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Kynurenin Pathway Modulation by Working in Multical Sclerosis: Последствия для защиты от нейро и воспаления.

Множественный склероз (MS) — хроническое, воспалительное и нейродегенеративное заболевание центральной нервной системы (CNS), характеризующееся иммунной диагностикой и нейронным воспалением. Благодаря образованию нейроактивных метаболитов, кинуреньский путь (КП), один из ключевых путей метаболизма триптофана, влияет на патогенез MS, регулируя иммунную реакцию и нейронный гомеостаз. Регулирование КП приводит к перепроизводству таких нейротоксичных метаболитов, как квинолинская кислота (QUIN), для которых характерна потеря гомеостаза между нейрозащитой (например, кинуриновой кислотой, KYNA) и не

Совпадение в аннотации оригинала
Multiple Sclerosis (MS) is a chronic, inflammatory, and neurodegenerative disease of the Central Nervous System (CNS) that is characterized by immune dysregulation and neuroinflammation. Owing to the generation of neuroactive metabolites, the kynurenine pathway (KP), one of the key pathways of tryptophan metabolism, influences the pathogenesis of MS by regul…

Autoimmune inflammation as a key risk factor for heart failure with preserved ejection fraction: the different types of inflammation driving to HFpEF.

IMPORTANCE: Heart failure with preserved ejection fraction (HFpEF), defined by an ejection fraction >50%, has emerged as the most prevalent form of heart failure at the community level. Multiple comorbidities, including diabetes, hypertension, obesity, atrial fibrillation, renal diseases, and autoimmune conditions, have been linked to its development. These conditions share common pathways involving oxidative stress, metabolic dysregulation, ischemia, and a chronic inflammatory milieu. OBSERVATIONS: Patients with autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythemato

The putative acceleration of optic neuritis when combined with chronic hepatitis B.

PURPOSE: To review the clinical features of optic neuritis (ON) combined with chronic hepatitis B (CHB) retrospectively. METHOD: Clinical d … end of the follow-up period, which averaged 13.7 (4-31) months. None of the patients progressed to multiple sclerosis (MS) or neuromyelitis optica (NMO). All blood samples were negative for serological aquaporin 4-antibody using the cell-based assay. CONCLUSIONS: CHB-ON usually presented as the atypical form. Chronic hepatitis B virus infection may lead to the ten …

Идентификация генов, связанных с Ферроптозом и Гипоксией, в олигодендроцитных клетках, созданных на основе iPSC, от множественных склерозных пациентов.

Множественный склероз (MS) — хроническое провокационное расстройство, характеризующееся обезвоживанием, с неудачным восстановлением, приводящим к постепенной потере аксона в хронической фазе. Клетки-прекурсоры олигодендроциты (ОПК) имеют решающее значение для ремиелиции. Недавние исследования показывают, что как гипоксия, так и ферроптоз играют важнейшую роль в дисфункциональной дифференциации ОПС. Цель этого исследования заключается в выявлении ключевых генов, связанных с гипоксией и ферропотозом и иммунной инфильтрацией в ОПС, которые получены из индуцированных плюрипотентных стволовых клето

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic inflammatory disorder characterized by demyelination, with failed remyelination leading to progressive axon loss in chronic stages. Oligodendrocyte precursor cells (OPCs) are critical for remyelination. Recent studies suggest that both hypoxia and ferroptosis play crucial roles in the dysfunctional differentiation of OPCs…

Perceived behavioral changes in early multiple sclerosis.

Acquired behavioral changes have essentially been described in advanced multiple sclerosis (MS). The present study was designed to determine whether behavioral modifications specifically related to the MS pathological process could be identified in the initial phase of the disease, as compared to control patients with chronic, relapsing and progressive inflammatory disorders not involving the central nervous system (CNS). Eighty-eight early MS patients (Expanded Disability Status Scale score <or= 2.5) and 48 controls were tested. Perceived changes by informants in behavioral control, goal-dire…

Genetic subtypes of multiple sclerosis severity are uncoupled from inflammatory lesion burden.

Determinants of long-term disability in multiple sclerosis (MS) remain incompletely understood, with clinical course varying greatly among individuals. Recent integrative genetic models have identified genomic clusters associated with divergent disability trajectories. Here, we integrated clinical, genetic, and postmortem neuropathological data from 291 MS brain donors from the UK MS Society Tissue Bank to test whether genomic severity clusters converge on distinct tissue phenotypes. Consistent with prior stratification, donors in genomic cluster 2 had lower age-adjusted disease duration score…

TNFR2 signaling in oligodendrocyte precursor cells suppresses their immune-inflammatory function and detrimental microglia activation in CNS demyelinating disease.

