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What the Intensivist Needs to Know About Hematopoietic Stem Cell Transplantation?

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… colitis Cystitis Nephritis Epstein-Barr virus (EBV) Posttransplant lymphoproliferative disorder (PTLD) Human herpesvirus (HHV-6, HHV-7, HHV-8) Pneumonitis Encephalitis Rash Fever Marrow suppression JC virus Multifocal leukoencephalopathy Common respiratory viruses Respiratory syncytial virus (RSV) Human metapneumovirus …

Pneumonia in Transplant Recipients: A Comprehensive Review of Diagnosis and Management.

Transplant recipients have an increased risk of complications, including graft dysfunction and infections, which can be life-threatening if not recognized early. Pneumonia ranks as one of the most frequent complications in both solid organ and hematopoietic stem cell transplants. Clinical symptoms manifest late during infections in immunocompromised patients. An aggressive approach centered on early confirmatory diagnosis and a low threshold for empiric therapy is often the most effective strategy. The isolation of a pathogen in an upper airway sample does not necessarily mean the same organis

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… Community-Acquired Respiratory Viruses Community-acquired respiratory viruses encompass influenza A/B, RSV, parainfluenza virus, adenovirus, metapneumovirus, rhinovirus, enterovirus, and human coronaviruses [ 62 ]. …

Twenty-five years of type I interferon-based treatment: a critical analysis of its therapeutic use.

The clinical exploitation of type I interferon (IFN) as an antiviral and antineoplastic agent is based on the properties originally attributed to this cytokine family, with schedules reflecting only their antiviral and antiproliferative activities. Nevertheless, type I IFN has emerged as a central activator of the innate immunity. As current schedules of treatment for chronic hepatitis C and for hematological and solid tumors, based on the continuous administration of recombinant type I IFN or pegylated formulations, disregard viral resistance, host genetic variants predicting treatment outcom

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… In vitro sensitivity of human metapneumovirus to type I interferons Viral Immunol 24 2011 159 164 21449726 10.1089/vim.2010.0073 21 Gibbert K. Schlaak J.F. Yang D. Dittmer U. …

A phase III randomized crossover trial of plerixafor versus G-CSF for treatment of WHIM syndrome.

BACKGROUNDWarts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function CXCR4 mutations. Myelokathexis is a kind of neutropenia caused by neutrophil retention in bone marrow and in WHIM syndrome is associated with lymphopenia and monocytopenia. The CXCR4 antagonist plerixafor mobilizes leukocytes to the blood; however, its safety and efficacy in WHIM syndrome are undefined.METHODSIn this investigator-initiated, single-center, quadruple-masked phase III crossover trial, we compared the total infection s

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… Pathogens were identified for only 18 infections: influenza A, metapneumovirus, rhinovirus, enterovirus, Moraxella sp. and Hemophilus sp . for airway infections; Pithomyces species and Trichophyton tonsurans for tinea corporis and tinea capitis; HSV-1 dermatitis; Cyclospora enteritis and Clostridium …

Overview of nutritional approach in hematopoietic stem cell transplantation: COVID-19 update.

The coronavirus disease 2019 (COVID-19) is caused by the newly discovered SARS-CoV-2. Hematopoietic stem cell transplantation (HSCT) is a high-risk procedure. The novelty of COVID-19 has created more uncertainty during all phases of HSCT. It is thought that HSCT patients taking immunosuppressive agents are more likely to contract COVID-19 than healthy individuals are. Appropriate care precautions should be taken with patients undergoing HSCT to minimize the risk of COVID-19, and appropriate treatment methods must be followed in patients infected with COVID-19. Malnutrition has become a signifi

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… Respiratory viruses such as influenza, respiratory syncytial virus, parainfluenza virus, human metapneumovirus, the rhinovirus and adenovirus are well defined in HSCT recipients. There are limited data on coronavirus infection in these patients[ 15 ]. …

Stem Cell Transplantation

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… RSV, influenza, rhinovirus, and metapneumovirus infections have a seasonal pattern, mirroring occurrences in the community, whereas parainfluenza virus infections occur during all seasons. …

Регулирование заразительных осложнений в создании химической антигенной приемной клетки (CAR-T)

Химерическая антигенная рецепторная T-клетка (CAR T-клетка) изменила парадигму управления лимфомой не Ходжкина (NHL) и множественной миеломой. Осложнения, связанные с инфекцией, стали предметом озабоченности, которая может возникнуть в процессе лечения и привести к заболеваемости и смертности. В ходе этого обзора мы классифицировали осложнения, связанные с инфекцией, в three Категория, этап предварительного вливания с момента предварительного лимфодерации (LD) до дня zero, ранний этап от дня вливания до дня 30 после введения в эксплуатацию и с запозданием изо дня в день 30 и дальше. Инфекции,

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… infection at the time of cell infusion. 55 In those with respiratory symptoms, who should undergo workup to test for the source of respiratory viral illness, a delay should be considered, especially for patients with COVID-19, respiratory syncytial virus, parainfluenza virus 1 to 4, influenza virus A or B, metapneumovirus …

Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016.

