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A Prospective Study of the IlluminOss Photodynamic Nail System for Pelvic Stabilization: Treatment of Impending and Actual Fractures from Metastatic Bone Disease, Multiple Myeloma, and Primary Bone Lymphoma.

BackgroundThe stabilization of metastatic lesions in the periacetabular region can be successfully performed using percutaneous techniques. Photodynamic nails (PDNs) are among the available tools for stabilization. Data on postoperative complications and functional outcomes are, however, scarce.MethodsPatients undergoing percutaneous stabilization using PDNs (IlluminOss Medical) for impending or actual minimally displaced pathological fractures of the pelvis from metastatic bone disease, multiple myeloma, or primary bone lymphoma were enrolled prospectively. Outcomes were assessed preoperative

Open retropubic colposuspension for urinary incontinence in women.

BACKGROUND: Urinary incontinence is a common and potentially debilitating problem. Stress urinary, incontinence as the most common type of incontinence, imposes significant health and economic burdens on society and the women affected. Open retropubic colposuspension is a surgical treatment which involves lifting the tissues near the bladder neck and proximal urethra in the area behind the anterior pubic bones to correct deficient urethral closure to correct stress urinary incontinence. OBJECTIVES: The review aimed to determine the effects of open retropubic colposuspension for the treatment …

Explosive Disease Progression After Single-Agent B-cell Maturation Antigen-Targeted Treatment in Multiple Myeloma: A Report of Three Cases in Sheikh Shakhbout Medical City.

Patients with "penta-refractory" multiple myeloma (MM) are challenging to treat given the limited treatment options available to them. Belantamab mafodotin is the first B-cell maturation antigen (BCMA)-targeting antibody-drug conjugate approved for the treatment of relapsed/refractory MM (RRMM). In this case report, we reviewed in detail three female patients who were diagnosed with MM international scoring system (ISS)-3 and were heavily pretreated, and refractory to CD38 monoclonal antibodies, two proteasome inhibitors, and two immunomodulatory agents. These patients were started on belantam

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… . | Multiple lucent lytic lesions noted in bilateral sacrum, ileum, pubic bones, and visible proximal femur | Numerous widespread bone lesion with pathological fractures of left sixth rib | No lytic or blasting lesions seen on complete osseous survey | Multiple lytic lesion seen in ribs, spine, and scapula …

Assessing Pain and Functional Outcomes of Percutaneous Stabilization of Metastatic Pelvic Lesions via Photodynamic Nails: A Bi-Institutional Investigation of Orthopaedic Outcomes.

BackgroundMinimally invasive surgical interventions for metastatic invasion of the pelvis have become more prevalent and varied. Our group hypothesized that the use of percutaneous photodynamic nails (PDNs) would result in decreased pain, improved functional outcomes and level of ambulation, and decreased use of opioid pain medication.MethodsWe performed a retrospective chart review of patients with metastatic pelvic bone disease undergoing stabilization with PDNs (IlluminOss Medical) at 2 institutions. Functional outcome measures assessed include the Combined Pain and Ambulatory Function (CPA

Case report and review: Angiosarcoma with thrombocytopenia after total hip arthroplasty.

Total hip arthroplasty (THA) is a common treatment for osteoarthritis and is also performed for other conditions, such as secondary arthritis due to developmental dysplasia of the hip. Various THA types may be complicated by osteolysis and an inflammatory pseudotumor due to an adverse reaction to metal debris. Rarely, THA has been associated with malignant tumors, but their causality remains unclear. In this case report, we describe a female patient with developmental dysplasia of the hip. She had undergone left metal-on-polyethylene THA, acetabular revision of the THA, and left total knee art

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… Her abdominal CT scan showed growth of the suspected pseudotumor (to 6 cm × 7.5 cm × 9 cm, Figure 2D ) and fractures of the pubic bone and trochanter major. The spleen appeared normal in size. A day later, a lower-limb ultrasound (US) was performed, which ruled out the presence of DVT. …

PB2108: SPINAL INVOLVEMENT IS ASSOCIATED WITH HIGH INCIDENCE OF SKELETAL RELATED EVENTS AND INFERIOR OVERALL SURVIVAL IN PATIENTS WITH MULTIPLE MYELOMA. A SINGLE CENTRE EXPERIENCE IN 653 PATIENTS.

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Metastatic lung adenocarcinoma causes extensive destruction of the hip and pelvis.

