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Quality of life of patients with chronic lymphocytic leukaemia in the Netherlands: results of a longitudinal multicentre study.

PURPOSE: To describe the health-related quality of life (HRQoL) of an unselected population of patients with chronic lymphocytic leukaemia (CLL) including untreated patients. METHODS: HRQoL was measured by the EORTC QLQ-C30 including the CLL16 module, EQ-5D, and VAS in an observational study over multiple years. All HRQoL measurements per patient were connected and analysed using area under the curve analysis over the entire study duration. The total patient group was compared with the general population, and three groups of CLL patients were described separately, i.e. patients without any ac

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… Data table: Incidence cases and rates for males, females and persons in the UK, England, Wales, Scotland and Northern Ireland. http://publications.cancerresearchuk.org/cancerstats/statsincidence/dtinccountries.html 2011: 2. …

49th ESCP virtual symposium on clinical pharmacy 19.10.2021-21.10.2021 Clinical pharmacy, working collaboratively in mental health care.

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Challenges of airway management in a patient with temporomandibular joint ankylosis complicating forceps delivery--a case report.

INTRODUCTION: These guidelines provide a comprehensive and practical framework for preventing osteoporosis. They are designed for use by healthcare professionals, including orthopaedic surgeons, primary care physicians, specialists, nurses, and allied health providers, as they work with patients at risk of or already diagnosed with osteoporosis. METHODOLOGY: This iterative process involved multiple questionnaires sent to a panel of 62 osteoporosis and bone health experts. Experts, including clinicians, researchers, and academicians, were selected based on their recognised expertise and contri

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… Offline crime bounces back to pre-COVID levels, cyber stays high: interrupted time-series analysis in Northern Ireland. Crime Sci. 2021;10:26. doi: 10.1186/s40163-021-00162-9. …

Abstract

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Abstracts 12th PCNE working conference 'Partnering for better patient outcomes: challenges and opportunities 3-6 February 2021, University of Basel, Switzerland (was held online).

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… Ireland. … Community pharmacists were purposefully sampled in Belfast, Northern Ireland, followed by snowball sampling. Written informed consent was obtained prior to commencing data collection. …

Ремдезивирско-ассоциированные результаты выживания среди иммунокомпромиссных пациентов, госпитализированных COVID-19: Реальные улики о микродоминантной эпохе.

Пациенты с иммунокомпромиссными заболеваниями подвергаются повышенному риску заболевания коронавирусом 2019 (В тыс.COVID-19) связанная с этим госпитализация и смерть. Случайные клинические испытания обеспечивают ограниченное число пациентов, если таковые имеются, для получения информации о результатах лечения таких пациентов ремдезивиром. COVID-19 в период с декабря 2021 и февраль 2024. Главным результатом этого стало то, что стационарная смертность была проверена у пациентов, у которых характерные показатели сравниваются с оценками, в группах ремдесивир против нередесивирных групп. Были прове

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… Severe COVID-19 outcomes after full vaccination of primary schedule and initial boosters: pooled analysis of national prospective cohort studies of 30 million individuals in England, Northern Ireland, Scotland, and Wales. Lancet 2022; 400:1305–20. 14. Kang SW, Kim JW, Kim JY, et al. …

Experience of life quality from patients with aplastic anemia: a descriptive qualitative study.

BackgroundDespite the increasing incidence of aplastic anemia in China, few studies have explored its effect on the patients' quality of life from the perspective of these patients. In fact, patients with aplastic disorder live with the disease for a long time, and need to face a variety of difficult realities, including multiple disease symptoms and drug side effects, heavy burden of medical costs, difficulties in social reintegration, and negative emotional distress. Therefore, this study used descriptive qualitative research to explore the direct and rich quality-of-life experiences of pati

Idiotypic DNA vaccination for the treatment of multiple myeloma: safety and immunogenicity in a phase I clinical study.

We report on the safety and immunogenicity of idiotypic DNA vaccination in a phase I, non-randomised, open-label study in patients with multiple myeloma. The study used DNA fusion gene vaccines encoding patient-specific single chain variable fragment, or idiotype (Id), linked to fragment C (FrC) of tetanus toxin. Patients in complete or partial response following high-dose chemotherapy and autologous stem cell transplant were vaccinated intramuscularly with 1 mg DNA on six occasions, beginning at least 6 months post-transplant; follow-up was to week 52. Fourteen patients were enrolled on study

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… Supplementary material 1 (PDF 691 kb) Acknowledgments This study was supported by grants from the Department of Health for England, Scotland, Northern Ireland and Wales and Cancer Research UK. Lindsey Chudley is supported by the NIHR CRUK Southampton Experimental Cancer Medicine Centre (ECMC). …

Population pharmacokinetics of atacicept in systemic lupus erythematosus: An analysis of three clinical trials.

