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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights.

Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing significant treatment challenges. Mesenchymal stromal cell (MSC) therapy has shown promise in DLC treatment, but the optimal dosing strategies and dose-dependent therapeutic mechanisms in humans remain unclear, limiting its clinical application. We conducted sequential Phase Ia/Ib trials using a single-arm, dose-escalation design to evaluate the safety and tolerability of MSC therapy in DLC patients while also exploring its immunomodulatory effects and gathering preliminary therape

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… On the other hand, resistin was reduced in patients but increased on D3 and D7 in Cohort IV (Supplementary Fig. 3b, c ). We also analyzed the variation in ligand‒receptor pairs between altered subpopulations (Fig. 4c , Supplementary Fig. 3d ). …

Cancer survivorship at heart: a multidisciplinary cardio-oncology roadmap for healthcare professionals.

In cancer, a patient is considered a survivor from the time of initial diagnosis until the end of life. With improvements in early diagnosis and treatment, the number of cancer survivors (CS) has grown considerably and includes: (1) Patients cured and free from cancer who may be at risk of late-onset cancer therapy-related cardiovascular toxicity (CTR-CVT); (2) Patients with long-term control of not-curable cancers in whom CTR-CVT may need to be addressed. This paper highlights the importance of the cancer care continuum, of a patient-centered approach and of a prevention-oriented policy. The

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… Nutr Res 2016 ( 18 ) Obesity | Adipokines, including adiponectin, leptin, and resistin, that are up-regulated in obesity | Adipokines induce miR- 21, a tumorigenesis regulator, and may impact on hypertension | Oesophageal, stomach, liver, pancreas, gallbladder, ovary, thyroid, kidney cancer, postmenopausal …

Multidisciplinary Progress in Obesity Research.

Obesity is a chronic disease that endangers human health. In recent years, the phenomenon of obesity has become more and more common, and it has become a global epidemic. Obesity is closely associated with many adverse metabolic changes and diseases, such as insulin resistance, type 2 diabetes mellitus, coronary heart disease, nervous system diseases and some malignant tumors, which have caused a huge burden on the country's medical finance. In most countries of the world, the incidence of cancer caused by obesity is increasing year on year. Diabetes associated with obesity can lead to seconda

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… These adipokines include TNF-α, leptin, resistin, visfatin, IL-6, and adiponectin. There are more than 50 known adipokines, which mainly differ in their role in inflammation. …

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.

Antioxidant-rich dietary regimens are considered the best practice to maintain health, control inflammation, and prevent inflammatory diseases. Yet, nutraceuticals as food supplements are self-prescribed and purchasable over the counter by healthy individuals for the purpose of beneficial effects on fitness and aging. Hence, the effectiveness, safety, and correct intake of these compounds need to be better explored. Since redox-modulating activity of these compounds appears to be involved in activation and or suppression of immune cells, the preventive use of nutraceuticals is very attractive

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… Next, free fatty-acids are increased in blood, and adipose tissue is accumulated producing endocrine factors (leptin and resistin) that block carbohydrate metabolism [ 16 ]. …

Obesity: pathophysiology and therapeutic interventions.

Over the past few decades, obesity has transitioned from a localized health concern to a pressing global public health crisis affecting over 650 million adults globally, as documented by WHO epidemiological surveys. As a chronic metabolic disorder characterized by pathological adipose tissue expansion, chronic inflammation, and neuroendocrine dysregulation that disrupts systemic homeostasis and impairs physiological functions, obesity is rarely an isolated condition; rather, it is frequently complicated by severe comorbidities that collectively elevate mortality risks. Despite advances in nutr

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… Hormonal regulation Adipocytes secrete a range of cytokines, including leptin, vastatin, interleukin- 6 (IL—6), adiponectin, tumor necrosis factor-alpha (TNF-α), resistin, angiotensinogen, aromatase, and adipsin. …

Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation.

A quarter-century after the discovery of autotaxin in cell culture, the autotaxin-lysophosphatidate (LPA)-lipid phosphate phosphatase axis is now a promising clinical target for treating chronic inflammatory conditions, mitigating fibrosis progression, and improving the efficacy of existing cancer chemotherapies and radiotherapy. Nearly half of the literature on this axis has been published during the last five years. In cancer biology, LPA signaling is increasingly being recognized as a central mediator of the progression of chronic inflammation in the establishment of a tumor microenvironmen

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… ATX and Neurological Disorders LPA also acts synergistically with adipokines (leptin, resistin, TNFα, IL-1β and IL-6) released by white adipose tissue in promoting inflammation and producing reactive oxygen species that disrupt blood brain barrier permeability, leading to hippocampal atrophy and dementia …

Cardiovascular Biomarkers in Cardio-Oncology: Antineoplastic Drug Cardiotoxicity and Beyond.

