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Вирус Эпштейн-Барр BALF0/1 подрывает пути кавеолина и ERAD, чтобы охватить комплексы рецепторов клеток B для разложения.

Вирус Эпштейн-Барр (ЭБВ) устанавливает стойкую инфекцию, вызывает инфекционный мононуклеоз, является одним из основных пусковых факторов множественного склероза и способствует возникновению множественных раковых заболеваний. Тем не менее, знания о том, как вирус реконструирует клетки В для поддержки литического воспроизведения, остаются неполными. Ранее мы обнаружили, что EBV литическое воспроизведение приводит к избирательному истощению комплексов рецепторов клеток В (КРВ), состоящих из иммуноглобулина, а также цепочек сигнализации CD79A и CD79B. Здесь мы использовали протеомные и биохимическ

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… By contrast, inhibition of the caveolae-dependent endocytosis by genistein ( 37 ) restored BCR expression to a similar degree as in bortezomib treatment in P3HR-1 in the presence of BALF0/1 ( SI Appendix , Fig. S3 C and D ). …

A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19.

The pandemic of the coronavirus disease 2019 (COVID-19) represents an unprecedented challenge to identify effective drugs for prevention and treatment. While the world's attention is focused on news of COVID-19 vaccine updates, clinical management still requires improvement. Due to the similarity of cancer-induced inflammation, immune dysfunction, and coagulopathy to COVID-19, anticancer drugs, such as Interferon, Pembrolizumab or Bicalutamide, are already being tested in clinical trials for repurposing, alone or in combination. Given the rapid pace of scientific discovery and clinical data ge

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… Reduce Mortality - | Irna | NCT04350684 | Hydroxychloroquine, lopinavir, ritonavir, umifenovir | Enrolling by invitation | Phase 4 | COVID-19 infection | Time to clinical improvement - | Several locations | NCT02735707 | Multifactorial | Recruiting | Phase 4 | COVID-19 infection | All-cause mortality Genistein …

Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies.

Food antioxidant supplementation has been widely proposed for cancer prevention and adjuvant therapy due to the pleiotropic role of antioxidants. Herein, particular attention is given to recent clinical trials based on the use of dietary supplements in cancer patients, both as monotherapy and in combination with standard treatments, exploring both their potential benefits and risks. This review focuses on the efficacy of the most important food antioxidants, highlighting how their action may change depending on different factors such as cancer type, dose, timing of administration and antioxida

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… Genistein belongs to the isoflavone class and can modulate the abundance of phenolic metabolites produced by gut microbes, modifying the metabolism of gut microbiota [ 103 ]. … Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects BMJ Open Diabetes Res. Care 2020 8 e000948 10.1136/bmjdrc-2019-000948 32152146 PMC7064085 104. Ladeira Bernardes A. Albuquerque Pereira M.F. Xisto Campos I. Ávila L. …

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies.

Current drugs against multiple human malignancies are limited, and developing new treatment strategies is improbable within a short time. So, considering the current situation, phytochemicals could be a viable option for developing chemotherapeutic agents for managing numerous types of malignancies. Therefore, we aimed to locate all phytochemicals of Eclipta prostrata and unravel their chemotherapeutic mechanisms and strategies individually. We defined 25 active compounds based on their anticancer activities after filtering through IMPPAT and literature search, and these compounds have chemoth

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… Structurally related to genistein, the most common soy isoflavone [ 62 ], orobol has demonstrated potential anticancer properties in different types of cancer despite its rarity. Orobol has shown remarkable effects on breast cancer (MCF‐7 cells). …

A Triazaspirane Derivative Inhibits Migration and Invasion in PC3 Prostate Cancer Cells.

Cancer is a serious health problem due to the complexity of establishing an effective treatment. The purpose of this work was to evaluate the activity of a triazaspirane as a migration and invasion inhibitor in PC3 prostatic tumor cells through a possible negative regulation of the FAK/Src signal transduction pathway and decreased secretion of metalloproteinases 2 and 9. Molecular docking analysis was performed using Moe 2008.10 software. Migration (wound-healing assay) and invasion (Boyden chamber assay) assays were performed. In addition, the Western blot technique was used to quantify prote

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… Genistein Inhibits Invasion and Migration of Colon Cancer Cells by Recovering WIF1 Expression. Mol. Med. Rep. 2018;17:7265–7273. doi: 10.3892/mmr.2018.8760. 34. Cathcart J., Pulkoski-Gross A., Cao J. Targeting Matrix Metalloproteinases in Cancer: Bringing New Life to Old Ideas. …

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies.

The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor progn

Nanotechnology and Matrix Metalloproteinases in Cancer Diagnosis and Treatment.

