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Feasibility of Sarcopenia Assessment and Association With Functional Outcome in Acute Ischemic Stroke.

Purpose: The primary aim was to report feasibility of sarcopenia assessment within 7 days of ischemic stroke. Secondary aims were to estimate prevalence of sarcopenia and its association with functional outcome after stroke. Method: Participants, ischemic stroke survivors from two hospital acute stroke units, underwent sarcopenia assessment steps using the revised European Working Group on Sarcopenia in Older People (EWGSOP-2) guidelines within 7 days after stroke. Functional outcome (modified Rankin Scale [mRS]) was assessed 4-6 months post-stroke. Assessment steps were feasible if all partic…

Саркопания у пациентов с множественной миеломой и автологической трансплантацией стволовых клеток.

Объект < < Саркопания > > определяется как обусловленная возрастом потеря количества и качества мышц. Кроме того, она связана с заболеваемостью и смертностью. Множественная миелома (ММ) имеет уникальный аспект с участием кости. Мы намеревались изучить воздействие трансплантации стволовых клеток на саркопию у пациентов ММ с использованием как КТ, так и метаболического отсека F-18 В него были включены FDG PET/CT.MethodsPatients with MM, которые прошли первичное лечение и имели право на аутлогическую трансплантацию стволовых клеток (ASCT). Снимки PET до и после трансплантации 120 Были

Совпадение в аннотации оригинала
ObjectiveSarcopenia is defined as an age-related loss of muscle quantity as well as quality. Also, it is associated with morbidity and mortality. Multiple myeloma (MM) has a unique aspect with its bone involvement. We aimed to investigate the effect of hematopoietic stem cell transplantation on sarcopenia in MM patients using both CT and metabolic compartmen…

Sarcopenia and frailty: An in-depth analysis of the pathophysiology and effect on liver transplant candidates.

Cirrhosis represents the end stage of chronic liver disease, significantly reducing life expectancy as it progresses from a compensated to a decompensated state, leading to serious complications. Recent improvements in medical treatment have created a shift in cirrhosis management. Various causes, including hepatitis viruses, alcohol consumption, and fatty liver disease, contribute to cirrhosis and are closely linked to liver cancer. The disease develops through hepatocyte necrosis and regeneration, resulting in fibrosis and sinusoidal capillarization, leading to portal hypertension and compli

Frailty or sarcopenia: which is a better indicator of mortality risk in older adults?

BACKGROUND: Despite the different conditions, frailty and sarcopenia overlap regarding their common link: the assessment of walking speed and muscle strength. This study aimed to compare the frailty phenotype to the sarcopenia using different cut-off points for low grip strength to determine which better identifies mortality risk over a 14-year follow-up period. METHODS: 4597 participants in the English Longitudinal Study of Ageing. Frailty was measured using the Fried phenotype. Sarcopenia (European Working Group on Sarcopenia in Older People 2) was defined using different cut-off points for…

The role of the circadian timing system in sarcopenia in old age: a scoping review.

PURPOSE: Sarcopenia is a progressive and generalized skeletal muscle disorder, involving the accelerated loss of skeletal muscle mass and function, associated with an increased probability of adverse outcomes including falls. The circadian timing system may be involved in molecular pathways leading to sarcopenia in older adults. We aimed to provide an updated and systematic map of the available evidence on the role of the circadian timing system in sarcopenia, specifically related to the aging process. METHODS: We developed a scoping review protocol following the PRISMA-ScR guidelines. Search…

Association of Leptin in Sarcopenia and Bone Density in Elderly Women: An Observational Analysis.

Background: Sarcopenia and osteoporosis are common age-related conditions that markedly increase fracture risk and morbidity in the elderly. Leptin, an adipokine secreted by adipose tissue, has been implicated in musculoskeletal health, but its clinical relevance in aging populations remains uncertain. This study aimed to evaluate the associations between serum leptin levels, skeletal muscle mass, muscle strength, bone mineral density (BMD), and fracture risk in elderly women. Methods: This observational analysis included 79 community-dwelling women aged 65 years and older. Participants underw…

Unraveling the dual threat: sarcopenia and insufficient physical activity in diabetes risk.

