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Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance.

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in most cases, it can only prolong life expectancy and does not guarantee a complete cure. Furthermore, chemotherapy is associated with severe adverse effects, one of the major complications of effective cancer therapy. In addition, newly published research outputs show that cancer stem cells are involved in cancer disease progression, drug resistance, metastasis, and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments.

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… drugs displayed very limited toxicity with interesting preliminary activity in low-grade gliomas 2 | Combination of 3 repurposed drugs after chemotherapy failure in lung cancer | A prospective phase II, randomized multi-center trial of a bio-modulatory treatment with metronomic low-dose treosulfan, pioglitazone … , and clarithromycin versus nivolumab in patients with squamous cell lung cancer and non-squamous cell lung cancer, respectively, after platin failure (ModuLung). | Lung cancer: Clarithromycin - antibiotic, Pioglitazone - anti-diabetes, Treosulfan - a chemotherapeutic drug used at a metronomic dose. …

Clinical and Therapeutic Implications of Male Obesity.

The prevalence of obesity, a disorder linked to numerous comorbidities and metabolic complications, has recently increased dramatically worldwide and is highly prevalent in men, even at a young age. Compared to female patients, men with obesity more frequently have delayed diagnosis, higher severity of obesity, increased mortality rate, and only a minority of obese male patients are successfully treated, including with bariatric surgery. The aim of this review was to present the current state of knowledge about the clinical and therapeutic implications of obesity diagnosed in males.

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… However, pioglitazone ad SGLT2 inhibitors have been studied for their potential benefits in managing MAFLD [ 90 , 91 ]. 6. Obesity Treatment After obesity diagnosis, the patient should be screened for obesity complications and obesity therapy should be commenced without further ado. … Effects of sodium glucose cotransporter 2 inhibitors and pioglitazone on FIB-4 index in metabolic-associated fatty liver disease. Hepatol. Res. 2023;53:618–628. doi: 10.1111/hepr.13898. 91. He K., Li J., Xi W., Ge J., Sun J., Jing Z. …

Mitochondrial biogenesis: pharmacological approaches.

Organelle biogenesis is concomitant to organelle inheritance during cell division. It is necessary that organelles double their size and div … ese authors remark the possibility to activate Sirt1 with resveratrol, to use PPAR agonists such as pioglitazone, rosiglitazone, fenofibrate and bezafibrate. Other strategies include the triggering of Nrf2/antioxidant response element (ARE) pathway by triterpenoids (derivatives of oleanolic acid) or by Bacopa monniera, the enhancement of ATP production by carn …

Различия по возрасту и полу при воздействии антигипергликемических препаратов и риск вновь диагностированного множественного склероза в показателях склонности соответствуют типу 2 Фиолетовые.

СОСТОЯНИЕ: Связь между воздействием антигипергликемических препаратов (A-HgM) для типа 2 Лечение диабетом Mellitus (T2D) и множественным склерозом (MS) у пациентов T2D является неясным. МЕТОДЫ: Этот ретроспективный когортный анализ проводился с использованием базы данных о претензиях компании " Маринер " . Количество пациентов, прошедших обследование на предмет диагноза MS 12 через несколько месяцев после диагноза Т2D. Пациенты должны были быть активно зачислены в регистры претензий " Маринер " six за несколько месяцев до и по крайней мере three Через несколько лет после ди

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… Consistent with the drug class indications, A-HgM therapeutic targets were predominately driven by class type (DPP4 inhibitors vs Glitazones vs Metformin) with only pioglitazone and glipizide targeting overlapping pathways beyond their drug class (eFigure2). …

Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with i

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… A Metabolic Inhibitory Cocktail for Grave Cancers: Metformin, Pioglitazone and Lithium Combination in Treatment of Pancreatic Cancer and Glioblastoma Multiforme. Biochem Genet. 2016;54(5):573–618. doi: 10.1007/s10528-016-9754-9. 93. Slingerland M, Guchelaar HJ, Gelderblom H. …

Synthetic Flozins in Cancer Prevention and Combination Strategies: Structural Insights and Therapeutic Potential.

