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Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.

The complex pathology of cancer development requires correspondingly complex treatments. The traditional application of individual single-target drugs fails to sufficiently treat cancer with durable therapeutic effects and tolerable adverse events. Therefore, synergistic combinations of drugs represent a promising way to enhance efficacy, overcome toxicity and optimize safety. Chinese Herbal Medicines (CHMs) have long been used as such synergistic combinations. Therefore, we summarized the synergistic combinations of CHMs used in the treatment of cancer and their roles in chemotherapy in terms

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… Induction of apoptosis in HeLa cells via caspase activation by resveratrol and genistein. J. Med. Food. 2013;16(2):139–146. doi: 10.1089/jmf.2012.0141. 42. Wang P., Phan T., Gordon D., Chung S., Henning S.M., Vadgama J.V. … Induction of apoptosis in HeLa cells via caspase activation by resveratrol and genistein. J. Med. Food. 2013;16(2):139–146. doi: 10.1089/jmf.2012.0141. 71. Harper C.E., Cook L.M., Patel B.B., Wang J., Eltoum I.A., Arabshahi A., Shirai T., Lamartiniere C.A. …

Polyphenols bind G4-Quadruplex structures and act as epigenetic modifiers with anti-cancer effects.

G4-quadruplexes (G4s) are non-canonical structures of nucleic acids that develop in guanine rich regions of DNA and RNA. Due to their presence in oncogenic promoters and telomeres, G4s represent attractive targets in anticancer drug designs. G4s have also been the subject of recent research regarding their role as epigenetic modulators, supporting their participation in epigenetic processes that control gene expression. The development of small compounds that preferentially target G4s have led to a better understanding of how G4s control these mechanisms. Natural products have greatly contribu

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… Bioactive compounds such as curcumin, resveratrol, EGCG, quercetin, genistein, and kaempferol influence epigenetic processes by reactivating tumor suppressor genes that have been silenced through hypermethylation. … The combination of genistein and sulforaphane inhibits HDACs and histone methyltransferases, reducing the viability of breast cancer cells and decreasing tumor size (Paul et al., 2018[ 130 ]). …

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to po

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… Genistein and daidzein inhibited cell migration, invasion, proliferation and sphere formation, and induced cell cycle arrest and apoptosis in metastatic ovarian cancer models ( 72 ). … Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein. Endocr Connect. (2018) 7:1472–9. 10.1530/EC-18-0459 75. Xie J, Wang J, Zhu B. …

Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.

Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life. The prevalence of ON in SLE patients is variable, ranging from 1.7% to 52%. However, the pathophysiology and risk factors for ON in patients with SLE have not yet been fully determined. Several mechanisms for SLE patients' propensity to develop ON have been proposed. Glucocorticoid is a widely used therapeutic option for SLE patients and high-dose glucocorticoid therapy in SLE patients is strongly assoc

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… Genistein aglycone, an isoflavone widely found in soybeans and seen as a natural alternative to selective estrogen receptor modulators, 207 protected mice from both ovariectomy‐induced bone loss and glucocorticoid‐induced bone loss 208 , 209 , 210 and showed a protective effect on bone loss in postmenopausal … women. 211 , 212 Bitto et al also found that, in some cases, genistein aglycone also showed a positive outcome for methylprednisolone‐induced necrotic deterioration of the femoral head. 209 Vinpocetine, a natural compound extracted from the leaves of Phyllostachys pubescens , 213 has also shown a protective …

Pancreatic cancer: chemotherapy and radiotherapy.

Pancreatic cancer in many cases appears in a non-curatively resectable stage when the diagnosis is made. Palliative treatment become an option in the patients with advanced stage. The present article reviewed chemotherapy and radiotherapy in various advanced stage of pancreatic cancer.

