Результаты поиска

Willingness and concerns of transfusion-dependent hematological patients toward the option of home transfusion therapy.

BackgroundOne of the main obstacles of providing home-based palliative care to transfusion-dependent hematology patients is the lack of home transfusions services. While healthcare professionals are concerned with safety and cost of home transfusions, the attitude of the patients toward home transfusions are mostly unknown.AimTo obtain quantitative data regarding the willingness and concerns of transfusion-dependent patients with hematological diseases toward the option of home transfusions.DesignA cross sectional survey including a self-administered questionnaire in one of the three main spok

Совпадение в полном тексте источника
… An evaluation of a domiciliary blood transfusion service for palliative care patients in Northern Ireland . Community Pract 2008 ; 81 ( 7 ): 32 – 35 . 18655644 8. Havet N Morelle M Remonnay R , et al . …

Student Summer Research Awards - SSRAAbstracts of the SSRA September 2022 meeting, UCD School of Medicine.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Глобальное, региональное и национальное бремя четырех основных неврологических заболеваний у женщин в период с 1990 по 2021 год.

Неврологические заболевания женщин недооцениваются. Цель этого исследования заключалась в оценке структуры и тенденций четырех основных заболеваний нервной системы у женщин. МЕТОДЫ: Использование данных из исследования 2021 года GBD о частотности заболевания Альцгеймера (AD) и других слабоумиях, болезни Паркинсона, множественном склерозе и идиопатической эпилепсии у женщин с 1990 по 2021 год. Мы провели оценку тенденций в разбивке по возрасту и социально-демографическому индексу (ИПД) на глобальном, региональном и национальном уровнях с использованием оценочных годовых процентных изменений (ЕА

Совпадение в полном тексте источника
… The highest ASDR were recorded in Islamic Republic of Afghanistan, United Arab Emirates, United Kingdom of Great Britain and Northern Ireland, and Republic of Zambia for AD and other dementias, Parkinson’s disease, multiple sclerosis, and idiopathic epilepsy, respectively ( Supplementary Figures S1–S4 …

Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia.

The therapeutic landscape of acute myeloid leukaemia (AML) has evolved beyond the classic '7 + 3'/DA regimen, through the approval and incorporation of targeted treatments in both front-line and relapsed/refractory settings. Indeed, the use of selective BCL-2 antagonists (e.g. venetoclax) and FLT3 inhibitors (e.g. midostaurin, gilteritinib) which target specific molecular characteristics of leukaemic cells, has enhanced outcomes and survival rates. Arguably one of the most exciting advancements has been the clinical development of menin inhibitors for the treatment of patients harbouring speci

Совпадение в полном тексте источника
… Acknowledgements Research in the laboratories of KML and GG is funded, in part, by Leukaemia and Lymphoma Northern Ireland; LER is supported by a research grant from Leukaemia and Lymphoma Northern Ireland (R2060CNR). …

Oral Communication abstracts

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

The role of funding and policies on innovation in cancer drug development.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… It is a joint initiative between Cancer Research UK and the Departments of Health in England, Scotland, Wales and Northern Ireland. See: http://www.ecmcnetwork.org.uk/ See http://www.cancerportfolio.org/wizsearch.jsp?add=FundingOrg for details on individual funders including full names. …

Неравный доступ к диагностике миальгического энцефаломиэлита в Англии.

Люди с мальгическим энцефаломелитом (ME/CFS; иногда называются синдромом хронической усталости) сталкиваются с низким качеством жизни, связанным со здоровьем, и лишь в редких случаях восстанавливаются. У МОС/КВПБ нет лечения и единого диагностического теста. Для принятия решений в области общественного здравоохранения и политики, имеющих отношение к МОС/КВПБ, требуется знание распространенности этого явления и препятствий на пути его диагностики. Вместе с тем люди, имеющие МОС/КВПБ, сообщают о длительных задержках с диагностикой и о том, что оценки распространенности значительно различаются из

Совпадение в полном тексте источника
… Population estimates for the UK, England, Wales, Scotland, and Northern Ireland: mid-2023. 2024. https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/bulletins/annualmidyearpopulationestimates/mid2023 . Accessed 31 Jan 2024. 39. …

Prevalence and determinants of polypharmacy among cancer patients: a systematic review and meta-analysis.