Cancer is still one of the leading causes of death worldwide. This great mortality is due to its late diagnosis when the disease is already at advanced stages. Although the efforts made to develop more effective treatments, around 90% of cancer deaths are due to metastasis that confers a systemic character to the disease. Likewise, matrix metalloproteinases (MMPs) are endopeptidases that participate in all the events of the metastatic process. MMPs' augmented concentrations and an increased enzymatic activity have been considered bad prognosis markers of the disease. Therefore, synthetic inhib

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… Likewise, other molecules that show an inhibitory effect on MMPs’ enzymatic activity are sulfamides and sulfonamide derivatives, pyrophosphate (PPi) analogs (bisphosphonates) such as zoledronic acid, the non-steroid drug letrozole, and natural MMP inhibitors (soy isoflavone [Genistein] and the shark … bisphosphonate) | MMP-2 MMP-9 MMP-14 MMP-15 | Breast | NA Letrozole (non-steroidal hormone | MMP-2, MMP-9 | Breast | NA Natural MMPI | Neovastat AE941 (shark cartilage extract) | MMP-1 MMP-2 MMP-7 MMP-9 MMP-12 MMP-13 | Refractory multiple myeloma, colorectal, breast, renal cancer carcinoma | NA, non-response Genistein …

Docosahexaenoic Acid Modulates a HER2-Associated Lipogenic Phenotype, Induces Apoptosis, and Increases Trastuzumab Action in HER2-Overexpressing Breast Carcinoma Cells.

In breast cancer, lipid metabolic alterations have been recognized as potential oncogenic stimuli that may promote malignancy. To investigate whether the oncogenic nature of lipogenesis closely depends on the overexpression of HER2 protooncogene, the normal breast cell line, HB4a, was transfected with HER2 cDNA to obtain HER2-overexpressing HB4aC5.2 cells. Both cell lines were treated with trastuzumab and docosahexaenoic acid. HER2 overexpression was accompanied by an increase in the expression of lipogenic genes involved in uptake (CD36), transport (FABP4), and storage (DGAT) of exogenous fat

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… Repression of mammary adipogenesis by genistein limits mammosphere formation of human MCF-7 cells Journal of Endocrinology 2013 218 1 135 149 10.1530/JOE-12-0520 2-s2.0-84878796442 23645249 5 Nieva C. Marro M. Santana-Codina N. Rao S. Petrov D. Sierra A. …

Study of Liposomes Containing Extract from the Leaves of Protium heptaphyllum (Aubl.) March in Animals Submitted to a Mutagenic Model Induced by Cyclophosphamide.

Cyclophosphamide (CPA) is an alkylating agent used as a chemotherapy agent in the treatment of cancer, but it has immunosuppressive effects. Protium heptaphyllum (P. heptaphyllum) is a plant rich in triterpenes and flavonoids, with some bioactive and therapeutic properties presented in the literature. Thus, the present study aimed to investigate the chemoprotective potential of P. heptaphyllum extract inserted into liposomes against oxidative damage chemically induced by CPA. Male Swiss mice received 1.5 mg/kg of P. heptaphyllum liposomes as a pre-treatment for 14 consecutive days (via gavage)

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… Furthermore, flavonoids such as quercetin, apigenin, and genistein have demonstrated the ability to reverse dysfunction caused by oxidative stress in brain endothelial cells [ 69 ]. …

Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia.

Prostate cancer (PCa) remains both a global health burden and a scientific challenge. We present a review of the molecular targets driving current drug discovery to fight this disease. Moreover, the preventable nature of most PCa cases represents an opportunity for phytochemicals as chemopreventive when adequately integrated into nutritional interventions. With a renovated interest in natural remedies as a commodity and their essential role in cancer drug discovery, Malaysia is looking towards capitalizing on its mega biodiversity, which includes the oldest rainforest in the world and an estim

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… Plasma genistein and risk of prostate cancer in Chinese population. Int. Urol. Nephrol. 2015;47:965–970. doi: 10.1007/s11255-015-0981-5. 16. Puangsombat K., Jirapakkul W., Smith J.S. Inhibitory Activity of Asian Spices on Heterocyclic Amines Formation in Cooked Beef Patties. J. … Understanding genistein in cancer: The "good" and the "bad" effects: A review. Food Chem. 2016;196:589–600. doi: 10.1016/j.foodchem.2015.09.085. 22. Vastag B. Soy and Prostate Cancer Study Results Mixed. JNCI J. Natl. Cancer Inst. 2007;99:1364–1365. doi: 10.1093/jnci/djm162. 23. …

Phytochemicals as Chemo-Preventive Agents and Signaling Molecule Modulators: Current Role in Cancer Therapeutics and Inflammation.