Multiple Sclerosis (MS) is a chronic degenerative disease of the central nervous system (CNS) characterized by inflammation, demyelination, and progressive neurodegeneration. These processes, combined with the failure of reparative remyelination initiated by oligodendrocyte precursor cells (OPCs), lead to irreversible neurological impairment. The cytokine tumor necrosis factor (TNF) has been implicated in CNS repair via activation of its cognate receptor TNFR2 in glia. Here, we demonstrate the important role of TNFR2 in regulating OPC function in vivo during demyelinating disease, and that TNF…

An mTORC1-Dependent Mouse Model for Cardiac Sarcoidosis.

Background Sarcoidosis is an inflammatory, granulomatous disease of unknown cause affecting multiple organs, including the heart. Untreated, unresolved granulomatous inflammation can lead to cardiac fibrosis, arrhythmias, and eventually heart failure. Here we characterize the cardiac phenotype of mice with chronic activation of mammalian target of rapamycin (mTOR) complex 1 signaling in myeloid cells known to cause spontaneous pulmonary sarcoid-like granulomas. Methods and Results The cardiac phenotype of mice with conditional deletion of the tuberous sclerosis 2 (TSC2) gene in CD11c+ cells (T

Clinical associations and characteristics of the polyspecific intrathecal immune response in elderly patients with non-multiple sclerosis chronic autoimmune-inflammatory neurological diseases - a retrospective cross-sectional study.

INTRODUCTION: The polyspecific intrathecal immune response (PSIIR), aka MRZ reaction (M = measles, R = rubella, Z = zoster, optionally Herpes simplex virus, HSV) is defined as intrathecal immunoglobulin synthesis (IIS) for two or more unrelated viruses. Although an established cerebrospinal fluid (CSF) biomarker for multiple sclerosis (MS), a chronic autoimmune-inflammatory neurological disease (CAIND) of the central nervous system (CNS) usually starting in young adulthood, the full spectrum of CAINDs with a positive PSIIR remains ill defined. METHODS: In this retrospective, cross-sectional s…

Связанные с сексом различия в факторах стиля жизни, влияющих на устойчивость к множественным склерозам и прогресс в области заболеваний.

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое затрагивает женщин чаще, чем мужчин. Этот разрыв между полами за последнее столетие увеличился и, как представляется, формируется не биологическими факторами, а факторами образа жизни. В настоящем докладе рассматриваются данные о различиях по признаку пола в факторах риска, влияющих на образ жизни, и их влиянии как на подверженность MS, так и на прогрессию заболеваний, что имеет последствия для диагностики, мониторинга и лечения. Курение, ожирение, недостаток витамина D, ультрафиолетовое облу

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that affects women more frequently than men. This sex gap has widened over the past century, and appears to be shaped by lifestyle factors more than biological factors. This narrative review examines the evidence for sex-specific differences in lifestyle risk factors and th…

Выборочное ингибирование митохондриала Kv1.3 предотвращает и смягчает множественный склероз в vivo.

Множественный склероз (MS) характеризуется вторжением в мозг с помощью эффектора памяти T (TEM) лимфоцитов, которые были активированы при повторной самоантигенной стимуляции. Существующие методы лечения нацелены на эти и другие автоматически реактивные лимфоциты, но их побочные эффекты включают общее иммуноусилительное воздействие и токсичность. Поскольку канал калия Kv1.3 характеризуется высокой активностью хронически активированных самореактивных ТЕА, мы изучили вопрос о том, может ли конкретная адресация митохондриала Kv1.3 с использованием фармакологического ингибитора PAPTP выборочно убит

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is characterized by invasion of the brain by effector memory T (TEM) lymphocytes that have been activated by repeated auto-antigen stimulation. Existing therapies target these and other autoreactive lymphocytes but their side effects include general immunosuppression and toxicity. Because the Kv1.3 potassium channel is highly expresse…

Воздействие физических упражнений, MitoQ и их комбинация на воспаление и гениальное выражение в женщинах с множественным склерозом.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, затрагивающее центральную нервную систему. Нынешние методы лечения направлены на регулирование симптомов и медленных темпов развития заболеваний, однако существует необходимость в эффективных мерах, направленных на устранение основных причин заболеваний. В этом исследовании мы изучили последствия физических упражнений, MitoQ (целевой антиоксидант митохондрии) и их комбинацию с генным выражением различных биомаркеров, связанных с MS, у постменопаузальных и предменопаузальных женщин. Мы измерили интерлейкин-6 (IL-6) и ключевые мо

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system. Current treatments aim to manage symptoms and slow disease progression, but there is a need for effective interventions that target underlying disease mechanisms. In this study, we investigated the effects of exercise, MitoQ (a mitochondria-targeted antioxidant), an…

The impact of ketogenic diet on the onset and progression of multiple sclerosis.

