Результаты поиска

GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.

Multiple myeloma is a genetically complex and heterogenous malignancy with a 5-year survival rate of approximately 60%. Despite advances in therapy, patients experience cycles of remission and relapse, with each successive line of therapy associated with poorer outcomes; therefore, therapies with different mechanisms of action against new myeloma antigens are needed. G protein-coupled receptor class C group 5 member D (GPRC5D) has emerged as a novel therapeutic target for the treatment of multiple myeloma. We review the biology and target validation of GPRC5D, and clinical data from early phas

Совпадение в полном тексте источника
… Rashes were responsive to emollients, and topical and oral corticosteroids in MonumenTAL-1, and topical glucocorticoids in the trial of MCARH109; in both trials, rashes did not result in study drug discontinuation [ 29 , 41 ]. … Nail-related AEs were reported frequently, were low grade, likely related to on-target activity, and while often resolved without intervention, were sometimes managed with emollients, nail hardeners, vitamin E oil, as well as hydration, biotin, and protective nail coverings based on investigator experience …

Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.

Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antide

Совпадение в полном тексте источника
… Management Eyelid dermatitis is typically managed with emollients, topical corticosteroids, and calcineurin inhibitors (tacrolimus ointment) [ 68 ]. Ocular involvement requires artificial tears, antihistamine or mast cell stabilizer eye drops, and eyelid hygiene (warm compresses and massage). … Emollients are key in maintaining skin barrier integrity and should be routinely used. If contact dermatitis does not respond to standard treatment, topical corticosteroids should be considered, but prolonged use should be avoided. Topical tacrolimus may be an effective alternative. …

An approach to treating older adults with chronic kidney disease.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Metoclopramide (2.5 mg orally every 4 h, as necessary) and ondansetron (4–8 mg orally every 8 h, as necessary). 43 Atypical antipsychotics such as olanzapine (2.5 mg orally every 4 h, as necessary) or low-dose haloperidol (0.5 mg orally every 4 h, as necessary) can be beneficial. 43 Pruritus | Thick emollients …

Application of GPRC5D Targeting Therapy in Relapsed Refractory Multiple Myeloma.

BackgroundAs a rapidly developing therapeutic method, targeted therapy plays an important role in the treatment of multiple myeloma. In recent years, mature B cell antigen-targeting therapy has brought new hope for patients with refractory/relapsed disease. While an increasing number of patients with relapse are exposed to this type of drug, changing the therapeutic target may be an effective strategy for patients with relapse/refractory multiple myeloma.ObjectivesThe expression of G protein-coupled receptor, class C Group 5 member D (GPRC5D), on the surface of myeloma tumor cells makes it a p

Совпадение в полном тексте источника
… Cutaneous‐directed therapeutic interventions, such as the topical application of corticosteroids and emollients, can effectively ameliorate skin‐related symptoms. Cerebellar Dysfunction Cerebellar disorder is a characteristic side effect of CAR‐T cells targeting GPRC5D for the treatment of RRMM. …

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

Совпадение в полном тексте источника
… H2= histamine 2 Topical Medications | Mode of action | Dose Emollients | Improve barrier function | Apply as needed Oat meal extracts | Anti-inflammatory Anti-oxidant | Apply as needed Corticosteroid | Anti-inflammatory | As prescribed Short-term use advocated Tacrolimus Pimecrolimus | Calcineurin inhibitor …

High Serum Carbohydrate Antigen (CA) 125 Level Is Associated With Poor Prognosis in Patients With Light-Chain Cardiac Amyloidosis.

Background and Aims: Patients with light-chain cardiac amyloidosis (AL-CA) are characterized by high levels of serum carbohydrate antigen 125 (CA 125). However, studies have not explored the correlation between CA 125 and AL-CA. The aim of this study was to explore the clinical implications of an increase in CA 125 in patients with AL-CA. Methods and Results: A total of 95 patients diagnosed with AL-CA at the Second Xiangya Hospital were enrolled in this study. Out of the 95 patients with AL-CA, 57 (60%) patients had elevated serum CA 125 levels. The mean age was 59.7 ± 10.0 years with 44 (77.

Bortezomib in the management of multiple myeloma.

Multiple myeloma (MM) is a B-cell malignancy characterized by clonal expansion of plasma cells within the bone marrow, the presence of a serum and/or urine monoclonal protein, lytic bone lesions, and anemia. On a cellular level, the disease is characterized by complex interactions between tumor cells and the surrounding bone marrow microenvironment. Understanding of the relationship between malignant plasma cells and the microenvironment has sparked ongoing efforts to develop targeted therapeutic agents for treatment of this disease. The successful development of the first-in-class small-molec

Совпадение в полном тексте источника
… study in bortezomib-treated MM patients. 60 Similarly, acetyl-L-carnitine, an ammonium-containing compound derived from the amino acids methionine and lysine, has antioxidant and neurotrophic activity and appears to ameliorate chemotherapy-induced PN. 61 In addition, the regular application of thick emollients …

Dermatologic Adverse Events Associated with Selective Fibroblast Growth Factor Receptor Inhibitors: Overview, Prevention, and Management Guidelines.

