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[Autoperfusion of ascitic fluid: 38 cases].

"38 observations of reperfusion of ascitic fluid ". In this study, the authors report their experiences of paracentesis associated with the perfusion or the reperfusion of the sick's own ascitic fluid in the treatment of tense ascite determined mostly by Schistosomiasis mansoni.

Fungal Planet description sheets: 1868-1920.

Novel species of fungi described in this study include those from various countries as follows: Australia, Marasmius ballator on leaf litter … Quercus ilex and Pinus halepensis, Inosperma subinodorum on calcareous soil in Picea abies forest. Madagascar, Oudemansiella viscida on dead wood or branches. Netherlands, Colletotrichum urticicola from leaf spots on Urtica dioica. Pakistan, Agrocybe punjabensis on soil on fallen remains of Saccharum officinarum. Panama, Ijuhya panamaensis and Sarcopodium p …

Global, regional and national epidemiological trends of multiple myeloma from 1990 to 2021: a systematic analysis of the Global Burden of Disease study 2021.

BackgroundMultiple myeloma (MM) is a growing global public health challenge. Known epidemiological data suggest that MM accounts for approximately 10% of all hematologic malignancies and remains the second most common hematologic cancer worldwide. This study utilized data from the 2021 Global Burden of Diseases (GBD) study to evaluate the prevalence, incidence, mortality, disability-adjusted life years (DALYs), and attributable risk factors of MM from 1990 to 2021, and to project future trends for the next 15 years.MethodsGBD 2021 data were analyzed to assess MM's global burden using four key

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… In contrast, countries like Madagascar [−0.12 (95%CI -0.34 to 0.1)], Somalia [−0.36 (95%CI -0.41 to −0.31)], Tajikistan [−0.570 (95%CI -0.87 to −0.27)], Burundi [−0.86 (95%CI -1.07 to −0.66)], and the Northern Mariana Islands [−1.12 (95%CI -1.4 to −0.83)] showed a slight but nonsignificant downward trend … In contrast, countries such as Argentina, Burundi, Canada, Central African Republic, Greenland, Guam, Japan, Jordan, Madagascar, Northern Mariana Islands, Republic of Nauru, Republic of San Marino, Rwanda, Singapore, Somalia, South Sudan, Sweden, Tajikistan, United States of America showed a downward …

Growth monitoring and promotion: review of evidence of impact.

UNLABELLED: [Table: see text] SUMMARY: The rationale for growth monitoring and promotion is persuasive but even in the 1980s the appropriat … ), and from large programmes in Tanzania (Iringa), India (Tamil Nadu Integrated Nutrition Project), Madagascar and Senegal that children whose growth is monitored and whose mothers receive nutrition and health education and have access to basic child health services have a better nutritional status and/or survival than children who do not. There is tentative …

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs.

Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants

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… Vinca Alkaloids and Their Derivatives The use of plants as anticancer agents was established with two alkaloids’ isolation, vincristine, and vinblastine, using Catharanthus roseus and Madagascar periwinkle [ 93 ]. These drugs have been clinically used in oncology for about 50 years. … Antiproliferative compounds from Pongamiopsis pervilleana from the Madagascar dry forest J. Nat. Prod. 2010 73 1559 1562 10.1021/np100430r 20804165 PMC2945424 74. Li J. Xiong C. Xu P. Luo Q. Zhang R. …

Medicinal Plants with Anti-Leukemic Effects: A Review.

Leukemia is a leukocyte cancer that is characterized by anarchic growth of immature immune cells in the bone marrow, blood and spleen. There are many forms of leukemia, and the best course of therapy and the chance of a patient's survival depend on the type of leukemic disease. Different forms of drugs have been used to treat leukemia. Due to the adverse effects associated with such therapies and drug resistance, the search for safer and more effective drugs remains one of the most challenging areas of research. Thus, new therapeutic approaches are important to improving outcomes. Almost half

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… C. roseus , usually known as Madagascar periwinkle, belongs to the Apocynaceae family. The plant has a short stem and glossy green leaves, and flowers appear in spring and autumn (three colors: pink, purple and white) [ 25 , 26 ]. … C. roseus is originally endemic to Madagascar, Jamaica and the Philippines [ 27 ]. The most potentially active chemical constituents of C. roseus are alkaloids. More than 400 alkaloids were isolated from this plant. …

Анализ тенденций и межнациональный анализ неравноправия в отношении иммунизированных подстрекательских заболеваний у детей и подростков в возрасте от 10 до 24 лет в период с 1990 по 2021 год.

