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Clinical Outcome Assessment Endpoints in Nephrotic Syndrome Drug Development: Research Partner Feedback on Patient-Centered Trial Design.

INTRODUCTION: Nephrotic syndrome (NS) clinical trials often rely on biomarkers or clinical measures as primary endpoints, but these may not … . METHODS: We conducted qualitative interviews with and surveyed clinical trialists from industry, academia, and patient advocacy organizations. Each queried participants on how COAs, including patient- and observer-reported outcomes, could be used to demonstrate treatment benefit in trials. Participants were asked about preferences for timing, frequency, …

Resilience as recovery: stakeholder perspectives on Uganda's health system response to infectious disease shocks.

BACKGROUND: The conceptualization, definition, and measurement of health system resilience remain contested, hindering policy integration. C … nt interviews with 15 purposively selected national-level stakeholders from the Ministry of Health, academia, and development and implementing partners between May and July 2025. Data were analyzed using a hybrid deductive-inductive (abductive) thematic analysis approach, drawing on Kruk et al.'s and the WHO's resilience frameworks while remaining open to …

Four decades of tinnitus pathology research: a bibliometric analysis of scientific trends, collaborations, and research hotspots.

INTRODUCTION: Tinnitus is a debilitating auditory disorder affecting approximately 14% of adults worldwide, often co-occurring with hearing … impact. Authors Dirk de Ridder and James A. Henry were identified as key points of dissemination of academia. Keyword analysis revealed a historical shift from peripheral auditory models to central neurophysiological frameworks, with recent emphasis on intervention-focused topics. Thematic mapping identified "pathology," "prevalence," and "diagnosis as cen …

Developing an early scientific advice framework for health technology assessment in Saudi Arabia: insights from global practices and expert consultations.

BACKGROUND: Early Scientific Advice (ESA) is an independent, non-binding guidance from Health Technology Assessment (HTA) bodies or regulato … th 15 experts representing policymakers, regulators, clinicians, HTA experts, industry, payers, and academia, ensuring multi-stakeholder input. RESULTS: Benchmarking ESA models implemented by National Institute for Health and Care Excellence (NICE), Canadian Agency for Drugs and Technologies in Health (CADTH), and European Medicines Agency (EMA) and integ …

Meat Quality Traits Using Gelatin-Green Tea Extract Hybrid Electrospun Nanofiber Active Packaging.

The adverse effects of polyethylene packaging waste on environmental pollution have driven academia to explore biodegradable active packaging (AP) solutions. In the present study, hybrid electrospun nanofiber (HENF) AP was produced using 30% gelatin (GE) combined with 1%, 2%, and 3% green tea extract powder (GTEP), termed HGGTNF. HENF was applied to Hanwoo beef as an AP to assess physicochemical, textural, microbiological, and sensory qualities in comparison to traditional polyethylene packing (PEP). The findings illustrate that the HGGTNF group maintained a significantly (p < 0.05) stable pH …

Advances in the extracellular vesicles treatment of alopecia.

BACKGROUND: Alopecia is a prevalent condition that significantly impacts appearance, mental health, and overall quality of life. Current cli … herapies. With continued innovation in manufacturing technologies and collaborative efforts between academia and industry, EVs hold great potential for advancing clinical treatments for alopecia in the future.

Getting on "the same page": a qualitative study on strategies for healthcare professionals in cross-cultural communication about serious neurological illness.

BACKGROUND: Serious illness communication with racial and cultural discordance can be challenging for both patients and providers. Furthermo … ary providers, recruited from an academic tertiary care center, a Veterans Affairs hospital, and an academia-affiliated county hospital, who provide care for patients with serious neurologic conditions. We used inductive and deductive content analysis methods with dual review. We used inductive and deductive content analysis methods with dual review. RESU …

Exercise Regimen for Mitigation of Neck Pain in Military Aircrew and Support Personnel.

INTRODUCTION: Operators of rotary wing aircraft and high-performance jet aircraft often face musculoskeletal pain and cervical spine injury … tflight recovery, and reduced in-flight pain. DISCUSSION: This collaborative Department of Defense-academia-Department of Veterans Affairs research highlights the effectiveness of regular PLED-based cervical musculature exercises in enhancing ROM and endurance. While promising, further research with larger datasets is needed to support definitive recommen …

Achievements and Approaches in the Search for Small-Molecule Dengue NS2B/NS3 Inhibitors.

With the escalation of viral infections in recent decades, including the COVID- 19 pandemic, viral infectious diseases have increasingly become a global concern, attracting significant attention. Among many viral epidemics, the dengue virus, an RNA virus from the Flaviviridae family, has been reported by the WHO as one of the most prevalent mosquito-borne diseases, infecting roughly 400 million people yearly and spreading across all continents worldwide. In the last two decades, researchers from academia and industry have diligently studied many aspects of the virus, including its structure, l…

Резюме совещания по проблеме вакцинации человека от вируса Западного Нила, 2024 год: изучение препятствий на пути развития.

Вирус Западного Нила (WNV) — нейротропический вирус, передаваемый комарами, который вновь появился за последние 25 лет, чтобы вызвать значительную краткосрочную и долгосрочную заболеваемость и смертность, особенно в Соединенных Штатах и Европе. Попытки смягчить последствия ВНВ путем борьбы с переносчиками болезней в значительной степени оказались безуспешными. Прививка от ВНВ может быть эффективной с точки зрения уменьшения бремени заболеваний. Выявляет и устраняет важные препятствия на пути лицензирования вакцин против ВНВ человека, США. В апреле 2024 года центры по борьбе с заболеваниями и и

Совпадение в аннотации оригинала
West Nile virus (WNV) is a neurotropic mosquito-borne virus that re-emerged in the last 25 years to cause substantial short- and long-term m … n convened a meeting of key stakeholders from the U.S. federal and municipal governments, industry, academia, and regulatory agencies in April 2024. Topics discussed included epidemiology, impact of outbreaks, rationale for human vaccines, animal models and correlates of protection, diagnostic considerations, candidate human vaccines in clinical developmen …

Calm me down, or I'll leave: anxiety and institutional support among Ukrainian academic staff during wartime.

