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Regulatory role of PI3K/Akt/WNK1 signal pathway in mouse model of bone cancer pain.

In the advanced stage of cancer, the pain caused by bone metastasis is unbearable, but the mechanism of bone cancer pain (BCP) is very complicated and remains unclear. In this study, we used 4T1 mouse breast cancer cells to establish a bone cancer pain model to study the mechanism of BCP. Then the paw withdrawal mechanical threshold (PWMT) and the hematoxylin-eosin staining were used to reflect the erosion of cancer cells on tibia tissue. We also determined the role of proinflammatory factors (TNF-α, IL-17, etc.) in BCP by the enzyme-linked immunosorbent assay in mouse serum. When GSK690693, a

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… Acknowledgements We thank the Inner Mongolia Autonomous region academic Scholarship, Inner Mongolia Medical University Renfu Scholarship and Peking University Cancer Hospital Inner Mongolia Hospital for scientific research support. …

[Establishment and validation of a risk prediction model for disseminated intravascular coagulation patients with electrical burns].

Objective: To establish and validate a risk prediction model of disseminated intravascular coagulation (DIC) by the screening independent risk factors for the occurrence of DIC in patients with electrical burns. Methods: The retrospective case series study was conducted. The clinical data of 218 electrical burn patients admitted to Baogang Hospital of Inner Mongolia from January 2015 to January 2023 who met the inclusion criteria were collected, including 198 males and 20 females, with the age of (38±14) years. The patients were divided into DIC group and non DIC group based on whether they we…

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

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… Incidence rates vary four‐fold to six‐fold across regions, with the highest rates in Eastern Asia—ranking highest in Mongolia for both sexes—followed by Eastern Europe and South America, and the lowest in Melanesia, Africa, and Northern America (Figure 12 ). … In Mongolia, HBV and HCV viruses, co‐infections of HBV carriers with HCV or hepatitis delta virus, and alcohol consumption collectively drive one of the world’s highest national rates in men and women. …

Measuring the global, regional, and national burden of multiple myeloma from 1990 to 2019.

BackgroundMultiple myeloma (MM) is a major health concern. Understanding the different burden and tendency of MM in different regions is crucial for formulating specific local strategies. Therefore, we evaluated the epidemiologic patterns and explored the risk factors for MM death.MethodsData on MM were collected from the 2019 Global Burden of Disease study. We used incidence, mortality, and disability adjusted life-years to estimate the global, regional, and national burden of MM.ResultsIn 2019, there were 155,688 (95% UI, 136,585 - 172,577) MM cases worldwide, of which 84,516 (54.3%, 70,924

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… ASDR: age standardized death rate Table 2 Three countries with the highest and lowest means of incidence, death, or DALYs Measure | Top three countries | Bottom three countries 2019ASR (per 100,000 people) ASIR | Monaco (14.95) | Barbados (8.57) | Dominica (7.25) | Kyrgyzstan (0.62) | Mali (0.66) | Mongolia … (0.67) ASDR | Monaco (9.81) | Barbados (6.17) | Dominica (5.89) | Kyrgyzstan (0.55) | Palau (0.59) | Mongolia (0.60) Age Standardized DALY Rate | Monaco (199.23) | Barbados (139.63) | Dominica (132.87) | Kyrgyzstan (13.33) | Thailand (14.67) | Palau (14.71) Percentage change in rates from 1990 to 2019 …

Global, regional, and national burden of 34 cancer groups across 204 countries and territories, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.

