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Изучение перспектив потребителей услуг в области здравоохранения на пути к интеграции питания в рутинную помощь с множественным склерозом: качественное исследование.

КОЛИЧЕСТВО: Люди, страдающие множественным склерозом, рассчитывают получить информацию о питании от медицинских работников (HCP), с тем чтобы самостоятельно справиться со своим заболеванием. Цель этого исследования заключалась в изучении опыта ПМСО в области обеспечения ухода, связанного с питанием, и в обеспечении понимания их потребностей и предпочтений в отношении того, каким образом его можно было бы обеспечить в рамках обычного ухода. МЕТОДЫ: Это качественное исследование, опирающееся на интерпретационный феноменологический подход, было проведено с использованием онлайновых целевых групп

Low-quality of patient-reported outcome reporting in randomized clinical trials of major depressive disorder-a meta-epidemiological review.

ObjectiveOur goal was to review current peer-reviewed articles in which the BDI (Beck Depression Inventory), PHQ-9 (Patient Health Questionnaire), or QIDS-SR16 (16-Item Quick Inventory of Depressive Symptomatology) was used as the primary or secondary outcome measure and to evaluate the quality of PRO (Patient-Reported Outcome) reporting in RCTs (Randomized Controlled Trials) according to the 2013 PRO-specific CONSORT (Consolidated Standards of Reporting Trials) extension.MethodsWe systematically searched in electronic databases. A study would be included if it included patients diagnosed with

Taste and smell disturbances in patients with chronic oral graft vs. host disease: An observational study.

BackgroundA common complication of allogeneic hematopoietic stem cell transplantation (alloHSCT) is chronic oral graft vs. host disease (cGvHD). Oral cGvHD may present as mucosal lesions, salivary gland dysfunction, and trismus. Moreover, taste and smell ability may be affected, but the prevalence, nature and severity of altered taste and smell function, and their impact on quality of life (QoL) are understudied.AimTo identify the prevalence, nature, and severity of taste and smell disturbances, their impact on QoL and to assess whether altered taste/smell ability is associated with oral mucos

Sarcopenia Diagnosis and Management in Hematological Malignancies and Differences with Cachexia and Frailty.

Sarcopenia is a geriatric syndrome characterized by a progressive loss of systemic muscle mass and decreased muscle strength or physical function. Several conditions have a role in its pathogenesis, significantly impacting adverse outcomes such as falls, functional decline, frailty, disability, multiple hospitalizations, and mortality. In the oncological setting, sarcopenia is associated with an increased risk of treatment toxicity, postoperative complications, and a higher mortality rate related to other causes (e.g., pneumonia). In the hematological field, even more so, sarcopenia predicts t

Long-Term Outcomes of Pituitary Gland Preservation in Pituitary Macroadenoma Apoplexy: Case Series and Review of the Literature.

Introduction  For patients presenting with neurological changes from pituitary tumor apoplexy, urgent surgical intervention is commonly performed for diagnosis, tumor resection, and optic apparatus decompression. Although identification and preservation of the pituitary gland during the time of surgery can be challenging, it may lead to improve endocrine outcomes. Methods  A retrospective case series of all patients with macroadenomas presenting with apoplexy at Loyola University Medical Center from 2016 to 2018 was studied. Demographic, radiographic, and intraoperative characteristics were co

Resilience provides mediating effect of resilience between fear of progression and sleep quality in patients with hematological malignancies.

BackgroundHematological tumors are common malignant tumors, with high morbidity and mortality rates. Most patients with hematological malignancies develop sleep disorders that seriously affect their life and health because of acute onset of disease, rapid progression, high recurrence rates, complex treatment methods, and treatment costs.AimTo explore the mediating effect of resilience on fear of disease progression and sleep quality in patients with hematological malignancies.MethodsA cross-sectional analysis of 100 patients with hematological malignancies, treated in the First Affiliated Hosp

Multidisciplinary Approach to Spinal Metastases and Metastatic Spinal Cord Compression-A New Integrative Flowchart for Patient Management.

Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative interaction between general mechanisms of bone growth and specific mechanisms of spinal metastases (SM) expansion. SM most commonly affects the thoracic spine, even though multiple segments may be affected concomitantly. The great majority of SM are extradural, while intradural-extramedullary and intramedullary metastases are less frequently seen. The ma

Какие прогнозы изменений в трудовой ситуации недавно диагностированных людей с множественным склерозом и применяются ли эти прогнозы также к здоровым людям?