BACKGROUND: Mental health conditions among academic staff are a growing global concern, driven by factors such as heavy workloads, job insecurity, and a lack of institutional support. Anxiety, one of the most common mental health problems, is particularly widespread in academia, affecting cognitive function and productivity. In Ukraine, the ongoing war has intensified these challenges, creating unprecedented working conditions for academic staff. This study investigates the prevalence of anxiety among Ukrainian academics during wartime. It explores the impact on their desire to change careers …

Perceived stress, sources of stress and coping strategies among undergraduate medical students of Nepal: a cross-sectional study.

Background: Medical students are subjected to various stressors throughout their training, which has a considerable impact on their physical … strategies. Conclusions: Stress level among the medical students is high and mainly in relation to academia. Inadequate guidance from teachers contributed significantly. Stressed students were likely to use maladaptive coping strategies. Strategies to enhance teacher-student communication and adaptive coping measures should be implemented. Further studies …

Associations between people experiencing homelessness (PEH) and neurodegenerative disorders (NDDs): A systematic review and meta-analysis.

BACKGROUND: Homelessness represents a widespread social issue globally, yet the risk of neurodegenerative diseases (NDDs) associated with pe … influenced by variations in healthcare systems and social environments. This will be beneficial for academia and government to prioritize the health of PEH with NDDs, aiming to mitigate disease incidence and economic burdens while preserving social stability and upholding basic human rights.

Assessing the performance of Bing Chat artificial intelligence: Dental exams, clinical guidelines, and patients' frequent questions.

OBJECTIVES: Bing Chat is a large language model artificial intelligence (AI) with online search and text generating capabilities. This study assessed its performance within the scope of dentistry in: (a) tackling exam questions for dental students, (ii) providing guidelines for dental practitioners, and (iii) answering patients' frequently asked questions. We discuss the potential of clinical tutoring, common patient communication and impact on academia. METHODS: With the aim of assessing AI's performance in dental exams, Bing Chat was presented with 532 multiple-choice questions and awarded …

Statistical analysis plan for the Petal trial: the effects of parental touch on relieving acute procedural pain in neonates.

BACKGROUND: Infants undergo multiple clinically-required painful procedures during their time in hospital, and there is an increasing desire … re of infant pain for use in clinical trials. This SAP is thus likely to be of interest to those in academia, pharmaceutical companies, and regulatory bodies. TRIAL REGISTRATION: ClinicalTrials.gov: NCT04901611, 25/05/2021; ISRCTN: ISRCTN14135962, 23/08/2021).

Recommendations for a Military Health System Auditory Blast Injury Prevention Standard.

INTRODUCTION: Although existing auditory injury prevention standards benefit warfighters, the Department of Defense could do more to underst … vocacy panel of auditory injury Subject Matter Expert (SME) Panel with members drawn from industry, academia, and government. The SME Panel selected evaluation factors, weighted priorities, and then evaluated the resulting candidate MHS Auditory Blast Injury Prevention Standards against the evaluation criteria. The SME Panel members provided rationales for …

Barriers to advancing women nurses in healthcare leadership: a systematic review and meta-synthesis.

BACKGROUND: Women comprise the majority of the nursing profession, yet nurses are underrepresented in healthcare leadership. We aimed to explore barriers for women nurses to advance in healthcare leadership to inform organisational interventions for career advancement. METHODS: In this systematic review and meta-synthesis, studies examining advancing women nurses and midwives in leadership within healthcare and academia in the international literature were included. Six databases (MEDLINE, EMCARE, EMBASE, PsycINFO, PubMed, and CINAHL PLUS) were searched for studies published in English betwee…

Multitask and Transfer Learning Approach for Joint Classification and Severity Estimation of Dysphonia.

OBJECTIVE: Despite speech being the primary communication medium, it carries valuable information about a speaker's health, emotions, and identity. Various conditions can affect the vocal organs, leading to speech difficulties. Extensive research has been conducted by voice clinicians and academia in speech analysis. Previous approaches primarily focused on one particular task, such as differentiating between normal and dysphonic speech, classifying different voice disorders, or estimating the severity of voice disorders. METHODS AND PROCEDURES: This study proposes an approach that combines t…

Vaccine value profile for cytomegalovirus.

Cytomegalovirus (CMV) is the most common infectious cause of congenital malformation and a leading cause of developmental disabilities such … value of CMV vaccines. The CMV VVP was developed by a working group of subject matter experts from academia, public health groups, policy organizations, and non-profit organizations. All contributors have extensive expertise on various elements of the CMV VVP and have described the state of knowledge and identified the current gaps. The VVP was developed …

Guidance on treatment endpoints and study design for clinical trials aiming to achieve cure in chronic hepatitis B and D: Report from the 2022 AASLD-EASL HBV-HDV Treatment Endpoints Conference.

Representatives from academia, industry, regulatory agencies, and patient advocacy groups convened under the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver (EASL) in June 2022 with the primary goal of achieving consensus on chronic HBV and HDV treatment endpoints to guide clinical trials aiming to "cure" HBV and HDV. Conference participants reached an agreement on some key points. The preferred primary endpoint for phase II/III trials evaluating finite treatments for chronic hepatitis B (CHB) is a "functional" cure, defined …