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Systematic analysis of spontaneous tandem genome amplification events in Yersinia pestis.

Tandem amplification of genomic fragments is quite common in bacteria growing under stress conditions, while spontaneous genome amplification events are rare, unstable and generally poorly described. Plague pathogen Yersinia pestis is a unique microorganism that contains an enormous number of short repeat sequences in its genome and as a result is very prone to spontaneous genome rearrangements including large tandem genome amplification events. Eleven Y. pestis strains sequenced during this study and more than thousand read archives from SRA were analyzed in this study. It was shown that geno…

Выдержка гемпта (Extractum Cannabis) в деле " Лечение кишечных расстройств и диспепсии: исторические сведения из Барселоны, Испания " .

В этом исследовании изучается траектория интереса и использования экстракта каннабиса (выдержка канабиса сативы L.) для симптоматического лечения легких желудочно-кишечных расстройств и диспепсии в Барселоне XIX и начала XX века (Каталония, Испания) 1939, на основе обзора первичных источников. Цель настоящего документа заключается в том, чтобы представить исторический фармацевтический и прикладный обзор использования гематома (Cannabis L.) в медицинских целях до его запрещения, способствуя тем самым его признанию в качестве медицинского продукта. Представленная информация свидетельствует об ис

Совпадение в аннотации оригинала
This study explores the trajectory of interest in and use of Extractum Cannabis (hemp extract, i.e., extract of Cannabis sativa L.) for the … tives. Within its limitations-including the scope, limited accessibility to, and varying quality of archives-this research contributes to a more granular understanding of the historical embeddedness of psychoactive hemp medicines in northeastern Spain, suggesting that medical and pharmaceutical traditions could play a role in informing contemporary approac …

Surveillance Program of Clinical Samples for Polio and Non-Polio Enteroviruses in the Slovak Republic during the 1958-2020 Period.

Enteroviruses (EVs) are associated with a wide spectrum of diseases involving various organs. Our aim was to give a historical overview of the genesis of clinical sample processing for EVs in the Slovak Republic (SR) during the 1958-2020 period, within the framework of the World Health Organization (WHO) polio program. Further, analyses were made of the data obtained from the archives of processed clinical sample surveillance using statistical methods. We used generalized additive models (GAM) with binomial distribution and logit link functions and an autoregressive moving average (ARMA) to an…

Lymphocyte-Peppered Sclerotic Collagen: An Additional Histological Clue in Lichen Sclerosus, Morphea, and Systemic Sclerosis.

BACKGROUND: "Line sign," "cookie cutter sign," "square biopsy sign," "high eccrine glands sign" have been previously described in morphoea and lichen sclerosus. We found focal areas of thickened collagen bundles with lymphocytes interspersed between them in several biopsies of these conditions. MATERIALS AND METHODS: We reviewed slides of sclerosing disorders obtained from the archives of the pathology department in our hospital for the period 2013-2019. RESULTS: A total of 73 slides including 40 of lichen sclerosus, 24 of morphea, 2 of lichen sclerosus-morphea overlap, and 7 of systemic scl…

[The activities of the field-doctor I. T. Voskoboynikov at Kama mills at the turn of XVIII-XIX centuries].

The article considers the main facts of the biography of the field-doctor I. T. Voskoboynikov during his activities in the Kama mills (Izhev … rial centers of the region. The research was based on materials from number of central and regional archives.

Occlusal dysesthesia-A clinical guideline.

BACKGROUND: The diagnosis and management of patients suffering from occlusal dysesthesia (OD) remain a major challenge for dental practitioners and affected patients. OBJECTIVES: To present the results of a literature-based expert consensus intended to promote better understanding of OD and to facilitate the identification and management of affected patients. METHODS: In 2018, electronic literature searches were carried out in PubMed, Cochrane Library and Google Scholar as well as in the archives of relevant journals not listed in these databases. This approach was complemented by a careful …

Class and classification: the London Word Blind Centre for Dyslexic children, 1962-1972.

