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3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT.

BACKGROUND: Oxaliplatin and fluoropyrimidine chemotherapy administered over 6 months is the standard adjuvant regimen for patients with high … ial. SETTING: A total of 244 oncology clinics from six countries: UK (England, Scotland, Wales and Northern Ireland), Denmark, Spain, Sweden, Australia and New Zealand. PARTICIPANTS: Adults aged ≥ 18 years who had undergone curative resection for high-risk stage II or III adenocarcinoma of the colon or rectum. INTERVENTIONS: The adjuvant treatment regimen was e …

Birthweight trends for babies born using Assisted Reproductive Treatments between 1991 and 2018: a national cohort study.

STUDY QUESTION: Has the average birthweight (BW) for singletons born in the UK through ART changed between 1991 and 2018 relative to the gen … previous live births, previous pregnancies, ethnicity, country of treatment within the UK (England, Northern Ireland, Scotland, and Wales), funding source, total number of oocytes retrieved, and infertility causes (endometriosis, idiopathic, ovulatory, tubal diagnosis, and male factor)). BW, LBW, and macrosomia models were additionally adjusted for gestational age …

RECOVERY- Respiratory Support: Respiratory Strategies for patients with suspected or proven COVID-19 respiratory failure; Continuous Positive Airway Pressure, High-flow Nasal Oxygen, and standard care: A structured summary of a study protocol for a randomised controlled trial.

OBJECTIVE: The trial objective is to determine if Continuous Positive Airway Pressure (CPAP) or High-Flow Nasal Oxygen (HFNO) is clinically effective compared to standard oxygen therapy in patients with confirmed or suspected COVID-19. TRIAL DESIGN: Adaptive (group-sequential), parallel group, pragmatic, superiority randomised controlled, open-label, multi-centre, effectiveness trial. PARTICIPANTS: The trial is being conducted across approximately 60 hospitals across England, Wales, Scotland, and Northern Ireland. Inpatients at participating hospitals are eligible to participate if they have…

Self-management for bronchiectasis.

BACKGROUND: Bronchiectasis is a long term respiratory condition with an increasing rate of diagnosis. It is associated with persistent sympt … t patient programme (EPP) in adults of mean age 60 years in a single regional respiratory centre in Northern Ireland (UK). The EPP was delivered in group format once a week for eight weeks using standardised EPP materials plus disease-specific education including airway clearance techniques, dealing with symptoms, exacerbations, health promotion and available supp …

Irish Endocrine Society 44th Annual Meeting.

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… Aim of Study: To assess the prevalence of endocrine dysfunction (pituitary, adrenal and thyroid) in patients receiving IO for the treatment of malignant melanoma in Northern Ireland. … Northern Ireland Biobank, Patrick G Johnston Centre for Cancer Research, Queen’s University, Belfast. Pituitary neuroendocrine tumours (PitNETs) are common intracranial tumours with widespread heterogeneity. …

A survey to determine usual care after cancer treatment within the United Kingdom national health service.

BackgroundApproximately one third of cancer survivors in the United Kingdom face ongoing and debilitating psychological and physical symptoms related to poor quality of life. Very little is known about current post-cancer treatment services.MethodsOncology healthcare professionals (HCPs) were invited to take part in a survey, which gathered both quantitative and free text data about the content and delivery of cancer aftercare and patient needs. Analysis involved descriptive statistics and content analysis.ResultsThere were 163 complete responses from 278 survey participants; 70% of NHS acute

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… Table 1 Respondent characteristics Country of service England 83% [231] Scotland 9% [26] Wales 4% [12] Northern Ireland 3% [9] Profession Other a 33% [89] Medical Oncologists 30% [82] Clinical Nurse Specialists 20% [54] Clinical Oncologists 7% [20] Surgeon 6% [16] Medical Oncology trainee 3% [9] Psychologist … Table 6 Demographics of free text respondents Country of service 100% [278] England 81% [110] Scotland 9% [12] Northern Ireland 4% [5] Wales 2% [3] Profession 97% [271] Medical Oncologists 35% [48] Other a 29% [40] Clinical Nurse Specialists 18% [24] Clinical Oncologists 9% [12] Surgeon 6% [8] Medical …

Cancer burden in Europe: a systematic analysis of the GLOBOCAN database (2022).

BackgroundCancer remains a significant public health challenge in Europe, with substantial regional disparities in incidence, mortality, and access to healthcare. This study analyses cancer patterns across Eastern, Northern, Southern, and Western Europe in 2022, highlighting key public health implications and gaps in prevention and treatment.MethodsUsing data from GLOBOCAN 2022, this study assessed total new cancer cases, age-standardized incidence and mortality rates (ASRs) per 100,000, and cumulative cancer risk at age 75. The top three cancers by sex and region were also analysed to identif

Factors influencing cancer patients' experiences of care in the USA, United Kingdom, and Canada: A systematic review.

