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Single-nucleus RNA sequencing reveals developmental dynamics and cellular heterogeneity in the mammary gland of young fillies and adult Mongolian mares.

Mongolian horses are famous for their lactation traits. Their milk contains a high protein content and low levels of fatty acids. Given their superior milk composition and historical use in dairy production across Inner Mongolia and Central Asia, Mongolian horses serve as a valuable model for understanding lactational biology. Multiple factors regulate the lactation process; however, a detailed study of this biological process has not been performed with single-nucleus RNA sequencing (snRNA-seq) technology. Insights gained from snRNA-seq of their mammary glands can inform molecular strategies …

Comprehensive Review on the Genus Haloxylon: Pharmacological and Phytochemical Properties.

AIMS: This review aimed to review the biological, pharmacological, and phytochemical aspects of the genus Haloxylon. BACKGROUND: Plants of the genus Haloxylon have been used for a long time in traditional medicine, and they are distributed in the western Mediterranean region to the Middle East, Iran, Mongolia, Burma, and southwest China. The studied parts of Haloxylon species include aerial parts, leaves, branches, seeds, roots, rhizosphere, soil, and whole plants, used to treat several diseases, including sexual disorders, hepatobiliary disorders, eye disorders, skin diseases and hemorrhoids…

[Comparison observation on the mature alveolar of Echinococcus sibiricensis and Echinococcus multilocularis in the experimentally infected white mice].

The alveolar echinococcus is one of the most dangerous worm parasites in man. Rausch and Schiller reported a new species, Echinococcus sibir … tages (alveolar echinococcus) from field voles, Microtus brandti in the Hulunbeier Pasture of Inner Mongolia, northeastern China in 1985 and 1998-1999. Two types of metacestodes with quite different styles of early development of E. sibiricensis and E. multilocularis were found from field voles and laboratory experimental white mice. As one characteristic …

[Effect of venetoclax plus chemotherapy on treatment-naive acute myeloid leukemia patients with moderate to poor cytogenetic profiles and the combination's influence on the expression of proteins of the anti-apoptoic family].

Objective: This was an open-label observational assessment aimed to evaluate whether venetoclax (VEN) plus chemotherapy could enhance the therapeutic benefits for treatment-naive acute myeloid leukemia (AML) patients with adverse cytogenetic profiles. Methods: A total of 38 adult patients (including 11 patients with moderate risk stratification and 27 patients with high risk stratification) who were treated at the Affiliated Hospital of Inner Mongolia Medical University from April 2019 to May 2022 were enrolled in this study. Patients were randomized into two cohorts according to the random nu…

[Early effects of low-level long-term occupational chromate exposure on workers'health].

OBJECTIVE: To explore the effects of low-level long-term occupational exposure to chromate on the health of workers, and the potential biomarkers of early health effects in terms of lung function, immune toxicity and genetic damage. METHODS: A total of 22 chromate contact workers and 44 non-chromate contact workers from an electroplating enterprise with long-term occupational environment monitoring in line with the national standards in Inner Mongolia were investigated. The questionnaire survey was conducted to collect the basic situation, the history of smoking, drinking, diseases and so on.…

Research on Time Series Monitoring of Surface Deformation in Tongliao Urban Area Based on SBAS-PS-DS-InSAR.

As urban economies flourish and populations become increasingly concentrated, urban surface deformation has emerged as a critical factor in … ecember 2021 are used as the data source in the urban area of Horqin District, Tongliao City, Inner Mongolia Autonomous Region, for example. A four-threshold (coherence coefficient threshold, FaSHPS adaptive threshold, amplitude divergence index threshold, and deformation velocity interval) GCPs point screening method for PS-DS, as well as a Small Baseline …

Trends in premature avertable mortality from non-communicable diseases for 195 countries and territories, 1990-2017: a population-based study.

BACKGROUND: The reduction by a third of premature non-communicable disease (NCD) mortality by 2030 is the ambitious target of Sustainable De … ies, the most populous examples being Afghanistan, the Central African Republic, Uzbekistan, Haiti, Mongolia, Turkmenistan, Pakistan, Ukraine, Laos, and Egypt, reported both an upward trend and high levels of premature avertable mortality from NCDs. Cardiovascular diseases, cancers, and chronic respiratory diseases have been the main drivers of the global …

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2).

