Результаты поиска

The field-testing of a novel integrated mapping protocol for neglected tropical diseases.

BACKGROUND: Vertical control and elimination programs focused on specific neglected tropical diseases (NTDs) can achieve notable success by … g it to current WHO mapping methodologies for each of the targeted diseases in one district each in Mali and Senegal. Results were compared in terms of public health intervention, and feasibility, including cost. In this study, the ITM methodology reached the same conclusions as the WHO methodologies regarding the initiation of public health interventi …

Intrafamilial transmission of extended-spectrum-beta-lactamase-producing Escherichia coli and Salmonella enterica Babelsberg among the families of internationally adopted children.

OBJECTIVES: International adoption from developing countries has become an increasing phenomenon in recent years. Given the high prevalence … doption practice and subsequently every month, from the adopted children of an orphanage of Bamako (Mali) and from all the members of their adoptive families were screened for MDR bacteria and bacterial pathogens. Bacteria were characterized by standard biochemical methods, disc diffusion antibiograms, PFGE and plasmid analysis. beta-Lactamase genes we …

Preterm Birth and Malaria Susceptibility in Offspring of Uninfected Multigravid Women.

IMPORTANCE: Pregnancy malaria (PM) is associated with adverse pregnancy outcomes such as stillbirth, early neonatal death, preterm delivery … r 9, 2014, into an observational longitudinal cohort study of mother-child pairs in Ouélessébougou, Mali, an area of high seasonal malaria transmission. Follow-up was completed through pregnancy. Children were enrolled at birth and followed up from January 21, 2011, to July 31, 2016, for as long as 5 years with monthly clinical visits during the malari …

Extremity soft tissue coverage in the combat zone: use of pedicled flap transfers by the deployed orthopedic surgeon.

BACKGROUND: In theaters of operation, military orthopedic surgeons have to deal with complex open extremity injuries and perform soft-tissue reconstruction on local patients who cannot be evacuated. Our objective was to evaluate the outcomes and discuss practical issues regarding the use of pedicled flap transfers performed in the combat zone on local national patients. METHODS: A retrospective study was conducted on data from patients treated by a single orthopedic surgeon during four tours in Chad, Afghanistan and Mali between 2010 and 2017. All pedicled flap transfers performed on extremit…

[Epidemiological study on the visual ability of official public transport drivers in Bamako].

The aim of this work was to evaluate the public transport drivers' visual driving ability in Bamako. We carried out a descriptive cross-sect … transport drivers must be subject to periodic eye examinations. In the absence of such measures in Malian legislation, 42.5% of drivers over 50 years old are unfit to drive. The improvement of road safety requires the renewal and application of the texts for the delivery and renewal of the driver's license of public transport drivers.

Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity.

BACKGROUND: Quantifying gametocyte densities in natural malaria infections is important to estimate malaria transmission potential. Two mole … tes (NF54, NF135, NF166). Pfs25 mRNA levels were also determined in samples from clinical trials in Mali and Burkina Faso using both methods. Agreement between the two methods and association with mosquito infection rates in membrane feeding assays were assessed. RESULTS: Intra- and inter-assay variability was larger in QT-NASBA compared to qRT-PCR, p …

Human Schistosoma haematobium antifecundity immunity is dependent on transmission intensity and associated with immunoglobulin G1 to worm-derived antigens.

BACKGROUND: Immunity that reduces worm fecundity and, in turn, reduces morbidity is proposed for Schistosoma haematobium, a parasite of major public health importance. Mathematical models of epidemiological trends suggest that antifecundity immunity is dependent on antibody responses to adult-worm-derived antigen. METHODS: For a Malian cohort (age, 5-29 years) residing in high-transmission fishing villages or a moderate-transmission village, worm fecundity was assessed using the ratio of urinary egg excretion to levels of circulating anodic antigen, a Schistosoma-specific antigen that is stea…

Changes in the gut microbiome during fasting-induced molting and its effects on gut-liver function.

Fasting-induced molting (FIM) rejuvenates the laying cycle in hens; however, the fasting process may result in intestinal dysbiosis, which c … ntestinal microbiota and gut-liver function. We identified key microorganisms (Liquorilactobacillus mali and Tissierellia bacterium KA00581) and functional metabolites (d-Panthenol and 3-hydroxyanthranilic acid (3-HAA)) involved in intestinal-liver function during FIM. Notably, d-Panthenol promotes chicken small intestinal organoid branching and growth …

A single dose of azithromycin versus placebo for malaria in infants: A cluster-randomized trial.

Azithromycin mass drug administration (MDA) has been shown to promote child survival in high mortality settings. Azithromycin has antimalarial effects, and one possible mechanism behind mortality reduction with azithromycin may be reduction in malaria. We aimed to test the effect of a single dose of azithromycin on malaria prevalence and parasite load in infants. This malaria substudy was part of a large double-blinded cluster-randomized clinical trial in Mali studying the effect of azithromycin MDA on infant mortality (ClinicalTrials.gov NCT04424511). Villages were randomized into either plac…

Clinical evaluation of commercial SARS-CoV-2 serological assays in a malaria endemic setting.

The levels of immune response to SARS-CoV-2 infection or vaccination are poorly understood in African populations and is complicated by cros … enScript cPass™ SARS-CoV-2 Neutralization Antibody Detection Kit (cPass) using samples collected in Mali in West Africa prior to the emergence of SARS-CoV-2. A total of one hundred samples were assayed. The samples were categorized in two groups based on the presence or absence of clinical malaria. Overall, thirteen out of one hundred (13/100) samples …

A review of indigenous knowledge and ethnopharmacological significance of African Copaiba Balsam Tree, Daniellia oliveri (Fabaceae).

