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Ashi Scalp Acupuncture in the Treatment of Secondary Trigeminal Neuralgia Induced by Multiple Sclerosis: A Case Report.

Background: Multiple sclerosis (MS) is an autoimmune, chronic, inflammatory, demyelinating, and axonal degeneration disease of the central nervous system. Trigeminal neuralgia (TN), a neuropathic facial paroxysmal pain, is prevalent among MS patients. Because of the inadequacy of the comprehension of MS-related TN pathophysiological mechanisms, TN remains arduous in its treatment approaches. Acupuncture as a non-pharmacological therapy could be a promising complementary therapy for the treatment of TN. MS gradual neural damage might affect the muscles' function. This can lead to acute or parox…

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions.

BACKGROUND: Angiogenesis is a common finding in chronic inflammatory diseases; however, its role in multiple sclerosis (MS) is unclear. Central nervous system lesions from both MS and experimental autoimmune encephalomyelitis (EAE), the animal model of MS, contain T cells, macrophages and activated glia, which can produce pro-angiogenic factors. Previous EAE studies have demonstrated an increase in blood vessels, but differences between the different phases of disease have not been reported. Therefore we examined angiogenic promoting factors in MS and EAE lesions to determine if there were cha…

Медленно расширяющиеся лизы при множественном склерозе: систематический обзор и мета-анализ.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Медленно расширяющиеся повреждения (SELs) были введены в качестве радиологического индикатора хронического активного обезвоживания и воспаления воспаления. Эти повреждения признаются в качестве показателей ухудшения состояния инвалидности и атрофии мозга у людей с множественным склерозом (PwMS). Мы намеревались представить обзор имеющихся данных о распространенности и клинической значимости SEL в PwMS. МЕТОДЫ: Пубмед, Эмбаза, Скопус и Веб-сайт науки систематически подвергались обыску 25 Май 2025, с целью выявления исследований, посвященных оценке СЭЛ в ПВМС. Риск отклоне

Совпадение в аннотации оригинала
BACKGROUND: Slowly expanding lesions (SELs) have been introduced as a radiological marker of chronic active demyelination and smoldering inflammation. These lesions are recognized as indicators of disability worsening and brain atrophy in people with multiple sclerosis (PwMS). We aimed to provide an overview of the available evidence on the prevalence and cl…

Factors associated with the progression of disability (EDSS) among MS patients.

BACKGROUND: Multiple sclerosis is a chronic, inflammatory, autoimmune disease of the central nervous system. Accumulating neurological disability has a substantial impact on the lives of patients with MS. The Expanded Disability Status Scale is a method of quantifying disability in MS. OBJECTIVE: The aim of this study was to analyze the disability trajectory across years of patients living with MS seen at the Neurological Institute and to explore factors associated with the rate of change per year. METHODS: A single-center study was conducted at the Neurological Institute located in the city…

Pineal calcification and its relationship to the fatigue of multiple sclerosis.

Fatigue is one of the most common clinical features of multiple sclerosis (MS) and is a frequent cause of disability. The pathogenesis of fatigue remains obscure. It may result from impaired propagation of action potentials in areas of demyelination. Other contributors may be mental depression, immobility, and physical disability. The fatigue of MS may be relieved by diverse pharmacological drugs such as amantadine and pemoline, but the mechanisms by which these agents act to ameliorate fatigue are unknown. Attention has been focused recently on the relationship between MS and the pineal gland…

Биомаркеры прогресса, не зависящие от обратной активности. Можем ли мы на самом деле измерить это?

Прогресс, не зависящий от рецидива (ИПРА), все чаще признается в качестве одного из основных факторов инвалидности при множественном склерозе (МС). Однако концепция ПИРА по-прежнему остается иллюзорной, поскольку ее определение, основополагающие механизмы и методы количественной оценки являются неопределенными. В настоящем обзоре анализируется нынешний ландшафт биомаркеров, используемых для прогнозирования и измерения ПИРА, с уделением особого внимания клиническим, визуальным и жидкостным биомаркерам. Такие показатели по инвалидности, как расширенная шкала взносов для инвалидов, широко использ

Совпадение в аннотации оригинала
Progression independent of relapse activity (PIRA) is increasingly recognized as a key driver of disability in multiple sclerosis (MS). However, the concept of PIRA remains elusive, with uncertainty surrounding its definition, underlying mechanisms, and methods of quantification. This review examines the current landscape of biomarkers used to predict and me…

Perivascular PDGFRB+ cells accompany lesion formation and clinical evolution differentially in two different EAE models.

BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) that may lead to progressive disability. Here, we explored the behavioral pattern and the role of vasculature especially PDGFRB+ pericytes/ perivascular cells, in MS pathogenesis. METHODS: We have evaluated vascular changes in two different experimental allergic encephalomyelitis (EAE) mice models (MOG and PLP-induced). PDGFRB+ cells demonstrated distinct and different behavioral patterns. In both models, fibrosis formation was detected via collagen, fibronectin, and extracellular matrix …

"A case report: Co-occurrence of cerebral amyloid angiopathy and multiple sclerosis".

Cerebral amyloid angiopathy (CAA) is a chronic pathological condition characterized by progressive accumulation of amyloid protein in the wa … rn of inheritance. Contrary to the rest of the family, the reported patient has been diagnosed with multiple sclerosis based on McDonald criteria. Recent studies shed light on the possible link between the APP accumulation and MS progression. It has been indicated that amyloid can prove a vital role in neuroimmunology, whereas the accumulation of APP in the CNS has …

Role of neuroimaging in multidisciplinary approach towards Non-Alzheimer's dementia.

Dementia is defined as chronic deterioration of intellectual function and cognitive skills significant enough to interfere with the ability … post hypoxic leukoencephalopathy (DPHL), HIV, Creutzfeldt-Jakob Disease (CJD), Sjogren's syndrome, multiple sclerosis (MS), radiation necrosis and Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS), which are difficult to treat and often require palliative care. This pictorial review emphasizes various non-Alzheimer's dementia entities and discusses their imaging …

Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities.

The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis, or rheumatoid arthritis. The pathological consequences of excessive IL-23 signaling have been linked to its ability to promote the production of inflammatory mediators, such as IL-17, IL-22, granulocyte-macrophage colony-stimulating (GM-CSF), or the tumor necrosis factor (TNFα) by target populations, mainly Th17 and IL-17-secreting TCRγδ cells (Tγδ17). Due to their pivotal role in inflammatory diseases, IL-23 and …

Системная гипотеза о диспропорции дофамина в ранних множественных склерозах.

Множественный склероз (MS) — хроническое аутоиммунное расстройство центральной нервной системы, при этом имеются данные, свидетельствующие о том, что возрастные изменения мозга могут повлиять на его развитие. Клинический изолированный синдром (CIS) часто обозначает раннюю фазу MS, при этом в качестве симптома часто проявляется оптический неврит. Несмотря на признание в качестве одного из первых показателей, механизмы воздействия оптического неврита и его вклад в продвижение НР остаются неясными. Традиционно иммунное воспаление доминировало в исследованиях MS; однако, появляющиеся данные свидет

Совпадение в аннотации оригинала
Multiple Sclerosis (MS) is a chronic autoimmune disorder of the central nervous system, with evidence suggesting that age-related brain changes may influence its progression. Clinically Isolated Syndrome (CIS) often marks an early phase of MS, with optic neuritis frequently presenting as a symptom. Despite recognition as an early indicator, the mechanisms dr…

На пути к глобальной программе исследований по предотвращению множественных склерозов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Был достигнут значительный прогресс в понимании генетических и экологических факторов риска в связи с множественным склерозом (МС), однако мы все еще не можем предотвратить НР. ЦЕЛИ: Достичь прогресса в первичной и вторичной профилактике НР путем разработки всеобъемлющей программы исследований на основе имеющихся знаний. МЕТОДЫ: В ходе глобального семинара-практикума были созваны люди, имеющие живой опыт, врачи, исследователи и разработчики политики, имеющие опыт работы в области MS, других хронических заболеваний, эпидемиологии, клинических испытаний, геномики, иммуноло

Совпадение в аннотации оригинала
BACKGROUND: Considerable progress has been made in understanding genetic and environmental risk factors for multiple sclerosis (MS), yet we still cannot prevent MS. OBJECTIVES: To drive progress in primary and secondary prevention of MS by developing a comprehensive research agenda based on current knowledge. METHODS: A global workshop convened people with…

Paramagnetic rim lesions are associated with inner retinal layer thinning and progression independent of relapse activity in multiple sclerosis.

BACKGROUND AND PURPOSE: Paramagnetic rim lesions (PRLs) are chronic active lesions associated with a severe disease course in multiple sclerosis (MS). This study was undertaken to investigate an association between retinal layer thinning (annualized loss of peripapillary retinal nerve fiber layer [aLpRNFL] and ganglion cell-inner plexiform layer [aLGCIPL]) and PRLs in patients with MS (pwMS). METHODS: In this study, pwMS with brain magnetic resonance imaging and ≥2 optical coherence tomography scans were included. Cox proportional hazard regression models were performed using progression inde…

The Role of Gut Microbiome in the Pathogenesis of Multiple Sclerosis and Related Disorders.