BackgroundLung cancer is the most prevalent tumor and frequently present with distant metastases, with the bone being one of the most common affected sites. However, bone metastases leading to complete resorption of the hip joint and pelvis are extremely rare. This case aimed to report an extensive destruction of the hip and pelvis in metastatic lung adenocarcinoma, and conduct a literature review to explore the factors influencing the diagnosis and treatment decisions of bone metastasis.Case presentationA 56-year-old woman presented with progressive pain in her left hip joint and pelvis accom

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… Pelvic radiographs showed extensive lamellar bone erosion involving the left sacrum, the left iliac bone, the left proximal femur, the left ischiatic bone, and bilateral pubic bone (Fig. 2 ). Most of the affected bone structures had disappeared, with evident osteolytic changes. … bone and spine | Osimertinib, an EGFR-tyrosine kinase inhibitor | Left proximal femoral replacement | No recurrence for 6 months Analysis of the 17 cases revealed that diagnostic delays were a common theme. …

Preoperative embolization in surgical treatment of long bone metastasis: a systematic literature review.

Surgery of long bone metastases is associated with a significant risk of perioperative blood loss, which may necessitate blood transfusion.Successful embolization (> 70% obliteration of vascularity) can be achieved in 36-75% of cases.The reported rate of embolization-related complications is 0-9%.Three out of six level III evidence studies showed a reduction in perioperative blood loss and/or blood transfusion requirement after preoperative embolization of renal cell carcinoma metastasis in long bones; three out of six studies did not.One level III evidence study did not show a reduction in pe

Tumor Type Agnostic Therapy Carrying BRAF Mutation: Case Reports and Review of Literature.

BackgroundPrecision medicine is based on molecular and genotypic patient characterization to define specific target treatment. BRAF mutation is an oncogenic driver, and the Cancer Genome Atlas has identified BRAF mutations in different cancer types. Tumor type agnostic therapy is based on targeting genomic alterations, regardless of tumor origin. In this context, novel therapeutic agents including BRAF and MEK inhibitors based on the molecular landscape in solid tumors have been investigated. Case presentation, Case 1: The first case is chemotherapy-refractory, BRAF V600E mutated intrahepaticc

Atypical Presentation of Multiple Myeloma Affecting Appendicular Skeleton Associated with Pathological Neck of Femur and Proximal Humerus Fractures - A Case Report.

INTRODUCTION: The increasing incidence of atraumatic neck of femur (NOF) fractures, often linked to age-related bone weakening, is a notable clinical trend. This case report highlights a 72-year-old male presenting with NOF and proximal humerus fractures post-trivial fall, revealing lytic lesions suggestive of multiple myeloma (MM). Despite inconclusive skeletal and metabolic evaluations, a comprehensive surgical approach confirmed MM, emphasizing the importance of thorough diagnostic and therapeutic management in complex cases. CASE REPORT: A 72-year-old male presented with a trivial fall re

Challenges in the management of bone metastases: focus on differentiated thyroid cancer and neuroendocrine tumors.

Bone metastases represent an uncommon but clinically significant complication in endocrine malignancies including differentiated thyroid cancer and neuroendocrine tumors. Although these malignancies typically follow an indolent course, the development of bone metastases is associated with a worse prognosis and increased risk of skeletal-related events. The optimal strategies for the prevention and management of bone metastases in these patients remain unclear and are largely extrapolated from studies in other solid tumors. This presents a unique clinical challenge as treatment decisions need t

What Proportion of Patients Undergoing Bernese Periacetabular Osteotomy Experience Nonunion, and What Factors are Associated with Nonunion?

BACKGROUND: The Bernese periacetabular osteotomy (PAO) is one of the most-used surgical techniques to treat symptomatic acetabular dysplasia. Although good functional and radiographic short-term and long-term outcomes have been reported, several complications after PAO have been described. One complication that may compromise clinical results is nonunion of an osteotomy. However, the exact prevalence and risk factors associated with nonunion are poorly elucidated. QUESTIONS/PURPOSES: (1) What proportion of patients have complete bony healing versus nonunion during the first year after PAO? (2

Polymyalgia rheumatica: An update (Review).

Polymyalgia rheumatica (PMR) is a chronic inflammatory disease which affects the connective vascular tissue, characterized by pain accompanied by morning stiffness, predominantly of the neck muscles, hip and shoulder girdle. Usually, patients with this disease are >50 years of age and biological inflammatory syndrome is present with an increase in both the erythrocyte sedimentation rate and C-reactive protein levels, aspects similar to giant cell arteritis. The aim of the present review was to depict the current pathogenic hypothesis, diagnostic and treatment approach for patients with PMR, an

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… All cases exhibited bilateral involvement of the common ischiocrural tendon, gluteus medius and minimus tendons, proximal rectus femoris origin and in 90% of cases enhancement of the adductor muscles at the inferior pubic bone. …

Ocrelizumab-Induced Hemophagocytic Lymphohistiocytosis: A Case Report.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon disorder marked by severe immune system dysfunction and excessive inflammation. Its clinical features often mimic those of severe sepsis, including persistent high fevers, multiorgan failure, cytopenia, and coagulation abnormalities. HLH can be triggered by infections, malignancies, rheumatological disorders, genetic factors, and medications, particularly those that cause immunosuppression. Ocrelizumab, an anti-CD20 monoclonal antibody used in the treatment of multiple sclerosis, has been associated with rare immune-mediated complications

High-Dose Continuous Infusion Ifosfamide as Effective Palliation in a Patient With Relapsed Ewing Sarcoma With Bone Marrow Infiltration and Severe Thrombocytopenia: A Case Report.

