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Mefloquine for preventing malaria in pregnant women.

BACKGROUND: The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine fo … zziness, and vomiting. MAIN RESULTS: Six trials conducted between 1987 and 2013 from Thailand (1), Benin (3), Gabon (1), Tanzania (1), Mozambique (2), and Kenya (1) that included 8192 pregnant women met our inclusion criteria.Two trials (with 6350 HIV-uninfected pregnant women) compared two IPTp doses of mefloquine with two IPTp doses of sulfadoxine-py …

Mefloquine for preventing malaria in pregnant women.

BACKGROUND: The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine fo … zziness, and vomiting. MAIN RESULTS: Six trials conducted between 1987 and 2013 from Thailand (1), Benin (3), Gabon (1), Tanzania (1), Mozambique (2), and Kenya (1) that included 8192 pregnant women met our inclusion criteria.Two trials (with 6350 HIV-uninfected pregnant women) compared two IPTp doses of mefloquine with two IPTp doses of sulfadoxine-py …

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. METHODS: We estimated incid

Mechanical and surgical interventions for treating primary postpartum haemorrhage.

BACKGROUND: Primary postpartum haemorrhage (PPH) is commonly defined as bleeding from the genital tract of 500 mL or more within 24 hours of … mall trials (944 women) conducted in Pakistan, Turkey, Thailand, Egypt (four trials), Saudi Arabia, Benin and Mali. Overall, included trials were at an unclear risk of bias. Due to substantial differences between the studies, it was not possible to combine any trials in meta-analysis. Many of this review's important outcomes were not reported. GRADE ass …

Оценка стабильности жажды в пальчиках (Eleusine coracana L.) с использованием многовариантных подходов.

Пальцы, как правило, выращиваются в полузасушливых тропиках, где они выращиваются главным образом фермерами-добытчиками. Однако урожайность зерна остается низкой из-за сложного количественного характера этой особенности и ее низкой наследственности. Таким образом, взаимодействие генотипа х с окружающей средой (ГЭИ) оказывает значительное влияние на производство. В этом исследовании изучается воздействие ГЭИ на качество генотипов пальца в различных средах, при этом особое внимание уделяется чувствительности урожая к изменчивости климата. Цель этого исследования заключалась в оценке воздействия

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… Genotype × Environment Interaction and Stability Analysis for Seed Yield and Yield Components in Sesame (Sesamum Indicum L.) in Benin Republic Using Ammi, GGE Biplot and Mtsi Heliyon 2023 9 11 p. e21656 10.1016/j.heliyon.2023.e21656 38034689 PMC10681942 18 Yan W. Hunt L. A. Sheng Q. Szlavnics Z. …

Impact of population ageing on cancer-related disability-adjusted life years: A global decomposition analysis.

BACKGROUND: As the global population ages, the burden of cancer is increasing. We aimed to assess the impact of population ageing on cancer-related disability-adjusted life years (DALYs). METHODS: We used the decomposition method to estimate the impact of ageing, population growth, and epidemiological change on cancer-related DALYs from 1990 to 2019, stratified by 204 countries/territories and by their sociodemographic index (SDI). This approach separates the net effect of population ageing from population growth and change in age-specific DALY rates. RESULTS: Cancer-related DALYs among indi

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… 68.92 | Thailand | 75.44 | United States Virgin Islands | 62.65 195 | Burkina Faso | −22.38 | Sao Tome and Principe | −30.52 | Sao Tome and Principe | −12.36 196 | Nigeria | −22.54 | Chad | −31.41 | Somalia | −15.15 197 | Guinea | −23.56 | Cabo Verde | −32.18 | Mozambique | −18.78 198 | Mali | −25.26 | Benin …

Burden of non-communicable diseases among adolescents aged 10-24 years in the EU, 1990-2019: a systematic analysis of the Global Burden of Diseases Study 2019.

BackgroundDisability and mortality burden of non-communicable diseases (NCDs) have risen worldwide; however, the NCD burden among adolescents remains poorly described in the EU.MethodsEstimates were retrieved from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Causes of NCDs were analysed at three different levels of the GBD 2019 hierarchy, for which mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) were extracted. Estimates, with the 95% uncertainty intervals (UI), were retrieved for EU Member Stat

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… Global Mental Health (K N Koly MSc), Medical Statistics Department (S Shivalli MD), Department of Non-communicable Disease Epidemiology (Prof P Perel PhD), London School of Hygiene & Tropical Medicine, London, UK; Department of Clinical Research (M M K Accrombessi PhD), Clinical Research Institute of Benin … , Abomey-Calavi, Benin; Department of Population Medicine (V Adekanmbi PhD), Cardiff University, Cardiff, UK; Lincoln Medical School (K Ahmadi PhD), Universities of Nottingham & Lincoln, Lincoln, UK; Geriatric and Long Term Care Department (H Al Hamad MD, B Sathian PhD), Rumailah Hospital (H Al Hamad …

Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 20

KSHV and cancer: understanding the oncogenic machinery for next-generation diagnostic tools and therapies.

Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV-8), is an oncogenic virus responsible for Kaposi's sarcoma (KS) and lymphoproliferative disorders like primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD). This review explores KSHV's oncogenic mechanisms, focusing on its ability to manipulate host cell signaling, evade immune detection, and promote tumorigenesis through latent and lytic viral proteins. Key oncoproteins, such as LANA, vCyc, vFLIP, and vGPCR, activate cancer hallmarks, as sustained proliferation, immune evasion, angiogenesis, and re

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… Mod Pathol 36(8):100191. 10.1016/j.modpat.2023.100191 Forae GD, Obaseki DE (2018) Trends and histopathological patterns of Kaposi sarcoma at the University of Benin Teaching Hospital, Benin City, Nigeria. …

Mapping Cancer in Africa: A Comprehensive and Comparable Characterization of 34 Cancer Types Using Estimates From GLOBOCAN 2020.

ObjectiveCancer incidence and mortality rates in Africa are increasing, yet their geographic distribution and determinants are incompletely characterized. The present study aims to establish the spatial epidemiology of cancer burden in Africa and delineate the association between cancer burden and the country-level socioeconomic status. The study also examines the forecasts of the cancer burden for 2040 and evaluates infrastructure availability across all African countries.MethodsThe estimates of age, sex, and country-specific incidence and mortality of 34 neoplasms in 54 African countries, we

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… Population | Incidence [95% UI] | ASIR | ASMR | Mortality [95% UI] | MIR Algeria | 58,418 [56,916–59,960] | 135.3 | 76.1 | 32,802 [31,875–33,756] | 0.56 Angola | 20,327 [18,854–21,915] | 130.6 | 86.5 | 12,599 [11,627–13,652] | 0.62 Benin | 6,747 [5,981–7,610] | 95.8 | 69.3 | 4,662 [4,065–5,347] | 0.69 …

Distribution and features of hematological malignancies in Eastern Morocco: a retrospective multicenter study over 5 years.

BackgroundHematological malignancies (HM) are a public health problem. The pattern and distribution of diagnosed hematological cancers vary depending on age, sex, geography, and ethnicity suggesting the involvement of genetic and environmental factors for the development of these diseases. To our knowledge, there is no published report on HM in the case of Eastern Morocco. In this report we present for the first time the overall pattern of HM for this region.MethodsRetrospective descriptive study of patients diagnosed with HM between January 2008 and December 2012 in three centres in Eastern M

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… The epidemiological features of lymphoid malignancies in Benin City, Nigeria: a 15 years study. Pan Afr Med J. 2012;11:10. 53. Mozaheb Z. Epidemiology of Lymphoid Malignancy in Asia, Epidemiology Insights. InTech. Edited by Dr. Maria De Lourdes Ribeiro De Souza Da Cunha. 325–354. …

Abstracts

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… PATIENT CANDIDATE TO ELECTIVE SURGERY POINT OF VIEW Ernest Ahounou 2 , Cedric Bigot 1 , Esther Hounvenou 2 , Eugène Zoumenou 2 1 Unit of Legal Medicine – FSS, University of Abomey-Calavi, Cotonou, Benin 2 Unit of Anesthesia and Reanimation- FSS, University of Abomey-Calavi, Cotonou, Bénin Oral Presentation … In Benin, the doctor has to inform the patient to obtain his freely given consent. This duty is essential in surgery and anesthesiology. This study's objective was to write down the perceived quality of the information delivered to patients during pre-anaesthetic consultations. …

Managing emotional and physical stress in sickle cell anemia: a review of effective strategies and approaches.

Sickle cell anemia (SCA) is a genetic blood disorder characterized by recurrent pain episodes, chronic complications, and significant emotional and physical stress. This review article explores effective strategies for managing both the emotional and physical aspects of stress in SCA patients. A comprehensive literature search was conducted across multiple databases, including PubMed, Scopus, and Google Scholar, using keywords such as "sickle cell anemia", "stress management", "psychological support", and "pain management". Emotional stress in SCA arises from chronic pain, frequent hospitaliza

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… Pain coping strategies used and its perceived effectiveness among patients attending sickle cell center in Benin City, Edo State, Nigeria . Nur Primary Care 2021 ; 5 : 1 – 8 . [55] Yawn BP Buchanan GR Afenyi-Annan AN . …

A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors.