Multiple sclerosis (MS) is a chronic, progressive neuroinflammatory disease with a complex pathophysiological background. A variety of diverse factors have been attributed to the propagation of inflammation and neurodegeneration in MS, mainly genetic, immunological, and environmental factors such as vitamin D deficiency, infections, or hormonal disbalance. Recently, the importance of the gut-brain axis for the development of many neurological conditions, including stroke, movement disorders, and neuroinflammatory disorders, has been postulated. The purpose of our paper was to summarize current…

Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.

We review progress towards greater mechanistic understanding and clinical translation of a strategy to improve respiratory and non-respirato … igations of tAIH in SCI and other clinical disorders that compromise motor function, including ALS, multiple sclerosis, and stroke.

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

BACKGROUND: Optic neuritis (ON) can occur as an isolated episode or will develop to multiple sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains poorly understood. METHODS: We characterised the antibody epitope repertoire in three independent clinical cohorts (discovery (n = 62), validation (n = 20) and external cohort (n = 421)) using mimotope variation analysis (MVA), a next generation phage display technology to identify epitopes that associate with prognosis of ON. FINDINGS: We observed distinct epitope profiles for ON, MS and the controls, whereas epi…

MiR-155-5p promotes fibroblast cell proliferation and inhibits FOXO signaling pathway in vulvar lichen sclerosis by targeting FOXO3 and CDKN1B.

Vulvar lichen sclerosis (VLS) is a chronic inflammatory skin disorder. Evidence is accumulating that microRNAs (miRNAs) exert crucial roles in initiation and development of a wide range of human diseases. MiR-155-5p has been frequently reported to be implicated in the tumorigenesis and progression of multiple types of cancers, however, its biological role in VLS remains unclear. This study aimed to explore the role of miR-155-5p in VLS and clarify the potential molecular mechanisms involved. In the present study, miR-155-5p was observed to be significantly upregulated in VLS tissues. Functiona

Surgical Management of Encapsulating Peritoneal Sclerosis: A Case Report in Kidney Transplant Patient.

INTRODUCTION: Encapsulating peritoneal sclerosis (EPS) is a clinical syndrome of progressive fibrotic change in response to prolonged, repetitive, and typically severe insult to the peritoneal mesothelium, often occurring in the setting of peritoneal dialysis (PD). Clear guidelines for successful management remain elusive. We describe the successful surgical management of EPS in a 28-year-old male s/p deceased donor kidney transplant for end-stage renal disease (ESRD) secondary to focal segmental glomerulosclerosis (FSGS). This patient received PD for 7 years but changed to hemodialysis (HD) i

Периферальное воспаление в качестве биомаркера деятельности в связи с заболеваниями при повторном выпуске MS.

СВЯЗЬ/AIMS: Множественный склероз (RRMS) - это хроническое аутоиммунное расстройство центральной нервной системы, отмеченное неожиданными эпизодами неврологического расстройства и воспаления. Периферийные подстрекательские показатели становятся признанными в качестве неинвазивных прогнозов активности, прогресса и последующей оценки заболеваний, дополняющих традиционные клинические и радиографические оценки. Изучение корреляции между активностью заболеваний и периферийными воспалительными биомаркерами-интерлейкин-6 (IL-6), опухолью некроз-альфа (TNF-α), высокочувствительным C-реактивным белком

Совпадение в аннотации оригинала
BACKGROUND/AIMS: Relapsing-remitting multiple sclerosis (RRMS) is a chronic autoimmune disorder of the central nervous system, marked by unexpected episodes of neurological impairment and inflammation. Peripheral inflammatory indicators are becoming recognized as noninvasive predictors of disease activity, progression, and subsequent assessment, complementin…

Hyperbaric oxygen therapy for multiple sclerosis.

BackgroundMultiple Sclerosis (MS) is a chronic, recurrent and progressive illness with no cure. On the basis of speculative pathophysiology, it has been suggested that Hyperbaric Oxygen Therapy (HBOT) may slow or reverse the progress of the disease.ObjectivesThe object of this review was to evaluate the efficacy and safety of HBOT in the treatment of MS.Search strategyWe searched the Cochrane MS Group trials register (July 2002), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 2, 2002), MEDLINE (January 1966 to October 2002) and the National Library of Medicine …