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysi … ival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

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… , China; Inner Mongolia Autonomous Region Big Data Center, Chilechuan Street No. 1, Hohhot 010091, China. … Funding The Inner Mongolia Science and Technology Major Special Projects (2019ZD016 and 2021ZD0005), Natural Science Foundation of Inner Mongolia Autonomous Region (2019MS03014) and Inner Mongolia Autonomous Region Graduate Research Innovation Project (S20210228Z). …

Global, regional, and national liver cancer attributable to smoking and alcohol use burden, 1990-2021: analysis for the global burden of disease 2021 study.

BACKGROUND: Liver cancer poses a significant global health challenge. Smoking and alcohol consumption are major risk factors for liver cance … dean Latin America had the lowest ASRs for both smoking- and alcohol-related liver cancer. Notably, Mongolia had the highest ASRs for liver cancer attributed to both smoking and alcohol consumption, with values hundreds of times greater than those in the country with the lowest burden, Morocco. CONCLUSION: Although the ASRs of smoking-related liver cancer …

Chemical composition and cardiotropic activity of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f.

ETHNOPHARMACOLOGICAL RELEVANCE: Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f. is a subshrub that is widely distributed in China, Kazakhstan, Kyrgyzstan, Mongolia, Russia, Tajikistan, Turkmenistan, and Uzbekistan. The species is used in traditional medicine for the relief of symptoms connected to cardiovascular diseases like coronary heart disease or hypertension. AIM OF THE STUDY: was to validate traditional use of Z. clinopodioides subsp. bungeana for the treatment of coronary hearth diseases using in vivo models and to find active compounds responsible for the activity. MATERIALS…

Analysis on agricultural carbon emissions transfer of inter-provincial trade in China.

The "carbon peaking and carbon neutrality goals" has put forward new requirements for China's agricultural carbon emission reduction. It is … ral carbon output increased from 15.87 million tons in 2015 to 23.37 million tons in 2021. In Inner Mongolia, the net agricultural carbon output increased from 17.03 million tons in 2015 to 23.05 million tons in 2021. Henan and Anhui have consistently maintained a high level of net agricultural carbon output, the net agricultural carbon output decreased fr …

[Clinical predictive value of sphinor kinase 1, D-lactic acid and intestinal fatty acid binding protein for septic gastrointestinal injury].

OBJECTIVE: To investigate the predictive value of sphinor kinase 1 (sphk1), D-lactic acid, and intestinal fatty acid binding protein (I-FABP) for gastrointestinal injury in patients with sepsis. METHODS: A prospective observational study was conducted. Sixty-eight patients with sepsis and gastrointestinal dysfunction admitted to the department of critical care medicine of the First Affiliated Hospital of Baotou Medical College Inner Mongolia University of Science and Technology from May 2024 to March 2025 were enrolled (sepsis group), and they were divided into acute gastrointestinal injury (…

The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: Oesophageal cancer is a common and often fatal cancer that has two main histological subtypes: oesophageal squamous cell carcino … dised incidence rates in 2017 were observed in Malawi (23·0 [19·4-26·5] per 100 000 population) and Mongolia (18·5 [16·4-20·8] per 100 000). In 2017, age-standardised incidence was 2·7 times higher, mortality 2·9 times higher, and DALYs 3·0 times higher in males than in females. In 2017, a substantial proportion of oesophageal cancer DALYs were attributabl …

Long-term efficacy and safety of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): extended follow-up of an open-label, multicentre, randomised, non-inferiority trial.

BACKGROUND: STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of … inoglycoside resistance at 13 clinical sites in seven countries (Ethiopia, Georgia, India, Moldova, Mongolia, South Africa, and Uganda). Participants were randomly assigned 1:2:2:2 (via permuted blocks and stratified by site and HIV status plus CD4 cell count) to the 2011 WHO long regimen (terminated early), a 9-month control regimen, a 9-month oral regime …

Combined spatial metabolomics and 4D-DIA quantitative proteomics approaches to explore the relationship between lung cancer and the heart.