B cell stimulating factor (BLyS) and a proliferation-inducing ligand (APRIL) are targets for novel treatments in patients with systemic lupus erythematosus (SLE). Atacicept is a recombinant, soluble fusion protein that blocks BLyS and APRIL activity. This study characterized the pharmacokinetic (PK) profile of atacicept using a population PK model and identified covariates explaining the PK variability. Total atacicept concentrations from a phase I study in healthy volunteers and two phase II studies in patients with SLE, using subcutaneous administration, were modeled using a quasi-steady-sta

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… Serum atacicept levels were assessed at 0, 1, 4, 8, 16, 24, 48, 72, 96, 144, 216, 312, 480, 648, 816, and 984 h postdose. 14 The protocol for the phase I study was approved by the Office for Research Ethics Committees Northern Ireland, and the study was conducted in accordance with the International …

Case report and review: Angiosarcoma with thrombocytopenia after total hip arthroplasty.

Total hip arthroplasty (THA) is a common treatment for osteoarthritis and is also performed for other conditions, such as secondary arthritis due to developmental dysplasia of the hip. Various THA types may be complicated by osteolysis and an inflammatory pseudotumor due to an adverse reaction to metal debris. Rarely, THA has been associated with malignant tumors, but their causality remains unclear. In this case report, we describe a female patient with developmental dysplasia of the hip. She had undergone left metal-on-polyethylene THA, acetabular revision of the THA, and left total knee art

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… Adverse reactions to metal debris occur with all types of hip replacement not just metal-on-metal hips: a retrospective observational study of 3340 revisions for adverse reactions to metal debris from the national joint registry for England, Wales, Northern Ireland and the Isle of Man . …

Burden of cancers attributable to modifiable risk factors in Malaysia.

BackgroundThis is a systematic assessment of the burden of cancers in Malaysia in 2018 using epidemiologic approach. The purpose of this study was to identify the proportion of cancers in Malaysia that were attributable to the modifiable risk factors of excess weight, alcohol intake, physical inactivity, tobacco smoking and to estimate the number of cancer cases that could be prevented if the exposure to the modifiable risk factor was reduced.MethodsWe estimated the Population Attributable Fraction (PAF) of the modifiable risk factors to cancers incidences in Malaysia. The two parameters used

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… The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015. Br J Cancer. 2018;118(8):1130-41. 10.1038/s41416-018-0029-6 PMC5931106 29567982 14. …

An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain.

Pain is a major symptom of bone metastases from advanced cancer and represents a clinical challenge to treat effectively. Basic neurobiology in preclinical animal models implicates enhanced sensory processing in the central nervous system, acting through N-methyl-D-aspartate (NMDA) glutamate receptors, as an important mechanism underpinning persistent pain. The non-receptor tyrosine kinase Src is thought to act as a hub for regulating NMDA receptor activity and the orally available Src inhibitor saracatinib has shown promise as a potential analgesic in recent animal studies. Here we tested the

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… Patients were randomized on a 1:1 basis using block randomization with a block size of 4; the randomization schedule was created by the company that prepared the treatment kits (Almac, Craigavon, Northern Ireland, UK). …

Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator.

ObjectiveTo generate evidence on the longer term cost effectiveness of disease modifying treatments in patients with relapsing-remitting multiple sclerosis.DesignProspective cohort study with historical comparator.SettingSpecialist multiple sclerosis clinics in 70 centres in the United Kingdom.ParticipantsPatients with relapsing-remitting multiple sclerosis who started treatment from May 2002 to April 2005 under the UK risk sharing scheme.InterventionsTreatment with interferon beta or glatiramer acetate in accordance with guidelines of the UK Association of British Neurologists.Main outcome me

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… A steering committee was set up with representation from the parties to the scheme—that is, the health departments in England, Wales, Scotland, and Northern Ireland, each manufacturer, the MS Trust, the MS Society, the Association of British Neurologists, the Royal College of Nursing, and the UK MS Nurse …

UK clinical guideline for the prevention and treatment of osteoporosis.