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation and neurodegeneration. Current research suggests that diet may influence disease course, severity of symptoms, and quality of life in MS patients. The ketogenic diet (KD) has been used for more than a century as a therapeutic approach for various medical conditions. It was originally developed in the 1920s as a treatment option for epilepsy, and especially in the last 30 years, has gained popularity for its potential benefits in a variety of neurological conditions other th…

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.

Multiple sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the central nervous system (CNS) and one of the leading causes of neurological deficits and disability in young adults in western countries. Current medical treatment mainly influences disease progression via immunomodulatory or immunosuppressive actions. Indeed, MS research has been foremost focused on inflammation in the CNS, but more recent evidence suggests that chronic disability in MS is caused by neurodegeneration. Imaging studies show an early involvement of neurodegeneration as brain atrophy and gray matte…

[Cormorbidity in multiple sclerosis and its therapeutic approach].

Multiple sclerosis (MS) is a long-term chronic disease, in which intercurrent processes develop three times more frequently in affected individuals than in persons without MS. Knowledge of the comorbidity of MS, its definition and measurement (Charlson index) improves patient management. Acting on comorbid conditions delays the progression of disability, which is intimately linked to the number of concurrent processes and with health states and habits. Moreover, the presence of comorbidities delays the diagnosis of MS, which in turn delays the start of treatment. The main comorbidity found in …

Management of neuropathic pain.

PURPOSE OF REVIEW: Neuropathic pain is a chronic pain condition arising from injury or disease of the peripheral or central nervous system w … ropathic pain conditions, lidocaine patches for postherpetic neuralgia and cannabinoids for pain in multiple sclerosis. Carbamazepine or oxcarbazepine is the treatment of choice for trigeminal neuralgia. The efficacy of these drugs in other neuropathic pain conditions as well as the efficacy of lamotrigine and topical capsaicin is questionable, but they may be usefu …

Altered neural mechanisms of cognitive control in patients with primary progressive multiple sclerosis: An effective connectivity study.

Primary progressive multiple sclerosis (PPMS) leads to physical and cognitive disability. Specifically, cognitive deficits in PPMS have been explained by both grey matter atrophy and white matter lesions. However, existing research still lacks in the understanding of how the brain of a patient with PPMS functions under cognitive control demands. Thus, the aim of the current study was to examine information integration in patients with PPMS using a search-based effective connectivity method. Fourteen patients with PPMS and 22 age- and gender-matched healthy controls (HC) performed the Stroop ta…

Deletion of mitochondrial anchoring protects dysmyelinating shiverer: implications for progressive MS.

The demyelinating disease multiple sclerosis (MS) has an early inflammatory phase followed by an incurable progressive phase with subdued inflammation and poorly understood neurodegenerative mechanism. In this study, we identified various parallelisms between progressive MS and the dysmyelinating mouse model Shiverer and then genetically deleted a major neuron-specific mitochondrial anchoring protein Syntaphilin (SNPH) from the mouse. Prevailing evidence suggests that deletion of SNPH is harmful in demyelination. Surprisingly, SNPH deletion produces striking benefits in the Shiverer by prolong…

"It's Like a Double Whammy!": A Photo-Phenomenological Analysis of the Experiences of Lesbian, Gay, Bisexual, and Queer People Living With Multiple Sclerosis.

Multiple sclerosis (MS) is a neurological, autoimmune condition which affects the nervous system, creating several physiological and psychosocial issues. Simultaneously, there is an expanding body of research on lesbian, gay, bisexual, and queer (LGBQ) populations which indicates health inequalities due to heteronormativity. Despite this, research exploring chronic illness, neurological conditions, and MS within LGBQ contexts remains limited. Therefore, we aimed to investigate the experience of LGBQ people living with MS. We undertook a culturally responsive multi-method approach, employing ve…

Заболеваемость медленно расширяющимися лизами у пациентов с множественным склерозом: систематический обзор и мета-анализ.

Хронические активные повреждения (CAL) отражают хроническое воспаление при множественном склерозе (MS). Медленно расширяющиеся повреждения (SELs) представляют собой КАЛ, выявленные на обычных МРТ в результате линейного концентрического расширения с течением времени, а парамагнитные повреждения обода (PRLs) - КАЛ, характеризующиеся парамагнитным ободом на чувствительных МRI. Вместе с тем остается неясным вопрос о распространенности СЭЛ и их совпадении с СПР. Цели этого исследования заключались в том, чтобы:1) оценить долю SEL среди всех повреждений Т2 и долю пациентов, имеющих по крайней мере 1

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Chronic active lesions (CALs) reflect chronic inflammation in multiple sclerosis (MS). Slowly expanding lesions (SELs) are CALs identified on conventional MRI by linear, concentric expansion over time, while paramagnetic rim lesions (PRLs) are CALs characterized by a paramagnetic rim on susceptibility-sensitive MRI. However, the pr…