ЦЕЛЬ: Изучение ассоциаций базовых прогнозов, испытывающих трудности с работой, и количества рабочих часов после одного года работы в недавно диагностированных склерозах (PwMS). Кроме того, для анализа вопроса о том, являются ли эти прогнозы общими, т.е. применимы к здоровым людям, или же они относятся к конкретным заболеваниям. В результате объединения данных TEMPRANO и MS@Work был получен набор данных о 135 недавно диагностированных PwMS (около 1 года) и 172 здоровых людях. Мы проанализировали ассоциации базовых прогнозов, которые вписываются в рамки международной классификации функционирован

Совпадение в полном тексте источника
… The importance of studying a combination of different predictive factors is further emphasized by the International Classification of Functioning, Disability and Health (ICF), a global conceptual framework of functioning [ 11 ]. …

The Danish health care system and epidemiological research: from health care contacts to database records.

Denmark has a large network of population-based medical databases, which routinely collect high-quality data as a by-product of health care provision. The Danish medical databases include administrative, health, and clinical quality databases. Understanding the full research potential of these data sources requires insight into the underlying health care system. This review describes key elements of the Danish health care system from planning and delivery to record generation. First, it presents the history of the health care system, its overall organization and financing. Second, it details d

Percutaneous balloon kyphoplasty for the treatment of vertebral compression fractures.

BackgroundVertebral compression fractures (VCFs) constitute a major health care problem, not only because of their high incidence but also because of their direct and indirect negative impacts on both patients' health-related quality of life and costs to the health care system. Two minimally invasive surgical approaches were developed for the management of symptomatic VCFs: balloon kyphoplasty and vertebroplasty. The purpose of this study was to evaluate the effectiveness and safety of balloon kyphoplasty in the treatment of symptomatic VCFs.MethodsBetween July 2011 and June 2012, one hundred

A Qualitative Study to Assess Collusion and Psychological Distress in Cancer Patients.

IntroductionCollusion is frequently encountered but least studied entity in palliative care services in India. Impact of collusion is manifold and identifying it requires good communication skills. Once identified, it gives an indication for existing healthy versus developing unhealthy collusion to be dealt within families.ObjectiveThe objective of this study was to identify the prevalence of collusion and its clinical and psychological correlates among patients and caregivers in a palliative cancer care.Materials and methodsWe describe systematic identification and unraveling of collusion acr

Оказание высококачественной комплексной помощи в области склероза в Германии: проблемы и региональные модели.

Множественная склерозовая (МС) помощь в Германии вступила в стадию, когда терапевтический прогресс все больше сдерживается возможностями родовспоможения. Более ранняя диагностика, более широкий доступ к высокоэффективным методам лечения заболеваний (ДМТ) и более совершенные стратегии мониторинга расширили возможности для достижения благоприятных долгосрочных результатов. В то же время эти достижения усилили потребность в специализированных экспертных знаниях, инфильтрации и инфраструктуре мониторинга, оперативном доступе к изображениям, структурированных процедурах обеспечения безопасности и м

Искусственный интеллект основывается на достижениях в области наномедицины для лечения мозговых расстройств: обновленный обзор повествования.

Наномедицина - это наномасштабные, биосопоставимые материалы, которые предлагают перспективные альтернативы традиционным методам лечения расстройств мозга. Технологические достижения в области искусственного интеллекта (АИ), в частности машинного обучения (МЛ) и глубокого обучения (ДЛ), трансформируют область наномедицины путем совершенствования диагностики заболеваний, биомаркировки, прогнозирования и мониторинга заболеваний, целевых поставок наркотиков и терапевтического вмешательства, а также содействия расчетным и методологическим разработкам. Эти успехи могут быть достигнуты за счет анали

An Individualized Exercise Intervention for People with Multiple Myeloma-Study Protocol of a Randomized Waitlist-Controlled Trial.