BackgroundEwing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing/recurring Ewing sarcoma treatment, yet when the disease relapses as bone marrow infiltration, combination chemotherapy might be difficult to administer and prognosis is poor.CaseThis report describes the case of a 22-year-old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, and who was treated with high-dose continuous infusion ifosfamide, obtaining bot

Occult olfactory neuroblastoma presenting with multiple bone metastases: a case report.

RATIONABLE: Olfactory neuroblastoma (ONB) is a rare malignant tumor of the nasal cavity, the primary local symptoms are usually inconspicuous. Patients are often admitted to various specialties based on different primary symptoms, which may result in delayed diagnosis and even a misdiagnosis. PATIENT CONCERNS: Here we report a case of ONB that presented initially as multiple ostealgia without any local symptoms of the tumor and primarily misdiagnosed as multiple myeloma. The patient was a 47-year-old female with bone pain at multiple sites. The initial diagnosis was considered as multiple mye

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… She was diagnosed as multiple myeloma (MM) by a local hospital for the growing bone pain and extensive lesions of the 3 rd , 4 th and 5 th lumbers, bilateral femoral bones, and pubic bones, which indicated by an magnetic resonance imaging (MRI) scan. …

A modified Harrington technique for periacetabular reconstruction in advanced metastatic bone disease and a discussion of alternative treatment options.

Management of periacetabular lesions involves complex clinical decision making. The modified Harrington procedure with total hip arthroplasty can recreate pelvic stability with a cement rebar construct as well as a functional hip. This study analyzes the modified Harrington procedure to assess construct longevity and patient outcomes. We queried a prospectively maintained database to identify all patients at a large academic medical center from 2017 to 2019 with periacetabular metastatic disease treated with a modified Harrington. Medical records were reviewed and complications, patient outcom

Effects of Percutaneous Sacroplasty on Pain and Mobility in Sacral Insufficiency Fracture.

ObjectiveSacral insufficiency fracture (SIF) contributes to severe low back pain. Prolonged immobilization resulting from SIF can cause significant complications in the elderly. Sacroplasty, a treatment similar to vertebroplasty, has recently been introduced for providing pain relief in SIF. The purpose of this study is to investigate the clinical short-term effects of percutaneous sacroplasty on pain and mobility in SIF.MethodsThis study is conducted prospectively with data collection. Sixteen patients (3 men and 13 women) with a mean age of 77.5 years (58 to 91) underwent sacroplasty. Patien

Венецоклакс в сочетании с азаситидином в лечении вторичного миэлодипластического синдрома после нескольких миелом: доклад о деле и обзор литературы.

Мы провели ретроспективный анализ клинических данных пациента с миелодипластическим синдромом (MDS) вторичной и стабильной миеломой (MM), который лечился вместе с венетоклаксом и азаситидином в Пятом народном госпитале Ченду. Кроме того, мы изучили соответствующую литературу. Пациентка, 74-year-old Мужчина был первоначально диагностирован миеломой (IgA-__, DS IIIA, ISS III, R-ISS II) и получил очень хороший частичный ответ (VGPR) после последовательного лечения в рамках режимов BCTD, RVD и PVD, которые впоследствии получали алидомидную терапию. Несмотря на постоянную ремиссию, у пациента появи

После-пересадки двойное злодейство: Множественная миелома и папиллярная рентгеновская ячейка Карцинома-А.

Фон и клиническая значимость: получатели почечных трансплантаций имеют 2-4-fold более высокий риск раковых заболеваний по сравнению с населением в целом. Целостное появление карциномы миеломы (ММ) и почечной клетки коренных почек (КЦК) является редким явлением и создает конкурирующие приоритеты между эффективностью борьбы с миломой и сохранением сплава. Представление дела: A 54-year-old с женщиной 2020 Пересадка живой донорской почки 2024 с болью в костях и опухолью плеча. КТ всего тела с низкой дозой выявила множественные остеолитические повреждения. Проверка показала, что М-протеин ИгГ. 38.5