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Gene therapy Исследование for kidney diseases.

A resurgence in the development of newer gene therapy systems has led to recent successes in the treatment of B cell cancers, retinal degeneration and neuromuscular atrophy. Gene therapy offers the ability to treat the patient at the root cause of their malady by restoring normal gene function and arresting the pathological progression of their genetic disease. The current standard of care for most genetic diseases is based upon the symptomatic treatment with polypharmacy while minimizing any potential adverse effects attributed to the off-target and drug-drug interactions on the target or oth

100 Questions in Livestock Helminthology Research.

An elicitation exercise was conducted to collect and identify pressing questions concerning the study of helminths in livestock, to help guide Исследование priorities. Questions were invited from the Исследование community in an inclusive way. Of 385 questions submitted, 100 were chosen by online vote, with priority given to open questions in important areas that are specific enough to permit investigation within a focused project or programme of Исследование. The final list of questions was divided into ten themes. We present the questions and set them briefly in the context of the current state of knowl…

JASPAC: Japan Spastic Paraplegia Research Consortium.

Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterized by weakness and spasticity of the lower extremities. HSPs are heterogeneous disorders that involve over 80 causative genes. The frequency of HSPs is estimated to be 10⁻100/1,000,000. With this background, the Japanese Исследование group "Japan Spastic Paraplegia Research Consortium: JASPAC" was organized in 2006 to elucidate the molecular epidemiologies of HSPs in Japan and the molecular pathologies of HSPs. To date, the JASPAC has collected 714 HSP families and analyzed 488 index patients. We found 279 …

Recent advances in precision oncology Исследование.

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… The specific collaborative and cooperative goals include establishing a national network of patient biological and clinical data, increasing health disparity Исследование, development of biomarkers, technology and preclinical Исследование models and, importantly, methods of data sharing, analytics and predictive … The second study was a collaborative effort (Arizona State University scientists with Исследованиеers from the National Center for Nanoscience and Technology of the Chinese Academy of Sciences and from the QIMR Berghofer Medical Research Institute in Australia) that was published in Nature Biotechnology …

Recent Advances in HBV Reactivation Research.

Hepatitis B virus (HBV) is an important public health problem that poses a serious threat to human health. HBV reactivation generally occurs … significantly. Therefore this review was expected to be used to provide recommendations for future Исследование in HBV reactivation.

Japan Wine, its characteristics and Исследование.

A new rule stipulates that wine made in Japan from grapes harvested in Japan be labeled as "Japan wine". The main grape varieties for Japan … revealed recently. These and other studies have been conducted in wine companies, universities, and Исследование institutes in Japan and support the development of Japan Wine. Abbreviations: SSR: simple sequence repeat; SNP: single nucleotide polymorphism; 3MH: 3-mercaptohexan-1-ol; 4-HDMF: 4-hydroxy-2,5-dimethyl-3(2H)-furanone; PCA: principal component analys …

Monkey Models and HIV Vaccine Research.

Since the discovery of acquired immunodeficiency syndrome (AIDS) in 1981, it has been extremely difficult to develop an effective vaccine or a therapeutic cure despite over 36 years of global efforts. One of the major reasons is due to the lack of an immune-competent animal model that supports live human immunodeficiency virus (HIV) infection and disease progression such that vaccine-induced correlates of protection and efficacy can be determined clearly before human trials. Nevertheless, rhesus macaques infected with simian immunodeficiency virus (SIV) and chimeric simian human immunodeficien

[Research progress on artificial meniscus implants].

Meniscus injury has been one of the most common knee injuries in current society. The Исследование on artificial meniscus implants as substitutes in meniscus reconstruction therapy has become global focus in order to solve clinical problems such as irreparable meniscus injury and symptoms after full or partial meniscectomy. At present, Исследованиеes on artificial meniscus implants mainly focus on biodegradable meniscus scaffolds and non-biodegradable meniscus substitutes. Although the commercialized meniscal implants, such as CMI ®, Actifit ® and NUsurface ®, have been applied in the clinical, none o…

Future Research Priorities in Fungal Resistance.

Improved understanding of basic mycological, pharmacological, and immunological processes has led to important advances in the diagnosis and treatment of invasive fungal infections. However, the rise of fungi that are resistant to existing antifungal agents poses a substantial threat to human health. Addressing this expanding problem is an urgent priority for the international Исследование community. In this article, we highlight important diagnostic and therapeutic advances that address the rise of resistant fungi as well as new public health initiatives that warrant further investigation to help…

Research progress in liver tissue engineering.

Liver transplantation is the definitive treatment for patients with end-stage liver diseases (ESLD). However, it is hampered by shortage of … hment, proliferation and secretion in forming extracellular matrix. The most promising scaffolds in Исследование include decellularized whole liver, collagens and biocompatible plastic. The development and function of cells in scaffold need a microenvironment which can provide them with oxygen, nutrition, growth factors, et al. Bioreactor is expected to fulfil …

Zika Virus and Future Research Directions.

There was a dramatic upsurge in Исследование activity after the recognition of Zika virus (ZIKV) transmission in South America in 2015 and its causal relationship to devastating anomalies in newborn infants. Progress in this area required a community of arbovirologists poised to refocus their Исследование efforts and rapidly characterize the features of ZIKV transmission and infection through diverse multidisciplinary collaborations. Significant gaps remain in our knowledge of the natural history of ZIKV infection, its effects on neurodevelopment, modes and risk of transmission, and its interrelations…

Tourette syndrome Исследование highlights from 2016.

This article presents highlights chosen from Исследование that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.

Taking Sides in E-cigarette Research.

In the last ten years, an eclectic mix of electronic nicotine delivery products ('e-cigarettes') and practices have proliferated in the US w … strust between these two warring "sides" animates the controversy over e-cigarettes. In our role as Исследованиеers conducting a qualitative study on e-cigarette use, we encountered suspicion and anger from members of an e-cigarette forum who felt that pro-vaping perspectives were often misrepresented by Исследованиеers. As a result, we dropped our initial plan to …

Human dermal fibroblasts in psychiatry Исследование.

In order to decipher the disease etiology, progression and treatment of multifactorial human brain diseases we utilize a host of different experimental models. Recently, patient-derived human dermal fibroblast (HDF) cultures have re-emerged as promising in vitro functional system for examining various cellular, molecular, metabolic and (patho)physiological states and traits of psychiatric disorders. HDF studies serve as a powerful complement to postmortem and animal studies, and often appear to be informative about the altered homeostasis in neural tissue. Studies of HDFs from patients with sc

[Basic Исследование overview in rheumatoid arthritis].

Rheumatoid arthritis (RA) is a common autoimmune disease with a prevalence of 0.5-1.0% worldwide. Although advances in understanding the pat … view, we summarize pathogenetic advances in these issues especially from the point of view of basic Исследование.

[The eosinophilic otitis media's Исследование progress].

The eosinophilic otitis media(EOM) is an intractable disease characterized by the presence of a highly viscous yellow effusion with extensive accumulation of eosinophils in the middle ear; granulation tissue can been discovered in the middle ear cavity; most of patients have association with bronchial asthma; resist to conventional treatment for otitis media; EOM patients show gradual deterioration of hearing and sometimes become deaf suddenly; effective treatment involves use of topical and oral steroids. This article summarizes the progress of the EOM's diagnosis and treatment.