IntroductionDetailed, comprehensive, and timely reporting on cancer incidence, mortality, and associated burdens is essential for understanding the evolving trends of this complex disease. This study aims to evaluate the burdens of 34 types of cancer across 204 countries and territories from 1990 to 2021, incorporating the latest epidemiological data to provide a framework for policy discussions, resource allocation, and research prioritization.MethodsUsing data from the Global Burden of Disease (GBD) 2021 study, we analyzed 34 cancer types across 204 countries from 1990 to 2021, stratifying b

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… For instance, Mongolia had the highest ASMR at 214.7, while Oman reported the lowest at 44.1. The USA, Monaco, and New Zealand recorded the highest ASIR and ASPR values, with the USA leading in both categories. … ASDRs were most severe in Mongolia (5526.0) and Zimbabwe (5381.8), while the lowest were found in Oman (1095.5) and Maldives (1146.9). …

Global burden and regional inequalities of cancer in older adults from 1990 to 2021 and its projection until 2050.

BackgroundGlobal ageing will further exacerbate the cancer burden, and the intersection of cancer and ageing represents an emerging and significant global public health challenge.MethodsBased on the Global Burden of Disease 2021 (GBD 2021) data, we utilized the estimated annual percentage change and Joinpoint regression model to examine the temporal trends in the global cancer burden among elderly population from 1990 to 2021. Pearson's rank correlation analysis was conducted to assess the relationship between disease burden and the socio-demographic index (SDI). Furthermore, an autoregressive

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… As illustrated in Supplementary Fig. 1, in 2021, Greenland in North America, Mongolia in Asia, Bolivia in South America, Zimbabwe in Africa, and several European countries presented significantly elevated mortality rates. … Conversely, mortality rates have continued to rise in Zimbabwe, Mongolia, and several European nations. Furthermore, while cancer mortality among the elderly population in India remains relatively low, it has demonstrated a significant upward trend. …

Impact of the National Health Insurance Coverage Policy on the Utilisation and Accessibility of Innovative Anti-cancer Medicines in China: An Interrupted Time-Series Study.

Objective: The study aimed to evaluate the impact of the National Health Insurance Coverage (NHIC) policy on the utilisation and accessibility of innovative anti-cancer medicines in Nanjing, China. Methods: We used the adjusted World Health Organisation and Health Action International methodology to calculate the price and availability of 15 innovative anti-cancer medicines included in the National Health Insurance drug list in 20 tertiary hospitals and six secondary hospitals in Nanjing before and after NHIC policy implementation. Interrupted time-series regression was used to analyse the cha

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… Another study in inner Mongolia found that the annual direct medical cost for cancer reached CNY 86,100 after the basic medical insurance reimbursement, which exceeded the “catastrophic health expenditure” defined by the World Health Organisation (WHO) and imposed a heavy economic and mental burden on … The exploration of medical insurance in precise poverty alleviation in inner Mongolia Bringing tumor targeting drugs into the payment of m4edical insurance. Chinese Health Insurance. (2016) 48–50. 10.369/j.issn.1674-3830.2016.3.009 12. China Daily USA . China Society. …

Бремя множественной миеломы в азиатских странах 1990 в адрес 2021 и прогнозирование тенденций 2050:: анализ, основанный на Глобальном исследовании бремени болезней 2021.

Множественная миелома (ММ) создает растущую угрозу для здоровья населения во всем мире, причем региональные различия в бремени болезней становятся все более заметными. Являясь самым густонаселенным континентом, Азия переживает быстрые демографические и социально-экономические изменения и играет решающую роль в формировании эволюционной траектории глобального бремени ММ. Цель этого исследования заключается в оценке бремени болезней, связанных с множественной миеломой в азиатских странах. 1990 в адрес 2021Данные этого исследования были получены на основе исследования глобального бремени болезней

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… East Asia includes China, Japan, the Republic of Korea, the Democratic People’s Republic of Korea, and Mongolia. Southeast Asia comprises Indonesia, Thailand, the Philippines, Vietnam, Myanmar, Cambodia, the Lao People’s Democratic Republic, Malaysia, Singapore, Brunei Darussalam, and Timor-Leste. … 38.1] | 6.8 [5.63–8.07] | 19.4 [15.88–23.06] | –0.46 [–1.26 to 0.34] Singapore | 6.12 [5.68–6.56] | 27.07 [25.13–29] | 13.11 [11.84–14.44] | 15.13 [13.62–16.67] | –1.74 [–1.86 to –1.62] Kazakhstan | 18.07 [14.09–21.82] | 12.78 [10.01–15.38] | 35.05 [29.28–41.36] | 17.74 [14.84–20.9] | 1 [0.75 –1.26] Mongolia …

Arctiin Inhibits Inflammation, Fibrosis, and Tumor Cell Migration in Rats With Ehrlich Solid Carcinoma.

