Результаты поиска

Digoxin remains useful in the management of chronic heart failure.

Despite the introduction of a variety of new classes of drugs for the management of heart failure, digoxin continues to have an important ro … kalemia, hypomagnesemia, or hypothyroidism coexist. Likewise, the concomitant use of agents such as quinidine, verapamil, spironolactone, flecainide, and amiodarone can increase serum digoxin levels and increase the likelihood of digoxin toxicity. 7. For patients with heart failure and atrial fibrillation with a rapid ventricular response, the administratio …

Delavirdine: a review of its use in HIV infection.

UNLABELLED: Delavirdine, a bisheteroarylpiperazine derivative, is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that allosterical … mmended for use with lovastatin, simvastatin, rifabutin, rifampicin, sildenafil, ergot derivatives, quinidine, midazolam, carbamazepine, phenobarbital or phenytoin. Importantly, the drug favourably increases the plasma concentration of several protease inhibitors. Delavirdine is generally well tolerated. Skin rash is the most frequently reported adverse eff …

Edoxaban for venous thromboembolism in patients with cancer: results from a non-inferiority subgroup analysis of the Hokusai-VTE randomised, double-blind, double-dummy trial.

BACKGROUND: Venous thromboembolism occurs commonly in patients with cancer. Direct oral anticoagulants are non-inferior to conventional anti … , bodyweight <60 kg, or who were receiving concomitant treatment with the P-glycoprotein inhibitors quinidine or verapamil) or warfarin (dose adjusted to maintain the international normalised ratio between 2·0 and 3·0) or placebos for either group for at least 3 months up to 12 months. All patients received initial therapy with open-label enoxaparin or unfr …

Сердечно-сосудистые заболевания

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Treatment with quinidine or digoxin followed by quinidine may be expensive and requires careful clinical and ECG monitoring to avoid toxic side effects. … Following this time, quinidine is administered as in (1) above. In all treatment protocols, side effects of quinidine such as diarrhea, rumen hypermotility, and tachycardia must be anticipated. …

Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

In vitro and in vivo pharmacological screening of Betulinic acid (BA) and five dihydro-BA derivatives modified at C-3 position [4-nitrobenzyl-oximino (1), 2-4-difluoro-benzoyloxy (2), 2-4-difluoro-benzylidene-amino (3), benzoyl-hydrazono (4), and 4-fluorophenyl-hydrazono (5)], having potent in vitro anti-cancer activity was carried out using ADME, animal PK and tumor studies. We found that BA and the derivatives had poor aqueous solubility (<0.1 microg/ml), low to moderate permeability (log Pe<-5.0) and high plasma protein binding (>70%). Although BA and 5 were metabolized by human liver micro

Сердечно-сосудистые заболевания

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.

PURPOSE: We characterized three canine P-gp (cP-gp) deficient MDCKII cell lines. Their relevance for identifying efflux transporter substrates and predicting limitation of brain penetration were evaluated. In addition, we discuss how compound selection can be done in drug discovery by using these cell systems. METHOD: hMDR1, hBCRP-transfected, and non-transfected MDCKII ZFN cells (all with knock-down of endogenous cP-gp) were used for measuring permeability and efflux ratios for substrates. The compounds were also tested in MDR1_Caco-2 and BCRP_Caco-2, each with a double knock-out of BCRP/MRP

Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features.

The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. This well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies also occur. These molecules are lysosomotropic amines th

Совпадение в полном тексте источника
… These observations indicate that, in association with all-trans retinoic acid, quinidine, quinine, chloroquine, or hydroxychloroquine regulates protein acetylation events and the combination with all-trans retinoic acid stimulates histone acetyltransferase and inhibits HDAC enzymes in breast cancers … Myc protein is differentially sensitive to quinidine in tumor versus immortalized breast epithelial cell lines. International Journal of Cancer. 2002;102(1):60–69. doi: 10.1002/ijc.10648. 76. Martirosyan A. R., Rahim-Bata R., Freeman A. B., Clarke C. D., Howard R. L., Strobl J. S. …

Results of a phase III, double-blind, placebo-controlled trial of megestrol acetate modulation of P-glycoprotein-mediated drug resistance in the first-line management of small-cell lung carcinoma.

