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[Ameliorative effect of refined polysaccharides from bran-fried Atractylodis Rhizoma on cyclophosphamide-induced immunosuppression and intestinal injury in mice by regulating linoleic acid metabolism].

By using a mouse model with cyclophosphamide-induced immunosuppression and intestinal injury, this study evaluated the therapeutic advantage … es from bran-fried Atractylodis Rhizoma(842 mg·kg~(-1)), and a positive control group(40 mg·kg~(-1) levamisole hydrochloride), with 10 mice in each group. The normal group was administered saline via gavage, while the other groups received their respective treatments for 15 consecutive days. Except for the normal group, all other groups were intraperitoneall …

The development and use of a drug-induced immunosuppressed rat-model to screen Phela for mechanism of immune stimulation.

ETHNOPHARMACOLOGY RELEVANCY: Phela, is code name for a medicinal product made from four South African traditional medicinal plants (Cleroden … ments, the effective dose of Phela in the study animals was determined in a dose ranging study with levamisole, a known immune stimulant as the positive control; the appropriate doses for immunosuppression by CsA, CP and Dex were determined; the time to reach 'established immunosuppression' with each drug was determined (it was also the time for intervention …

Saliva как матрица для терапевтического мониторинга наркотиков и биомаркеров заболеваний у детей и подростков.

Saliva — более доступная, менее напряженная и менее дорогостоящая биологическая матрица, чем кровь, и она может применяться в терапевтическом мониторинге лекарственных средств (ПТМ). Концентрации слюны отражают фармацевтический активный ненавязанный препарат. В этом обзоре содержится последняя информация о слюне в качестве матрицы для лечебного контроля за наркотиками и определения биомаркеров у младенцев, детей и подростков. К октябрю 2024 года по базе данных PubMed были проведены обыски литературы, 64 исследования были включены в TDM, стероиды, добавки, биомаркеры заболеваний, стоматология,

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… The concentrations below 1 ng/mL were determined for enalapril, enalaprilat, and levamisole (0.1 µg/L for each) [ 33 , 36 ], aliskiren (0.59 ng/mL) [ 33 ], and mycophenolate mofetil (0.025 ng/mL) [ 65 ], whereas 1.0 ng/mL was set for perampanel [ 6 ]. … Levamisole saliva concentrations were slightly higher due to the drug protonation, limiting its return from saliva to plasma [ 36 ]. …

[Multicenter survey of diagnostic and therapeutic status in Chinese childhood patients with steroid-sensitive, relaping/steroid-dependent nephrotic syndrome].

OBJECTIVE: Nephrotic syndrome (NS) was recognized as a clinical syndrome caused by massive proteinuria, leading to hypoalbuminemia and edema … .4%) and FK506 40 cases(10.0%). The cases treated with ACEI accounted for 24.0% (894 cases),ARB and levamisole accounted for 0.8% (28 cases) and 2.8% (106 cases), respectively. CONCLUSION: In recent years, the proportion of children with PNS in the hospitalized childhood patients with urologic-kidney diseases was stable. The most common cases were the first …

Role of liquid chromatography-high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology.

BACKGROUND: Gas chromatography (GC) and liquid chromatography (LC) coupled with mass spectrometry (MS) are widely used to confirm drug scree … R/MS has been used to detect designer drugs, doping agents, (neurosteroids) and adulterants such as levamisole, a veterinary antihelmitic found in street cocaine, and pharmaceuticals in herbal medications marketed to contain only natural ingredients. LC-HR/MS has proved useful for cases where existing tests were unable to identify the cause of the intoxicati …

Optimal duration of adjuvant therapy for stage III colon cancer.

