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Omics approaches in insect diapause Исследование.

Diapause is a genetically programmed developmental or reproductive arrest that helps insects survive adverse seasonal conditions. Our understanding of the molecular regulation of this complex trait has significantly improved through the use of omics technologies over the last few decades. In this review, we have compiled current omics Исследование on insect diapause, spanning transcriptomics, proteomics, metabolomics, lipidomics, epigenomics, genomics, and post-transcriptional regulatory approaches. Transcriptomics has led the field, showing that the diapause program develops gradually through a s…

Applying Principles of Community-Engaged Research.

Community-engaged Исследование (CEnR) is a participatory approach that foregrounds community priorities and applies Исследование results to community action. CEnR embodies shared decision-making by including community partners' values, preferences, and experiences within the Исследование process. CEnR projects can help medical student learners acquire skills in conducting needs assessments and more fully appreciate the social determinants of health and challenges faced by communities. CEnR does not prescribe specific methods for addressing Исследование questions. Rather, it is a collaborative approach with co…

Equitable Language Access in Neonatal Research.

Participation in neonatal randomized controlled trials (RCTs) is associated with improved or equivalent outcomes for infants and is widely viewed as a cornerstone of high-quality neonatal care. Equitable access to Исследование participation is therefore essential to scientific validity, ethical integrity, and generalizability. Although substantial efforts have focused on improving the representation of racial and ethnic minority groups in neonatal Исследование, the inclusion of families who speak languages other than English remains inadequately examined. In this perspective, we synthesize existing ev…

[Research progress on cell surface RNA].

Conventionally, it is believed that the biological functions of RNA are confined to the interior of cells, and the existence of functional RNAs on cell surface as well as their potential mechanisms of action have long remained unclear. In recent years, the discovery and functional Исследование of cell surface RNA have completely revolutionized this traditional perception, confirming its important biological significance as a class of novel surface functional molecules. This review systematically summarizes the latest Исследование advances in the field of cell surface RNA, focusing on four aspects: its…

Epistemic reflexivity for AI-augmented Исследование.

Using generative AI in science necessitates that institutions and Исследованиеers practice epistemic reflexivity to protect intellectual diversity and resist the threat of scientific monoculture. We argue that Исследованиеers and institutions can position generative AI both as a tool for epistemic reflexivity and as an object that must be examined reflexively.

Sample Size Justification in Quantitative Research.

BACKGROUND: Sample-size justification remains a central element of quantitative Исследование, yet classical a priori power analysis is frequently applied to designs for which it is neither required nor conceptually appropriate. When power calculations are used indiscriminately, they may misalign with the aims of studies that do not need them. This poses challenges for Исследованиеers and student nurses, particularly those without specialist training in statistics, and can lead to methodological inconsistencies across the published nursing literature. OBJECTIVES: In this paper, I aim to clarify how sa…

Emerging Trends in Hypertrophic Cardiomyopathy Research.

Hypertrophic cardiomyopathy (HCM), recognized as the most prevalent inherited heart condition, is found in about 0.2% to 0.5% of the population globally. Recent years have witnessed a notable surge in HCM-related scholarly investigations. The aim of this study was to delineate the trajectory of HCM Исследование over the preceding decade through a comprehensive bibliometric analysis. Utilizing the Web of Science Core Collection (WoSCC) database, we retrieved data on HCM-related studies conducted between 2013 and 2023. The acquired bibliographic data were methodically processed and examined using VO…

Research progress on abdominal cocoon syndrome.

Abdominal Cocoon Syndrome (ACS) is an uncommon medical condition defined by the encasement of the small intestine within a robust fibrocolla … , pathological features, treatment modalities, and prognostic implications. Recent case studies and Исследование have clarified the correlation between ACS and conditions such as tuberculous peritonitis, underscoring the necessity for differential diagnosis. Enhancements in imaging methodologies have facilitated improved preoperative identification, while surg …

[Research progress on external cervical resorption].

External cervical resorption (ECR) is a progressive, osteoclast-mediated destructive disease of dental hard tissues that originates at the c … sis, and management of ECR, aiming to provide insights for precise clinical decision-making. Future Исследование directions, such as early biomarker identification and targeted pharmacological intervention, are also discussed.

Milestones in Hereditary Colorectal Cancer Research.

This reviews the historical evolution of our understanding of the familial gastrointestinal cancer syndromes. It begins centuries ago with t … e past 50 years is remarkable and highlights the rapid evolution of new technologies and insightful Исследование.

Creating and Disseminating Meaningful Education Research.

Surgical education Исследование has become increasingly important as training programs evolve from apprenticeship-based models toward evidence-based, theory-informed educational practices. This primer provides a structured overview for clinicians and educators seeking to develop and disseminate meaningful education Исследование in surgery. We outline strategies for generating impactful Исследование questions, selecting theoretical and conceptual frameworks, and addressing ethical considerations unique to studying learners. Methodological approaches including quantitative, qualitative, and mixed methods ar…

Research progress on Haemophilus parasuis vaccines.

Haemophilus parasuis (HPS) is the causative agent of porcine Glässer's disease, which has become prevalent in China in recent years. It is characterized by fibrinous polyserositis, arthritis, and meningitis, but often shows mixed infection with other upper respiratory tract pathogens, causing heavy economic losses to the pig industry. Vaccination is an important means to prevent and control HPS infection, and the currently available vaccines are mainly the inactivated type or subunit vaccines containing immunogenic HPS proteins. This study reviews recent advances in HPS vaccines, analyzes the

Is Gene Drive Research Losing Traction?

Significant progress has been made in developing gene drives, especially for mosquito vectors of malaria. It is widely agreed that a critical next step in advancing this technology is to evaluate it through small-scale field trials. However, obtaining permission to move forward with these trials has stalled, threatening this potentially transformative line of Исследование. In this paper, roadblocks delaying progress are identified from the perspective of a developer group tasked with translating this technology to the field. We suggest that groups engaged in long-running discussions about risk and…

Communicating Health Research With Plain Language.

Although critical to enacting change, effectively communicating clinical and public health Исследование results remains a challenge. In a webinar that occurred on December 7, 2023, a group of clinical and public health Исследованиеers and communications specialists convened to share their experiences using plain language materials to communicate Исследование results. Herein, they provide practical guidance and case examples of lay summaries, infographics, data dashboards, and zines, along with challenges and potential solutions. Discussion illuminated the critical importance of partnering with communities…

NAPCON 2025 – Best Original Research Abstracts

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… *This article was selected for NAPCON 2025 best Исследование award presentation. … *This article was selected for NAPCON 2025 best Исследование award presentation. …

Artificial intelligence in natural products Исследование.

Artificial intelligence (AI) has emerged as a transformative technology in accelerating drug discovery and development within natural medicines Исследование. Natural medicines, characterized by their complex chemical compositions and multifaceted pharmacological mechanisms, demonstrate widespread application in treating diverse diseases. However, Исследование and development face significant challenges, including component complexity, extraction difficulties, and efficacy validation. AI technology, particularly through deep learning (DL) and machine learning (ML) approaches, enables efficient analysis…

Metal-organic frameworks in pharmaceutical Исследование.

Metal-organic frameworks (MOFs) have emerged as a highly versatile class of porous materials with significant potential to advance pharmaceutical Исследование. This review provides a comprehensive overview of the current landscape of MOFs, encompassing their synthesis strategies, characterization methodologies, and diverse biomedical applications. We detail various synthesis approaches (e.g., hydrothermal, electrochemical, microwave) and essential characterization techniques (e.g., X-ray diffraction (XRD), scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area analysis) that…