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Incomplete brain infarction of reperfused cortex may be quantitated with iomazenil.

BACKGROUND AND PURPOSE: [123I]Iomazenil is a specific radioligand for the central benzodiazepine receptor that may be useful as an indicator of the intactness of cortical neurons after focal cerebral ischemia. We evaluated the binding of this receptor in reperfused cortex among patients with ischemic stroke to detect viable neurons in cortex that appeared structurally intact on conventional neuroimaging studies. METHODS: Fourteen patients were selected by (1) angiography within 24 hours of onset showing embolic occlusion of an intracranial artery, (2) cerebral blood flow showing ischemia of m

A case of neovagina surgical creation using the uterine cervix remnant in a patient with Mayer-Rokitansky-Küster-Hauser syndrome.

OBJECTIVE: To study the efficacy of a novel approach to vaginoplasty in a patient with vaginal aplasia and a preserved cervix. DESIGN: We p … ith conventional laparoscopic instruments, a 30-degree laparoscope, a high-definition video system, xenon light source, insufflator, irrigator, and bipolar and monopolar energy sources. PATIENT(S): A single patient, mentioned previously. INTERVENTION(S): Surgical vaginoplasty using the preserved cervix. The details are explained in the Design section. …

Posttraumatic cerebral arterial spasm: transcranial Doppler ultrasound, cerebral blood flow, and angiographic findings.

Thirty patients admitted after suffering closed head injuries, with Glasgow Coma Scale scores ranging from 3 to 15, were evaluated with transcranial Doppler ultrasound monitoring. Blood flow velocity was determined in the middle cerebral artery (MCA) and the intracranial portion of the internal carotid artery (ICA) in all patients. Because proximal flow in the extracranial ICA declines in velocity when arterial narrowing becomes hemodynamically significant, the extracranial ICA velocity was concurrently monitored in 19 patients. To assess cerebral perfusion, cerebral blood flow (CBF) measureme

Evaluation of intracardiac shunts.

This article will review the qualitative and quantitative methods of radionuclide evaluation of intracardiac shunts. Radionuclide angiocardiography of the cardiopulmonary system has proven adequate, with few exceptions, for qualitative detection of left-to-right and right-to-left intracardiac shunts. Numerous authors have reported on the detection of intracardiac shunts using qualitative methods such as rapid sequential visualization of nuclide angiocardiography using the scintillation camera with Polaroid, 35mm or 70mm film. Recent development of videotape storage systems and computers offers

Exoscopic Supraorbital Keyhole Approach for Skull Base Lesions: An Institutional Experience.

Background  In recent times, the supraorbital approach via eyebrow incision has gained tremendous popularity in targeting the anterior skull … oscopy, Tuttlingen, Germany) with a 10-mm outer diameter and a shaft length of 14 cm, light source (Xenon Nova 300, Karl Storz GmBH and Co., Tuttlingen, Germany), camera head, video display monitor, and a holding arm. Results  Out of 50 cases, the majority were pituitary adenomas (30%) and meningiomas (38%), with aneurysms comprising 6%; only 4 cases (8 …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

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… lamp, 400-780 nm, 72 J/cm 2 , 15 min | C. albicans | 100 µM, 30 min | No viable cells | ( 59 ) Xenon lamp, 400-780 nm, 72 J/cm 2 , 15 min | Azole-sensitive clinical isolate of C. albicans | 100 µM, 30 min | 6.01 log 10 reductions | ( 59 ) Xenon lamp, 400-780 nm, 72 J/cm 2 , 15 min | Azole-resistant … | ( 67 ) Xenon lamp, 435 ± 10 nm, 72 J/cm 2 , 30 min | T. rubrum (clinical strain) | 1 μM, 2 h | Decreased survival rate to 18.63% | ( 67 ) Xenon lamp, 400-780 nm, 96 J/cm 2 , 20 min | Malassezia furfur | 10 μM, 30 min | No viable cells | ( 68 ) Celastrol and T. wilfordii extract | 425nm | LED, 660 …

Fast and accurate reconstruction of human lung gas MRI with deep learning.