The extent to which individual and structural factors influence cancer patients' reports of their experiences are not yet well understood. We sought to identify which groups of patients consistently report poorer experiences and whether structural care factors might also be associated with better or worse reports. We conducted a systematic review of literature in PubMed and Web of Science with the date of last search as 27th of February 2022 following PRISMA guidelines. We focused on studies from three established population-based surveys datasets and instruments. After screening 303 reference

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… Prue et al., 2021 65 | Exploring patient experiences of cancer care in Northern Ireland: A thematic analysis of free-text responses to the 2018 Northern Ireland Patient Experience Survey (NICPES) | A qualitative study using CPES data from 2018 in Northern Ireland | The study aimed to analyse free-text … responses from CPES in Northern Ireland in 2018 to understand patients’ experiences of care | 2 | Overall, respondents reported very positive experiences of the cancer service in Northern Ireland. …

Автономная трансплантация стволовых клеток с помощью гематопоиетической гематомии для множественных склерозов в Соединенном Королевстве: A 20-year Ретроспективный анализ деятельности и гематологических результатов Британского общества трансплантации крови и мозга и клеточной терапии (BSBMTCT).

Автологическая трансплантация стволовых клеток (AHSCT) была разработана в качестве средства лечения множественных склерозов (MS) с тех пор. 1995. Соединенное Королевство one :: из наиболее активных стран Европы, осуществляющих АХСХТ для НР. Мы сообщаем об опыте Соединенного Королевства в области AHSCT для MS 364 :: пациенты, имеющие MS, которые лечатся AHSCT между 2002 и 2023. Мы представляем данные о смертности, связанной с трансплантацией (ТМР), осложнениях и эффективности АХСПП, определяемых расширенной шкалой показателей инвалидности (ЭДСС) в условиях бесперебойного выживания (ПФС) 2 годы

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… Ireland 0 0 0 0 0 0 0 0 0 1 903 175 0 UK NHS total 232 1 62 6 3 7 1 0 312 66 937 324 4.66 Republic of Ireland 15 0 0 0 0 0 0 0 15 5 149 139 a 2.91 Unknown b 7 1 5 1 0 0 0 22 36 ‐ ‐ Total UK + Ireland 254 2 67 7 3 7 1 22 363 72 086 463 5.04 Abbreviations: NE, North East; NHS, National Health … There is a referral pathway for patients from the Republic of Ireland; however, the rest of the UK‐devolved nations, in particular Scotland and Northern Ireland, have shown no activity. NHS Wales commissioners have recently agreed a pathway, but this still means patients travelling to Sheffield. …

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial.

BACKGROUND: Ovarian and tubal cancers are lethal gynaecological cancers, with over 50% of the patients diagnosed at advanced stage. TRIAL DESIGN: Randomised controlled trial involving 27 primary care trusts adjacent to 13 trial centres based at NHS Trusts in England, Wales and Northern Ireland. METHODS: Postmenopausal average-risk women, aged 50-74, with intact ovaries and no previous ovarian or current non-ovarian cancer. INTERVENTIONS: One of two annual screening strategies: (1) multimodal screening (MMS) using a longitudinal CA125 algorithm with repeat CA125 testing and transvaginal scan…

Reimbursement of licensed cell and gene therapies across the major European healthcare markets.

ObjectiveThe aim of this research is to identify the pricing, reimbursement, and market access (P&R&MA) considerations most relevant to advanced therapy medicinal products (ATMPs) in the Big5EU, and to inform their manufacturers about the key drivers for securing adoption at a commercially viable reimbursed price.MethodologyThe research was structured following three main steps: 1) Identifying the market access pathways relevant to ATMPs through secondary research; 2) Validating the secondary research findings and addressing any data gaps in primary research, by qualitative interviews with nat

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… Although commissioning decisions made by NHS England influence those made by NHS Northern Ireland, NHS Scotland and NHS Wales, these UK regions maintain autonomy with respect to P&R&MA processes. … NICE guidance on service developments and therapies considered to be suitable for reimbursement within the NHS extend to Northern Ireland, albeit being subject to local review and funding. The early benefit assessment is a central part of the AMNOG P&R reform, which was introduced in 2010. …

Teledentistry as a Supportive Tool for Dentists in Diagnosing MRONJ in Northern Cyprus.

OBJECTIVE: This web-based survey, as a tool of teledentistry, is aimed at assessing the level of knowledge, attitudes, and awareness regarding MRONJ among dental professionals in Northern Cyprus. METHODS: An online self-administered questionnaire about MRONJ was sent to all dentists in Northern Cyprus through Google Forms. The first part of the questionnaire consists of demographic and professional information, and the second part included questions about knowledge and awareness questions about MRONJ. The SPSS software was used for statistical data analysis. A Chi-square test was performed to

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… The application of teledentistry in oral medicine and diagnosis was evaluated through research performed in Northern Ireland, where the authors used a prototype teledentistry system as part of a service advancement scheme and the authors expressed that teledentistry may serve as an alternative way to …

Immediate improvement in patient care: Auditing adherence to the British Society for Haematology guidelines on screening and management of the long-term consequences of multiple myeloma and treatment.