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… Int was reported in vitro and in vivo preclinical evidence in support of chemo-sensitization of drug-resistant cells by a non-toxic chemopreventive agent (genistein). … Genistein pretreatment together with low concentration of OxP showed significant reduction in cell viability and colony formation concomitant with increased apoptosis, which was highly synergistic. …

Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

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… Genistein ( Figure 6 ), originally labeled as a phytoestrogen, is one of the major isoflavones found in soy products and has been shown to inhibit cancer growth in vitro and in vivo [ 194 , 203 ]. … In vitro, genistein inhibits endothelial cell proliferation at concentrations that are in the range of those found in urine of subjects consuming a plant-based diet. …

Prediction of cancer drugs by chemical-chemical interactions.

Cancer, which is a leading cause of death worldwide, places a big burden on health-care system. In this study, an order-prediction model was built to predict a series of cancer drug indications based on chemical-chemical interactions. According to the confidence scores of their interactions, the order from the most likely cancer to the least one was obtained for each query drug. The 1(st) order prediction accuracy of the training dataset was 55.93%, evaluated by Jackknife test, while it was 55.56% and 59.09% on a validation test dataset and an independent test dataset, respectively. The propos

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… Genistein-Cancers of the lung and pleura Genistein (DB01645) is an experimental agent for the treatment of prostate cancer [125] . … Moreover, Lian et al. reported that genistein may be a promising agent to treat NSCLC because genistein induced apoptosis of NSCLC cells by a p53-independent pathway [126] . …

Healthy Effects of Plant Polyphenols: Molecular Mechanisms.

The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have

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… For example, genistein, one of the phytoestrogens found in soybeans, reduces DNMT activity, forming a complex with it, and activates tumor suppressor genes, with possible significance for cancer prevention and therapy [ 267 ]. … Finally, it appears that the inhibition of DNMT is a chemopreventive effect on cancer cell growth by genistein, suggesting its use as anti-neoplastic drug in some malignancies [ 272 ]. 6.2. …

Polyphenols as Antitumor Agents Targeting Key Players in Cancer-Driving Signaling Pathways.

Polyphenols constitute an important group of natural products that are traditionally associated with a wide range of bioactivities. These are usually found in low concentrations in natural products and are now available in nutraceuticals or dietary supplements. A group of polyphenols that include apigenin, quercetin, curcumin, resveratrol, EGCG, and kaempferol have been shown to regulate signaling pathways that are central for cancer development, progression, and metastasis. Here, we describe novel mechanistic insights on the effect of this group of polyphenols on key elements of the signaling

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… A study by Zhou et al. in 2021 concluded that curcumin had stronger cytotoxic activity against acute myeloid leukemia cells compared with three other types of phytochemicals (epigallocatechin 3-gallate, genistein, and resveratrol). … Of these, apigenin, kaempferol, and genistein were able to reverse the transformed phenotypes, affecting cellular proliferation, morphological change, and colony formation in soft agar. …

Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.

Glucose-dependent insulinotropic polypeptide (GIP) acts as a glucose-dependent growth factor for beta-cells. Here we show that GIP and glucose also act synergistically as anti-apoptotic factors for beta-cells, using the well-differentiated beta-cell line, INS-1. Mitogenic and anti-apoptotic signaling of GIP were dependent upon pleiotropic activation of protein kinase A (PKA)/cAMP regulatory element binder (CREB), mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3-kinase)/PKB signaling modules. The signaling modules activated by GIP were dependent on glucose metaboli

Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma.

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabolites depended on the expression levels of certain non-coding RNAs, in particular, of small microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The development of tumor resistance towards antimetabolites was regulated by non-coding RNAs. An overview of the interplay between gemcitabine/pemetrexed antimetabolites and non-coding RNAs in mesothelioma is provided. Further to th

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… Soy ( Glycine max ) is an integral component of the daily diet of millions of people all over the world and its isoflavone component genistein was identified as a suppressor of the oncomir miR-21. … The well-studied oncogenic lncRNA HOTAIR was distinctly suppressed by genistein [ 113 ]. …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

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… WO2022135652A1 (2021) describes genistein-loaded phytosomes aimed at liver cancer treatment through oral administration, using various phospholipid types to improve solubility and bioavailability. 30 Similarly, Patent No. … Genistein Promotes Proliferation of Human Cervical Cancer Cells Through Estrogen Receptor-Mediated PI3K/Akt-NF-κB Pathway. J Cancer . 2018;9(2):288–295. doi: 10.7150/jca.20499 51. Arya A, Paul S, Gangwar A. …

A technical note on emerging combination approach involved in the onconanotherapeutics.