Colon cancer remains a major cause of mortality worldwide. Following adequate surgical resection of lymph node-positive colon cancer, the standard of care since 2004 has been to administer an oxaliplatin-containing regimen (eg, FOLFOX or CAPOX) for 6 months. These regimens have consistently improved oncologic outcomes compared with non-oxaliplatin therapies in multiple adjuvant randomized controlled trials. However, oxaliplatin-induced cumulative dose-dependent neurotoxicity is a major cause of morbidity that can persist years after treatment. The IDEA collaboration is a study that pooled data

Efficacy and safety of thalidomide for recurrent aphthous stomatitis: a systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Recurrent aphthous stomatitis (RAS) is considered as the most common oral mucosal lesion affecting up to 25% of people worldwide. Thalidomide has been reported for the treatment of RAS, but the evidence has not been systematically evaluated. We first systematically reviewed the efficacy and safety of thalidomide for the treatment of RAS. METHODS: We searched The Cochrane Library, PubMed, Scopus, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Chinese BioMedical Literature Database (CBM), Wanfang Data, and VIP information from inception to December 2023. Ran

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… For systemic drugs, corticosteroids, thalidomide, levamisole, dapsone, colchicine, seem to exert certain effects through different mechanisms [ 7 ]. In addition, the Consensus of China also recommends Traditional Chinese Medicine (TCM) for RAS [ 8 ]. … weeks, G3: Thalidomide 25 mg/d for 8 weeks, G4: Thalidomide 50 mg/d for 4 weeks, G5: Thalidomide 50 mg/d for 8 weeks, | G1: basic treatment | 4 or 8 weeks | Recurrence interval, VAS score, number of ulcers, adverse effects Gao Q [ 24 ] | major RAS | RCT | 30 | 30 | thalidomide:25 mg×2/d for 8 weeks | levamisole …

G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior.

In this study, we address why metabotropic and ionotropic cholinergic signaling pathways are used to facilitate motor behaviors. We demonstrate that a G alpha(q)-coupled muscarinic acetylcholine receptor (mAChR) signaling pathway enhances nicotinic acetylcholine receptor (nAChR) signaling to facilitate the insertion of the Caenorhabditis elegans male copulatory spicules into the hermaphrodite during mating. Previous studies showed that ACh (acetylcholine) activates nAChRs on the spicule protractor muscles to induce the attached spicules to extend from the tail. Using the mAChR agonist Oxo M (o

Rare complication of a commonly used antihypertensive agent: A case of hydralazine-induced ANCA-associated vasculitis presenting as rapidly progressive glomerulonephritis.

Hydralazine-induced ANCA-associated vasculitis is a rare clinical entity, with complications including rapidly progressive glomerulonephritis, pulmonary hemorrhage, and pulmonary-renal syndrome. We present this case to highlight the clinical features that support this challenging diagnosis and to emphasize the importance of prompt recognition and aggressive intervention given its significant morbidity and mortality.

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… , 12 Although idiopathic AAV is well‐documented in the literature, drug‐induced vasculitis is a subset of AAV that remains ill‐defined; predominately related to key medication exposures, including hydralazine, allopurinol, propylthiouracil, minocycline, phenytoin, penicillamine, sulfasalazine, and levamisole‐adulterated …

The treatment of multiple myeloma--an important MRC trial.

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… Alternating combination chemotherapy and levamisole improves survival in multiple myeloma: a Southwest Oncology Group Study. 1 8 8 1983 453 461 J Clin Oncol 6366141 10.1200/JCO.1983.1.8.453 Samson D. Gaminara E. Newland A. Van de Pette J. Kearney J. McCarthy D. Joyner M. Aston L. Mitchell T. …

Update on cutaneous calciphylaxis.

Calciphylaxis is a devastating disorder with a mortality rate of 80% due to sepsis and organ failure. Hallmarks of this rare disease are arteriolar media calcification, thrombotic cutaneous ischemia, and necrotic ulcerations. Different mechanisms of vascular calcification can lead to calciphylaxis. Early diagnosis by deep cutaneous ulcer biopsy is most important for prognosis. Here, dermatologists play a significant role although treatment usually needs an interdisciplinary approach. Surgical procedures had been the cornerstone of treatment in the past including parathyroidectomy, but recently

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… a) Calcium-containing phosphate binders. b) Vitamin-K antagonists. c) Systemic corticosteroids. d) Levamisole. Which medical drugs seem to be beneficial in multimodal therapy of calciphylaxis? a) Heparin. b) Cinacalcet. c) Systemic corticosteroids. d) Sodium thiosulfate. …

Treatment of multiple myeloma according to the extension of the disease: a prospective, randomised study comparing a less with a more aggressive cystostatic policy. Cooperative Group of Study and Treatment of Multiple Myeloma.

