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Repurposing existing drugs for monkeypox: applications of virtual screening methods.

BACKGROUND: Monkeypox is endemic to African region and has become of Global concern recently due to its outbreaks in non-endemic countries. … esults indicated that selected drug compounds displayed strong binding affinity for p37 receptor of monkeypox virus and therefore can potentially be used in future studies to confirm their effectiveness against the disease.

What's in a name: The impact of monkeypox nomenclature.

The monkeypox outbreak has garnered significant global attention and has since been declared a Public Health Emergency of International Concern (PHEIC). Even though the virus is not novel and has been endemic in African countries, most cases in the present outbreak have been detected in Europe and the Americas. Disease nomenclature has historically included references to places, animals, and people. There could be unintended negative consequences emanating from these references. The COVID-19 pandemic has exposed some of these consequences, with terms such as "China virus" and fueling racism an

Monkeypox: considerations for the understanding and containment of the current outbreak in non-endemic countries.

The neglected and rare zoonotic disease caused by monkeypox virus (MPV) has recently spread widely, resulting in the largest known monkeypox outbreak outside of Africa, where it is endemic. MPV belongs to the Poxviridae family, genus Orthopoxvirus. At least two different clades have been identified, each having different fatality rates but recent cases are all phylogenetically related to the West African clade. MPV is transmitted directly by either person-to-person, -animal, or virus-contaminated fomite contact. The disease is often self-limited, and clinical symptoms include fever, skin lesio…

A study on the recognition of monkeypox infection based on deep convolutional neural networks.

INTRODUCTION: The World Health Organization (WHO) has assessed the global public risk of monkeypox as moderate, and 71 WHO member countries … ientNet-B5. DISCUSSION: This method realizes high-precision identification of skin symptoms of the monkeypox virus to provide a fast and reliable auxiliary diagnosis method for monkeypox cases for front-line medical staff.

Monkeypox Emergence Post-COVID: Insight into Egyptian Older Adult's Awareness, Concern, and Mental Health.

Aim: To identify Egyptian older adults' awareness, concerns, and mental health about the monkeypox outbreak. Background: In light of the ongoing COVID-19 pandemic, monkeypox disease is receiving more attention. The monkeypox virus outbreak has posed a global concern, especially to older adults with comorbidities. Natural disasters, and endemic affect older persons' mental health. Design: A cross-sectional descriptive design was followed. Methods: 254 older adults were recruited from three outpatient clinics using consecutive sampling using four tools. Results: 74.0% of older study participants…

Poxvirus Vaccines: Past, Present, and Future.

Smallpox was a significant cause of mortality for over three thousand years, amounting to 10% of deaths yearly. Edward Jenner discovered smallpox vaccination in 1796, which rapidly became a smallpox infection preventive practice throughout the world and eradicated smallpox infection by 1980. After smallpox eradication, monkeypox vaccines have been used primarily in research and in outbreaks in Africa, where the disease is endemic. In the present, the vaccines are being used for people who work with animals or in high-risk areas, as well as for healthcare workers treating patients with monkeypo

Insights on monkeypox disease and its recent outbreak with evidence of nonsynonymous missense mutation.

The 2022 monkeypox outbreak has created a new global health threat and pandemic. Monkeypox virus is a descendant of the genus Orthopoxvirus, producing a febrile skin rash disease in humans. Monkeypox is zoonotic transmitted and transmitted from human to human in several ways. Even though this disease is self-limited, it creates important community health worries due to its inconvenience and widespread complications. Herein, we discussed the up-to-date current situation of monkeypox regarding its epidemiology, clinical manifestations, current in-use therapeutics, necessary protective measures, …

First case report of human monkeypox in Latin America: The beginning of a new outbreak.

On 13 May 2022, a familial cluster of two cases of monkeypox was reported in the United Kingdom (UK) by the UK Health Security Agency (UKHSA … cases, without any report of death. This outbreak involves 23 countries that are not endemic to the monkeypox virus. Latin America had no reported cases. We describe a case of imported monkeypox in Mexico City, Mexico.

Обезьяна - нарождающаяся пандемия.

Обезьянопокс - зоонотическая болезнь, вызванная вирусом обезьянопокс, членом семьи ортопоксинов. В последнее время число случаев обезьяньей оспы растет тревожными темпами в США и во всем мире. Медицинские работники должны иметь высокий показатель подозрительности в связи с этим заболеванием у любого лица с новой лихорадкой, везикулярной или пуштуальной сыпью с центральной пумикалией и лимфаденопатией. Такие пациенты должны быть изолированы дома или в больнице, чтобы предотвратить вторичную передачу инфекции. Такие случаи, как правило, носят ограниченный характер, и большинство людей нуждаются

Совпадение в аннотации оригинала
Monkeypox-a zoonotic disease caused by the monkeypox virus, an orthopoxviruses family member. Recently monkeypox cases are increasing at an alarming rate in the US and worldwide. Health care professionals should keep a high index of suspicion for the disease in anyone with new onset fever, a vesicular or pustular rash with central umbilication, and lymphaden…

Adding New Fuel to the Fire: Monkeypox in the Time of COVID-19-Implications for Health Care Personnel.

Monkeypox virus is reemerging, with cases reported on every inhabited continent at a time when clinical and public health resources have been stretched to the limit by COVID-19. As the monkeypox outbreak grows, health care workers must understand the threat and be prepared to address an infectious disease risk that may herald yet another unprecedented epidemic.

Socio-Demographic Factors Influencing Monkeypox Vaccination Intentions Among Healthcare Workers and the General Population of Makurdi, Nigeria: A Cross-Sectional Study.