Cancer is the second cause of mortality worldwide, and the currently available conventional treatment approach is associated with serious side effects and poor clinical outcomes. Based on the outcome of the exploratory preclinical and clinical studies, it was found that therapeutic response increases multiple folds when anticancer drugs are used in combination. However, the conventional combination of anticancer drugs was associated with various limitations such as increased cost of treatment, systemic toxicity, drug resistance, and reduced pharmacokinetic attributes. Hence, attempts were made

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… Considering these factors, a recent study designed a liposomal nanocarrier, encapsulated with celecoxib and genistein, due to their antitumoral properties. … Reactive oxygen species were not formed when cells were treated with empty liposomes (EL), celecoxib liposomes (CL) and genistein (GL), while a 3-fold rise in production of ROS was obtained in the cells subjected to celecoxib-genistein complex treatment. …

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.

In recent decades Chinese medicine has been used worldwide as a complementary and alternative medicine to treat cancer. Plenty of studies have shown that microRNAs (miRNAs) play fundamental roles in many pathological processes, including cancer, while the anti-cancer mechanisms of Chinese medicinal herbs targeting miRNAs also have been extensively explored. Our previous studies and those of others on Chinese medicinal herbs and miRNAs in various cancer models have provided a possibility of new cancer therapies, for example, up-regulating the expression of miR-23a may activate the positive regu

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… Genistein is a kind of isoflavone which has shown activity inducing apoptosis in prostate cancer cells. MiR-1260b was down-regulated by more than 50 percent after genistein treatment in prostate cancer cells. Knocking down miR-1260b caused inhibition of two target genes, sFRP1 and Smad4. … Genistein downregulates onco-miR-1260b and upregulates sFRP1 and Smad4 via demethylation and histone modification in prostate cancer cells. Br. J. Cancer. 2014;110:1645–1654. doi: 10.1038/bjc.2014.48. 34. Lin Y., Lin L., Jin Y., Zhang Y., Wang D., Tan Y., Zheng C. …

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma.

Background and objectivesESC or Ehrlich solid carcinoma is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is a highly aggressive and fast-growing carcinoma that can create a solid mass when inserted under the skin. Its solid, undifferentiated form makes it an ideal model for researching cancer biology, tumor immunology, and testing various anti-cancer treatments. Additionally, arctiin has multiple beneficial properties, such as anti-proliferative, anti-oxidative, anti-adipogenic, and anti-bacterial. This study aimed to explore the potential anti-cancer benefi

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… 10.1080/01635580701277585 11 Nigella sativa oil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis Redox Rep Al-Gayyar MM Hassan HM Alyoussef A Abbas A Darweish MM El-Hawwary AA 50 60 21 2016 26221999 10.1179/1351000215Y.0000000035 PMC6837667 12 Genistein … 13510002.2023.2218679 PMC10236962 37260037 13 Curative effects of crocin in ulcerative colitis via modulating apoptosis and inflammation Int Immunopharmacol Albalawi GA Albalawi MZ Alsubaie KT Albalawi AZ Elewa MA Hashem KS Al-Gayyar MM 118 2023 10.1016/j.intimp.2023.110138 37030122 14 Therapeutic effects of genistein …

Drug Delivery Approaches for the Treatment of Cervical Cancer.

Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer chemotherapy. In this review, we summarized some of the recent research in systematic and localized drug delivery systems and compared the advantages and disadvantages of these methods.