Fibroblast growth factor receptor (FGFR) tyrosine kinases, which are expressed on the cell membrane, are involved in a wide range of biological functions such as cell proliferation, survival, migration, and differentiation. The identification of FGFR fusions and other alterations in a wide range of solid tumors, including cholangiocarcinoma and bladder cancer, has resulted in the development of several selective FGFR inhibitors for use in these indications, for example, infigratinib, erdafitinib, derazantinib, pemigatinib, and futibatinib. In addition to the typical adverse events associated w

Совпадение в полном тексте источника
… Patients are also advised to avoid biting nails or cutting nails too short and to use topical emollients and loose‐fitting socks and footwear. Preventive correction of nail curvature may be considered. …

T-cell redirecting bispecific antibodies in multiple myeloma: Current landscape and future directions.

T-cell engaging bispecific antibodies (BsAbs) have substantial activity in heavily pretreated patients with multiple myeloma (MM). The overall response rate obtained with B-cell maturation antigen (BCMA)-targeting BsAbs is approximately 60%-70%, including a high proportion of patients achieving very good partial response or complete response. Comparable efficacy is seen with BsAbs targeting GPRC5D or FcRH5. Cytokine release syndrome is frequently observed with BsAb treatment, but mostly during the step-up doses and the first full dose. Early intervention with IL-6 receptor blocking antibodies

Совпадение в полном тексте источника
… A single‐centre study showed that these GPRC5D‐specific adverse events can be managed with topical medications (e.g., triamcinolone cream and emollients for skin toxicities; saliva substitute sprays and rinses for oral toxicities), while dose interruptions are only needed in case of severe adverse events …

Взгляды на амбулаторное лечение би-специальных T-Cell-Worker терапий для нескольких миелом.

В последние несколько лет была разработана новая перспективная терапия под названием < < Участок Т-клеток > > (TCE), которая в настоящее время доступна во многих странах для пациентов с повторной или рефрактной множественной миеломой. Лица, занимающиеся деятельностью Т-клеток, связаны с устойчивыми показателями эффективности и беспрогрессивными льготами по выживанию у пациентов с хорошо обработанной миеломой. Однако такие осложнения, как синдром высвобождения цитокина (CRS), синдром нейротоксичности, связанный с иммунным эффектом клеток (ICANS), и инфекционные заболевания затрудняю

Совпадение в полном тексте источника
… For skin toxicities, moisturizing lotions, emollients, and topical steroids are encouraged. For oral symptoms, optimal mouth hygiene should be maintained, adequate hydration is essential, and saliva substitutes and corticosteroid mouthwash can be used. …

T-cell redirecting bispecific and trispecific antibodies in multiple myeloma beyond BCMA.

Purpose of reviewB-cell maturation antigen (BCMA)-directed T-cell immunotherapies, such as chimeric antigen receptor T-cells (CAR T-cells) and bispecific antibodies (BsAbs) have markedly improved the survival of triple-class refractory multiple myeloma (MM). However, the majority of patients still develops disease progression, underlining the need for new agents for these patients.Recent findingsNovel T-cell redirecting BsAbs targeting alternative tumor-associated antigens have shown great promise in heavily pretreated MM, including patients previously exposed to BCMA-directed therapies. This

Совпадение в полном тексте источника
… Skin toxicities can be managed with supportive care (emollients, triamcinolone cream, and oral steroids for more severe cases) [ 54 ]. Dysgeusia is typically managed by supportive care (e.g., saliva substitute spays and rinses) combined with dose reduction or less frequent administration [ 54 ]. …

Stevens–Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) : Immunologic Reactions

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Treatment with preservative-free emollients, antiseptic or antibiotic eye drops, and vitamin A are the interventions recommended early in the disease course to limit subsequent development of complications. These treatments tend to be more effective if administered earlier [ 64 ]. …

Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity.

Acute radiation dermatitis (ARD) is a common adverse effect experienced by patients undergoing radiation therapy. Effective assessment tools to accurately measure and manage ARD's impact on patients' quality of life and treatment outcomes is needed. The aim of this study was to evaluate the diverse tools and outcome measures used in the assessment of ARD. A systematic review of MEDLINE®, Embase, and Cochrane was conducted for records 1946-March 2024. A total of 423 studies, including 227 randomized controlled trials (RCTs), were included in the analysis. The review identified 58 distinct tools

Совпадение в полном тексте источника
… A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams. Radiother Oncol. 2013;108(2):287–292. doi: 10.1016/j.radonc.2013.05.033. 55. … A novel, multi-active emollient for the prevention of acute radiation dermatitis in breast cancer patients: a randomized clinical trial. Support Care Cancer. 2023;31(12):625. doi: 10.1007/s00520-023-08096-5. 69. Salehi Z., Tavakoli A., Hamedi S.H., Samimi S., Namjooyan F., Ansari M., et al. …

Seamless Navigation of Bispecific Therapies: Optimizing Management and Outpatient Access With a Focus on Coordination.

