Результаты поиска

Уровни гингивальной креветочной жидкости пролактина у пациентов, страдающих периодонтитом, с контролируемым или неконтролируемым типом 2 диабет. Контролируемое клиническое испытание.

В ходе этого исследования были исследованы уровни гингивальной кревикулярной жидкости (ГХФ) гормона пролактина (ПРЛ) на этапе III периодонтит (П) пациентов с типом 2 сахарный диабет (T2DM) до и 3 через несколько месяцев после нехирургической периодической терапии (НППТ). В этом деле под контролем суда, 80 Темы были разделены на 4 группы: группа I: здоровый контроль; группа II: системно здоровый этап III P пациентов; группа III: этап III P пациентов с контролируемым Т2ДМ; группа IV: этап III P пациентов с неконтролируемым Т2ДМ. Все пациенты П получили NSPT. Three Спустя несколько месяцев после

Совпадение в полном тексте источника
… Insulin resistance associated with T2DM impacts immune cells (T and B cells, macrophages, and neutrophils), causing elevated levels of pro-inflammatory cytokines (TNF-α, IL-6) and adipokines (leptin, resistin), this, in turn, exacerbate insulin resistance and promote a vicious cycle of metabolic and …

Obesity, Bariatric Surgery, and Cancer Risk: Nutritional Perspectives and Long-Term Clinical Implications.

Obesity is recognized as a causal risk factor for the development of multiple cancers, with risk magnitude varying by tumor site, sex, life stage, and adipose tissue distribution. This narrative review synthesizes recent epidemiological evidence linking excess body fatness with cancer incidence and mortality and integrates the biological mechanisms that explain this association. Chronic low-grade inflammation, insulin resistance with compensatory hyperinsulinemia, dysregulation of adipose-derived hormones and sex steroids, impairment of anti-tumor immune responses, alterations in the gut micro

Совпадение в полном тексте источника
… Resistin Resistin, primarily secreted by immune cells within adipose tissue in humans, is elevated in obesity and closely linked to chronic inflammation and insulin resistance. … Increasing evidence implicates resistin in cancer biology through activation of pro-inflammatory and pro-tumorigenic pathways, including Toll-like receptor 4 (TLR4) and NF-κB signaling. …

Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies.

Bone disease, including osteolytic lesions and/or osteoporosis, is a common feature of multiple myeloma (MM). The consequences of skeletal involvement are severe pain, spinal cord compressions, and bone fractures, which have a dramatic impact on patients' quality of life and, ultimately, survival. During the past few years, several landmark studies significantly enhanced our insight into MM bone disease (MBD) by identifying molecular mechanisms leading to increased bone resorption due to osteoclast activation, and decreased bone formation by osteoblast inhibition. Bisphosphonates were the main

Совпадение в полном тексте источника
… Adipocytes, which are increased in the BM of MM patients, stimulate the proliferation and mediate the drug resistance of malignant plasma cells via secretion of adipokines, such as leptin and resistin. In addition, pre-adipocytes promote migration of MM cells [ 36 , 37 , 38 , 39 ]. … Resistin induces multidrug resistance in myeloma by inhibiting cell death and upregulating ABC transporter expression Haematologica 2017 102 1273 1280 10.3324/haematol.2016.154062 28360146 PMC5566043 40. Pratt G. Goodyear O. Moss P. Immunodeficiency and immunotherapy in multiple myeloma Br. J. …

Correlation analysis of PGC-1β, HIF-1α and RETN with the degree of joint destruction in gouty arthritis.

BACKGROUND: To explore the expression levels of resistin (RETN), hypoxia-inducible factor-la (HIF -l<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span> ), and peroxi-some proliferator-activated receptor g coactivator-1<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">β</span> (PGCip ) in gouty arthritis (GA) patients and to analyse their cor-relations with the degree of joint destruction. METHODS: The GA group consisted of 134 patients with GA who were…

Roles of Microvesicles in Tumor Progression and Clinical Applications.

Microvesicles are extracellular vesicles with diameter ranging from 100 to 1000 nm that are secreted by tumor cells or other cells in the tumor microenvironment. A growing number of studies demonstrate that tumor-derived microvesicles are involved in tumor initiation and progression, as well as drug resistance. In addition, tumor-derived microvesicles carry a variety of immunogenic molecules and inhibit tumor response to immunotherapy; therefore, they can be exploited for use in tumor vaccines. Moreover, because of their high stability, tumor-derived microvesicles extracted from body fluids ca

Совпадение в полном тексте источника
… Examples of markers include PKM2, resistin, EMMPRIN, and MAGE-1. TMVs can carry a variety of immunogenic molecules, including proteins, nucleic acids, and polysaccharides. … Examples of markers include PKM2, resistin, EMMPRIN, and MAGE-1. TMVs can carry a variety of immunogenic molecules, including proteins, nucleic acids, and polysaccharides. …

Leptin, Adiponectin, and Sam68 in Bone Metastasis from Breast Cancer.