The growing number of cancer cases highlights the urgent need to develop new therapies based on effective molecules. Although anticancer activity remains a key element of oncological pharmacology, the importance of agents that support physiological functions and improve the quality of life of cancer patients is also recognised. Compounds that combine these two functions could represent a significant trend in oncology. Moreover, repurposing approved drugs for conditions beyond their original indications could be a promising strategy. An interesting example of this is synthetic flozins (SGLT2 in

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… This is warranted when considering that another anti-diabetic agent, pioglitazone, has previously been linked to increased risk of bladder cancer [ 50 ]. The role of SGLT2i in the process of neoplastic transformation remains an undeveloped topic, and research in this area is still lacking. … Pioglitazone and bladder cancer risk: A systematic review and meta-analysis Cancer Med. 2018 7 1070 1080 10.1002/cam4.1354 29476615 PMC5911601 51. Gautier P. Elbaz M. Bouisset F. Despas F. Montastruc F. …

Chronic Kidney Disease: Strategies to Retard Progression.

Chronic kidney disease (CKD), defined as the presence of irreversible structural or functional kidney damages, increases the risk of poor outcomes due to its association with multiple complications, including altered mineral metabolism, anemia, metabolic acidosis, and increased cardiovascular events. The mainstay of treatments for CKD lies in the prevention of the development and progression of CKD as well as its complications. Due to the heterogeneous origins and the uncertainty in the pathogenesis of CKD, efficacious therapies for CKD remain challenging. In this review, we focus on the follo

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… Similarly, uremic toxins such as p-cresol can impair the function of MSCs, and the concomitant use of pioglitazone helps to restore the MSC function [ 174 ]. Table 3 Potential novel agents targeting CKD progression. … Pioglitazone Improves the Function of Human Mesenchymal Stem Cells in Chronic Kidney Disease Patients. Int. J. Mol. Sci. 2019;20:2314. doi: 10.3390/ijms20092314. …

Обзор " Метформин " и " нейродегенерация: всеобъемлющий обзор " .

В рамках этого всеобъемлющего обзора изучается терапевтический потенциал метаформина, хорошо зарекомендовавшего себя лекарство от диабета, при лечении нейродегенеративных расстройств. Первоначально использованная в качестве первой линии обработки для типа 2 диабет, недавние исследования начали изучать эффекты метаформина, выходящие за рамки метаболических расстройств, особенно его нейрозащитные способности против таких заболеваний, как болезнь Паркинсона, болезнь Альцгеймера, болезнь Хантингтона и множественный склероз. Ключевые выводы показывают, что нейрозащитный эффект метформина действует

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… In neurodegenerative diseases, while other insulin sensitizers like pioglitazone improve insulin sensitivity, metformin’s broader impact on oxidative stress, mitochondrial dysfunction, and protein aggregation, through AMPK activation and mTOR inhibition, offers a more comprehensive neuroprotective strategy …

Каннабидиол как иммунный модулятор: всеобъемлющий обзор.

Каннабидиол (КБР), непсихоактивный фитоканнабиноид, полученный из сативы Каннабиса, стал многообещающим терапевтическим агентом в силу его разнообразных фармакологических свойств, включая сильные антивоспалительные, нейрозащитные и иммунодуляторные эффекты. КБР модифицирует иммунную реакцию, включая регулирование активности клеток Т, введение апоптоза макрофага, подавление провоспалительных цитокинов и модуляцию сигнальных путей воспаления и иммунной гомеостазии. Был проведен всеобъемлющий поиск литературы с использованием баз данных PubMed, Scopus и Web of Science в целях выявления соответств

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… enzyme substrates, inducers, inhibitors and transport proteins (Brown and Winterstein 2019 ) CYP3A4 Substrates Inducers Inhibitors Chemotherapeutics, immunosuppressants, antipsychotics, calcium channel blockers, statins Phenytoin, Carbamazepine, topiramate, phenobarbital, rifampicin, efavirenz, pioglitazone …

Ксантин Оксидореводаза: Меч с двойным отростком в неврологических заболеваниях.