Advances in myeloma have resulted in improved prognosis for patients. However complications of the disease and treatment, pose a risk of specific long-term consequences. An audit tool was adapted to assess adherence to the British Society for Haematology guidelines for screening and management of long-term myeloma consequences. Thereafter a screening checklist was developed to prompt the implementation of guideline recommendations, followed by a re-audit evaluating the effectiveness of the checklist. Good baseline practice was identified relating to vaccinations, herpes prophylaxis, dental ass

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… A baseline audit was carried out to assess adherence to BSH guidance within a sample of myeloma patients in the Northern Health and Social Care Trust (NHSCT), Northern Ireland (NI). …

50th ESCP Symposium on Clinical Pharmacy, Polypharmacy and ageing - highly individualized, interprofessional, person-centered care : 19–21 October 2022, Prague, Czech Republic

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… In Northern Ireland reviews are carried out in secondary care. … Medication errors in Northern Ireland are estimated to cause 20 patient deaths, lead to around 800 non-elective hospital admissions and cost the health service £1.9 million annually 2 . …

Может ChatGPT4-vision Идентификация радиологического развития множественного склероза на МРТ мозга?

Крупноязычная модель ChATGP теперь может принимать входные изображения GPT4-vision (GPT4V) версия. Цель заключалась в том, чтобы сравнить показатели работы GPT4V с подготовленными U-Net и ViT моделями трансформатора зрения (ViT) для идентификации развития множественных склерозов (MS) на магнитных резонансных изображениях (MRI). МЕТОДЫ: В качестве вклада в ChATGPT4V были представлены совместно зарегистрированные изображения MR с и без прогрессирования. zero- Эксперимент по выявлению радиологической прогрессии. Его показатели были сопоставлены с предварительно подготовленными моделями U-Net и VI

The level of knowledge about palliative care in Iranian patients with cancer.

BackgroundPatient awareness plays an important role in integrating palliative care into the patient care process. Lack of awareness can create a negative attitude towards palliative care and affect patients' decisions during the treatment process. The present study was conducted to determine the level of knowledge about palliative care in Iranian patients with cancer.MethodsThe descriptive study was conducted with a convenience sample of 103 cancer patients admitted to an oncology center in Yazd, Iran, A three-part questionnaire including demographic information, sources of palliative care inf

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… A survey of public opinion in Northern Ireland found that most people see the goal of palliative care as reducing pain, providing comfort and maintaining dignity [ 41 ]. … McIlfatrick S Hasson F McLaughlin D Johnston G Roulston A Rutherford L Public awareness and attitudes toward palliative care in Northern Ireland BMC Palliat Care 2013 12 1 1 7 24044631 10.1186/1472-684X-12-34 PMC3848719 43. …

Estimating complete cancer prevalence in Europe: validity of alternative vs standard completeness indexes.

IntroductionComparable indicators on complete cancer prevalence are increasingly needed in Europe to support survivorship care planning. Direct measures can be biased by limited registration time and estimates are needed to recover long term survivors. The completeness index method, based on incidence and survival modelling, is the standard most validated approach.MethodsWithin this framework, we consider two alternative approaches that do not require any direct modelling activity: i) empirical indices derived from long established European registries; ii) pre-calculated indices derived from U

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… Ireland, Wales, Balearic Islands, Basque Country, Granada (Spain) , Graubünden and Glarus, Eastern Switzerland (Switzerland) , Bas Rhin, Doubs, Haut-Rhin, Isere, Somme, Tarn (France) , Modena, Ragusa, Romagna (Italy) | 44,230,482 (10%) d) | Complete prevalence estimation | >=5 | 62 | Registries in dataset … Broggio (National CR) ; UK-Northern Ireland: A. Gavin* (National CR) ; UK-Scotland: D. Morrison (National CR) ; UK-Wales: D. W. Huws* (National CR). *EUROCARE Steering Committee. Acknowledgments The authors would like to thank Tonino Sofia for the English-language revision. …

Quality indicators and patient outcome measures for palliative care in cancer patients: a systematic review.

IntroductionWith the exponential rise in global cancer incidence, the surge in demand for palliative care has outstripped capacity, limiting patients' access to quality and holistic palliative care, especially in low- and middle-income countries. Despite an upturn in research activity, evidence in palliative care remains limited, given its complexity as well as the shortage of standardised quality indicators (QIs) and patient outcome measures (POMs). The objective of this systematic review is to assess the QIs and POMs used to evaluate palliative care service on aggregated and individual level

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… . | General | Process | Emergency room visits, hospitalisation, ICU admission and chemotherapy administration in the last 30 days of life and hospital death Northern Ireland | McFerran et al [ 29 ] | Cost consequences of unscheduled emergency admissions in cancer patients in the last year of life | Public … Health Agency of Northern Ireland, Cancer Focus Northern Ireland and Health Data Research UK, Macmillan-NI Cancer Registry Partnership (2016) | Quantitative | Descriptive, observational | 3,134 | Cancer | To examine the utilisation of unscheduled emergency end-of-life healthcare and estimates expenditure …