the clinical curative effect of dupilumab in the treatment of children with AD, and its influence on the quality of life (QoL) of children. MATERIAL AND METHODS: 54 children with AD, who were treated in the outpatient and inpatient departments of the hospital from August 2023 to July 2024, we

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… At present, the standard treatment in Western medicine is composed of the regular use of emollients and local application of glucocorticoids [ 7 ]. …

Interventions to reduce Staphylococcus aureus in the management of eczema.

BACKGROUND: Staphylococcus aureus (S. aureus) can cause secondary infection in eczema, and may promote inflammation in eczema that does not look infected. There is no standard intervention to reduce S. aureus burden in eczema. It is unclear whether antimicrobial treatments help eczema or promote bacterial resistance. This is an update of a 2008 Cochrane Review. OBJECTIVES: To assess the effects of interventions to reduce S. aureus for treating eczema. SEARCH METHODS: We updated our searches of the following databases to October 2018: Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE

NTP Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CAS No. 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies).

Oleic acid diethanolamine condensate is widely used as an emollient, thickener, and foam stabilizer present in cosmetic formulations of bath additives, shampoos, conditioners, lipsticks, and hair dyes. Male and female F344/N rats and B6C3F1 mice received dermal applications of diethanolamine in 95% ethanol for 13 weeks or 2 years. Genetic toxicology studies were performed in Salmonella typhimurium and L5178Y mouse lymphoma cells. 13-WEEK STUDY IN RATS: Groups of 10 male and 10 female rats were admin istered 0, 25, 50, 100, 200, or 400 mg oleic acid diethanolamine condensate/kg body weight in e