Background and objectivesESC or Ehrlich solid carcinoma is a type of tumor originating from a spontaneous mammary adenocarcinoma in mice. It is a highly aggressive and fast-growing carcinoma that can create a solid mass when inserted under the skin. Its solid, undifferentiated form makes it an ideal model for researching cancer biology, tumor immunology, and testing various anti-cancer treatments. Additionally, arctiin has multiple beneficial properties, such as anti-proliferative, anti-oxidative, anti-adipogenic, and anti-bacterial. This study aimed to explore the potential anti-cancer benefi

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… Meanwhile, Mongolia reported the highest cancer-related mortality rate, with 175.9 people per 100,000 [ 21 ]. Cancer treatment can cause severe physical and emotional symptoms, leading to a decrease in the quality of life and depression. …

Potential diagnostic value of circulating miRNA for multiple myeloma: A meta-analysis.

BackgroundMultiple myeloma (MM) is the second incurable hematological malignancy. In recent years, due to the rise of microRNA (miRNA), many scholars have participated in the study of its value in the diagnosis of MM, and have obtained good but inconsistent results. Therefore, in order to determine the role of miRNA in the early diagnosis of MM, we performed this meta-analysis.MethodsWe searched for related studies including PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and Wanfang Database as of July 20, 2020 to conduct this meta-analysis. To

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… [J] Inner Mongolia Med. 2019;51(8):903–906. doi: 10.16096/J.cnki.nmgyxzz.2019.51.08.003. 33. Jones C.I., Zabolotskaya M.V., King A.J., Stewart H.J., Horne G.A., Chevassut T.J., Newbury S.F. Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma. Br. J. …

The impact of government reimbursement negotiation on targeted anticancer medicines use and cost in China: A cohort study based on national health insurance data.

BackgroundHigh prices of targeted anticancer medicines (TAMs) result in financial toxicity for patients and the health insurance system. How national price negotiation and reimbursement policy affect the accessibility of TAMs for cancer patients remains unknown.MethodsIn this population-based cohort study, we used national health insurance claims data in 2017 and identified adult patients with cancer diagnoses for which price-negotiated TAMs were indicated. We estimated the half-month prevalence of price-negotiated TAMs use before and after the policy implementation in September 2017. We calcu

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… Eastern region: Beijing, Tianjin, Hebei, Liaoning, Shanghai, Jiangsu, Zhejiang, Fujian, Shandong, Guangdong, and Hainan; Central region: Shanxi, Jilin, Heilongjiang, Anhui, Jiangxi, Henan, Hubei, and Hunan; Western region: Inner Mongolia, Chongqing, Guangxi, Sichuan, Guizhou, Yunnan, Xizang, Shaanxi, …

Всеобъемлющая оценка взаимодействия капсикум генотипа-окружающей среды с использованием моделей Biplot AMMI и GПЭ в различных поэтапных средах трансплантации.

Генотип х взаимодействие с окружающей средой (ГЭИ) создает серьезную проблему для выявления стабильных, высокоурожайных капсикум генотипов при неоднородных агроклиматических условиях. В настоящем исследовании дается оценка 96 Генотипы различных капсикум (Capsicum annuum L.) four поэтапная трансплантация среды в течение 2022 и 2023 в северо-западных Гималаях для разборки ГЭИ в целях получения фруктовой урожайности и ее составных характеристик. Совокупный анализ разницы показал, что она весьма значительна (p) ≤ 0.01) воздействие генотипа, окружающей среды и ГЭИ на все признаки, что свидетельству

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… Liu WC Stability and high-yield analysis of buckwheat varieties in Inner Mongolia based on the AMMI model J. North. Agric. 2021 49 18 24 10.12190/j.issn.2096-1197.2021.05.03 Liu, W. C. et al. Stability and high-yield analysis of buckwheat varieties in Inner Mongolia based on the AMMI model. J. …

Global variations in elderly cancer mortality pattern in 2020 & prediction to 2040: A population-based study.