The objective of this study was to determine if the addition of megestrol acetate (MA), a modulator of P-glycoprotein-mediated drug resistance, to first-line cytotoxic therapy in patients with limited and advanced stage small-cell lung cancer (SCLC) would improve median time to disease progression and median overall survival. Secondary outcomes evaluated were response rates and patient symptom profile. Between 1992 and 1995, 130 eligible patients were randomized in a double-blind fashion to receive standard first-line therapy consisting of alternating courses of cyclophosphamide/doxorubicin/vi

Совпадение в полном тексте источника
… Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled randomized trial. 12 9 9 1994 1771 1777 J Clin Oncol 8083699 10.1200/JCO.1994.12.9.1771 de Jong S. Zijlstra J. G. de Vries E. G. Mulder N. H. …

Использование нефротоксичных препаратов у взрослых, страдающих хроническим заболеванием почек, в рамках обычного лечения в Швеции и США.

Характеристика применения нефротоксичных препаратов у пациентов с хроническим заболеванием почек (CKD) G3-5 в обычном уходе. Мы изучали когорты взрослых с подтвержденным ККД G3-5 :: рутинная медицинская помощь 1 Январь 2016 до конца 31 декабрь 2018 В two [Stockholm CREAM, Стокгольм, Швеция (N = 57 880) и Geininger, PA, USA (N = 16 255] Мы оценили долю пациентов, получающих нефротоксичные препараты внутри 1 Год в целом и по базовой функции почек, ранжировали основных плательщиков и изучили связь между получением нефротоксичных лекарств и возрастом, сексом, СКД G-стадиями коморбиды и осведомленн

Совпадение в полном тексте источника
… medications in Geisinger and ranking of most commonly prescribed drug classes, overall and by eGFR category Values are presented as % ( n ) unless stated otherwise. a Among NSAID users, proportions receiving one/two/three or more dispensations, overall and by eGFR category. b Medications included in others: quinidine … Medications included in the ‘Others’ class are isotretinoin, amphotericin B, normal human immunoglobulins, deferasirox and palifermin for SCREAM (Panel A) and quinidine, isotretinoin, amphotericin B, normal human immunoglobulins, deferasirox and palifermin for Geisinger (Panel B). …

Genetic and Mechanistic Insights Inform Amyotrophic Lateral Sclerosis Treatment and Symptomatic Management: Current and Emerging Therapeutics and Clinical Trial Design Considerations.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both upper and lower motor neurons. ALS is classically characterized by painless progressive weakness, causing impaired function of limbs, speech, swallowing, and respiratory function. The disease is fatal within 2-4 years, often the result of respiratory failure. The pathologic hallmark for a majority of ALS cases is aberrant cytoplasmic accumulations of the nuclear protein TAR-DNA binding protein (TDP-43). A total of 10-15% of ALS can be attributed to a single gene mutation, known as genetic or "familia

Совпадение в полном тексте источника
… Currently there is one medication, dextromethorphan/quinidine (DMQ) (marketed as Nuedexta), specifically FDA-approved for PBA. … Patient-reported episodes of PBA were reduced in patients taking DMQ compared with quinidine alone with significant improvement in quality-of-life measures over 29 days. The most common side effects were nausea, dizziness, and loose stools. …

Исследование безопасности фамфридина у пациентов с различными стадиями множественного склероза.