Infectious complications after allogeneic haematopoietic stem cell transplantation (allo-HCT) remain a clinical challenge. This is a guideline provided by the AGIHO (Infectious Diseases Working Group) of the DGHO (German Society for Hematology and Medical Oncology). A core group of experts prepared a preliminary guideline, which was discussed, reviewed, and approved by the entire working group. The guideline provides clinical recommendations for the preventive management including prophylactic treatment of viral, bacterial, parasitic, and fungal diseases. The guideline focuses on antimicrobial

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… RSV followed by influenza, parainfluenza, metapneumovirus, and adenovirus are the main viruses causing severe diseases [ 215 ]. These viruses can contribute significantly to morbidity after allo-HCT; however, mortality rates seem to be mixed due to heterogeneity of various risk situations [ 216 ]. …

mRNA vaccine development and applications: A special focus on tumors (Review).

Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic strategies usually result in the acquisition of drug resistance, thus highlighting the need for more personalized treatment. mRNA vaccines transfer the gene sequences of exogenous target antigens into human cells through transcription and translation to stimulate the body to produce specific immune responses against the encoded proteins, so as to enable the body to obtain immune protection against said antigens; this approach may be adopted for personalized cancer therapy. Since the recent coronaviru

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… Currently, several mRNA vaccines are being tested in clinical settings or are readily accessible to combat cancer and several infectious diseases, including the Zika virus, cytomegalovirus, influenza virus, metapneumovirus and parainfluenza virus ( 30 ). …

High-Dose Intravenous Immunoglobulins in the Treatment of Severe Acute Viral Pneumonia: The Known Mechanisms and Clinical Effects.

The current outbreak of viral pneumonia, caused by novel coronavirus SARS-CoV-2, is the focus of worldwide attention. The WHO declared the COVID-19 outbreak a pandemic event on Mar 12, 2020, and the number of confirmed cases is still on the rise worldwide. While most infected individuals only experience mild symptoms or may even be asymptomatic, some patients rapidly progress to severe acute respiratory failure with substantial mortality, making it imperative to develop an efficient treatment for severe SARS-CoV-2 pneumonia alongside supportive care. So far, the optimal treatment strategy for

Nanoparticles Based Therapeutic Approaches in Oncogenic Viral Infections: A Review.

Nanotechnology has revolutionized biomedical research by providing novel strategies for the prevention, diagnosis, and treatment of oncogenic viral infections. Nanoparticles, possessing tunable physicochemical properties, enable targeted drug delivery, enhance vaccine efficacy, and facilitate advanced viral diagnostics, addressing key limitations of conventional therapies. Oncogenic viruses contribute substantially to the global burden of cancer through persistent infections and are influenced by environmental and lifestyle factors. The objective of this review is to synthesize and critically

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… In addition, several viral diseases and infections, such as the common cold, can result in significant economic losses worldwide, apart from significant morbidity and mortality rates. 120 Influenza A and B viruses, metapneumovirus, parainfluenza viruses, rhinovirus, coronavirus, enterovirus, and syncytial …

Abstracts for NAPCON 2025

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… Maharashtra, India Introduction: Human metapneumovirus (hMPV), a single-stranded RNA virus identified in 2001, primarily impacts high-risk populations. … Conclusion: Human metapneumovirus (hMPV) diagnosis is challenging due to overlapping clinical pictures but it has certain unique features. Lower respiratory involvement is common in elderly immunosuppressed patients and is associated with significant mortality. …

Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations.

Curcumin has been extensively investigated as an anticancer agent, yet its clinical application remains constrained by low bioavailability, incomplete mechanistic understanding, and limited therapeutic optimization. In light of growing resistance to conventional chemotherapies and the demand for safer, multi-targeted agents, this review revisits curcumin with a contemporary lens. We critically evaluate the literature published since 2020, focusing on newly elucidated molecular mechanisms by which curcumin regulates tumor progression, including modulation of oncogenic signaling pathways (Wnt/β-

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… Impact of Nonthermal Plasma on Human Metapneumovirus (HMPV): Mechanisms of Viral Inactivation and Replication Inhibition Contrib. Plasma Phys. 2025 e70044 10.1002/ctpp.70044 6. Singh N. Sharma A. …

The multiple roles of interferon regulatory factor family in health and disease.

Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores the diverse functions of nine mammalian IRF members, each featuring conserved domains essential for interactions with other transcription factors and cofactors. These interactions allow IRFs to modulate a broad spectrum of physiological processes, encompassing host defense, immune response, and cell development. Conversely, their pivotal role in immune regulation implicates them in the pathophysiology of v

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… as IFN-α and IFN-β1 production, and/or protein degradation in various cell types, which drive antiviral immunity to multiple clinically important viruses, including hepatitis C virus (HCV), West Nile virus,yellow fever virus, human immunodeficiency virus type 1(HIV1), gamma herpes virus, and human metapneumovirus …

2020 CIS Annual Meeting: Immune Deficiency & Dysregulation North American Conference.

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Pleuropulmonary Changes Induced by Drugs in Patients with Hematologic Diseases

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… BAL samples should be processed with special stains, cultures and molecular techniques for the detection of bacteria, fungi and protozoa and viruses, including the recently recognized metapneumovirus and H1N1 [ 51 ]. …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… P1235: Human metapneumovirus infection among children hospitalised with acute respiratory illness in Taiwan C.Y. Lin, J.S. … Lin (Changhua, TW) Objectives: To understand the association of human metapneumovirus (hMPV) with acute respiratory infection (RI) among hospitalized children in Taiwan, we conducted this study. …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Sessions (O009-O155).

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Abstracts cont.

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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