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Comparison of human monkeypox, chickenpox and smallpox: a comprehensive review of pathology and dermatological manifestations.

Variola virus, the causing agent of smallpox, was eradicated in 1980s and today no new cases are reported. The first human infectious illness to be eliminated globally is variola. On the contrary to Variola, monkeypox, which is a zoonotic and variola-like disease, has nowadays turned to be a major health problem worldwide. VZV is a neurotropic virus and the cause of varicella (chickenpox) and herpes zoster (shingles), which is also a highly infectious disease, especially prevalent in children. These three skin diseases-monkeypox, smallpox, and chickenpox-are frequently mistaken with one anothe

Network Pharmacology and Molecular Docking Analysis Reveal Insights into the Molecular Mechanism of Shengma-Gegen Decoction on Monkeypox.

BACKGROUND: A new viral outbreak caused by monkeypox has appeared after COVID-19. As of yet, no specific drug has been found for its treatme … ory response to infection and viral replication. Therefore, SMGGD might suppress the replication of monkeypox virus through the MAPK signaling pathway while also reducing inflammatory damage caused by viral infection. CONCLUSION: SMGGD may have positive therapeutic effects on monkeypox by reducing inflammatory damage and limiting virus replication.

Monkeypox 2022 Identify-Isolate-Inform: A 3I Tool for frontline clinicians for a zoonosis with escalating human community transmission.

Monkeypox 2022, a zoonotic virus similar to smallpox, presented as a rapidly escalating human outbreak with community transmission outside e … ith an incubation period of 5-21 days (usually 6-13 days). The prodrome may be subclinical, and the monkeypox virus may be transmissible from person-to-person before observed symptom onset. Most clinicians are unfamiliar with monkeypox. Information is rapidly evolving, producing an urgent need for immediate access to clear, concise, fact-based, and actionable inf …

Monkeypox Cross-Sectional Survey of Knowledge, Attitudes, Practices, and Willingness to Vaccinate among University Students in Pakistan.

This study aimed to explore knowledge, attitude, perceptions, and willingness regarding vaccination among university students in Pakistan. T … respondents. Our findings emphasize the need to raise public awareness by educating students on the monkeypox virus. This will improve adherence to preventative recommendations.

Bibliometric analysis of human monkeypox research from 1975 to 2022 and novel prevention and control strategies.

BACKGROUND: Since human monkeypox was reported, many related literatures have been published. This study aimed to evaluate the research hots … obtained through cluster analysis: (1) human monkeypox epidemiology and species research. (2) human monkeypox virus vaccine and experimental research. (3) human monkeypox disease diagnosis and treatment studies. (4) human monkeypox disease prevention and immunization studies. To curb the spread, regions or countries have developed and implemented detailed managem …

Monkeypox: Origin, Transmission, Clinical Manifestations, Prevention, and Therapeutic Options.

Monkeypox is a rapidly spreading transmissible disease induced by the monkeypox virus (MPXV), a major public health problem worldwide. The origin of monkeypox might be tracked to the continent of Africa, where it first afflicted primate species prior to spreading to the world. Severe health issues for the public have been raised as a result of the disease's current breakouts in nonendemic areas and its subsequent dissemination to several nations throughout the globe. Monkeypox spreads by having contact with infected creatures or people, as well as respiratory droplets and contaminated things. …

Monkeypox treatment: Current evidence and future perspectives.

As of September 11, 2022, 57 669 reports of monkeypox infection raised global concern. Previous vaccinia virus vaccination can protect from monkeypox. However, after smallpox eradication, immunization against that was stopped. Indeed, therapeutic options following the disease onset are of great value. This study aimed to review the available evidence on virology and treatment approaches for monkeypox and provide guidance for patient care and future studies. Since no randomized clinical trials were ever performed, we reviewed monkeypox animal model studies and clinical trials on the safety and

Monkeypox Entry and Emergence Preparation in Pakistan.

Monkeypox (Mpox) is a virus that first emerged in Africa in 1970 [...].

Otorhinolaryngological manifestations in monkeypox.

BACKGROUND AND OBJECTIVE: In the current health emergency declared by the World Health Organization (WHO) for monkeypox, few data on the oto … s confirmed polymerase chain reaction (PCR) positivity for monkeypox in all patients. CONCLUSIONS: Monkeypox virus infection can occur in the ENT area with multiple manifestations that require a high degree of epidemiological suspicion and confirmation with PCR to reach a diagnosis of certainty.

Genitourinary Lesions Due to Monkeypox.

BACKGROUND: Since May 2022, 31 000 cases of monkeypox infection have been reported in nonendemic areas. OBJECTIVE: To describe a series of cases of monkeypox with genitourinary involvement. DESIGN, SETTING, AND PARTICIPANTS: This was a prospective observational study of men diagnosed with monkeypox disease with genitourinary involvement. RESULTS AND LIMITATIONS: A total of 14 patients were recruited. The median age was 42 yr. Of these patients, 43% sought a consultation for genitourinary symptomatology, and 71% had engaged in sex with other men. Eight patients (57%) were positive for human

Monkeypox: Another Sexually Transmitted Infection?