The purpose of the study was to ascertain whether the prognostic significance of staging in multiple myeloma (MM) is influenced by the aggressiveness of effective induction treatment and/or by continuing or discontinuing maintenance chemotherapy. Patients with untreated stage I MM (defined according to Durie and Salmon) were randomised between being followed without cytostatics until the disease progressed and receiving six courses of melphalan and prednisone (MP-P) just after diagnosis; stage II patients were uniformly treated with MPH-P and stage III patients were randomised between MPH-P an

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… Alternating combination chemotherapy and levamisole improves survival in multiple myeloma: a Southwest Oncology Group Study. 1 8 8 1983 453 461 J Clin Oncol 6366141 10.1200/JCO.1983.1.8.453 Ucci G. Petrini M. Riccardi A. Invernizzi R. Carulli G. Luoni R. Giordano M. Danova M. …

Increased Cytoplasmic CD138 Expression Is Associated with Aggressive Characteristics in Prostate Cancer and Is an Independent Predictor for Biochemical Recurrence.

Syndecan-1 (CD138) is a transmembrane proteoglycan expressed in various normal and malignant tissues. It is of interest due to a possible prognostic effect in tumors and its role as a target for the antibody-drug conjugate indatuximab ravtansine. Here, we analyzed 17,747 prostate cancers by immunohistochemistry. Membranous and cytoplasmic CD138 staining was separately recorded. In normal prostate glands, CD138 staining was limited to basal cells. In cancers, membranous CD138 positivity was seen in 19.6% and cytoplasmic CD138 staining in 11.2% of 12,851 interpretable cases. A comparison with cl

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… Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines Indian Journal of Cancer 2017 54 3 566 571 10.4103/ijc.IJC_349_17 2-s2.0-85047779631 29798960 15 Brimo F. Vollmer R. T. Friszt M. Corcos J. Bismar T. A. …

37th International Symposium on Intensive Care and Emergency Medicine (part 1 of 3) : Brussels, Belgium. 21–24 March 2017

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Secondary Neutropenias.

Neutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that typically present with muted symptoms. Neutropenias encompass a heterogeneous set of disorders, comprising primary neutropenias, in which specific genes are mutated, and the more common secondary neutropenias, which have diverse non-genetic causes. These include hematological and other cancers, inv

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… paclitaxel, vinblastine biological agents | ipilimumab, nivolumab, pembrolizumab, rituximab cell-based therapies | CAR-T therapy, HSCT Other drugs | analgesics/NSAIDs | aspirin, diclofenac, ibuprofen, tenoxicam anticonvulsants | carbamazepine, phenytoin, valproate antimicrobials | acyclovir, chloroquine, levamisole … , penicillins, tetracycline, trimethoprim-sulfamethoxazol antipsychotics | amoxapine, clozapine, diazepam, olanzapine, phenothiazines antirheumatics | gold, levamisole antithyroids | carbimazole, methimazole, propylthiouracil non-cancer biologicals | tocizulimab other | aminopyrine, deferiprone, digoxin …

IL-38 as a Novel Biomarker in Multiple Myeloma Patients: A Prospective Clinical Evaluation.

IntroductionMultiple myeloma (MM) is a refractory haematological malignancy. Interleukin 38 (IL-38) is a novel cytokine that has attracted significant research in recently years. However, no study has investigated IL-38 expression in MM. This study aims to investigate the expression of IL-38 in MM and to provide valuable insights for clinical treatment and efficacy evaluation.MethodsA total of 241 patients with MM (146 males, 95 females; R-ISS stage I: 111 cases, stage II: 74 cases, stage III: 56 cases) and 50 healthy individuals were included in this study. Medical records were reviewed for s

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… Effect of levamisole on expression of CD138 and interleukin-6 in human multiple myeloma cell lines . Indian J Cancer . 2017 ; 54 ( 3 ): 566 – 571 . PMID: 29798960 . doi: 10.4103/ijc.IJC_349_17 29798960 25. Alexandrakis MG , Goulidaki N , Pappa CA , et al. …

Interventions for prevention of herpes simplex labialis (cold sores on the lips).