Неинфекционные неврологические расстройства являются второй основной причиной смерти, и их бремя продолжает расти по мере роста и старения населения мира. Окисляющий стресс и воспаление во многом связаны с активацией и развитием множественных склерозов, болезни Альцгеймера, амиотропического бокового склероза, болезни Хантингтона, болезни Паркинсона и даже инсульта. В ходе этого обзора мы изучаем роль деятельности и продуктов " xanthine oxidoreducase " (XOR) во всех вышеупомянутых неврологических заболеваниях. Редоксальный дисбаланс, вызывающий окислительный стресс, может возникнуть и

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… However, none of the antioxidants tested so far in clinical trials, such as creatine, vitamin E, coenzyme Q10, pioglitazone, melatonin, and desferrioxamine, significantly improved PD patient outcomes [ 60 ]. …

Связь между окисляющим стрессом, митохондриальной дисфункцией, железным метаболизмом и микроглией в множестве склерозов: обзор нарации.

В последние годы в патогенезе множественного склероза особое внимание уделяется митохондриальным процессам, влияющим на начало заболевания. Окисляющий стресс будет одним из последствий митохондриальной дисфункции, и его воздействие на ткани мозга хорошо описано. Микроглия, как макрофаж мозга, имеет важную функцию в удалении нежелательных метаболитов, а также железа, который является усилителем окислительного стресса. Существуют новшества с точки зрения связи между этими процессами, которые в большей степени перенаправляют исследования на сам процесс нейродегенерации, с тем чтобы больше не дела

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… As inhibitors of ferroptosis, deferoxamine, vitamins C and E, ferrostatin 1, lipostatin 1, ebselen (has the function of the enzyme GSHPx), and idebenone (synthetic coenzyme Q), as well as rosiglitazone, troglitazone and pioglitazone are proposed. …

The Rise of Oncoendocrinology: How Modern Cancer Therapies Are Reshaping Endocrine Practice.

The emergence of immune checkpoint inhibitors, targeted therapies, CAR T-cell therapy, and antibody-drug conjugates has transformed modern oncology, significantly improving survival across a wide range of malignancies. However, these advances have also introduced a growing spectrum of endocrine and metabolic complications, redefining the scope of endocrine practice. Therapy-induced endocrinopathies, including thyroid dysfunction, hypophysitis, adrenal insufficiency, diabetes, pancreatitis, dyslipidemia, gonadal dysfunction, and metabolic syndrome, are recognized as clinically significant and o

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… Metformin is started as a first-line agent, followed by pioglitazone or SGLT2 inhibitors in selected patients, while insulin is generally reserved for severe or refractory cases due to concerns regarding potential interference with antitumor efficacy [ 46 ]. …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… Medication class | Weight‐promoting medications | Alternate considerations (weight loss or weight‐neutral) Antidiabetic medications | Pioglitazone, rosiglitazone, insulin (all formulations), glyburide, glipizide, glimepiride, tolbutamide, nateglinide, repaglinide | Metformin, GLP‐1 agonists, GIP/GLP‐ …

Стратегии защиты от нейропии в множестве склерозов: обновление статуса и формирующиеся парадигмы.