Background Monkeypox, now known as mpox, is a viral zoonotic disease caused by the monkeypox virus (MPXV) and is endemic to parts of Central and West Africa. Historically considered a regional health issue, mpox has gained global attention due to recent outbreaks in non-endemic regions. In 2022, the World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern (PHEIC) following widespread transmission in countries where the virus had not been previously reported. This declaration was renewed in August 2024 after a surge in cases, particularly across Africa, i…

Comparison of Transcriptomic Signatures between Monkeypox-Infected Monkey and Human Cell Lines.

Monkeypox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus of the family Poxviridae. Unlike smallpox with no animal reservoir identified and patients suffering from milder symptoms with less mortality, several animals were confirmed to serve as natural hosts of MPV. The reemergence of a recently reported monkeypox epidemic outbreak in nonendemic countries has raised concerns about a global outburst. Since the underlying mechanism of animal-to-human transmission remains largely unknown, comprehensive analyses to discover principal differences in gene signatures during d…

Emergence of Monkeypox as the Most Important Orthopoxvirus Infection in Humans.

Monkeypox is an emerging zoonotic disease recognized as the most important orthopoxvirus infection in humans in the smallpox post-eradicatio … there are huge gaps in our understanding of the disease's emergence, epidemiology, and ecology. The monkeypox virus is considered a high threat pathogen causing a disease of public health importance. Therefore, there is an urgent need to focus on building surveillance capacities which will provide valuable information for designing appropriate prevention, prepare …

Mpox in a Couple Living with HIV: Relapse or Reinfection?

Mpox is caused by a zoonotic orthopoxvirus capable of infecting several animal species, including humans. The analysis of cases in the current outbreak showed that, differently from what happens in the classical disease, mpox has mostly affected men who have sex with men (MSM) and bisexuals, including a high proportion of people living with HIV/AIDS. The role of the immune system in fighting mpox has been discussed in literature and experts believe that immunity conferred by natural infection may be lifelong, advocating against the possibility of reinfection by monkeypox virus. This report pre…

The Historical Epidemiology of Human Monkeypox: A Review of Evidence from the 1970 Emergence to the 2022 Outbreak.

Human Monkeypox (HMPX) outbreak in the year 2022 occurs in many countries outside of the African regions, a common location of such outbreak … erties of this outbreak, herein we systematically described and compared the historical evidence of monkeypox virus outbreaks in the aspects of epidemiological, clinical, and molecular evolutions since its emergence, as well as an explanation of the previous investigations and considerations of WHO and other international health societies over time. The history o …

A Case of Persistently Positive Mpox PCR for 1 Year in a Patient With Advanced HIV.

Mpox (previously called monkeypox) is a self-limited vesiculopustular skin disease caused by the monkeypox virus. Symptoms and skin findings typically resolve within 4 weeks in immunocompetent patients. This report describes a case of persistent Mpox infection with polymerase chain reaction positivity lasting greater than 1 year after initial infection in a patient with advanced HIV.

Knowledge, attitude, and practice of university students towards monkeypox in Bangladesh.

The recent outbreak of viral zoonotic disease-monkeypox-caused by the monkeypox virus, has infected many people worldwide. This study aims to explore the knowledge, attitudes, and practices (KAP) concerning monkeypox among university students in Bangladesh. Data were collected using purposive snowball sampling from 887 university students through an online survey using Google Form. The participants were mostly in their twenties (M = 22.33 [SD 2.01] years), and they spent, on average, 2.59 [SD 1.91] hours/day on electronic and social media. The participants generally showed moderate knowledge (…

Qualitative assessment of risk for monkeypox associated with domestic trade in certain animal species, United States.

In 2003, US officials identified several human monkeypox cases and traced the virus exposure to infected captive prairie dogs. The virus was likely introduced through a shipment of imported African rodents, which were kept with other mammals, including prairie dogs, in a pet distribution facility in the Midwest. To prevent the further introduction and spread of the virus, federal agencies restricted the importation of African rodents and restricted the domestic trade or movement of prairie dogs and certain other rodents. In this qualitative assessment of the risk for monkeypox associated with

Pathogenicity and transmissibility of Mpox virus in African dormice.

UNLABELLED: The global spread of Mpox virus (MPXV) poses a major public health challenge, yet reliable and consistent animal models for MPXV … essential given their potential role in MPXV transmission chains. IMPORTANCE: The global spread of monkeypox virus (MPXV) clade IIb has highlighted the urgent need for reliable animal models to investigate its biological characteristics. This study established an African dormouse (Graphiurus spp.) model and systematically characterized the pathogenicity and tran …

Пересмотр статьи "Возможная взаимосвязь между сердечно-сосудистыми заболеваниями и обезьяньей оспой".

Сердечно-сосудистое участие в контексте вирусных инфекций является хорошо задокументированным явлением, поскольку оно может вызвать миокардит, перикардит и другие сердечные осложнения. В то время как обезьянопокс в основном известен своей предрасположенностью к коже и слизистой мембране, что проявляется как типичные повреждения кожи, новые исследования указывают на то, что обезьянопокс может также проникать в эндотелиальные клетки, распространяя таким образом системно и потенциально воздействуя на различные системы органов, включая сердечно-сосудистую систему. Это привело к выявлению нескольки

Совпадение в аннотации оригинала
Cardiovascular involvement in the context of viral infections is a well-documented phenomenon, for their potential to induce myocarditis, pe … d mucous membranes, manifesting as characteristic skin lesions, emerging research suggests that the monkeypox virus can also infiltrate endothelial cells, thereby disseminating systemically and potentially impacting various organ systems, including the cardiovascular system. This has led to the identification of several inflammatory conditions, such as myocarditi …