UNLABELLED: The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. Accredited by NICE, this guideline is relevant for all healthcare professionals involved in osteoporosis management. INTRODUCTION: The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013 and 2017. This paper presents a major update of the guideline, the scope

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… After hip fracture the mean hospital length of stay is 20 days, accounting for half a million hospital bed days used each year, with 3,600 hospital beds (3,159 in England, 325 in Wales, and 133 in Northern Ireland) occupied at any one time by patients recovering from hip fracture [ 19 , 20 ]. … Ireland; the initial decision from NICE is negative, but this is currently under consultation. …

Program-Abstracts

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Mortality-Related Risk Factors in Patients with Hematologic Neoplasm Admitted to the Intensive Care Unit: A Systematic Review.

BackgroundHematooncology patients admitted to intensive care units (ICUs) are at high risk for mortality due to the severity of their critical illness. Such complications can develop into complex clinical management, thus signaling an urgent need to identify mortality-related factors to improve interventions and outcomes for these patients.MethodsA systematic review of studies published between 2012 and 2023 in databases such as PubMed, Scopus, and Web of Science was conducted, following the PRISMA guidelines. A meta-analysis was carried out to determine the significance of mortality-related f

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… Characteristics and outcome of cancer patients admitted to the ICU in England, Wales, and Northern Ireland and national trends between 1997 and 2013*. Crit. Care Med. 2017;45:1668–1676. doi: 10.1097/CCM.0000000000002589. 40. Hampshire P.A., Welch C.A., McCrossan L.A., Francis K., Harrison D.A. …

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs).

Antibody-drug conjugates (ADCs) are emerging as effective tools in cancer therapy, combining the antibody's exquisite specificity for the target antigen-expressing cancer cell together with the cytotoxic potency of the payload. Much success stems from the rational design of "toxic warheads", chemically linked to antibodies, and from fine-tuning the intricate properties of chemical linkers. Here, we focus on the antibody moiety of ADCs, dissecting the impact of Fab, linkers, isotype and Fc structure on the anti-tumoral and immune-activating functions of ADCs. Novel design approaches informed by

Is COVID-19 Still a Threat? An Expert Opinion Review on the Continued Healthcare Burden in Immunocompromised Individuals.

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a profound global impact. The emergence of several variants during the pandemic has presented numerous challenges in preventing and managing this disease. The development of vaccines has played a pivotal role in controlling the pandemic, with a significant portion of the global population being vaccinated. This, along with the emergence of less virulent SARS-CoV-2 variants, has led to a reduction in the severity of COVID-19 outcomes for the overall population. Nevertheless, i

Травматический стресс затронул людей с множественным склерозом во время пандемии SARS-COV-2.

Фон/цели: Травма представляет собой психологическое повреждение в результате тревожного или подавляющего события. Пандемия SARS-COV-2 была разрушительной и травмирующей для многих людей с множественным склерозом (pwMS). Взаимосвязь между характеристиками пациентов и травмами, полученными в ходе пандемии, еще не была тщательно изучена. Цель этого бицентрического перспективного когортного исследования состояла в том, чтобы проанализировать распространенность и развитие вероятного посттравматического стрессового расстройства (ПТСР) среди ПТСР во время пандемии SARS-COV-2 и определить параметры па

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… The lifetime prevalence of PTSD in high-income countries ranges from 1.3% (Japan) to 8.8% (Northern Ireland) [ 5 ]. Improper handling of a traumatic event due to various risk factors can lead to the development of somatic and psychological symptoms, which may result in PTSD. …

THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY.

Obesity is recognized as a significant risk factor for various types of cancer. Although the incidence of some types of cancer across various primary sites is decreasing due to specific prevention measures (screening programs, smoking cessation), the incidence of neoplasms in the young population shows a significant increase associated with obesity. There is sufficient evidence to say that bariatric surgery has been shown to significantly lower the risk of developing obesity-associated cancers, which are linked to metabolic dysregulation, chronic low-grade systemic inflammation, and hormonal a

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… Brown KF Rumgay H Dunlop C Ryan M Quartly F Cox A The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015 Br J Cancer 2018 118 8 1130 41 10.1038/s41416-018-0029-6 29567982 PMC5931106 10. …