ВВЕДЕНИЕ: MS представляет собой континуум заболеваний, в котором с момента начала и с течением времени происходит злокачественное воспаление и нейродегенерация. Недавний прогресс в недостатке патобиологии MS создает новые перспективы для новых терапевтических стратегий нейрозащиты. ОБЛАСТЬ ПРИМЕНЕНИЯ: Авторы кратко рассматривают механизмы, лежащие в основе воспаления и нейродегенерации в MS, и обсуждают нынешние и формирующиеся стратегии поощрения нейрозащиты в MS. Данные были получены в значительной степени на основе обширного обзора опубликованной литературы, имеющейся на PubMed (до 5 марта

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… As mentioned above, strategies against mechanisms of neuronal damage in MS (e.g. antioxidants to combat oxidative stress, anti-glutamatergic drugs for excitotoxicity, channel modulators for redistribution of ion channels, cannabinoids for wallerian degeneration, pioglitazone for mitochondrial dysfunction …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… Domperidone interacts with pioglitazone but not with ondansetron via common CYP metabolism in vitro. Youssef AS, Parkman HP, Nagar S. Xenobiotica. 2014;44:792–803. doi: 10.3109/00498254.2014.899406. 33. Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. …

Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

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… Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice. PLoS ONE. 2021;16(5):e0251069. doi: 10.1371/journal.pone.0251069. …

Guidelines for the management of osteoporosis and fragility fractures.

The purpose of this document, a result of the harmonisation and revision of Guidelines published separately by the SIMFER, SIOMMMS/SIR, and SIOT associations, is to provide practical indications based on specific levels of evidence and various grades of recommendations, drawn from available literature, for the management of osteoporosis and for the diagnosis, prevention, and treatment of fragility fractures. These indications were discussed and formally approved by the delegates of the Italian Scientific Associations involved in the project (SIE, SIGG, SIMFER, SIMG, SIMI, SIOMMMS, SIR, and SIO

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… The use of pioglitazone and rosiglitazone is strongly associated with a significant increased (three to fourfold) risk of fracture of the hip and humerus in postmenopausal women. …

Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies.

BackgroundPeripheral neuropathies are a group of diseases characterized by malfunctioning of peripheral nervous system. Neuropathic pain, one of the core manifestations of peripheral neuropathy remains as the most severe disabling condition affecting the social and daily routine life of patients suffering from peripheral neuropathy.MethodThe current review is aimed at unfolding the possible role of mitochondrial dysfunction in peripheral nerve damage and to discuss on the probable therapeutic strategies against neuronal mitotoxicity. The article also highlights the therapeutic significance of

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… Rosiglitazone, Pioglitazone). It has been recently observed that PPARγ agonists can effectively prevent the glucose induced neurotoxicity and various deficits in streptozotocin (STZ) induced experimental DN [ 141 ]. …

Metronomic Anti-Cancer Therapy: A Multimodal Therapy Governed by the Tumor Microenvironment.

The concept of cancer as a systemic disease, and the therapeutic implications of this, has gained special relevance. This concept encompasses the interactions between tumor and stromal cells and their microenvironment in the complex setting of primary tumors and metastases. These factors determine cellular co-evolution in time and space, contribute to tumor progression, and could counteract therapeutic effects. Additionally, cancer therapies can induce cellular and molecular responses in the tumor and host that allow them to escape therapy and promote tumor progression. In this study, we descr

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… In this sense, a phase II trial that compared the efficacy of a combined biomodulatory therapy (pioglitazone + clarithromycin + low-dose metronomic treosulfan) with nivolumab (anti-PD-1) as a single-agent in patients with locally advanced, unresectable, or metastatic NSCLC showed that biomodulatory therapy … A Randomized Phase II Trial Comparing the Efficacy and Safety of Pioglitazone, Clarithromycin and Metronomic Low-Dose Chemotherapy with Single-Agent Nivolumab Therapy in Patients with Advanced Non-small Cell Lung Cancer Treated in Second or Further Line (ModuLung) Front. …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

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… Currently rosiglitazone and pioglitazone are used as antidiabetic agents. This novel class of drugs increases insulin-stimulated glucose uptake by skeletal muscle cells; therefore, these agents decrease insulin resistance in peripheral tissues. … Rosiglitazone and pioglitazone appear equally effective in achieving glycemia reductions. In controlled trials, TZDs generally lower HbA1c to the same degree as other antidiabetic agents. …