Lung cancer and cardiovascular disease pose persistent threats to human health, despite advancements in targeted therapy, percutaneous coronary intervention, and drug treatments. Challenges such as side effects, drug resistance, hospitalization rates, and mortality remain high. These diseases are closely linked, sharing common risk factors and intricately influencing each other. This study aims to investigate the interplay between lung disease and cardiovascular disease by examining changes in cardiac metabolites and protein expression using spatial metabolomics and 4D-DIA quantitative proteom

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… Acknowledgements We thank the Affiliated Hospital of Inner Mongolia Minzu University and the Experimental Centre of Inner Mongolia Medical University for providing the platform. Author contributions B.T.-T. conceived the study, made the figures and wrote the original paper, W.Q., Y.C.-C., D.S. … Institutional review board statement The animal study protocol was approved by the Animal Care and Experiment Committee of Affiliated Hospital of Inner Mongolia Minzu University (LicenseNo.:NM-LL-2024-03-15-01) approved on 15 March 2024. …

Incidence of multiple sclerosis in China: A nationwide hospital-based study.

BACKGROUND: Multiple sclerosis (MS) is a leading cause of disability among young adults and effects considerable social and economic burdens. Data of MS incidence in China at the national level is lacking. We conducted the first nationwide hospital-based study to estimate the incidence and hospitalization burden of MS in China. METHODS: This study is based on an administrative database of the National Hospital Quality Monitoring System, which covers all 1665 tertiary hospitals in mainland China. The "Medical Record Homepage" of all patients, including 346 variables including demographic chara

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… The estimated crude incidence in the context of geographic distribution varied from 0•049 (95% CI 0•006–0•093) in Tibet (30° N) to 0•541 (95% CI 0•488–0•593) in Inner Mongolia (40° N) ( Fig. 1 ). … In the present study, the incidence of MS in Inner Mongolia and Shanxi Province, which are in the same latitude zone as Japan and South Korea, were 0•33 and 0•54 /100,000. …

Traditional and Complementary Medicine Use among Cancer Patients in Asian Countries: A Systematic Review and Meta-Analysis.

Globally, cancer patients frequently use T&CM during their treatment for various reasons. The primary concerns regarding the use of T&CM among cancer patients are the potential risks associated with interactions between pharmaceuticals and T&CM, as well as the risk of noncompliance with conventional cancer treatments. Despite the higher prevalence of T&CM use in Asia, driven by cultural, historical, and resource-related factors, no prior review has tried to estimate the prevalence and influencing factors of T&CM use and disclosure among cancer patients in this region. This study aims to examin

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… Health insurance coverage for T&CM was categorized based on World Health Organization data as follows [ 8 ]: (1) national health insurance (Iran, Lebanon, Thailand, Mongolia), (2) private health insurance (Turkey, Malaysia, Singapore), (3) both (China, India, Korea, and Taiwan), and (4) T&CMs are not … Complementary and alternative medicine use among patients with cancer in Mongolia: A National hospital survey. BMC Complement. Altern. Med. 2017;17:58. doi: 10.1186/s12906-017-1576-8. 64. Azhar Y., Achmad D., Lukman K., Hilmanto D., Aryandono T. …

Case Report: Cord blood-derived natural killer cells as new potential immunotherapy drug for solid tumor: a case study for endometrial cancer.

Adoptive transfer of natural killer (NK) cells represents a viable treatment method for patients with advanced malignancies. Our team previously developed a simple, safe, and cost-effective method for obtaining high yields of pure and functional NK cells from cord blood (CB) without the need for cell sorting, feeder cells, or multiple cytokines. We present the case of a 52-year-old female patient diagnosed with poorly differentiated stage IVB (T3N2M1) endometrial cancer, who exhibited leukemoid reaction and pretreatment thrombocytosis as paraneoplastic syndromes. The patient received two cours

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… Acknowledgments We gratefully acknowledge all the faculty and staff in the Clinical and Laboratory Unit of the Department of Interventional, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology for their clinical and technical support. … Author YY is employed by the company Inner Mongolia Stem Cell(ProterCell) Biotechnology Co., Ltd. Author XW is employed by the company Beijing Stem Cell(ProterCell) Biotechnology Co., Ltd. and Inner Mongolia Stem Cell(ProterCell) Biotechnology Co., Ltd. …

[Effects of applying human umbilical cord mesenchymal stem cell exosomes through different pathways to treat full-thickness skin defect wounds in mice].

Objective: To investigate the effects of human umbilical cord mesenchymal stem cell (hUCMSC) exosomes in the treatment of full-thickness ski … women aged 25-35 years in the Department of Obstetrics and Gynecology of Baogang Hospital of Inner Mongolia and successfully identified. Totally 120 male BALB/c mice aged 6-8 weeks were selected, and full-thickness skin defect wounds were prepared on the back of them. According to the random number table, the injured mice were divided into control group ( …