The Word Blind Centre for Dyslexic Children opened in London in 1963. It was not only the first clinic established in Britain specifically to cater for children diagnosed with dyslexia. It was also intended to provide compelling evidence that a condition called dyslexia actually existed. The results of this work were published in Sandhaya Naidoo's path-breaking study, Specific Dyslexia, which did exactly what its promoters had hoped it would, drawing on in-depth studies of 196 children to argue that dyslexia was indeed a distinct 'constitutional disorder'. Using the archives produced by Naidoo…

Haematopoiesis, or Blood Poetry.

"It was just a few small red dots," I would recount to innumerable sympathetic nurses. They-the dots, not nurses-clustered together on my so … rsation with friends? In dreams from which I wake gasping? By scouring the sentences of authors and archives? From the discoveries of Paul Ehrlich to the scattered words of Emily Dickinson to the constant mechanical chugging of the IV pump, this interdisciplinary essay delves into the medical and cultural history of blood and bone marrow to tell an acutely …

A Humanist Neurosurgeon: A Legacy of Dr. Roy Selby.

The article is dedicated to the life and work of Dr. Roy Selby (1930-2002), an American neurosurgeon who founded neurosurgery in Malaysia. D … ated international standards of training in neurosurgery. From 1985 to 1994, he was chairman of the Archives Committee of the American Association of Neurological Surgeons. Dr. Selby serves as a model of a physician as a humanist.

Granulomatous Lobular Mastitis: Clinicopathologic Presentation of 90 Cases.

OBJECTIVE: Granulomatous lobular mastitis is a rare benign chronic breast disease first described by Milward in 1970, and then by Kessler and Wolloch in 1972. In this study, we aimed to present clinicopathologic features of granulomatous lobular mastitis with literature data. MATERIAL AND METHOD: In this study, the archives of Uludag University Medical Faculty Department of Pathology were screened for granulomatous lobular mastitis cases between 2005 and 2017. RESULTS: A total of 90 patients with granulomatous lobular mastitis diagnosed between 2005 and 2017 were identified. All of the cases…

The re-awakening of hCG expression. Its role in the diagnosis of cervical squamous cell carcinoma.

OBJECTIVES: To compare immunohistochemical detection of Human chorionic gonadotropin (hCG) expression in paraffin embedded tissue of squamous cell carcinomas (SCC) and high grade squamous intraepithelial lesions (HSIL). METHODS: The samples in this retrospective study were obtained from the archives of the Pathology Department at Gaziantep University, Gaziantep, Turkey, over the period from January 2012 to September 2016. The study group consisted of 55 cases of SCC and 45 cases of HSIL. Tissue expression of hCG was detected by specific binding of anti-hCG antibody using an automated immunohi…

Multiple sclerosis as an adverse drug reaction: clues from the FDA Adverse Event Reporting System.

BACKGROUND: Possible relationship between drug exposure and multiple sclerosis (MS) development is insufficiently investigated, and further challenged by the incomplete understanding of MS etiopathogenesis. The study aims to investigate whether drug exposure could contribute to MS, by analyzing worldwide spontaneous reporting archives of adverse drug reaction (ADRs). RESEARCH DESIGN AND METHODS: We retrieved information from the US Food and Drug Administration Adverse Event Reporting System (FAERS) over a 13-year period. Reporting odds ratio (ROR) for MS was calculated for each single substan…

The Yellow Fever Vaccine Misadventure of 1942.

In 1942, a hepatitis B outbreak occurred in the US Army after vaccination with contaminated lots of 17D yellow fever vaccine; long-term sequelae were surprisingly limited, and retrospective studies of carrier rates, cirrhosis, and hepatocellular carcinoma were found to be minimal. Later studies identified the contaminant as hepatitis B virus (HBV) in the human serum component of the vaccine. Other than 2 follow-up studies of long-term sequelae and reports within US Military archives, the event has never been fully elucidated in its proper historical context in the medical literature available …

ERG expression in multiple myeloma-A potential diagnostic pitfall.