Daniellia oliveri has found its indigenous relevance in the management of diseases including but not limited to diabetes mellitus, tuberculo … review is majorly limited to Africa particularly western countries (such as Nigeria, Burkina Faso, Mali, Ghana, Togo, and Benin) and the plant is found to be largely underutilized, it is evident that limited information exists on the in vivo pharmacological evaluation, bioactive compounds identification, and there is a lack of preclinical and clinical …

Isolation and genome sequencing of cytomegaloviruses from Natal multimammate mice (Mastomys natalensis).

Distinct cytomegaloviruses (CMVs) are widely distributed across their mammalian hosts in a highly host species-restricted pattern. To date, evidence demonstrating this has been limited largely to PCR-based approaches targeting small, conserved genomic regions, and only a few complete genomes of isolated viruses representing distinct CMV species have been sequenced. We have now combined direct isolation of infectious viruses from tissues with complete genome sequencing to provide a view of CMV diversity in a wild animal population. We targeted Natal multimammate mice (Mastomys natalensis), whic…

У мавританских животных и людей устойчиво распространяется вирусная зоонотическая болезнь лихорадки долины Рифт: обзор повествования.

Согласно сообщениям, в Мавритании в 1987, 2010, 2012, 2015 и 2020 годах постоянно распространяется вирус лихорадки Рифт долины (RVF). Мавритания, как представляется, отдается предпочтение вирусу RVF из-за его постоянной вспышки. В последнее время в девяти мавританских вилайях было подтверждено, что в период с 30 августа по 17 октября 2022 года было зарегистрировано 47 случаев гибели людей (23 человека с 49 процентами КФР). В большинстве случаев речь шла о скотоводах, занимающихся животноводством. Целью обзора было понимание происхождения, причин и мер по борьбе с этим вирусом.МЕТОДЫ: Были проа

Совпадение в аннотации оригинала
BACKGROUND AND AIM: Rift valley fever (RVF) virus (RVFV) is reportedly steadily circulating in Mauritania being repeated in 1987, 2010, 2012 … e infected animal. CONCLUSION: RVFV infection was predominant in the Mauritanian regions bordering Mali, Senegal, and Algeria. High human and domesticated animal density as also the existing zoonotic vectors further contributed to RVF virus circulation. Mauritanian RVF infection data confirmed that RVFV was zoonotic that included small ruminants, catt …

The prevalence of onchocerciasis in Africa and Yemen, 2000-2018: a geospatial analysis.

BACKGROUND: Onchocerciasis is a disease caused by infection with Onchocerca volvulus, which is transmitted to humans via the bite of several … ca. Focal areas of Angola, Cameroon, the Democratic Republic of the Congo, Ethiopia, Ghana, Guinea, Mali, Nigeria, South Sudan, and Uganda continue to have mean microfiladermia prevalence estimates exceeding 25%. At and above this level, the continuation or initiation of mass drug administration with ivermectin is supported. If national programs aim to …

Burden of anemia and its underlying causes in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019.

BACKGROUND: Anemia is a common disease which affects around 40% of children and 30% of reproductive age women and can have major health cons … st national point prevalences of anemia were found in Zambia [49327.1 (95% UI: 46,838.5-51,700.1)], Mali [46890.1 (95% UI: 44,301.1-49,389.8)], and Burkina Faso [46117.2 (95% UI: 43,640.7-48,319.2)]. In 2019, the global point prevalence of anemia was highest in the 15-19 and 95+ age groups in females and males, respectively. Also, the burden of anemia …

Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries.

INTRODUCTION: There are growing concerns about the emergence of resistance to artemisinin-based combination therapies (ACTs). Since the wide … from travellers with symptomatic Plasmodium falciparum malaria returning from Senegal (n = 1,993), Mali (n = 2,372), Cote d'Ivoire (n = 4,778) or Cameroon (n = 3,272) and recorded in the French Malaria Reference Centre during the period 1996-2011. Temporal trends of the proportion of parasite isolates that carried the mutant genotype, pfcrt 76T, a mar …

[Ileal typhoid perforations: clinical and therapeutic aspects in tropical area].

AIMS: The aim of this study was to describe the clinical and therapeutic aspects of peritonitis by typhoid ileal perforation in a tropical typhoid fever endemic area. PATIENTS AND METHODS: A descriptive retrospective study over an 8 year period (January 2000 to December 2007) was undertaken in a visceral service of the Point G teaching hospital in Bamako, Mali. Only patients diagnosed and operated for peritonitis presenting lesions or perforations of the final ileum were included in the study. RESULTS: The data from 120 patients meeting the inclusion criteria was collected. The average age w…

Molecular characterization of Fasciola gigantica from Mauritania based on mitochondrial and nuclear ribosomal DNA sequences.

Fasciolosis caused by Fasciola hepatica and Fasciola gigantica (Platyhelminthes: Trematoda: Digenea) is considered the most important helminth infection of ruminants in tropical countries, causing considerable socioeconomic problems. From Africa, F. gigantica has been previously characterized from Burkina Faso, Senegal, Kenya, Zambia and Mali, while F. hepatica has been reported from Morocco and Tunisia, and both species have been observed from Ethiopia and Egypt on the basis of morphometric differences, while the use of molecular markers is necessary to distinguish exactly between species. Sa…

Interventions to reduce postoperative mortality in low- and middle-income countries: systematic review.

BACKGROUND: Postoperative mortality is the third leading cause of death worldwide and disproportionately affects patients in low- and middle … aternal death reviews and implementation of best practice after caesarean deliveries in Senegal and Mali). Adherence to interventions was generally high and similar between simple and complex interventions (93.6% versus 96.8% respectively), although adherence varied substantially across trials. CONCLUSION: Few RCTs have targeted postoperative mortalit …