PURPOSE: To fast and accurately reconstruct human lung gas MRI from highly undersampled k-space using deep learning. METHODS: The scheme was comprised of coarse-to-fine nets (C-net and F-net). Zero-filling images from retrospectively undersampled k-space at an acceleration factor of 4 were used as input for C-net, and then output intermediate results which were fed into F-net. During training, a L2 loss function was adopted in C-net, while a function that united L2 loss with proton prior knowledge was used in F-net. The 871 hyperpolarized 129 Xe pulmonary ventilation images from 72 volunteers

ASENT 2022 Annual Meeting.

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… Rogawski, School of Medicine, University of California, Davis, Sacramento, CA; Simon Pimstone, Xenon Pharmaceuticals; Ernesto Aycardi, Xenon Pharmaceuticals; Cynthia Harden, Xenon Pharmaceuticals; Yi Xu, Xenon Pharmaceuticals; Constanza Luzon Rosenblut, Xenon Pharmaceuticals; Christopher Kenney, Xenon … Rogawski, School of Medicine, University of California, Davis, Sacramento, CA; Cynthia Harden, Xenon Pharmaceuticals; Jenny Qian, Xenon Pharmaceuticals; Greg Beatch, Xenon Pharmaceuticals Abstract X-TOLE was a randomized, double-blind, placebo-controlled, study to assess the efficacy and safety of XEN1101 …

Predominance of cellular edema in traumatic brain swelling in patients with severe head injuries.

OBJECT: The edema associated with brain swelling after traumatic brain injury (TBI) has been thought to be vasogenic in origin, but the results of previous laboratory studies by the authors have shown that a cellular form of edema is mainly responsible for brain swelling after TBI. In this study the authors used magnetic resonance (MR) imaging techniques to identify the type of edema that occurs in patients with TBI. METHODS: Diffusion-weighted MR imaging was used to evaluate the apparent diffusion coefficient (ADC) in 44 patients with TBI (Glasgow Coma Scale Score < 8) and in eight healthy v

Регулирование Kynurenin Pathway в Relapping Rising Multial Sclerosis и его корреляции с прогрессивным нейродегенерацией.

Несмотря на отсутствие острых повреждений при многократном склерозе (MS), хроническое нейродегенерация продолжает развиваться, и потенциальным основополагающим механизмом может быть кинурайнский путь (КП). Как известно, продолжительная активация КП от хронического воспаления усугубляет прогресс нервно-дегенеративных заболеваний за счет производства нейротоксичных метаболитов. В числе 8 КП метаболиты, six из них, а именно: кинурень (КИН), 3- Гидроксилкилинин (3ГК), антраиличная кислота (АА), кинуриновая кислота (КИНА) и квинолинская кислота (QUIN) были связаны с нейродегенерацией.Чтобы получить

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… High Performance Liquid Chromatography To quantify the plasma levels of TRP, KYN, 3HK, 3HAA, and anthranilic acid (AA), we used the Agilent 1,290 Infinity ultra-high performance liquid chromatography (HPLC) (Agilent, CA) equipped with both a diode array (G4212A; Agilent) and a fluorescence (G1321B; xenon … For the measurement of KYNA levels in plasma, we used the Agilent 1,260 Infinity HPLC (Agilent, CA) with the fluorescence detector (G1321B xenon flash lamp, Agilent, CA).This analysis, also performed according to previously described methods26, involved injecting a 10 μL sample into a ZORBAX Rapid Resolution …

Effects of a Cognitive Behavioral Digital Therapeutic on Anxiety and Depression Symptoms in Patients With Cancer: A Randomized Controlled Trial.

