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Predictors of Opioid Prescription Refill After Lung Cancer Resection.

INTRODUCTION: Thoracic surgery patients are among the least likely to be on opioids before surgery but have the highest rate of new persistent opioid use after surgery compared to other surgical cohorts. Nearly 27% of opioid-naïve lung cancer resection patients become new persistent opioid users. We aimed to identify risk factors for postdischarge opioid prescription refill within 90 ds of surgery for lung cancer resection patients. METHODS: Retrospective cohort study of all opioid-naïve patients undergoing lung cancer resection from July 2018 to May 2021 at an academic medical center. Multiv

Prescript peritoneal dialysis: Patterns of iron prescribing in peritoneal dialysis.

BackgroundIron deficiency and anaemia are prevalent in people undergoing peritoneal dialysis (PD), necessitating effective iron supplementation. While oral iron is often preferred for its accessibility and cost, it may be insufficient or poorly tolerated. Intravenous (IV) iron is generally well tolerated and associated with improved haemoglobin response and reduced erythropoiesis-stimulating agent requirements, yet optimal dosing, administration intervals, and haematological targets remain under-researched, particularly in PD populations. Current prescribing practices vary significantly, refle

[Evaluation of compliance with prescription proposals for COPD in the Alsace region of France].

INTRODUCTION: The use of inhaled treatments for chronic obstructive pulmonary disease (COPD) in France follows the management proposals issu … n at one of the two centers. RESULTS: Out of the 250 patients recruited, 183 (73.2%) had compliant prescriptions. Among those with non-compliant prescriptions, 38 exhibited over-prescribing (56.7%), often secondary to inappropriate use of inhaled corticosteroids (ICS), while 29 cases showed under-prescribing (43.3%), due mainly to lack of treatment with long-a …

Corticosteroid prescription in children with respiratory symptoms: A real-life study.

Asthma is one of the most common childhood diseases. Most children respond to low doses of corticosteroids and/or anti-leukotrienes. However, a small percentage remain symptomatic. They require high doses of inhaled corticosteroids (ICS) and anti-leukotrienes, sometimes with long-acting bronchodilators (LABA) and occasionally systemic corticosteroids (SC). However, we frequently observe that the only treatment they receive for exacerbations is short-acting beta-agonists (SABA) and oral corticosteroids (OC) without adding ICS as a maintenance treatment to prevent new episodes. This leads to fre

Antidepressant Medication Prescription and Incident Cardiovascular Disease in Women Veterans.

Objective: Antidepressants are commonly prescribed, yet understanding of consequences for cardiovascular disease (CVD) risk is less well-dev … isit, prior CVD or antidepressant prescription, and no encounters after index visit. Antidepressant prescriptions were documented in pharmacy data. Our primary outcome was an incident CVD composite, comprising first-onset ischemic heart disease, stroke, atrial fibrillation/flutter, heart failure/ cardiomyopathy, and pulmonary hypertension based on diagnostic co …

Ceftazidime prescription and antibiotic resistance patterns in a tertiary care hospital.

Ceftazidime, a third-generation cephalosporin, is effective for treating infections caused by gram-negative bacteria. However, increasing antibiotic resistance, particularly in multidrug-resistant gram-negative bacilli, complicates treatment decisions and patient outcomes. This study aimed to assess the clinical epidemiology and characteristics of patients treated with intravenous ceftazidime and clarify the drug resistance patterns of the isolated pathogens. A retrospective cross-sectional study was conducted at a tertiary care center in the West Bank between June 2021 and June 2023. The stud

Identifying Drug Prescription in Newly Diagnosed Hypertension Patients in India.

This study evaluated initial antihypertensive drug prescription patterns in Indian healthcare settings. An observational, cross-sectional, prospective prescription registry analyzed prescriptions for 4723 newly diagnosed hypertension patients. Additionally, it investigated the extent to which physicians adhered to either European or Indian hypertension guidelines. Angiotensin receptor blockers (ARBs) were the most commonly prescribed drugs, given to 79% of patients, followed by calcium channel blockers (CCBs) at 55%. Diuretics and beta-blockers (BBs) were prescribed to 27% and 17% of patients,…

Antibiotic Prescription for Acute Diverticulitis: Evaluation of Compliance With National Guidelines.