Cancer is one of the deadliest non communicable diseases. Numerous anticancer medications have been developed to target the molecular pathways driving cancer. However, there has been no discernible increase in the overall survival rate in cancer patients. Therefore, innovative chemo-preventive techniques and agents are required to supplement standard cancer treatments and boost their efficacy. Fruits and vegetables should be tapped into as a source of compounds that can serve as cancer therapy. Phytochemicals play an important role as sources of new medication in cancer treatment. Some synthet

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… Ursolic acid, kaempferol, resveratrol, gingerol, sulforaphane, genistein, and isothiocyanates are some of the most well-studied plant chemicals and have been shown to cause apoptosis in cancer cells through the MAPK and ERK pathways [ 27 , 28 ]. … Ellagic acid, EGCG, genistein, and anthocyanin-rich berry extracts exhibit antiangiogenic properties by inhibiting the expression of angiogenic factors, including the vascular endothelial growth factor, vascular endothelial growth factor receptor-2, hypoxia-inducible factor 1a, platelet-derived growth …

A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy.

Background: Cancer has become a major disease endangering human health around the world. Conventional chemotherapy suffers from many side effects including pain, cardiotoxicity, hepatotoxicity, and renal toxicity. This review aims to describe a natural product of resveratrol as a chemoprotective and synergistic agent in the modulation of cancer chemotherapy. Methods: The publications were identified by comprehensive searching of SciFinder, PubMed, Web of Science, and our own reference library. Search terms included combinations of "resveratrol," "cancer," "natural products," "chemotherapy," an

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… Effects of resveratrol and genistein on nuclear factor-κB, tumor necrosis factor-α and matrix metalloproteinase-9 in patients with chronic obstructive pulmonary disease. Mol. Med. Rep. 13 4266 – 4272 . 10.3892/mmr.2016.5057 27035424 PMC4838123 Lucas R. M. McMichael A. J. Armstrong B. K. Smith W. …

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning.

Breast cancer faces significant therapeutic challenges, particularly for triple-negative breast cancer (TNBC), due to limited targeted therapies and drug resistance. Drug repositioning leverages existing safety and pharmacokinetic data to expedite the identification of new indications with cost-effective benefits compared to de novo drug discovery. In this critical narrative review, we examine recent advances in computational repositioning strategies for breast cancer, focusing on network-based methods, computer-aided drug design, artificial intelligence and machine learning, transcriptomic si

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… Through this approach, mitoxantrone and genistein emerged as potential therapeutics capable of reversing the gene expression signature associated with HR deficiency via a novel chemotherapeutic mechanism [ 55 ]. F. …

Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms.

Cancer is the leading cause of mortality worldwide. Various chemotherapeutic drugs have been extensively used for cancer treatment. However, current anticancer drugs cause severe side effects and induce resistance. Therefore, the development of novel and effective anticancer agents with minimal or no side effects is important. Notably, natural compounds have been highlighted as anticancer drugs. Among them, many researchers have focused on mushrooms that have biological activities, including antitumor activity. The aim of this review is to discuss the anticancer potential of different mushroom

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… Twardowski Agaricus blazei Murill (AndoSan) | Multiple myeloma | Phase 2 | Completed | Agaricus polysaccharides | NCT00970021 | Jon-Magnus Tangen Lentinula edodes | Prostate cancer | Not mentioned | Completed | Genistein Combined Polysaccharide (GCP) | NCT00269555 | Robert Hackman Lentinula edode | Hepatocellular …

Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications.

Epigenetic regulation is a fundamental mechanism controlling gene expression and cellular function, primarily mediated through reversible modifications such as DNA methylation, histone acetylation, and chromatin remodeling. Dysregulation of critical epigenetic enzymes, including histone deacetylases (HDACs), DNA methyltransferases (DNMTs), and bromodomain and extraterminal domain (BET) proteins, has been closely associated with tumor initiation, progression, metastasis, immune evasion, and resistance to conventional therapies. Targeting these epigenetic regulators with small-molecule inhibitor

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… Phase 1, Completed), NCT04177693 (Phase 1, Completed), etc Quercetin | Modulates DNMT function; affects methylation of tumor suppressor genes | Low toxicity; multi-pathway effects | NCT03476330 (Phase 2, Active, not recruiting), NCT01912820 (Phase 1, Completed), NCT06355037 (Phase 2, Recruiting), etc Genistein … Other examples include genistein, a soy isoflavone, which has been reported in preclinical studies to inhibit DNMT and HDAC activity, reactivate ERα expression in breast cancer cells, and enhance tumor sensitivity to hormonal therapy [ 37 ]. …

Pancreatic Neuroendocrine Tumors: Signaling Pathways and Epigenetic Regulation.