PURPOSE: Patients with cancer often experience elevated levels of distress. This double-blind, randomized controlled trial compared the impact of an app-based version of cognitive behavioral stress management (CBSM) versus a health education sham app on anxiety and depression symptoms. METHODS: Patients with nonmetastatic (stage I-III) cancer who were receiving or recently completed (≤6 months) systemic treatment were recruited nationwide. The primary outcome of change in anxiety symptoms (PROMIS-Anxiety) over 12 weeks and the top secondary outcome of change in depression symptoms (PROMIS-Dep

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… Ganz Leadership: Intrinsic LifeSciences (I) Stock and Other Ownership Interests: Xenon Pharma (I), Intrinsic LifeSciences (I), Silarus Therapeutics (I), Teva, Novartis, Merck, Johnson & Johnson, Pfizer, GlaxoSmithKline, Abbott Laboratories, Disc Medicine (I) Consulting or Advisory Role: InformedDNA … Ganz Leadership: Intrinsic LifeSciences (I) Stock and Other Ownership Interests: Xenon Pharma (I), Intrinsic LifeSciences (I), Silarus Therapeutics (I), Teva, Novartis, Merck, Johnson & Johnson, Pfizer, GlaxoSmithKline, Abbott Laboratories, Disc Medicine (I) Consulting or Advisory Role: InformedDNA …

Clinical impact of airflow obstruction after allogeneic hematopoietic stem cell transplantation.

Criteria for airflow obstruction (AFO) at one year after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in pulmonary function tests (PFTs) are more stringent than the bronchiolitis obliterans syndrome (BOS) criteria of the National Institutes of Health. This single-center, retrospective cohort study evaluated the clinical impact of the AFO criteria at any time after transplantation. In 132 patients who underwent allo-HSCT from 2006 to 2016, the 2-year cumulative incidence of AFO was 35.0%, and the median time to diagnosis of AFO was 101 days after transplantation (range 35-716

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… Walkup LL Myers K El-Bietar J Nelson A Willmering MM Grimley M Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry Eur Respir J 2019 53 5 1801779 10.1183/13993003.01779-2018 30846475 PMC6945824 Walkup LL, Myers K, El-Bietar J, Nelson A, … Xenon-129 MRI detects ventilation deficits in paediatric stem cell transplant patients unable to perform spirometry. Eur Respir J. 2019;53(5):1801779. 10.1183/13993003.01779-2018. 30846475 10.1183/13993003.01779-2018 PMC6945824 17. …

Different lasers and techniques for proliferative diabetic retinopathy.

BACKGROUND: Diabetic retinopathy (DR) is a chronic progressive disease of the retinal microvasculature associated with prolonged hyperglycae … ith any other laser modality. We excluded studies of lasers that are not in common use, such as the xenon arc, ruby or Krypton laser. DATA COLLECTION AND ANALYSIS: We followed Cochrane guidelines and graded the certainty of evidence using the GRADE approach. MAIN RESULTS: We identified 11 studies from Europe (6), the USA (2), the Middle East (1) and A …

Chemotherapy-Induced Neuropathy and Drug Discovery Platform Using Human Sensory Neurons Converted Directly from Adult Peripheral Blood.

Chemotherapy-induced peripheral neuropathy (PN) is a disorder damaging the peripheral nervous system (PNS) and represents one of the most common side effects of chemotherapy, negatively impacting the quality of life of patients to the extent of withdrawing life-saving chemotherapy dose or duration. Unfortunately, the pathophysiological effects of PN are poorly understood, in part due to the lack of availability of large numbers of human sensory neurons (SNs) for study. Previous reports have demonstrated that human SNs can be directly converted from primitive CD34+ hematopoietic cells, but was

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… Calcium flux was monitored using an Olympus IX81 inverted epi‐fluorescence microscope (Olympus, Markham, ON, Canada) coupled to a xenon arc lamp (EXFO, Quebec, QC, Canada). …

Targeted synthesis of a trimethoxyphenyltetrahydropyrimidine analogue designed as a DNA intercalator: in silico, multi-spectroscopic, thermodynamic, and in vitro approaches.