BACKGROUND: Herpes simplex labialis (HSL), also known as cold sores, is a common disease of the lips caused by the herpes simplex virus, whi … nd yellow fever vaccine in preventing HSL. There were no consistent data supporting the efficacy of levamisole and interferon, which were also associated with an increased risk of adverse effects such as fever. AUTHORS' CONCLUSIONS: The current evidence demonstrates that long-term use of oral antiviral agents can prevent HSL, but the clinical benefit is sma …

Nursing Procedures for the Prevention and Treatment of Mucositis Induced by Cancer Therapies: Clinical Practice Guideline Based on an Interdisciplinary Consensus Process and a Systematic Literature Search.

BackgroundPatients with cancer receiving tumor therapy often suffer from oral mucositis.ObjectivesThe aim of this project was to summarize experiences with nursing procedures by experts in integrative oncology and to establish recommendations for nursing interventions that can prevent or cure mucositis.MethodsThe study design was an interdisciplinary consensus process based on a systematic literature search.ResultsThe panel discussed and agreed on 19 nursing procedures, which included mouthwashes, such as teas, supplements, oil applications, and different kinds of ice cubes to suck, as well as

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… Study | Methods | Patients | Intervention/Control | Aims/Outcomes | Results | Conclusion Fidler et al 11 | Randomized, double-blind, placebo-control, 2 parallel arms | 165 patients with cancer receiving first 5-FU–based chemotherapy (6 different regimes with 5-FU leucovorin ± levamisole or 5-FU and L-isomer …

Skin manifestations associated with systemic diseases - Part I.

The skin demonstrates what is happening in the body in many diseases, as it reflects some internal processes on the surface. In this sense, skin as an organ, goes beyond its protective and barrier functions, as it provides clues for the identification of some systemic diseases. The dermatologist then raises diagnostic hypotheses for conditions related to all systems and refers them to the appropriate specialty. With easy access to examination by trained eyes and biopsies, the skin can present specific or non specific alterations on histopathology. In the first case this combination establishes

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… Medications (resolution with drug withdrawal) anti-TNFa, levamisole, propylthiouracil, hydralazine, rituximab, montelukast, statins. 39 Neoplasms Paraneoplastic syndromes (lymphoproliferative and myeloproliferative diseases) Others Dermatomyositis Systemic sclerosis Inflammatory bowel diseases COVID … Medications (resolution with drug withdrawal) | anti-TNFa, levamisole, propylthiouracil, hydralazine, rituximab, montelukast, statins. 39 Neoplasms | Paraneoplastic syndromes (lymphoproliferative and myeloproliferative diseases) Others | Dermatomyositis Systemic sclerosis Inflammatory bowel diseases …

Неожиданное возрождение в отсутствие матричной металопротеины 7.

В множестве склерозов (MS) приток иммунных клеток в центральную нервную систему приводит к обезвоживанию мозга, зрительного нерва и спинного мозга. По мере того как MS прогрессирует, воспоминание становится все более неэффективным, что делает нейронные аксоны уязвимыми для дегенерации и приводит к постоянной неврологической инвалидности. При хронических поражениях MS аберрантная аккумуляция молекул внеклеточной матрицы (ECM), включая фибронектин и гиалуронан, ухудшает олигодендроцитную дифференциацию клеточных клеток, что ведет к сбоям в ремилинации. Таким образом, устранение ингибиторских УХМ

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… Next, slides were developed in the dark at 37°C in predevelopment buffer to which 1 mM levamisole, 262.5 μg/mL, and 225 μg/mL BCIP were added. After 2 h, the color reaction was stopped by washing in 10 mM Tris and 1 mM EDTA. …