IMID - это хронические подстрекательские заболевания, вызываемые дисрегулированием иммунной системы и затрагивающие многочисленные системы и органы. Дети и подростки в возрасте от 10 до 24 лет относятся к группам повышенного риска, и глобальное бремя является значительным. МЕТОДЫ: Используя самые последние данные о глобальном бремени заболеваний (ГБЗ) 2021 года, мы использовали регрессионный анализ " Компонт " , корреляционный анализ социально-демографического индекса (ИОД) и межнациональный анализ справедливости для разъяснения диспропорциональных различий в бремени ИМНИ среди детей

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… The countries with the highest asthma incidence rates were Haiti (1193.12, 95% UI: 813.90 to 1632.27), Puerto Rico (1179.42, 95% UI: 762.40 to 1700.48), and Madagascar (1075.17, 95% UI: 687.02 to 1498.92). …

Ассоциации физического партнерского насилия и пережитого сексуального насилия с рисковыми поведениями и психическим здоровьем среди студентов университетов из 25 стран.

ИСТОРИЯ ВОПРОСА: Исследование было направлено на изучение связей между виктимизацией физического партнера и/или сексуальным насилием и различными видами поведения, сопряженными с риском для здоровья, и психическим здоровьем студентов университетов 25 странами. МЕТОДЫ: С использованием плана перекрестного исследования, 18,335 Студенты высших учебных заведений среднего возраста 20 лет с 25 страны Африки, Северной и Южной Америки и Азии ответили на сообщения о случаях насилия в отношениях между людьми, действиях, подрывающих здоровье, мерах по охране психического здоровья и защитных факторах.РЕЗУ

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… Asia: Indonesia, Laos, Philippines, Singapore and Thailand; South Asia and China: India, Pakistan and China; North Africa and Central Asia: Egypt, Tunisia, Turkey, Russia and Kyrgyzstan; the Americas: Barbados, Columbia, Grenada, Jamaica and Venezuela and in sub-Saharan Africa: Cameroon, Ivory Coast, Madagascar …

Demographic, epidemiological, and health transitions: are they relevant to population health patterns in Africa?

BackgroundStudies of trends in population changes and epidemiological profiles in the developing world have overwhelmingly relied upon the concepts of demographic, epidemiological, and health transitions, even though their usefulness in describing and understanding population and health trends in developing countries has been repeatedly called into question. The issue is particularly relevant for the study of population health patterns in Africa and sub-Saharan Africa, as the history and experience there differs substantially from that of Western Europe and North America, for which these conce

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… 59.05 | 0.38 | 0.12 Eritrea | 39.4; 48.0 | 8.0; 27.8 | 19.3; 31.2 | 5.2; 7.0 | 1960 | 35.84 | 59.95 | 0.27 | 0.54 Ethiopia | 36.4; 49.3 | 9.5; 29.9 | 19.3; 30.3 | 5.3; 7.4 | 1955 | 34.08 | 59.26 | 0.30 | 0.53 Kenya | 38.2; 51.5 | 10.0; 23.6 | 27.7; 37.7 | 4.8; 8.1 | 1970 | 42.30 | 57.23 | 0.43 | −0.09 Madagascar …

Mapping Cancer in Africa: A Comprehensive and Comparable Characterization of 34 Cancer Types Using Estimates From GLOBOCAN 2020.

ObjectiveCancer incidence and mortality rates in Africa are increasing, yet their geographic distribution and determinants are incompletely characterized. The present study aims to establish the spatial epidemiology of cancer burden in Africa and delineate the association between cancer burden and the country-level socioeconomic status. The study also examines the forecasts of the cancer burden for 2040 and evaluates infrastructure availability across all African countries.MethodsThe estimates of age, sex, and country-specific incidence and mortality of 34 neoplasms in 54 African countries, we

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… 0.74 Kenya | 42,116 [40,219–44,103] | 149.2 | 103.2 | 27,092 [25,708–28,550] | 0.64 Lesotho | 1,876 [1,711–2,057] | 109 | 74.8 | 1,256 [1,148–1,374] | 0.67 Liberia | 3,552 [2,842–4,439] | 119.3 | 90.5 | 2,603 [2,114–3,205] | 0.73 Libya | 7,661 [7,063–8,309] | 132.2 | 88.2 | 4,750 [4,381–5,150] | 0.62 Madagascar …

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial.

Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessme

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… Introduction Vinca alkaloids were extracted from Catharanthus roseus leaves of the Madagascar periwinkle plant in the late 1950s [ 1 ]. They were initially used as antidiabetic and antimalarial remedies [ 2 ]. …

Antimitotic drugs in the treatment of cancer.

Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of antimitotic compounds, their mechanisms of action and cancer cell res

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… Vinca alkaloids The first vinca alkaloids were extracted from the plant catharamthus roseus , native to Madagascar, and were found to possess anticancer activities in 1960 [ 20 ]. Vina alkaloids include vincristine which was approved as chemotherapy treatment in 1963 in the USA [ 20 ]. …

Multiplex Screening for Interacting Compounds in Paediatric Acute Myeloid Leukaemia.

Paediatric acute myeloid leukaemia (AML) is a heterogeneous disease characterised by the malignant transformation of myeloid precursor cells with impaired differentiation. Standard therapy for paediatric AML has remained largely unchanged for over four decades and, combined with inadequate understanding of the biology of paediatric AML, has limited the progress of targeted therapies in this cohort. In recent years, the search for novel targets for the treatment of paediatric AML has accelerated in parallel with advanced genomic technologies which explore the mutational and transcriptional land

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… Vinblastine was originally isolated from the Madagascar periwinkle Catharanthus roseus (formerly Vinca rosea ) over 50 years ago [ 54 ]. …

Narrative Review of Drug-Associated Nail Toxicities in Oncologic Patients.

IntroductionNail toxicity represents one of the most common cutaneous adverse effects of both classic chemotherapeutic agents and new oncologic drugs, including targeted treatments and immunotherapy.ObjectivesWe aimed to provide a comprehensive literature review of nail toxicities derived from conventional chemotherapeutic agents, targeted therapies (EGFR inhibitors, multikinase inhibitors, BRAF and MEK inhibitors) and immune checkpoint inhibitors (ICIs), including clinical presentation, implicated drugs and approaches for prevention and management.MethodsRetrieved literature from PubMed regis

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… Vinca Alkaloids: Vincristine Vinca alkaloids were historically extracted from the leaves of the Madagascar periwinkle (Catharanthus roseus). …

Barriers to the Provision and Utilization of Palliative Care in Africa: A Rapid Scoping Review.

Palliative care (PC) has continued to be less available, underutilized, and unintegrated in many of the healthcare systems, especially in Africa. This scoping review synthesized existing published papers on adult PC in Africa, to report the barriers to PC and to assess the methodologies used in these studies. Eight electronic databases and Google Scholar were searched to identify relevant studies published between 2005 and 2018. Overall, 42 publications (34 empirical studies and 9 reviews) that reported issues related to barriers to adult PC were selected. Three themes identified were individu

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… African countries have made some improvement, with Uganda and South Africa still having the highest number (229 and 160, respectively) of hospice or PC services.[ 45 ] Rwanda, Kenya, and Nigeria, have 54, 70, and 17 hospice or PC services, respectively, while Republic of Congo, Equatorial Guinea, and Madagascar …