Based on the rational design of DNA intercalators and Topo-II inhibitors and taking into consideration the main pharmacophoric features of doxorubicin (Dox) as a reference standard, we theoretically designed novel substituted tetrahydropyrimidine analogues (T1-35). The designed analogues (T1-35) were investigated for their inhibitory potential towards the hybrid DNA and Topo-II target receptor using molecular docking. Interestingly, the theoretically designed analogue T30 with a 3,4,5-trimethoxy phenyl side chain was found to be the superior candidate, achieving a binding score of -7.06 kcal m

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… The spectra of various mixture solutions containing ctDNA (97.0 μM) and fluorescent probes, specifically RB (1.27 μM) and EB (7.0 μM), acting as groove and intercalation binding probes respectively, were obtained using an Agilent Technologies Cary Eclipse Fluorescence Spectrometer equipped with a Xenon …

Theranostic Potentials of Gold Nanomaterials in Hematological Malignancies.

Hematological malignancies (HMs) are a heterogeneous group of blood neoplasia generally characterized by abnormal blood-cell production. Detection of HMs-specific molecular biomarkers (e.g., surface antigens, nucleic acid, and proteomic biomarkers) is crucial in determining clinical states and monitoring disease progression. Early diagnosis of HMs, followed by an effective treatment, can remarkably extend overall survival of patients. However, traditional and advanced HMs' diagnostic strategies still lack selectivity and sensitivity. More importantly, commercially available chemotherapeutic dr

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… The viability of K562 cells decreased significantly compared to ALA alone in all three light sources: a 502 nm light-emitting diodes (LEDs), xenon lamp, and 635 nm continuous-wavelength semiconductor laser. … Among these three light sources, 5-ALA-AuNPs were highly effective at LEDs in reduction (nearly 70%) in K562 cell viability compared to xenon lamp (~50%) and a 635 nm laser (~56%). …

Vision of Life's Code: Molecular Probe Nanoarchitectonics for Deep RNA/DNA Illumination.

Visualization of RNA and DNA provides a window of opportunity for the early detection of multiple diseases and approaches to manipulate them before any pathological processes occur. However, current imaging systems often fail to meet these demands due to the need for multiple RNA and DNA chemical probes, which increases experimental complexity, reduces awareness of false positives, and limits imaging accuracy in complex biosystems. In this work, we identify the key challenges associated with using multiple probes for RNA and DNA imaging and analyze the mechanisms and performance of existing im

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… Due to their high molar absorption coefficients, they are compatible with a wide range of fluorescence-based instruments that use either laser excitation or traditional broadband light sources such as mercury- or xenon-arc lamps. …

Структурный анализ процесса сбора света с помощью антенн, содержащих родопсины в морской архееи Асгарда.

Акватические бактериальные редопсиновые протонные насосы собирают световую энергию для фотогетертрофного роста и, как известно, содержат гидроксилированные каротеи, расширяющие волны используемого света, но они не характеризуются морской археей. Здесь, комбинируя морскую хромофорную экстракт с очищенными архейскими родопсинами, выявленными в морских метагеномах, мы показываем передачу легкой энергии из различных гидроксилоидных каротеоидных в геймдаллархаэ (HeimdallRs) из некультурных морских планктонных членов «Candidatus Cariarachaeceae» (Candidatus Asgardarchaeota). Эти светообрабатывающие

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… Samples were kept in the dark until the pH stabilized, and illuminated using a Max-303 compact xenon lamp (Asahi Spectra). …

RNA метилтрансферазы METTL8 устанавливает m3C32 в митохондриальном tRNASThr/Ser (UCN) для оптимизации структуры trNA и митохондриального перевода.

Модифицированные нуклеотиды в tRNA являются важными определяющими факторами сворачивания, структуры и функции. Здесь мы идентифицируем METTL8 как митохондриальный белок и активный РНК метилтрансферазы, ответственный за установку m3C32 в митохондриале человека (mt-)tRNAThr и mt-tRNAser (UCN). METTL8 имеет перекрестные связи с антикодоновой стволовой петлей (ASL) многих мт-тРНК в клетках, в связи с чем возникает вопрос о том, каким образом достигается целевая специфичность метилирования. Расчленение элементов распознавания mt-tRNA выявило наличие U34G35 и t6A37/(ms2)i6A37, которые одновременно п

37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3) : Brussels, Belgium. 21-24 March 2017

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