Background & objectives Cancer contributes to decreasing life expectancy, especially in low- and middle- income countries (LMIC) and countries in transition where resources for diagnosis and care are limited. As the world population is ageing, and by 2050, two-thirds of the population in LMIC will be elderly, the greater impact of cancer on the expectation of life in years at a given age of an adult will be seen in these countries. Methods Estimated cancer mortality for older adults (60 yr or above) was estimated using statistics available on Globocan 2020 platform (gco.iarc.fr). This platform

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… Supplementary Figure 3 The highest mortality rate of stomach cancer is seen in Eastern Asia (Mongolia has the highest incidence and mortality rate in both males and females). In contrast, lower rates are seen in Northern America and Australia and New Zealand ( Supplementary Fig. 4 ). …

Construction and validation of nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma.

ObjectiveTo construct and validate a nomogram prediction model for anxiety and depression in chemotherapy patients with multiple myeloma (MM).MethodsFrom May 2021 to May 2023, 333 MM chemotherapy patients treated at our hospital were selected. The patients were randomly divided into a modeling group and a validation group in a 7:3 ratio (using a random number table method). According to whether the modeling group patients had anxiety and depression, they were grouped into a non-anxiety and depression group and an anxiety and depression group; a nomogram model constructed using R software was b

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… Edited by: Lamyae Benzakour , University of Geneva, Switzerland Reviewed by: Kuanjun He , Inner Mongolia University for Nationalities, China Fillipe Pereira , Federal University of São Carlos, Brazil Data availability statement The raw data supporting the conclusions of this article will be made …

CRISPR application in hematological disorders: from bench to bedside.

AbstractClustered regularly interspaced short palindromic repeats (CRISPR)-associated protein genome editing has advanced from an experimental tool to a clinically validated therapeutic platform in hematology. Landmark successes in inherited blood diseases, including sickle cell disease, β-thalassemia, and severe combined immunodeficiency, have demonstrated that precise and durable genetic modifications can be safely and effectively implemented in human hematopoietic cells, positioning hematology at the forefront of translational genome editing. Beyond monogenic disease, CRISPR-based approache

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… Funding Statement Supported by Capital’s Funds for Health Improvement and Research (Grant No. 2022-1-5082), Grants from the National Natural Science Foundation of China (Grant No. 82273245), Inner Mongolia Autonomous Region Science and Technology Program (Grant No. 2022YFSH0041). …

The MODIFY Study Protocol: An Open-Label, Single-Arm, Multicenter, Prospective Pragmatic Study of Ixazomib-Based Triple-Drug Therapy in Chinese Patients with Multiple Myeloma.

BACKGROUND: Although the bortezomib-based triple-drug therapy is considered as a front-line therapy for multiple myeloma (MM) in Chinese patients, increased level of toxicity leads to treatment dissatisfaction. Treatment with ixazomib, an oral proteasome inhibitor, has demonstrated better efficacy and safety profile without increasing the toxicity. In this study, we investigate the safety and clinical outcomes of Chinese patients with newly diagnosed MM (NDMM) who transitioned from a bortezomib-based triple-drug therapy to an ixazomib-based triple-drug therapy in a real-world clinical setting.

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… oncology hospital, Beijing Jishuitan Hospital, the West China Hospital of Sichuan University, the Shengjing Hospital of China Medical University, Qingdao Municipal Hospital, Henan Provincial People’s Hospital, the First Affiliated Hospital of Nanchang University, and the Affiliated Hospital of Inner Mongolia …

Global epidemiological trend of cancer incidence and death in adults aged 60 years and older: a systematic analysis of data from GLOBOCAN 2022 and GBD2021.