BACKGROUND: Polypharmacy (PP) is a rising clinical challenge among patients with a cancer diagnosis. Uncertainty remains regarding its exact burden, exact prevalence estimates, and definitional themes in this vulnerable cohort of patients. METHODS: We searched PubMed, EMBASE, Scopus, the Cochrane Database of Systematic Reviews (CDSR), and Google Scholar, for studies published between 2000 and 2025 for eligible studies reporting on polypharmacy in cancer patients. These were critically appraised for eligibility and inclusion by two independent reviewers. Using quality and random effect models,

Keyword Index for Volume 88

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Оценка спроса на паллиативный уход у пациентов, не имеющих онкологов, в Чили.

Доступ к паллиативному уходу представляет собой новую глобальную проблему в области здравоохранения. В Чили недавно был принят закон о паллиативном уходе, предусматривающий охват паллиативным уходом неонологического населения. Таким образом, для надлежащего планирования политики в области здравоохранения необходима надежная и законная оценка спроса на паллиативную помощь. Годовая смертность от выявленных заболеваний оценивалась за периоды 2018-2020. Оценка спроса соответствует определению доли умерших пациентов, нуждающихся в паллиативном уходе, исходя из тяжести тяжелых страданий, связанных с

Экономическое бремя множественного склероза в Словакии 2015 в адрес 2020.

Множественный склероз (MS) является хроническим, подстрекательским заболеванием центральной нервной системы, которое обычно диагностируется в молодом возрасте. Доля прямых и косвенных расходов на НР варьируется в зависимости от условий. Международное исследование по множественным склерозам, охватывающее 1152 пациенты, имеющие MS от 19 страны, сообщили, что среднегодовые расходы на одного пациента составляют евро41,212, с прямыми расходами на медицинское обслуживание в евро21,093, прямые немедицинские расходы в евро2110и евро16,318 , помеченные в качестве косвенных расходов. Однако точных данны

A Map of the Initiatives That Harmonize Patient Cohorts Across the World.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Is the Scope of Costs Considered in Budget Impact Analyses for Anticancer Drugs Rational? A Systematic Review and Comparative Study.

Background: With the increasing disease burden of cancer worldwide, more and more anticancer drugs have been approved in many countries, and the results of budget impact analyses (BIAs) have become important evidence for related reimbursement decisions. Objectives: We systematically reviewed whether BIAs for anticancer drugs consider the scope of costs rationally and compared the results of different cost scopes to provide suggestions for future analyses and decision-making. Methods: Eligible BIAs published in PubMed, Embase, Web of Science, and the Cochrane Library from 2016 to 2021 were iden

Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority.

BackgroundA cancer diagnosis can have a substantial impact on mental health and wellbeing. Depression and anxiety may hinder cancer treatment and recovery, as well as quality of life and survival. We argue that more research is needed to prevent and treat co-morbid depression and anxiety among people with cancer and that it requires greater clinical priority. For background and to support our argument, we synthesise existing systematic reviews relating to cancer and common mental disorders, focusing on depression and anxiety. We searched several electronic databases for relevant reviews on can

Совпадение в полном тексте источника
… Evaluation of more recent personalised approaches to follow-up care that have been adopted in several areas including England and Northern Ireland [ 51 ] are needed to understand the role they may have in preventing longer term depression and anxiety amongst cancer survivors. …

Множественный склероз оказывает значительное воздействие на членов семьи/партнеров: свидетельства с использованием показателя результатов, сообщенных семьей (FROM-16).