Serum biomarkers represent a reproducible, sensitive, minimally invasive and inexpensive method to explore possible adverse cardiovascular effects of antineoplastic treatments. They are useful tools in risk stratification, the early detection of cardiotoxicity and the follow-up and prognostic assessment of cancer patients. In this literature review, we aim at describing the current state of knowledge on the meaning and the usefulness of cardiovascular biomarkers in patients with cancer; analyzing the intricate relationship between cancer and cardiovascular disease (especially HF) and how this

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… 1 (cMLC-1), vascular endothelial growth factor (VEGF), placental growth factor (PIGF), procollagen-derived type-I C-terminal-propeptide (PICP), epicardial adipose tissue (EAT) volume, circulating bilirubin, hemopexin, glycated hemoglobin (HbA(1)c), advanced oxidation protein products (AOPP), human resistin …

The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis.

Extracellular vesicles (EVs) are complex phospholipidic structures actively released by cells. EVs are recognized as powerful means of intercellular communication since they contain many signaling molecules (including lipids, proteins, and nucleic acids). In parallel, changes in epigenetic processes can lead to changes in gene function and finally lead to disease onset and progression. Recent breakthroughs have revealed the complex roles of non-coding RNAs (microRNAs (miRNAs) and long non-coding RNAs (lncRNAs)) in epigenetic regulation. Moreover, a substantial body of evidence demonstrates tha

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… Adipocytes transfer via EVs adipocyte-specific transcripts such as adiponectin, resistin , and peroxisome proliferator-activated receptor gamma 2 ( Pparγ2 ) into macrophages [ 110 ] or leptin , tumor necrosis factor alpha ( Tnfα ), and fibroblast growth factor alpha ( Fgfα ) into endothelial cells, thereby …

A scoping review of biopsychosocial risk factors and co-morbidities for common spinal disorders.

OBJECTIVE: The purpose of this review was to identify risk factors, prognostic factors, and comorbidities associated with common spinal disorders. METHODS: A scoping review of the literature of common spinal disorders was performed through September 2016. To identify search terms, we developed 3 terminology groups for case definitions: 1) spinal pain of unknown origin, 2) spinal syndromes, and 3) spinal pathology. We used a comprehensive strategy to search PubMed for meta-analyses and systematic reviews of case-control studies, cohort studies, and randomized controlled trials for risk and pro

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… Biver and colleagues found that fat mass may influence bone metabolism and density through the production of adipokines (leptin, adiponectin, resistin, visfatin) and found that adiponectin was negatively associated with bone density (independent of sex and fat mass) [ 124 ]. …

Cellular and Molecular Mechanisms Associating Obesity to Bone Loss.

Obesity is an alarming disease that favors the upset of other illnesses and enhances mortality. It is spreading fast worldwide may affect more than 1 billion people by 2030. The imbalance between excessive food ingestion and less energy expenditure leads to pathological adipose tissue expansion, characterized by increased production of proinflammatory mediators with harmful interferences in the whole organism. Bone tissue is one of those target tissues in obesity. Bone is a mineralized connective tissue that is constantly renewed to maintain its mechanical properties. Osteoblasts are responsib

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… The hypertrophy of adipocytes, caused by excessive fat accumulation, enhances the expression of proinflammatory mediators, such as TNF-α, IL1β, IL6, resistin, and leptin in the adipose tissue. …

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies.

Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host's immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal li

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… Resistin is increased in periodontal cells and tissues: in vitro and in vivo studies. Mediators Inflamm . 2020;2020:p. 9817095. doi: 10.1155/2020/9817095. 57. Belluci M. M., de Molon R. S., Carlos Rossa S. T., Jr., et al. …

The Role of Irisin and Physical Activity in Breast Cancer.