Fampridine является единственным лекарственным средством, утвержденным Администрацией США по контролю за продуктами питания и лекарствами для лиц с множественным склерозом (MS) в целях улучшения их передвижения и продемонстрировал клинически существенное улучшение функции похода в группе пациентов с повышенным уровнем инвалидности (ESDSS) из группы MS. 4 в адрес 7. Тем не менее, согласно сообщениям, это лекарство имеет некоторые неблагоприятные последствия (АЭ), такие, как припадок из-за его фармакологических свойств. Цель этого исследования заключалась в оценке распространенности побочных эфф

Совпадение в полном тексте источника
… Patients using metformin, cimetidine, and quinidine were not included in the study due to the contraindication of these drugs with fampridine. …

A randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts (MeCOVID Trial): A structured summary of a study protocol for a randomised controlled trial.

OBJECTIVES: Primary objective: to evaluate the efficacy of melatonin as a prophylactic treatment on prevention of symptomatic SARS-CoV-2 inf … romycin, halofantrine, haloperidol, lumefantrine, mefloquine, methadone, pentamidine, procainamide, quinidine, quinine, sotalol, sparfloxacin, thioridazine, amiodarone.Hereditary intolerance to galactose, Lapp lactase deficiency or glucose or galactose malabsorption.Treatment with fluvoxamine.Treatment with benzodiazepines or benzodiazepine analogues such a …

Recommendations from the Clinical Toxicology Recommendations Collaborative on the administration of activated charcoal in acute oral overdose.

INTRODUCTION: The Clinical Toxicology Recommendations Collaborative was established by three international clinical toxicology societies and … ds, organophosphorus insecticides, paracetamol (acetaminophen), paraquat, phenobarbital, phenytoin, quinidine and quinine, salicylates, selective serotonin reuptake inhibitors, sulfonylureas, thallium, theophylline, tricyclic antidepressants, valproic acid, venlafaxine, and warfarin. An additional dose of activated charcoal to complete gastrointestinal deco …

Randomized clinical trial to compare the efficacy of ivermectin versus placebo to negativize nasopharyngeal PCR in patients with early COVID-19 in Peru (SAINT-Peru): a structured summary of a study protocol for randomized controlled trial.

OBJECTIVES: The primary objective is to determine the effect of a daily dose of ivermectin administered in three consecutive days to non-sev … 5. Capable to give informed consent. 6. Not current use of CYP 3A4 or P-gp inhibitor drugs such as quinidine, amiodarone, diltiazem, spironolactone, verapamil, clarithromycin, erythromycin, itraconazole, ketoconazole, cyclosporine, tacrolimus, indinavir, ritonavir, cobicistat or critical CYP3A4 substrate drugs such as warfarin. Exclusion criteria 1. COVID- …

Diagnosis and management of neutropenia in adults: Expert guidance.

Neutropenia in general is defined as a blood neutrophil count of less than 1.5 × 109/L, in severe neutropenia counts drop to less than 0.5 × 109/L, but the definition of neutropenia varies according to the patient's ethnic origin and age. For Caucasian adults, the absolute neutrophil count (ANC) threshold of 1.8 × 109/L is adopted for the definition of neutropenia according to the World Health Organization (see Fioredda et al. (1)). It can be inherited or acquired, and it is an uncommon haematological finding in adult outpatient clinics. Neutropenia can result from decreased production of neut

Совпадение в полном тексте источника
… sulfasalazine, vancomycin, rifampicin, fluconazole, ketoconazole), anti‐diuretics (furosemide, spironolactone), antiretroviral human immunodeficiency virus (HIV) therapy, anti‐thyroids (tiamazofe, metimazole), clozapine (olanzapine), deferiprone, dipyrone (metamizole), phenothiazines (alimemazine) and quinine/quinidine …

Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer.

AimSSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.ResultsHigh levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.ConclusionIncreases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmati

Совпадение в полном тексте источника
… Pharmacokinet. 14 1 35 51 1988 3280212 10.2165/00003088-198814010-00003 • A comprehensive account on the pharmacology and pharmacokinetics of amantadine. 36 Gaudry SE Sitar DS Smyth DD McKenzie JK Aoki FY Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine …