Результаты поиска

Maintenance of prehospital anaesthesia in trauma patients: inconsistencies and variability in practice.

BACKGROUND: Literature on prehospital anaesthesia predominantly focuses on preparation and induction, while there is limited guidance on anaesthesia maintenance. The hypothesis of this study was that for prehospital trauma patients, protocols and practice for anaesthesia maintenance may vary considerably between services. Hence, we sought to describe the practice of prehospital anaesthesia maintenance for trauma patients in Australia, New Zealand, and the UK. METHODS: An online practice survey of prehospital and retrieval services in Australia, New Zealand, and the UK was conducted from May t…

Prevalence and determinants of thirst distress amongst patients on maintenance haemodialysis.

BACKGROUND: Thirst and xerostomia are the main causes of poor adherence to fluid restriction and of excessive intake of fluids in patients o … ly selected regions of Cameroon. Patients received twice-weekly dialysis. Three hundred patients on maintenance haemodialysis for over 3 months were evaluated for thirst distress using the thirst distress scale and its characteristics, using a structured questionnaire before dialysis sessions. RESULTS: About 184 (61.33%) patients had thirst distress, with 12 …

INTERMUSCULAR ADIPOSE TISSUE AND MUSCLE FUNCTION IN PATIENTS ON MAINTENANCE HEMODIALYSIS.

BACKGROUND AND AIMS: Sarcopenia, defined as a loss in muscle mass and strength, is common in patients with advanced chronic kidney disease (CKD), leading to poor outcomes. Intermuscular adipose tissue (IMAT) accumulation is associated with metabolic and functional abnormalities in chronic disease conditions. This study assesses IMAT in maintenance hemodialysis (MHD) patients and its association with metabolic markers and physical performance. METHODS AND RESULTS: We performed a cross-sectional study comparing MHD patients with controls. IMAT accumulation was measured by analyzing the fat-to-m…

The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice.

Proteasomes undergo dynamic changes in their types and activities during mammalian spermatogenesis. While the spermatogenesis-specific 20S proteasome (s20S), characterized by PSMA8 substitution of PSMA7, is known to be essential for meiosis I completion, the functions of the constitutive PSMA7-containing 20S proteasomes (c20S) in spermatogenesis remain poorly understood. Here, we show that c20S proteasomes are required for the maintenance and differentiation of spermatogonia. PSMA7 is ubiquitously expressed in male germ cells beginning at the early spermatogonial stage, preceding PSMA8 express…

A predictive model for olfactory dysfunction in patients undergoing maintenance hemodialysis.

OBJECTIVE: To analyze the current status and risk factors of olfactory dysfunction in patients undergoing maintenance hemodialysis (MHD), establish a prediction model, and evaluate its effectiveness. MATERIALS AND METHODS: The demographic characteristics and laboratory tests of MHD patients at the Second Affiliated Hospital of Soochow University's hemodialysis center from February to May 2024 were collected. Basic information from individuals with normal renal function at the physical examination center served as a normal control group. Olfactory function was assessed using Sniffin' Sticks, c…

Role of the hedgehog pathway in the formation, maintenance, and degeneration of intervertebral disc.

Low back pain (LBP), one of the most common health problems, is the leading cause of disability globally. Intervertebral disc degeneration (IDD) accounts for most LBP. However, the molecular mechanism underlying IDD remains unclear, and the existing treatment strategy for IDD is still limited. A growing body of evidences suggest that the Hedgehog (HH) pathway plays an essential role in the formation, maintenance, and degeneration of intervertebral discs (IVDs), with Sonic HH (SHH) being primarily involved in the development and maturation of the IVDs and a strong link between Indian HH(IHH) an…

Improvement and maintenance of clinical outcome assessments in atopic dermatitis with amlitelimab.

BACKGROUND: Amlitelimab, a fully human, nondepleting, anti-OX40 ligand monoclonal antibody, demonstrated reductions in lesional and pruritic endpoints in adults with moderate-to-severe atopic dermatitis (AD) in phase 2a and 2b trials. OBJECTIVES: Here, we examined the effect and durability of amlitelimab on clinical outcome assessments (COAs) in the randomized STREAM-AD phase 2b trial. METHODS: Adults with moderate-to-severe AD with prior inadequate response to or inadvisability of topical medications received subcutaneous amlitelimab (250 mg with 500-mg loading dose, 250 mg, 125 mg or 62.5 

Tofacitinib monotherapy as maintenance treatment in juvenile dermatomyositis: a case report.

Juvenile dermatomyositis (JDM) is a multisystem autoimmune disease associated with considerable morbidity and mortality, having a significant impact on patient health. Early diagnosis and appropriate treatment play a key role in optimising outcomes. JDM management remains challenging, particularly in severe or refractory cases, due to the limited evidence regarding therapeutic options. Given these challenges, Janus kinase inhibitors, including tofacitinib, have emerged as promising alternatives, yet evidence in paediatric populations is still scarce. We present the case of a child with JDM who

Impact of Rituximab Maintenance on outcomes in Follicular Lymphoma: An indian experience.

BACKGROUND: Follicular lymphoma (FL) is the second most common subtype of non-Hodgkin lymphoma (NHL) and comprises 9 % of total NHL in India. Rituximab maintenance (RM) after induction immunochemotherapy improves PFS. However, currently, no data exists from the Indian continent regarding the impact of Rituximab maintenance (RM) on overall survival (OS) & progression-free survival (PFS). Our study aims to assess if RM improves the outcomes in FL patients. METHODS: This retrospective study included 95 patients diagnosed with FL meeting GELF criteria and registered at our institute All India Ins…

Maintenance and Reversibility of Paroxysmal Atrial Fibrillation in JDP2 Overexpressing Mice.

Heart-specific overexpression of transcriptional regulator JDP2 (jun dimerization protein 2) for 5 weeks provokes paroxysmal atrial fibrilla … s indicates that the downregulation of calcium proteins and connexins is an important factor in the maintenance of the disease.

Intermuscular adipose tissue and muscle function in patients on maintenance hemodialysis.

Sarcopenia is common in advanced chronic kidney disease (CKD), contributing to poor outcomes. Intermuscular adipose tissue (IMAT) may worsen muscle function through metabolic and inflammatory pathways. We conducted a cross-sectional study comparing maintenance hemodialysis (MHD) patients and controls to assess IMAT and its associations. IMAT was measured via calf muscle MRI, and body composition (BMI, fat mass index), metabolic markers (hs-CRP, TNF-α, IL-6, insulin resistance), and circulating cell-free mitochondrial DNA (ccf-mtDNA) were assessed. Muscle function was evaluated with handgrip st…

The polyadenylase PAPI is required for virulence plasmid maintenance in pathogenic bacteria.

Many species of pathogenic bacteria harbor critical plasmid-encoded virulence factors, and yet the regulation of plasmid replication is ofte … pcnB encoding the polyadenylase PAP I is required for regulation of pYV plasmid copy number (PCN), maintenance of pYV in the bacterial population outside the host, robust T3SS activity, and Yersinia virulence in a mouse infection model. Likewise, pcnB/PAP I is required for robust expression of the Shigella flexneri T3SS that, similar to Yersinia, is encoded …

Квитание протеина в Myelin, обслуживание и регенерация в центральной нервной системе.

Скомбинированная олигодендроцитами (OLGs) в центральной нервной системе (CNS), миелиновая оболочка представляет собой многоламелларную структуру, которая позволяет быстро передавать потенциалы действий и обеспечивает метаболическую поддержку окружающих ее аксонов. При множественном склерозе (MS), хроническом неврологическом расстройстве, мембрана миелина становится объектом приступов с иммунной помощью. Эти нападения приводят к высвобождению подстрекательских цитокинов и активируют микроглию (MG) и астроциты, что приводит к сильному обезвоживанию и нейродегенерации. Квакинг (QKI) — многофункци

Совпадение в аннотации оригинала
Synthesized by oligodendrocytes (OLGs) in the central nervous system (CNS), the myelin sheath is a multilamellar structure that enables the … s context, this review summarizes current evidence positioning QKI as a central regulator of myelin maintenance and regeneration and highlights its potential as a therapeutic target for demyelinating diseases.

Are telocytes related to maintenance of vascular homeostasis in normal and pathological aorta?

The telocyte (TC) is a new interstitial cell type described in a wide variety of organs and loose connective tissues around small vessels, but its presence in large arteries remains unexplored. TCs have small cell bodies and remarkably thin, long, moniliform processes called telopods (Tps). Using transmission electron microscopy and immunofluorescence, we identified TCs in normal human thoracic aortas and in those with aneurysm or acute dissection (TAAD). In normal aortas the TCs were distributed throughout the connective tissue of the adventitial layer, in its innermost portion and at the zon

Synergistic Effect of Retinoic Acid and Lactoferrin in the Maintenance of Gut Homeostasis.

Lactoferrin (LF) is a glycoprotein that binds to iron ions (Fe2+) and other metallic ions, such as Mg2+, Zn2+, and Cu2+, and has antibacterial and immunomodulatory properties. The antibacterial properties of LF are due to its ability to sequester iron. The immunomodulatory capability of LF promotes homeostasis in the enteric environment, acting directly on the beneficial microbiota. LF can modulate antigen-presenting cell (APC) biology, including migration and cell activation. Nonetheless, some gut microbiota strains produce toxic metabolites, and APCs are responsible for initiating the proces

Dupilumab response onset, maintenance, and durability in patients with severe CRSwNP.

BACKGROUND: Responder analyses of SINUS phase 3 study data have shown clinically meaningful improvements across multiple outcomes of treatme … of at least 8.9 points on the 22-Item Sino-Nasal Outcome Test (SNOT-22), was assessed for rapidity, maintenance, and durability. RESULTS: The study included 303 patients (150 of whom received dupilumab and 153 of whom received placebo). For each outcome measure, a greater proportion of patients achieved a first response by week 16 (rapidity) with dupilumab v …

Fear of falling and associated influencing factors in patients on maintenance hemodialysis.

INTRODUCTION: This cross-sectional study analyzed the fear of falling (FOF) and associated influencing factors in patients undergoing maintenance hemodialysis (MHD). METHODS: Patients on MHD (n = 131) were assessed using the short Falls Efficacy Scale International, Generalized Anxiety Disorder-7, Patient Health Questionnaire-9, Perceived Social Support Scale, and Barthel Index questionnaires. RESULTS: The total FOF score was positively correlated with total anxiety and depression scores but negatively correlated with the total score of activities of daily living. There were significant diff…

The impact of health maintenance organizations on improving cardiac surgery outcomes.

BACKGROUND AND OBJECTIVES: California is one of a few states with mandatory reporting of mortality after coronary artery bypass graft (CABG) … f issues beginning years preoperatively and extending for decades. Therefore, we studied one health maintenance organization (HMO) from 2009 to 2020 compared to surrounding individual hospitals. We divided 58 hospitals in Northern California in 2009 according to income and population. To focus on changes introduced because of COVID-19, we compared a public da …