Bispecific antibodies (BsAbs) have emerged as crucial therapeutic agents for patients with relapsed/refractory diffuse large B-cell lymphoma, multiple myeloma, and most recently, lung cancer. These therapies have demonstrated remarkable efficacy in clinical trials; however, multidisciplinary collaboration is essential to ensure optimal patient outcomes amid the operational complexities associated with BsAb therapy. As BsAbs are being prepared for broader adoption, clinicians and treatment centers must navigate operational challenges, including financial considerations, patient selection, careg

Совпадение в полном тексте источника
… Management of skin reactions with emollients and steroids has proven effective in preliminary trials ( Chari et al., 2022 ; Mailankody et al., 2022 ). …

Clinical perspectives on the optimal use of lenalidomide plus bortezomib and dexamethasone for the treatment of newly diagnosed multiple myeloma.

To improve the outcomes of patients with the otherwise incurable hematologic malignancy of multiple myeloma (MM), a key paradigm includes initial treatment to establish disease control rapidly followed by maintenance therapy to ensure durability of response with manageable toxicity. However, patients' prognosis worsens after relapse, and the disease burden and drug toxicities are generally more challenging with subsequent lines of therapy. It is therefore particularly important that patients with newly diagnosed multiple myeloma (NDMM) receive optimal frontline therapy. The combination of lena

Совпадение в полном тексте источника
… Other strategies as supportive care may also ameliorate toxicities, including emollients and supplements for treatment-emergent PN or infusion of normal saline during bortezomib administration. 57 Stem cell collection following RVd induction is an important consideration for patients who can later pursue …

Potential Protective Role Exerted by Secoiridoids from Olea europaea L. in Cancer, Cardiovascular, Neurodegenerative, Aging-Related, and Immunoinflammatory Diseases.

Iridoids, which have beneficial health properties, include a wide group of cyclopentane [c] pyran monoterpenoids present in plants and insects. The cleavage of the cyclopentane ring leads to secoiridoids. Mainly, secoiridoids have shown a variety of pharmacological effects including anti-diabetic, antioxidant, anti-inflammatory, immunosuppressive, neuroprotective, anti-cancer, and anti-obesity, which increase the interest of studying these types of bioactive compounds in depth. Secoiridoids are thoroughly distributed in several families of plants such as Oleaceae, Valerianaceae, Gentianaceae a

Palliative radiotherapy.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Narrative Review of Drug-Associated Nail Toxicities in Oncologic Patients.

IntroductionNail toxicity represents one of the most common cutaneous adverse effects of both classic chemotherapeutic agents and new oncologic drugs, including targeted treatments and immunotherapy.ObjectivesWe aimed to provide a comprehensive literature review of nail toxicities derived from conventional chemotherapeutic agents, targeted therapies (EGFR inhibitors, multikinase inhibitors, BRAF and MEK inhibitors) and immune checkpoint inhibitors (ICIs), including clinical presentation, implicated drugs and approaches for prevention and management.MethodsRetrieved literature from PubMed regis

Совпадение в полном тексте источника
… Furthermore, daily use of topical emollients on the total nail apparatus (cuticles, plate, and periungual folds) is a prophylactic management for chemotherapy-induced nail toxicity [ 48 ]. …

Talquetamab in Multiple Myeloma: Efficacy, Safety, and Future Directions.

Relapsed and refractory multiple myeloma (RRMM) remains a challenging condition despite advances in immunotherapies. Novel bispecific antibodies (BsAbs), including talquetamab, have shown promising efficacy in heavily pretreated patients, even those with triple- and penta-refractory disease. Talquetamab, recently approved by the FDA and EMA, is indicated for patients who have progressed after at least three or four prior lines of therapy (LOTs). Administered following a step-up dosing phase to manage cytokine release syndrome (CRS), talquetamab demonstrated a high overall response rate (ORR) o

Совпадение в полном тексте источника
… Nail toxicities may be managed with topical moisturizers, topical corticosteroids, emollients, nail soaks, and protective nail coverings. Grade 3 rashes could be managed with topical or oral corticosteroids and talquetamab may be restarted in the majority of patients. …

"Is this the GVHD?" A qualitative exploration of quality of life issues in individuals with graft-versus-host disease following allogeneic stem cell transplant and their experiences of a specialist multidisciplinary bone marrow transplant service.

BackgroundGraft-versus-host disease (GVHD) is a significant cause of morbidity and mortality following allogeneic stem cell transplantation. These patients face unique challenges due to the complexity of GVHD which can affect multiple organ systems, and the toxicity of treatments. Despite the known impact on quality of life (QOL), qualitative data within the bone marrow transplantation (BMT) literature is rare, and there has been no qualitative work exploring patient experience of specialist healthcare provision for GVHD in the United Kingdom.MethodsWe conducted a primary explorative qualitati