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… In another study, genistein-encapsulated ε-caprolactone-based NPs exhibited more cytotoxicity and tumor cell growth inhibition compared with pristine genistein in the subcutaneous HeLa xenograft tumor model in BALB/c nude mice [ 67 ]. … Fabrication of genistein-loaded biodegradable TPGS- b -PCL nanoparticles for improved therapeutic effects in cervical cancer cells Int. J. Nanomed. 2015 10 2461 2473 10.2147/IJN.S78988 PMC4383221 25848264 68. Zhang C. Zhang Z. Zhao L. …

Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

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… Disease Characteristics | Pure Compounds: | Extracts: | Composite Mixtures: Alzheimer’s disease cognitive impairment | Resveratrol [ 11 , 12 , 32 , 33 , 34 ] Silymarin [ 35 , 36 ] Chlorogenic Acid [ 37 ] Isoflavone [ 38 ] Sesamin [ 39 ] Genistein [ 40 ] Catechins [ 41 , 42 ] Epigallocatechin Gallate … Genistein in the control of AD progression: From molecular mechanisms to clinical improvement: The GENIAL clinical trial ( NCT01982578 ) J. Nutr. Health Aging. 2022;26:469. 41. Carmichael O.T., Pillai S., Shankapal P., McLellan A., Kay D.G., Gold B.T., Keller J.N. …

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors.

The N-methyl-D-aspartate (NMDA) receptor contributes to synaptic plasticity in the central nervous system and is both serine-threonine and tyrosine phosphorylated. In CA1 pyramidal neurons of the hippocampus, activators of protein kinase C (PKC) as well as the G-protein-coupled receptor ligands muscarine and lysophosphatidic acid enhanced NMDA-evoked currents. Unexpectedly, this effect was blocked by inhibitors of tyrosine kinases, including a Src required sequence and an antibody selective for Src itself. In neurons from mice lacking c-Src, PKC-dependent upregulation was absent. Thus, G-prote

Нацеливание на природные полифенолы антиоксидантов в целях защиты от нейроинфламмации и нейродегенеративных заболеваний: всеобъемлющий обзор.

Полифенолы, природные фитонутриенты, встречающиеся в растительных продуктах питания, привлекли значительное внимание к их потенциальному терапевтическому воздействию в неврологических заболеваниях и нейроинфламмации. Эти соединения обладают различными возможностями нейрозащиты, включая антиоксидантные, антивоспалительные и антиамильоидные свойства, которые способствуют смягчению развития таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), деменция, множественный склероз (MS), Строк и болезнь Хантингтона (HD). Полифенолы были тщательно изучены на предме

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… Kwatra et al. (2020) Naringenin Grapefruit, oranges 10–50 µM Antioxidant, anti-inflammatory, inhibits NF-κB, promotes neuroprotection Atoki et al. (2024) Fisetin Strawberries, apples 5–50 µM Antioxidant, enhances autophagy, promotes synaptic plasticity, increases BDNF Ravula et al. (2021) Genistein … Genistein, sourced from soybeans and legumes, reduces oxidative stress, modulates estrogen receptors, and inhibits neuroinflammation ( Dogra et al., 2023 ). …

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.

The pivotal role of cancer stem cells (CSCs) in the initiation and progression of malignancies has been rigorously validated, and the specific methods for identifying and isolating the CSCs from the parental cancer population have also been rapidly developed in recent years. This review aims to provide an overview of recent research progress of Chinese medicines (CMs) and their active compounds in inhibiting tumor progression by targeting CSCs. A great deal of CMs and their active compounds, such as Antrodia camphorate, berberine, resveratrol, and curcumin have been shown to regress CSCs, in t

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… Genistein, glycitein, and daidzein are the three major components and the most studied isoflavones in soybean. … These data suggest that genistein has anti-tumor activity, which is in part mediated by deregulation of several CSC-related miRNAs during the development and progression of tumors. …