INTRODUCTION: ERG expression has been described as a frequent event in prostate cancer indicating poor prognosis and promoting oncogenesis. … sequently selected 12 formalin-fixed, paraffin-embedded tissue samples of multiple myeloma from our archives and performed immunohistochemical staining for ERG. RESULTS: All 12 analyzed cases showed strong nuclear expression of ERG in >90% of tumor cells (myeloma cells). CONCLUSIONS: This report highlights a potential and critical diagnostic pitfall in b …

Safety in ready mixed concrete industry: descriptive analysis of injuries and development of preventive measures.

Ready mixed concrete (RMC) industry, one of the barebones of construction sector, has its distinctive occupational safety and health (OSH) r … . This study aims to fill this gap by conducting data mining in Turkish Social Security Institution archives and performing univariate frequency and cross tabulation analysis on 71 incidents that RMC truck drivers were involved. Also, investigations and interviews were conducted in seven RMC plants in Turkey and Netherlands with OSH point of view. Based on …

Invited commentary on comparison of robotics, functional electrical stimulation, and motor learning methods for treatment of persistent upper extremity dysfunction after stroke: a randomized controlled trial.

In this issue of Archives of Physical Medicine and Rehabilitation, Jessica McCabe and colleagues report findings from their methodologically sound, dose-matched clinical trial in 39 patients beyond 6 months poststroke. In this phase II trial, the effects of 60 treatment sessions, each involving 3.5 hours of intensive practice plus either 1.5 hours of functional electrical stimulation (FES) or a shoulder-arm robotic therapy, were compared with 5 hours of intensive daily practice alone. Although no significant between-group differences were found on the primary outcome measure of Arm Motor Abili…

A cadaver study revisiting the original methodology of Lauge-Hansen and a commentary on modern usage.

BACKGROUND: The study by Lauge-Hansen published in the Archives of Surgery in 1950 still stands as the seminal work for our understanding of the pathomechanics of ankle fractures. The purpose of the present study was to recreate Lauge-Hansen's experiments for the supination-external rotation (SER) fracture mechanism and to determine whether the predicted sequence of osseous and soft-tissue injury is reproducible on the basis of his originally described methodology. METHODS: Ten fresh-frozen cadaver specimens amputated above the knee were utilized. The foot was axially loaded in a position of …

Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature.

AIMS: To study the clinicopathologic features of Stewart-Treves syndrome (STS) in postmastectomy patients including the epidemiology, presentation, morphology, differentiation, pathogenesis and therapeutic options. METHODS AND RESULTS: Ten cases of STS in postmastectomy patients were retrospectively identified in our archives, and immunohistochemistry for CD34, CD31, D2-40, HHV-8, CK, EMA and Ki-67 was performed. All ten patients presented with lymphedema after mastectomy as the first sign. Physical examination revealed multiple raised, pinkish-red papulo-vesicular lesions or ulceration as th…

Harvey Cushing's Early Operative Treatment of Skull Base Fractures.

Objectives To review Dr. Harvey Cushing's early surgical cases at the Johns Hopkins Hospital, revealing details of his operative approaches to fractures of the skull base. Design Following institutional review board approval and through the courtesy of the Alan Mason Chesney Archives, we reviewed the Johns Hopkins Hospital surgical files. Setting The Johns Hopkins Hospital, 1896 to 1912. Participants A total of 24 patients underwent operative treatment for suspected fractures of the skull base. Main Outcome Measures The main outcome measure was operative approach, postoperative mortality, and …

Descendant of daughter Brazilian BCG Moreau substrain in Poland.

In this study we assessed the genomic stability of Mycobacterium bovis BCG Moreau seed lots used in Poland for BCG vaccine production since 1955 by pulsed field gel electrophoresis (PFGE), amplified fragment length polymorphism (AFLP) and random amplification of polymorphic DNA (RAPD). BCG vaccine lots were more closely related the original lot -M. bovis BCG Rio de Janeiro Moreau compared with seeds used before 1980, which is consistent with seed lot distribution recorded in the archives. We confirmed the presence of RD8, RD2, senX3-regX3, RD14, DU2-I, whiB3, trcR, the second copy of IS6110 in…