INTRODUCTION: Diverticulitis is a common surgical problem that can be categorised as uncomplicated or complicated diverticulitis. National guidelines for managing acute diverticulitis recommend that antibiotics should only be given to patients who are systemically unwell, have a background of immunosuppression or have complicated diverticulitis. We analysed the compliance with these guidelines at our hospital, identified gaps, and introduced appropriate measures to improve service provision. METHODS: This was a closed-loop audit. The first cycle was a retrospective analysis conducted between

Osteoporosis diagnosis and ingredients of prescription medications: a population-based study.

BACKGROUND: Osteoporosis (OP) is common in the elderly, who typically have multiple comorbidities. Current guidelines for managing drug-induced OP are limited due to the complexity of multi-agent medications and the lack of sufficient clinical data. METHODS: Information of demographics, health status, prescription medication use, OP diagnoses, and bone fracture history in US adults aged ≥50 years was from NHANES. Administration of individual medication ingredients was extracted and association between medication component use and OP diagnosis was determined. National trends in OP diagnosis, p

Prescription-dispensing mismatch leading to vitamin D intoxication in an infant.

Vitamin D is a fat-soluble vitamin synthesised in the skin through sunlight exposure and is routinely supplemented in infants due to its limited presence in human milk. The recommended dose is 400 IU/day until 1 year of age. However, excessive supplementation can result in hypervitaminosis D, a serious condition in infants. We report a case of a term male infant who presented with poor feeding and an irritable cry, especially during urination, for 3 days. It was found that he had been receiving 6000 IU/day of vitamin D for 45 days, with a cumulative dose of 320 000 IU. Laboratory results revea

Prescription and Nonprescription Drug Use Among People With Eating Disorders.

IMPORTANCE: There are few effective pharmacotherapies for treating eating disorders (EDs). High rates of substance use among individuals with EDs suggest potential self-medication of symptoms. OBJECTIVE: To explore the experiences of individuals with EDs regarding use of prescribed and nonprescribed drugs. DESIGN, SETTING, AND PARTICIPANTS: This survey study assessed responses to the Medications and Other Drugs for Eating Disorders (MED-FED) survey, which was advertised internationally using social media, online forums, and clinical services and recruited adults who self-reported an ED or di

Идентификация схемы рецептов на кладрибин в MS: итальянское многоцентральное исследование.

Характеристика рецептов кладрипиновых таблеток в повседневной клинической практике имеет решающее значение для оптимизации лечения множественным склерозом (МС). ЦЕЛИ: Описание эффективности, характеристик безопасности и новых предписаний в отношении корректирующей болезни терапии (ДМТ) после лечения кладрибина. DESIGN: Независимое ретроспективное когортное исследование пациентов проводилось в шести итальянских центрах MS. МЕТОДЫ: Пациенты, у которых был диагностирован повторный синдром MS (RMS) в соответствии с критериями McDonald 2017 года, включавшие кладрипин в период с января 2019 года по

Совпадение в аннотации оригинала
BACKGROUND: Characterizing Cladribine tablets prescription pattern in daily clinical practice is crucial for optimizing multiple sclerosis (MS) treatment. OBJECTIVES: To describe efficacy, safety profile and new disease-modifying therapy (DMT) prescriptions following Cladribine treatment. DESIGN: Independent retrospective cohort study in patients followed …

Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis.

BACKGROUND: The gut-liver axis and bacterial translocation are important in cirrhosis, but there is no available universal biomarker of cellular bacterial translocation, for which presepsin may be a candidate. AIM: To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious infection. METHODS: This study included 48 patients with Child-Pugh cirrhosis classes B and C and 15 healthy controls. The fecal microbiome was assessed using 16S rRNA gene sequencing. Plasma levels of presepsin were measured. A total of 22 patient

Blanket or tailored prescription of retainers in orthodontics: a questionnaire-based study.