BACKGROUND: Updated and comprehensive global assessments of cancer statistics specifically targeting adults aged ≥ 60 years have remained limited. To address this gap, we conducted a systematic epidemiological analysis of cancer burden in this rapidly growing demographic worldwide. METHODS: Population-based data from the Global Cancer Observatory (GLOBOCAN) 2022 and the Global Burden of Diseases (GBD) 2021 were used and analyzed in this study. The main outcomes of this study were age-standardised incidence (ASIR) or mortality rate (ASMR), and average annual percent change (AAPC). A Bayesian ag

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… Monaco, Bermuda, and the United States of America had the highest ASIR (Table S3), and the highest ASMR was observed in Monaco, Mongolia, Greenland, Zimbabwe, and Uruguay (Table S3). …

Бремя хронической почечной болезни по категориям KDIGO Glomerular Filtration Standard and Albuminuria: системный обзор.

ВВЕДЕНИЕ: Заболевание почек: улучшение глобальных результатов (KDIGO) 2012 Руководящие принципы рекомендуют категоризировать пациентов по гломерулярной скорости фильтрации (GFR) и альбуминурии для прогнозирования хронического заболевания почек (CKD). Цель этого систематического обзора заключалась в изучении эпидемиологического бремени ОВД, стратифицированного КДИГО 2012 категории. МЕТОДЫ: МЕДЛИНЕ и Эмбасе были найдены для наблюдения за пациентами с ККД, результаты которых были стратифицированы в соответствии с KDIGO 2012 классификация. В числе исследованных результатов можно назвать распростра

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… These numbers are broadly consistent with those of a recent cross-sectional study that evaluated the global prevalence of CKD stratified by the KDIGO 2012 categories based on the results of general population CKD screening programmes performed in China, Mongolia, India, Nepal, Iran, Nigeria, Moldova …

Watchful waiting in children with unifocal osseous Langerhans cell histiocytosis.

BackgroundLangerhans cell histiocytosis (LCH) is a rare inflammatory neoplasm most commonly involving bone. However, data on single-system, single-site LCH (SS-s-LCH), particularly with unifocal bone disease, remain limited. Management strategies for unifocal osseous LCH vary globally, and the safety of a watchful-waiting approach is not well-defined. This study aimed to evaluate whether patients with osseous SS-s-LCH can be managed with observation alone without compromising long-term outcomes.MethodsIn this retrospective, multicenter study, we enrolled children with biopsy-proven osseous SS-

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… listed in alphabetical order) Children’s Hospital of Chongqing Medical University; Children’s Hospital of Hebei Province; Henan Children’s Hospital (Zhengzhou Children’s Hospital); Hunan Children’s Hospital, Children’s Hospital Affiliated to Xiangya Medical College, Central South University; Inner Mongolia …

Advances in the Study of Denosumab Treatment for Osteoporosis and Sarcopenia in the Chinese Middle-Aged and Elderly Population.

Osteosarcopenia (OS) is a geriatric syndrome characterized by the concurrent presence of osteoporosis and sarcopenia, predominantly affecting the elderly population. Osteoporosis (OP) is a systemic skeletal disorder characterized by decreased bone mass, compromised bone microarchitecture, and heightened bone fragility, substantially elevating fracture risk. Sarcopenia (SP) is defined by decreased muscle mass, strength, and/or functional capacity. Both conditions are age-related degenerative diseases with overlapping pathophysiological mechanisms, commonly co-occurring in elderly individuals an

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… Inner Mongolia Med J . 2022 ; 54 ( 10 ): 1252 – 1253,1256 . doi: 10.16096/J.cnki.nmgyxzz.2022.54.10.030 48. Miedany YE , Gaafary ME , Toth M , et al. Is there a potential dual effect of denosumab for treatment of osteoporosis and sarcopenia? …