People with multiple myeloma (MM) are second only to people with lung cancer for the poorest reported health-related quality of life (HRQoL) of all cancer types. Whether exercise can improve HRQoL in MM, where bone pain and lesions are common, requires investigation. This trial aims to evaluate the efficacy of an exercise intervention compared with control on HRQoL in people with MM. Following baseline testing, people with MM (n = 60) will be randomized to an exercise (EX) or waitlist control (WT) group. EX will complete 12-weeks of supervised (24 sessions) and unsupervised (12 sessions) indiv

Comparing the Influence of Surgical and Conservative Therapy on Quality of Life in Patients with Early-Stage Medication-Related Osteonecrosis of the Jaw-A Prospective Longitudinal Study.

Background and Objectives: The purpose of this study was to evaluate the impact of surgical and conservative, non-surgical treatment on general health-related (QoL) and oral health-related quality of life (OHRQoL) in patients suffering from AAOMS stage I MRONJ. Materials and Methods: In the course of this prospective clinical study, QoL and OHRQoL using QLQ-C30 and QHIP G14 questionnaire were longitudinally assessed in N = 174 prospectively enrolled patients with indication of treatment of MRONJ stage I over a period of 12 months. Patients received conservative or surgical treatment. The measu

Short-term assessment of functional outcomes and quality of life after thoracic and lumbar spinal metastasis surgery.

BackgroundBecause of improvements in initial tumor identification and treatment, as well as longer life expectancies, more people are receiving diagnoses for spinal metastases.ObjectiveThe aim of this study was to assess early functional outcomes and quality of life (QOL) after surgical management of patients with spinal metastases.Patients and methodsIn this prospective cohort study, a total of 33 patients with thoracic and lumbar spine metastases who underwent surgical management between November 2021 and August 2023 were followed up for 1 year or until death. Oswestry Disability Index and t

Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions.

BackgroundIn end-of-life patients with advanced cancers, oral examination, oral care, and oral re-examination are crucial. Although oral symptoms are among the major complaints of end-of-life patients, few studies have focused on oral care in these patients. In this study, the association between oral symptoms and oral dryness among end-of-life patients was examined, and improvement of oral conditions after oral care interventions by a professional dentist was quantified.MethodsThis prospective intervention study included 27 terminally ill patients with advanced cancers in a hospice ward. Prof

Post-traumatic growth and cancer survivorship: experiences of living with treatment-related impairment.

PurposeIncreased distress has been associated with impairment related to cancer treatment and with post-traumatic growth (PTG), but the influence of treatment-related impairment on PTG has not been explored. This study aimed to understand the lived experience of PTG for cancer survivors living with treatment-related impairment.MethodsHermeneutic phenomenology was used to develop a deep understanding of the lived experience of adult cancer survivors living with ongoing treatment-related impairment who had experienced self-perceived PTG following their cancer experience. Semi-structured individu

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… The World Health Organization (2001) International Classification of Functioning, Disability and Health (ICF) defines impairment as “problems in body function or structure such as a significant deviation or loss” [ 10 ]. …

Oral Health-Related Quality of Life and Mental Health Impairment in Patients Affected by Medication-Related Osteonecrosis of the Jaws: A Case-Control Pilot Study.

In the present case-control study, the impact of medication-related osteonecrosis of the jaws (MRONJ) on patients' oral health-related quality of life (OHRQoL), overall quality of life (QoL), and psychological status was evaluated using a set of questionnaires. These questionnaires included the Oral Health Impact Profile-14 (OHIP-14), the Short Form 36 Health Survey Questionnaire (SF-36), and the hospital anxiety and depression scale (HADS). A total of 25 MRONJ patients and 25 controls were included in the study. The results showed that MRONJ patients had a significantly poorer OHRQoL (OHIP-14

Oral Food Supplement with Bio-Activated Silicium and Vitamins D3 and K2 in the Conservative Management of Osteoporotic Vertebral Compression Fractures.

Background: Osteoporotic vertebral compression fractures (OVCFs) are the most prevalent manifestation of osteoporotic skeletal disease, associated with severe pain, functional decline, and elevated risk of subsequent fractures. Conservative management remains the first-line approach for stable fractures, yet pain control is often suboptimal, and vertebral collapse progresses in up to 37% of patients. Bio-activated orthosilicic acid combined with vitamins D3 and K2 (BioSi-DK) may support fracture healing through complementary mechanisms acting on osteoblast differentiation, collagen synthesis,