OBJECTIVE: To explore retainer protocols and how they are influenced by orthodontic presentation and the nature of occlusal correction. MATERIALS AND METHODS: A prepiloted 45-item online questionnaire targeting orthodontists was developed. The questionnaire covered clinical preferences in terms of retainer type, fabrication, and follow-up during retention; the clinical indications for adjunctive surgical procedures; and the use of active designs to mitigate relapse in specific malocclusions. RESULTS: A total of 206 responses were obtained. The majority of the respondents prescribed maxillary

Diuretic drug utilization in neonates: a French prescription database analysis.

Background: The use of diuretics is extremely common in infants cared for in neonatal wards, despite the lack of proven efficacy for many conditions. The main objective of this study was to assess the rate of diuretics exposure in a multicenter French cohort. The secondary objectives were to describe the evolution of this exposure over time, the indications, the prescription practices, and the exposure rates among centers. Methods: An observational study was conducted in 40 Level 3 French neonatal intensive care units using the same computerized order-entry system. Neonates hospitalized betwee

Inconsistencies in the Indian Guidelines for the Prescription of Antibiotics for Critically Ill Patients.

UNLABELLED: The recently formulated guidelines by Khilnani GC et al. for the prescription of antibiotics for critically ill patients present an extensive compilation of evidence and recommendations. Despite their comprehensive nature, several inconsistencies need addressing. In this commentary, we delve into some of these discrepancies in the order in which they appeared in the guidelines, starting with the misrepresentation of "nonbronchoscopic bronchoalveolar lavage (BAL)" and "mini BAL" as different techniques when they are, in fact, identical. Secondly, the Centers for Disease Control and

Prescription Medication Use and Expenditure for Atrial Fibrillation in the United States.

OBJECTIVES: To study the national trends of anticoagulants, antiarrhythmic drugs (AADs), and expenditures in the civilian noninstitutionalized atrial fibrillation (AF) population. METHODS: The Medical Expenditure Panel Survey was queried from January 2016 to December 2021 to identify adults (age ≥18 years) with a diagnosis of AF utilizing the International Classification of Diseases, Tenth Revision, Clinical Modification code I48. Prevalence of anticoagulants (AAD) and its expenditure and AF expenditure across clinical settings in the United States were estimated. The predictors of anticoagul

Racial Disparities in Clozapine Prescription Patterns Among Patients With Schizophrenia.

OBJECTIVE: Previous research has suggested that demographic factors affect the likelihood of a patient with schizophrenia receiving a clozapine prescription. The authors aimed to determine the impact of race, social determinants of health, gender, rurality, and care patterns on clozapine prescription rates. METHODS: This cross-sectional observational study used structured electronic health records data from 3,160 adult patients diagnosed as having schizophrenia between October 1, 2015, and November 30, 2021, in a multifacility health system. The social vulnerability index (SVI) was used to qu

Clinical Presentations of Bupropion Prescription Drug Misuse: A Systematic Review.

BACKGROUND: Among prescribers, bupropion is considered a substance of low misuse potential, with some studies showing lesser misuse potential than caffeine. However, several case reports exist of recreational bupropion misuse and diversion. Our goal is to understand at-risk populations, clinical courses, interventions, and outcomes after acute ingestion of bupropion via oral, intravenous route, and insufflation. METHODS: The systematic review was registered with PROSPERO on August 5, 2023. We conducted a systematic literature search on July 30, 2023, utilizing 8 databases with the help of the

Oestrogens in oral contraception: considerations for tailoring prescription to women's needs.

BACKGROUND: The oestrogenic component of combined oral contraceptives (COCs) has changed over years with the aim of reducing oestrogen-related side effects and risks, whilst maintaining oestrogen beneficial effects, particularly on cycle control. PURPOSE: To describe the pharmacological profiles of different oestrogens commonly used in COCs to provide insights on contraceptive prescription tailored to women's needs. RESULTS: All COCs ensure a high contraceptive efficacy. COCs containing the natural oestrogens oestradiol (E2), oestradiol valerate (E2V) and estetrol (E4) have limited impact on