Monkeypox virus is a zoonotic DNA virus (Poxviridae family), identified in 1958 in Asian monkeys (mostly Macaca fascicularis) in a polio vaccine research animal facility in Copenhagen, Denmark [...].

Understanding the infection severity and epidemiological characteristics of mpox in the UK.

In May 2022, individuals infected with the monkeypox virus were detected in the UK without clear travel links to endemic areas. Understanding the clinical characteristics and infection severity of mpox is necessary for effective public health policy. The study period of this paper, from the 1st June 2022 to 30th September 2022, included 3,375 individuals that tested positive for the monkeypox virus. The posterior mean times from infection to hospital admission and length of hospital stay were 14.89 days (95% Credible Intervals (CrI): 13.60, 16.32) and 7.07 days (95% CrI: 6.07, 8.23), respectiv…

Monkeypox Presenting as an Isolated Finger Infection: A Case Report.

CASE: A 50-year-old man with HIV presented with an isolated dorsal index finger abscess. He underwent incision and debridement, but no pus was encountered. Surgical pathology demonstrated pox virus features. He then developed body pustules confirmed as monkeypox through polymerase chain reaction. The surgical wound deteriorated, prompting a second debridement of necrotic skin. Vesicles consistent with viral infection then appeared. The finger healed with local wound care within 3 months, achieving excellent function. CONCLUSION: This case illustrates an uncommon presentation of monkeypox, res

Обезьяна: Кожа распространяется от первоначального контакта в трех случаях.

Onekeypox — зооноз, вызванный вирусом обезьяноксина. В 2022 году Всемирная организация здравоохранения объявила < < обезьянопокс > > чрезвычайной ситуацией в области здравоохранения, вызывающей озабоченность международного сообщества, в связи с его беспрецедентным глобальным распространением. С июня 2023 года в материковой части Китая вновь появилось несколько новых дел, что свидетельствует о сохраняющейся опасности передачи инфекции. Наши три случая, подтвержденные количественной цепной реакцией полимеразы в режиме реального времени с дермоскопическими и гистопатологическими данны

Совпадение в аннотации оригинала
Monkeypox is a zoonosis caused by the monkeypox virus. In 2022, the World Health Organization declared monkeypox a Public Health Emergency of International Concern due to its unprecedented global spread. Since June 2023, several new cases have re-emerged in mainland China, underscoring the ongoing transmission risk. Our three cases, confirmed by real-time qu…

Nigericin is a potent inhibitor of the early stage of vaccinia virus replication.

Poxviruses remain a significant public health concern due to their potential use as bioterrorist agents and the spread of animal borne poxviruses, such as monkeypox virus, to humans. Thus, the identification of small molecule inhibitors of poxvirus replication is warranted. Vaccinia virus is the prototypic member of the Orthopoxvirus genus, which also includes variola and monkeypox virus. In this study, we demonstrate that the carboxylic ionophore nigericin is a potent inhibitor of vaccinia virus replication in several human cell lines. In HeLa cells, we found that the 50% inhibitory concentra…

[Otorhinolaryngological manifestations in monkeypox].

BACKGROUND AND OBJECTIVE: In the current health emergency declared by the World Health Organization (WHO) for monkeypox, few data on the oto … s confirmed polymerase chain reaction (PCR) positivity for monkeypox in all patients. CONCLUSIONS: Monkeypox virus infection can occur in the ENT area with multiple manifestations that require a high degree of epidemiological suspicion and confirmation with PCR to reach a diagnosis of certainty.

Detection and differentiation of old world orthopoxviruses: restriction fragment length polymorphism of the crmB gene region.

A restriction fragment length polymorphism (RFLP) assay was developed to identify and differentiate Old World, African-Eurasian orthopoxviruses (OPV): variola, vaccinia, cowpox, monkeypox, camelpox, ectromelia, and taterapox viruses. The test uses amplicons produced from virus genome DNA by PCR with a consensus primer pair designed from sequences determined for the cytokine response modifier B (crmB) gene of 43 different OPV strains of known taxonomic origin. The primer pair amplified a single specific product from each of the 115 OPV samples tested. Size-specific amplicons identified and diff

NIH scientists charged with smuggling viruses into U.S.

Inactivated monkeypox virus samples may have been used for routine diagnostics.

Assessment of knowledge, attitudes and behavior, perception, risk factors, practices, One Health, and interventions regarding Monkeypox in Pakistan.

INTRODUCTION: The monkeypox virus, a species of the Orthopoxvirus genus in the Poxviridae family, is the etiological agent of monkeypox, a rare but re-emerging zoonotic disease in non-endemic regions. AIM AND OBJECTIVES: This study assessed the knowledge, attitudes, and awareness, as well as the risk factors related to monkeypox, among the general population of Pakistan. It also investigated preventive practices, healthcare-seeking behavior, and One Health awareness to inform evidence-based strategies for reducing monkeypox incidence in Pakistan. METHODOLOGY: A cross-sectional study was cond…