Observational and ecological studies are generally used to determine the presence of effect of cancer risk-modifying factors. Researchers generally agree that environmental factors such as smoking, alcohol consumption, poor diet, lack of physical activity, and low serum 25-hdyroxyvitamin D levels are important cancer risk factors. This ecological study used age-adjusted incidence rates for 21 cancers for 157 countries (87 with high-quality data) in 2008 with respect to dietary supply and other factors, including per capita gross domestic product, life expectancy, lung cancer incidence rate (an

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… The other 70 countries: Algeria, Angola, Bangladesh, Benin, Bolivia, Botswana, Burkina Faso, Burundi, Cambodia, Cameroon, Cape Verde, Central African Republic, Chad, Chile, China, Comoros, Djibouti, Ethiopia, French Polynesia, Gabon, Gambia, Ghana, Guadeloupe, Guinea, Guinea-Bissau, Honduras, India, …

The 4th Global Congress on Sickle Cell Disease Abstract Book 2022

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Community-acquired pneumonia

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… Benin A.L., Benson R.F., Besser R.E. Trends in Legionnaires disease, 1980–1998: declining mortality and new patterns of diagnosis. Clin Infect Dis. 2002;35:1039–1046. doi: 10.1086/342903. 25. Arancibia F., Bauer T.T., Ewig S. …

Examining the potentials of stem cell therapy in reducing the burden of selected non-communicable diseases in Africa.

Stem cell therapy (SCT) is a promising solution for addressing health challenges in Africa, particularly non-communicable diseases (NCDs). With their regenerative potential, stem cells have the inherent capacity to differentiate into numerous cell types for tissue repair. Despite infrastructural, ethical, and legal challenges, SCT holds immense promise for managing chronic illnesses and deep-seated tissue injuries. The rising prevalence of NCDs in Africa highlights the need for innovative strategies and treatment options. SCT offers hope in combating conditions like burns, osteoarthritis, diab

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… In Nigeria, the first successful stem cell transplant was performed in 2011 on a sickle cell anaemia patient at the University of Benin Teaching Hospital [ 48 ]. Since then, six more successful transplants have been reported. …

The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease.

Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed. During the last five years, the landscape of the pharmacotherapy of SCD has changed dramatically. Currently, 54 drugs have been used or under consideration to use for the treatment of SCD. These fall into 3 categories: the first category includes the four drugs (Hydroxyurea, L-Glutamine, Crizanlizumab tmca and Voxelotor) that have been approved by the United States Food and Drug Administration (FDA) based on suc

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… five, 2010–2050: modelling based on demographics, excess mortality, and interventions PLoS Med 2013 10 7 e1001484 10.1371/journal.pmed.1001484 23874164 PMC3712914 2 Odame I Developing a global agenda for sickle cell disease: report of an international symposium and workshop in Cotonou, Republic of Benin …

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill

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… –66·6) | 57·5 (52·7–60·7) | 58·1 (56·3–60·1) | 55·4 (51·9–58·6) | 55·1 (52·1–58·1) | 50·4 (46·4–53·8) | 51·1 (48·6–53·4) Western sub-Saharan Africa | 56·2 (55·0–57·4) | 65·3 (63·6–66·9) | 53·3 (52·0–54·5) | 61·7 (60·2–62·9) | 47·8 (45·1–50·1) | 56·0 (53·0–58·7) | 45·9 (43·5–48·1) | 53·5 (50·9–56·0) Benin … ) | 13·7 (12·5–15·1) | 12·3 (11·6–13·3) | 11·6 (10·7–12·3) | 10·9 (9·8–12·1) | 9·8 (8·5–11·1) | 9·0 (8·0–10·1) | 8·4 (7·4–9·3) Western sub-Saharan Africa | 13·6 (12·9–14·4) | 15·3 (14·4–16·2) | 12·8 (12·1–13·5) | 13·9 (13·2–14·5) | 9·8 (8·7–10·8) | 11·2 (9·9–12·4) | 9·3 (8·2–10·2) | 10·2 (9·1–11·2) Benin …

Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of dying before age 70 years (70q0) and the mean age at death by cause and sex. This study enables comparis