The most serious aspect of neoplastic disease is the spread of cancer cells to secondary sites. Skeletal metastases can escape detection long after treatment of the primary tumour and follow-up. Bone tissue is a breeding ground for many types of cancer cells, especially those derived from the breast, prostate, and lung. Despite advances in diagnosis and therapeutic strategies, bone metastases still have a profound impact on quality of life and survival and are often responsible for the fatal outcome of the disease. Bone and the bone marrow environment contain a wide variety of cells. No longer

Совпадение в полном тексте источника
… Adiponectin and resistin—New hormones of white adipose tissue Med. Sci. Monit. 2003 9 RA55 RA61 12601307 31. Cawthorn W.P. Scheller E.L. Learman B.S. Parlee S.D. Simon B.R. Mori H. Ning X. Bree A.J. Schell B. Broome D.T. … Evaluation of diagnostic and predictive value of serum adipokines: Leptin, resistin and visfatin in postmenopausal breast cancer Obes Res. Clin. Pract. 2016 10 442 453 10.1016/j.orcp.2015.08.017 26388139 62. Aliustaoglu M. Bilici A. Gumus M. Colak A.T. Baloglu G. Irmak R. Seker M. Ustaalioglu B.B. …

New insight into adiponectin role in obesity and obesity-related diseases.

Obesity is a major health problem strongly increasing the risk for various severe related complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders, diabetic retinopathy, and cancer. Adipose tissue is an endocrine organ that produces biologically active molecules defined "adipocytokines," protein hormones with pleiotropic functions involved in the regulation of energy metabolism as well as in appetite, insulin sensitivity, inflammation, atherosclerosis, cell proliferation, and so forth. In obesity, fat accumulation causes dysregulation of adipokine production tha

Совпадение в полном тексте источника
… Amongst the others, the most biological relevant adipokines are leptin, plasminogen activator inhibitor (PAI-1), tumor necrosis factor (TNF- α ), interleukin 6 (IL-6), resistin, and adiponectin [ 19 , 20 ]. … The inflammatory state in MetS is represented by elevated concentrations of a variety of inflammatory regulators such as C-reactive protein, TNF- α , resistin, IL-6, IL-8, visfatin, and adiponectin. The latter is inversely related to both adiposity and proinflammatory cytokines [ 84 ]. …

The ambiguous role of obesity in oncology by promoting cancer but boosting antitumor immunotherapy.

Obesity is nowadays considered a pandemic which prevalence's has been steadily increasingly in western countries. It is a dynamic, complex, and multifactorial disease which propitiates the development of several metabolic and cardiovascular diseases, as well as cancer. Excessive adipose tissue has been causally related to cancer progression and is a preventable risk factor for overall and cancer-specific survival, associated with poor prognosis in cancer patients. The onset of obesity features a state of chronic low-grade inflammation and secretion of a diversity of adipocyte-derived molecules

Biochemical and Clinical Impact of Organic Uremic Retention Solutes: A Comprehensive Update.

In this narrative review, the biological/biochemical impact (toxicity) of a large array of known individual uremic retention solutes and groups of solutes is summarized. We classified these compounds along their physico-chemical characteristics as small water-soluble compounds or groups, protein bound compounds and middle molecules. All but one solute (glomerulopressin) affected at least one mechanism with the potential to contribute to the uremic syndrome. In general, several mechanisms were influenced for each individual solute or group of solutes, with some impacting up to 7 different biolo

Совпадение в полном тексте источника
… This review furthermore also contains information on the adipokines leptin, resistin and adiponectin that are discussed elsewhere in the present review. 4.12. Endothelin Endothelins are strong vasoconstrictors [ 365 ]. Their concentration was shown to be increased in CKD [ 366 ]. … Resistin Resistin is included in the review on cytokines which is part of this special issue [ 296 ] but is not considered a uremic toxin. In spite of a few suggestive experimental studies, no link with hard outcomes in CKD could as yet be demonstrated [ 296 ]. 4.28. …

Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.