Pancreatic neuroendocrine tumors (PNETs) are characterized by dysregulated signaling pathways that are crucial for tumor formation and progression. The efficacy of traditional therapies is limited, particularly in the treatment of PNETs at an advanced stage. Epigenetic alterations profoundly impact the activity of signaling pathways in cancer development, offering potential opportunities for drug development. There is currently a lack of extensive research on epigenetic regulation in PNETs. To fill this gap, we first summarize major signaling events that are involved in PNET development. Then,

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… Genistein, a potent antioxidant and demethylating agent in soybean-enriched foods, induces cell apoptosis and inhibits the cell proliferation of multiple types of kidney cancer cells. It achieves this through the expression of CDKN2A via decreased CDKN2A methylation [ 89 ]. … Genistein inhibited the proliferation of kidney cancer cells via CDKN2a hypomethylation: Role of abnormal apoptosis Int. Urol. Nephrol. 2020 52 1049 1055 10.1007/s11255-019-02372-2 32026308 90. Xia L. Zhang W. Gao L. …

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

BACKGROUND AND AIM: Recently, optimal immune function has become a primary focus of worldwide attention not only in the prevention of chronic disease but also as one strategy to reduce the severity of acute illness. Inflammation, a process largely controlled by the immune system, has long been studied and recognized for its role in chronic disease. Optimizing immune function or managing inflammation using individual nutrients and phytonutrients is not well understood by the average person. Thus, this narrative literature review summarizes many of the more recent findings about how certain nutr

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… Phytonutrients, such as aloe polysaccharides, curcumin, genistein, lentinan, and rice bran arabinoxylan complex, have also been evaluated for their efficacy on immune functioning and immunomodulation. …

Изучение механизма Shengmai San для лечения аденокарциномы легких на основе биоинформатики и моделирования молекулярной динамики.

Изучение механизма Shengmai San (SMS) в лечении аденокарциномы легких (LUAD) на основе комплексной стратегии, сочетающей «сетевую фармакологию, биоинформатику, стыковку молекулярной стыковки и моделирование молекулярной динамики», в целях разработки точной стратегии комбинированной терапии и выявления потенциальных биоактивных соединений. Дифференцированные гены в LUAD были выявлены в базе данных Gene Express Omnibus с использованием R (первоначально разработанные в Bell Laboratories и в настоящее время управляемые Lucent Technologies). Из энциклопедии традиционной китайской медицины были извл

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… Modeling the functionalized genistein-hyoscyamine derivatives. Sci Rep. 2025;15:16662. [47] Zamani M, Mokarram P, Jamshidi M, Siri M, Ghasemi H. Molecular modelling of resveratrol derivatives with SIRT1 for the stimulation of deacetylase activity. Curr Comput Aided Drug Des. 2024;20:943–54. …

Targeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer.

Epigenetics shapes all aspects of cancer occurrence and progression. Among them, chromatin methylation is a particularly important regulator of oncogenic processes. The dynamic shifts in methylation can influence the development or death of tumor cells. In the therapeutic context, effectively targeting and modulating DNA, RNA, and histone methylation brings promise for the early detection, prognostic assessment, and treatment of cancer. In particular, novel methylation inhibitors or modulators powerfully kill tumor cells or improve existing therapeutic strategies through different signaling pa

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… Epigenetic diet Furthermore, the new term “epigenetic diet” refers to a class of bioactive dietary compounds, such as isothiocyanates in broccoli, genistein in soybeans, and resveratrol in red grapes, which are common components in foods [ 214 ]. … For example, green tea polyphenols (dietary DNMTi) plus sulforaphane (dietary histone deacetylase inhibitor) or soybean isoflavone (genistein, dietary HDACi) enable ERα reactivation to upregulate p21/KLOTHO or enhance the efficacy of the estrogen antagonist tamoxifen, thereby exhibiting potential for …

Why Is Wnt/β-Catenin Not Yet Targeted in Routine Cancer Care?

Despite significant progress in cancer prevention, screening, and treatment, the still limited number of therapeutic options is an obstacle towards increasing the cancer cure rate. In recent years, many efforts were put forth to develop therapeutics that selectively target different components of the oncogenic Wnt/β-catenin signaling pathway. These include small molecule inhibitors, antibodies, and more recently, gene-based approaches. Although some of them showed promising outcomes in clinical trials, the Wnt/β-catenin pathway is still not targeted in routine clinical practice for cancer mana

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… These include dietary phytochemicals, such as naringenin, resveratrol, avenanthramides, epigallocatechin, curcumin, quercetin, silibinin, genistein, mangiferin, and many others that are considered serious options for cancer chemoprevention and treatment, given their anti-stem cell, anti-metastasis, and …