BACKGROUND/AIM: Irisin, a myokine released during physical activity, has been proposed as a mediator of exercise's protective effects against breast cancer (BC). This review underscores the critical role of irisin in mediating the anticancer effects of exercise and its potential application in BC prevention and prognosis. MATERIALS AND METHODS: Studies published up to 2025 were identified in PubMed, Scopus, and Web of Science databases. Data from experimental models, clinical trials, and observational studies were analyzed with emphasis on exercise-induced irisin secretion and its effects on

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… In addition, WAT secretes adipokines such as leptin, resistin, adiponectin, IL-6, and TNF-α ( 149 - 151 ). …

Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate exist

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… Furthermore, in the adipocytes, genes responsible for insulin-dependent glucose uptake ( GLUT4 , IRS-1 , IRS-2 , and c-Cbl associated protein) and adipokines (adiponectin, resistin, leptin, and tumor necrosis factor-α) are also PPARγ responsive [ 15 ]. …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

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… Curcuminoids have been demonstrated in diabetes mellitus type 2 patients to improve insulin resistance, reduce glucose and insulin levels, enhance adiponectin secretion, and lower levels of leptin, resistin, interleukin (IL-6, IL-1β), and TNF-α ( Hajavi et al., 2017 ). …

Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer.

Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment. Metabolic reprogramming is considered a hallmark of cancer and includes increased glucose uptake and processing, and increased glutamine utilization, but also the deregulation of lipid and cholesterol-associated signal transduction, as highlighted in recent years. In the first part of the review, we will i) provide an overview of the major types of lipids found in eukaryotic cells and their importance as med

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… After the discovery of leptin [ 197 ], many other adipokines have been identified including adiponectin, resistin, tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6) and apelin, creating a challenging complexity in the field [ 198 , 199 ]. …

Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword.

Multiple myeloma (MM) is a hematological malignancy defined by the abnormal proliferation and accumulation of plasma cells (PC) within the bone marrow (BM). While multiple myeloma impacts the bone, it is not classified as a primary bone cancer. The bone marrow microenvironment significantly influences the progression of myeloma and its treatment response. Mesenchymal stromal cells (MSCs) in this environment engage with myeloma cells and other bone marrow components via direct contact and the secretion of soluble factors. This review examines the established roles of MSCs in multiple facets of

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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… Also, non-survivors P had higher PELOD, Resistin, and anion gap and lower EF (p < 0.05); non-survivors A showed a trend for higher eHSP72, nHSP72, and Resistin levels. In both age groups, the rs6457452 and rs1061581 HSP72 haplotypes were not related to mortality. … For predicting sepsis-3 in both groups CRP, resistin, lactate, and eHSP72 in P, achieved a receiver operating characteristic curve (AUROC) > 0.80 (p < 0.05). In a logistic regression model resistin and mHSP72 independently discriminated S from SIRS in children only (p < 0.001). …

Postbiotics as Emerging Strategy Targeting Obesity- and Aging-Related Breast Cancer-Prospects in Prophylaxis and Therapy.

Aging and obesity accompanied with hormonal disequilibrium represent critical, inter-related risk factors for breast cancer, significantly influencing disease incidence, progression, and therapeutic outcomes. This review aims to elucidate the multifaceted biological mechanisms linking obesity and aging to breast carcinogenesis, with a particular focus on the emerging therapeutic and preventive potential of postbiotics as molecules targeting cellular events important for cancer growth and responsiveness. Despite continuous advancement, breast cancer therapy still poses several challenges, such

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… These include leptin, resistin, visfatin, osteopontin, apelin, chimerin, oncostatin M, and lipocalin, for which a positive correlation between their elevated concentrations and the risk of breast cancer has been observed. …

Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression.

Multiple myeloma (MM) is a hematological malignancy of plasma cells that proliferate and accumulate within the bone marrow (BM). Work from many groups has made evident that the complex microenvironment of the BM plays a crucial role in myeloma progression and response to therapeutic agents. Within the cellular components of the BM, we will specifically focus on mesenchymal stromal cells (MSCs), which are known to interact with myeloma cells and the other components of the BM through cell to cell, soluble factors and, as more recently evidenced, through extracellular vesicles. Multiple structur

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… BM adipocytes secrete several adipokines and growth factors (e.g., MCP-1, SDF-1α, leptin, TNFα, insulin, resistin) which recruit myeloma cells and promote myeloma growth and protection from chemotherapy [ 187 , 188 , 189 ]. …

The underexplored links between cancer and the internal body climate: Implications for cancer prevention and treatment.

In order to effectively manage and cure cancer we should move beyond the general view of cancer as a random process of genetic alterations leading to uncontrolled cell proliferation or simply a predictable evolutionary process involving selection for traits that increase cell fitness. In our view, cancer is a systemic disease that involves multiple interactions not only among cells within tumors or between tumors and surrounding tissues but also with the entire organism and its internal "milieu". We define the internal body climate as an emergent property resulting from spatial and temporal in

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… Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice. Genes Nutr (2020) 15(1):12. doi: 10.1186/s12263-020-00671-3 44. Rosenbaum M, Knight R, Leibel RL. …