PURPOSE: This study aimed to investigate the alterations in diabetes risk associated with sarcopenia and insufficient physical activity, as well as the demographic shifts within the diabetic population. METHOD: Utilizing pertinent data from the National Health and Nutrition Examination Survey (NHANES) database spanning 2011 to 2018, the criteria for sarcopenia were established by the Foundation for the National Institutes of Health. These criteria were calculated using lean body mass data in conjunction with body mass index data. Physical activity levels were assessed using the PAQ questionna…

Effects of changes in body composition on cardiometabolic diseases by sex and presence of sarcopenia.

BACKGROUND: Muscle mass loss and fat mass increase are risk factors for cardiometabolic disease. We evaluated the effect of changes in body composition on the incidence of cardiometabolic diseases in older adults with or without sarcopenia, over two-year follow-up. MATERIALS AND METHODS: Changes in body composition and the development of cardiometabolic diseases over 2 years were measured in community-dwelling older adults recruited from the Korean Frailty Aging Cohort Study. Individuals with sarcopenia were 1:1 matched to those without sarcopenia via propensity score matching. RESULTS: Amon…

Nomogram to screen older adult patients attending the radiology department for sarcopenia.

BACKGROUND: Sarcopenia is an age-related syndrome that can impact the physical and mental health of older adults. However, it is often overlooked in clinical practice. Therefore, we aim to construct a nomogram based on simplified discriminant parameters for screening older adult patients for sarcopenia risk. METHODS: This cross-sectional study included 654 patients aged ≥ 60 years who underwent an examination in the radiology department between October 2023 and June 2024. Patients were diagnosed with sarcopenia according to the method and cutoff value criteria proposed the Asian Working Group…

Sarcopenia as a Risk Factor for Mortality in NAFLD: How Should We Diagnose It?

OBJECTIVES: Sarcopenia increases the risk of nonalcoholic steatohepatitis (NASH) and cirrhosis in patients with nonalcoholic fatty liver disease (NAFLD). Subsequently, poorly managed NAFLD can result in adverse health outcomes. Lifestyle interventions are effective for both NAFLD and sarcopenia; however, diagnosis of sarcopenia in this population is not well defined. This review aimed to examine current methods to diagnose sarcopenia in NAFLD patients. METHODS: MEDLINE, EMBASE, and CINAHL databases were searched for articles published until July 2023 using the terms "Non-alcoholic fatty liver…

The impact of lifestyle factors across the life course on sarcopenia and physical frailty.

PURPOSE OF REVIEW: Muscle health helps maintain locomotor capacity, a key component of intrinsic capacity, which is required for healthy ageing. Sarcopenia is characterized by the age-related decline in muscle mass and strength leading to impaired physical performance, and has been described as a biological substrate of physical frailty. Both sarcopenia and physical frailty share phenotypic features of weakness and slowness, lead to common adverse outcomes, and have potential for reversal through early identification and intervention. The purpose of this review is to present recent evidence fo…

Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis.

Although some studies have confirmed the efficacy of probiotics in the treatment of sarcopenia, the intervention of sarcopenia is a comprehensive consideration of many factors, and the efficacy of probiotics is still controversial. Therefore, this study systematically evaluated the efficacy of probiotics in the intervention of sarcopenia via high-quality meta-analysis, providing a basis for the clinical diagnosis and treatment of sarcopenia. Randomized controlled trials related to probiotics in the treatment of sarcopenia were searched in PubMed, Embase, the Cochrane Library and Web of Science…

Sarcopenia and sarcopenic obesity: Their association with postoperative outcomes in patients with hip fractures.

BACKGROUND: Sarcopenia, characterized by age-related loss of muscle mass and function, significantly impacts the quality of life of older adults. This condition is prevalent among elderly patients with hip fractures. OBJECTIVE: To investigate the association of sarcopenia and sarcopenic obesity with mortality and length of hospital stay in patients admitted for hip fracture. Additionally, this study aims to investigate possible risk factors associated with higher mortality rates in the same patient groups. METHODS: A retrospective cohort study was conducted involving patients aged 60 and old…

Biochemical Markers of Sarcopenia as Predictors of Outcomes Among Patients Undergoing Laryngectomy.