ЦЕЛЬ: Множественный склероз (МС) может оказывать серьезное воздействие на физическое, социальное и психологическое благополучие людей с множественным склерозом (СМС) и членов их семей/партнеров. AIM: Измерять влияние MS человека на качество жизни членов его семьи/партнера и сообщников воздействия среди членов семьи с использованием проверенного типового инструмента оценки качества жизни для конкретной семьи (FROM-16). МЕТОДЫ: Было проведено онлайновое межсекторальное исследование с целью набора членов семей/партнеров ПТМС через группы поддержки пациентов Соединенного Королевства.Результаты: В

What are the attitudes of health professionals regarding patient reported outcome measures (PROMs) in oncology practice? A mixed-method synthesis of the qualitative evidence.

BackgroundThe adoption of Patient Reported Outcome Measures (PROMs) in cancer care has been widely advocated, but little is known about the evidence for the implementation of PROMs in practice. Qualitative research captures the perspectives of health professionals as end-users of PROMs and can be used to inform adoption efforts. This paper presents a systematic review and synthesis of qualitative research conducted to address the question: What are the attitudes of health professionals towards PROMs in oncology, including any barriers and facilitators to the adoption of PROMS, reported in qual

Совпадение в полном тексте источника
… (p.2) Y Y Y Y Y N Y Y Y Y Semple et al. [ 50 ] 2018 Northern Ireland Clinic MM Interviews Oral/ Oro-phryngeal Doctors ( n = 2) and a nurse UWQOLv4, Patient Concern Inventory “Test the feasibility of using a disease- specific HRQOL tool and holistic item prompt list, for personalised identification and … (p.2) | Y | Y | Y | Y | Y | N | Y | Y | Y | Y Semple et al. [ 50 ] | 2018 | Northern Ireland | Clinic | MM | Interviews | Oral/ Oro-phryngeal | Doctors ( n = 2) and a nurse | UWQOLv4, Patient Concern Inventory | “Test the feasibility of using a disease- specific HRQOL tool and holistic item prompt list …

Evaluating the Link between BAFF System Gene Expression and Acute Rejection Development in Kidney Transplantation.

B-cell activating factor (BAFF) system signaling is critical for B-cell homeostasis, effector functions, and tolerance maintenance in transplants, but it has not been studied in kidney transplant recipients (KTRs). The aim was to analyze the changes in BAFF system expression in KTRs with/without acute rejection (AR/NAR). The BAFF system expression was analyzed by qPCR in 40 KTRs. A meta-analysis of BAFF system expression and histological renal damage was identified by the Chronic Allograft Damage Index (CADI) and performed from the GEO database. Proliferation-inducing ligand (APRIL) expression

Совпадение в полном тексте источника
… The extent of and factors associated with self-reported overdose and self-reported receipt of naloxone among people who inject drugs (PWID) in England, Wales and Northern Ireland. Int. J. Drug Policy. 2017;46:34–40. doi: 10.1016/j.drugpo.2017.05.017. 17. …

Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study.

Objectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case-control study, conducted in six European countries in 1998-2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any typ

COVID-19 burden of illness in people who are immunocompromised due to cancer: an expert opinion review.

From the beginning of the pandemic, people with cancer have experienced a high burden from COVID-19 compared with the general population, both in terms of severe COVID-19-related outcomes and reduced health-related quality of life and mental health. This review presents and discusses expert views on the burden of COVID-19 in individuals with cancer throughout the pandemic. The literature suggests that early in the pandemic, people with cancer had a disproportionately high risk of COVID-19-related hospitalization compared with the general population. This trend continued throughout the pandemic

Совпадение в полном тексте источника
… Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. …

A clinician survey for management of the secondary immunodeficiency caused by hematological malignancies in China.

AbstractUnlike Western countries, there are still few clinical immunology specialists in China, and the optimal care for secondary immunodeficiency caused by hematological malignancies is unknown. Therefore, we initiated this clinician survey study to describe the current situation of the care for malignancy patients with hypogammaglobulinemia in China.We adapted a previously published online questionnaire of current clinical practices regarding the management of secondary immunodeficiency caused by hematological malignancies and then distributed the questionnaire to 52 hematologists in China