BackgroundGenetic studies have found that a germline BRCA1 gene mutation is the origin of highly increased cancer risk. Clinical studies have suggested that increased cancer risk in type-2 diabetes may be attributed to unhealthy lifestyle factors and bad habits.PurposePatients with either BRCA1 gene mutation or type-2 diabetes similarly exhibit increased cancer risk, insulin resistance, and fertility disorders. It was suggested that these three alterations derive from a common genomic failure, and its recognition may shed light on the unsolved secret of cancer.Results(1) Germline mutations on

Совпадение в полном тексте источника
… Resistin is an anti-obesity hormone whose levels increase in parallel with weight gain. Estradiol benzoate treatment decreased resistin levels in subcutaneous adipose tissue [ 163 ]. Ghrelin is a multifaceted hormone secreted by gastric and intestinal cells showing endocrine function. …

Взаимосвязь между множественным склерозом и ожирением: сравнительное исследование.

Множественный склероз (MS) — хроническое аутоиммунное расстройство, затрагивающее центральную нервную систему. Она характеризуется воспалением, обезвоживанием и разрушением аксонов. Ожирение является глобальной проблемой здравоохранения, которая связана с чрезмерным накоплением жира в организме, что приводит к негативному метаболическому воздействию и воздействию на здоровье человека. В последние годы все больше внимания уделяется связи между НР и ожирением. ЦЕЛИ: Текущее исследование направлено на оценку взаимосвязи между MS и ожирением и на определение того, является ли ожирение фактором рис

Совпадение в полном тексте источника
… Indeed, the concentrations of certain adipokines, such as leptin, adiponectin, and resistin have been seen to correlate with autoimmune disorders, including MS. …

Лептин и Лептин Сигналинг в множестве склерозов: обзор скрипта.

Ожирение - проблема, связанная с пандемией здоровья, - в настоящее время рассматривается как хроническое провокационное состояние, связанное со многими аутоиммунными заболеваниями, такими, как множественный склероз. Таким образом, адипокины, подстрекательские посредники, скрытые жировой тканью, играют важную роль в стимулировании иммунной реакции. В этом контексте ожирение, особенно в подростковом возрасте, как представляется, является одним из ключевых факторов развития множественного склероза. Лептин, главный провоспалительный адипокин, скрытый жировой тканью, был обнаружен у пациентов с мно

Совпадение в полном тексте источника
… As anti-inflammatory adipokines are adiponectin or apelin, whereas in the pro-inflammatory ones can be found resistin, chemerin, visfatin, or the adipokine leptin, which is the objective of this review. …

Антиопухальное воздействие опухоли данделиона на множественные клетки миэломы и ее механизм.

Множественная миелома (ММ) — широко распространенная гематологическая порча, характеризующаяся неконтролируемым распространением моноклонных плазменных клеток в костном мозге и чрезмерным производством моноклонального иммуноглобулина, что ведет к повреждению органов. Несмотря на терапевтический прогресс, рецидивы и резистентность к лекарственным препаратам по-прежнему остаются серьезными проблемами. ЦЕЛЬ: В рамках этого исследования изучаются последствия использования флавона данделиона (ДФ) для распространения, миграции и вторжения клеток MM с целью разъяснения механизмов, связанных с метаста

Совпадение в полном тексте источника
… M2 Mφs are often induced in response to IL-4 and/or IL-13 (produced during the Th2 polarization of T lymphocytes) and highly express Arginase (Arg1), chitin enzymes such as Ym1, resistin-like molecule a (Fizzl), fatty acid translocases CD36 and CD206. …

Глобальные, региональные и национальные факторы метаболического риска, связанные с множественной миеломой, 1990-2021:: анализ на основе глобального исследования бремени болезней; 2021.

Цель настоящего исследования заключалась в изучении глобального бремени болезней, связанных с множественной миеломой (ММ), которая связана с метаболическими факторами. Использование данных GHDx тарирования 1990-2021, случаи MM были выявлены через ICD-10 коды (C90.0). Были проанализированы ключевые показатели, включая коэффициент смертности и коэффициент лет жизни с поправкой на инвалидность (DALY); стандартизированные по возрасту показатели (ASMR, ASDR) и расчетные годовые процентные изменения (EAPC) были рассчитаны с использованием R для сопоставления различий между регионами, полами и возрас

Совпадение в полном тексте источника
… Dyslipidemia promotes lipid uptake through the aberrant expression of LDL receptors (LDLR) and syndecan-1 on MM cells, while obesity-induced BMA remodeling inhibits apoptosis and exacerbates osteolytic lesions via the secretion of leptin and resistin ( 11 ). …

Aqueous Extract of Cimicifuga dahurica Reprogramming Macrophage Polarization by Activating TLR4-NF-κB Signaling Pathway.

PurposeCimicifuga dahurica (C. dahurica), which has been used in traditional oriental medicine for a long period, was reported to exert extensive antitumor activity, but the effect and molecular biological mechanism of C. dahurica on multiple myeloma (MM) has not been elaborated. Tumor-associated macrophages (TAMs) exhibit a sustained polarization between tumor killing M1 subtype and tumor supporting M2 subtype. And a lower ratio of M1/M2 is associated with tumor angiogenesis, proliferation and invasion. We explored the inhibitory effect of the aqueous extract of the root of C. dahurica (CRAE)

Совпадение в полном тексте источника
… M2-polarized macrophages highly express arginase-1 (Arg-1), resistin-like molecules α (RELMα), scavenger receptor (CD163) and mannose receptor (CD206). …

Sarcopenia in Older Adults with Hematologic Malignancies: A Comprehensive Review of Epidemiology, Prognosis, and Interventions.

Hematologic malignancies, including leukemias, lymphomas, and multiple myeloma, are diseases of older adults (age ≥ 60 years). Treatment decisions in older adults with cancer are heavily influenced by patient fitness: the ability of an individual patient to tolerate the off-target effects of anti-cancer therapy. Sarcopenia, defined as low muscle mass and strength, is increasingly recognized as an important marker of fitness. Furthermore, sarcopenia is known to be modifiable with nutrition and exercise interventions in older adults without cancer, but such evidence is limited for patients with

Совпадение в полном тексте источника
… Key adipokines include resistin, a driver of insulin resistance, and the food intake regulators leptin and adiponectin. These later two adipokines play countering roles; adiponectin has been shown to stimulate food intake while leptin suppresses appetite, reduces food intake, and reduces weight. … Similarly, Smiechowska et al. demonstrated a decrease in plasma leptin levels with no changes in adiponectin and resistin in patients with cachexia in a variety of solid tumors [ 116 ]. In this study, low leptin levels were associated with anorexia and increased IL-6. …

Педиатрическое ожирение - долгосрочные последствия и последствия потери веса.

Согласно ВОЗ, детский ожирение - это one наиболее серьезных проблем, с которыми сталкивается 21st Столетие. Более 100 million Сегодня у детей ожирение. Уже в детстве почти все органы подвергаются риску ожирения. В этом обзоре мы представляем текущие знания о болезнях, связанных с детским ожирением, и о том, как они влияют на потерю веса. One Основным побудительным фактором является вызванное ожирением низкосортное хроническое воспаление, которое уже наблюдается у детей дошкольного возраста. Это воспаление в сочетании с эндокринным, паракринным и метаболическим воздействием ожирения повышает до

Совпадение в полном тексте источника
… Thus, the secretion of pro‐inflammatory cytokines—such as tumor necrosis factor–alpha (TNF‐α), resistin, and retinol binding protein‐4 (RBP‐4)—increases, whereas the secretion of anti‐inflammatory adipokines such as adiponectin is reduced. …

Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019.

BackgroundMultiple myeloma (MM) is a major health concern. Understanding the different burden and tendency of MM in different regions is crucial for formulating specific local strategies. Therefore, we evaluated the epidemiologic patterns and explored the risk factors for MM death.MethodsData on MM were collected from the 2019 Global Burden of Disease study. We used incidence, mortality, and disability adjusted life-years to estimate the global, regional, and national burden of MM.ResultsIn 2019, there were 155,688 (95% UI, 136,585 - 172,577) MM cases worldwide, of which 84,516 (54.3%, 70,924

Совпадение в полном тексте источника
… Low circulating adiponectin and resistin, but not leptin, levels are associated with multiple myeloma risk: a case-control study. Cancer causes & control : CCC. 2009;20(2):193–199. doi: 10.1007/s10552-008-9233-7. 34. Ferlin M, Noraz N, Hertogh C, Brochier J, Taylor N, Klein B. …

Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies.

Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production. Despite the high efficacy of several developed NAMPT inhibitors (i.e., FK866 (APO866)) in preclinical studies, their clinical activity was proven to be limited. Here, we report the synthesis of new NAMPT Inhibitors, JJ08, FEI191 and FEI199, which exhibit a broad anticancer activity in vitro. Results show that these compounds are potent NAMPT inhibito

Совпадение в полном тексте источника
… Adipocytokine levels in gastric cancer patients: Resistin and visfatin as biomarkers of gastric cancer J. Gastroenterol. 2009 44 685 690 10.1007/s00535-009-0063-5 19430715 16. Galli U. Colombo G. Travelli C. Tron G.C. Genazzani A.A. Grolla A.A. …

UMIB Summit 2015

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.