BACKGROUND: Sarcopenia, the systemic loss of skeletal muscle mass and function, is prevalent and particularly detrimental to head and neck cancer (HNC) patients. Cancer-associated sarcopenia involves complex mechanisms of poor nutrition and inflammation, highlighting the necessity for preoperative identification of these high-risk patients. METHODS: A multi-site retrospective chart review (2016-2021) was performed on HNC patients undergoing total laryngectomy with or without reconstruction. Preoperative lab values were utilized to calculate markers of sarcopenia including systemic immune infl…

Are There Differences in Postural Control and Muscular Activity in Individuals with COPD and with and Without Sarcopenia?

AIM: The aim of this study was to compare balance performance and electromyographic activity in individuals with COPD, with and without sarcopenia. METHOD: Thirty-five patients with COPD were classified with and without sarcopenia according to EWGSOP criteria. Balance was assessed using a force platform under four conditions: standing with feet apart and eyes opened (FHEO), eyes closed (FHEC), on an unstable surface (US), and on one leg (OLS). The surface electromyography activity of lower limb muscles and trunks was recorded. Additionally, the timed up and go test (TUG) and the Brief Balance…

Risk of sarcopenia among older adults and associated factors in daily life.

BACKGROUND: Sarcopenia-associated lifestyle factors are not fully recognised. Community nurses could identify such factors and promote intervention strategies, mitigating the risk of sarcopenia. AIMS: To investigate the health indicators and lifestyle factors that have an impact on increased sarcopenia risk among older adults in the community. METHODS: A cross-sectional study was conducted with data collected using a structured questionnaire. The SARC-F questionnaire was used for the risk assessment of sarcopenia. The Barthel index, Fatigue Severity Scale, Visual Analogue Scale and Athens In…

Bidirectional association between sarcopenia and depression: A systematic review and meta-analysis.

PURPOSE: Recent research has reported a potential bidirectional association between sarcopenia and depression, yet systematic evidence supporting this relationship is still lacking. This study evaluated the bidirectional association of sarcopenia with depression to provide reliable evidence for the development of specific prevention and control strategies. METHODS: Relevant articles were extracted from PubMed, Embase, Cochrane, and Web of Science from inception to July 4, 2024. Quality was assessed using the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, and the Joanna Brig…

The association between sarcopenia and cardiovascular disease: An investigative analysis from the NHANES.

BACKGROUND AND AIMS: Sarcopenia, a multifaceted chronic condition, exhibits an ambiguous association with cardiovascular disease (CVD). This study aimed to elucidate the connection between sarcopenia and CVD, as well as its implications for cardiovascular prognosis, by analyzing globally representative data from the National Health and Nutrition Examination Survey (NHANES). The findings aim to provide valuable insights for clinical practice and future research endeavors. METHODS AND RESULTS: We used data from the NHANES database covering the period from 2011 to 2018. Sarcopenia was defined ac…

Preoperative Prediction of Sarcopenia in Patients Scheduled for Gastric and Colorectal Cancer Surgery.

INTRODUCTION: Sarcopenia negatively impacts surgical outcomes in gastrointestinal cancer patients, yet practical preoperative screening tools are lacking. The CRP/ALB ratio, a novel biomarker of systemic inflammation and nutritional status, may enhance sarcopenia prediction but remains underexplored in surgical oncology. This study aims to identify the predictors for preoperative sarcopenia prediction in gastric and colorectal cancer patients. METHODS: This retrospective study analyzed 145 patients undergoing curative surgery (2019-2021). Sarcopenia was defined by sex-specific CT-measured L3 …

Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study.

As populations age, sarcopenia increasingly impacts healthcare due to its associations with morbidity, mortality, and cognitive decline. This study is a cross-sectional analysis of prospectively collected data from 140 older adults hospitalized in an internal medicine department. Sarcopenia was measured by handgrip strength, and cognitive function by the Digit Symbol Substitution Test (DSST). Sarcopenic patients (n=78) had lower DSST scores (p=0.003) and Norton scores (p<0.001) compared to non-sarcopenic patients. Handgrip strength showed a significant positive correlation with DSST scores (R=…