Результаты поиска

Effect on topical 5-methoxypsoralen on tumorigenesis induced in albino and pigmented hairless mouse skin by UV irradiation.

A new line of the Skh:HRII hairless pigmented mouse (black juvenile coat) is described which has been selectively bred for the capacity to respond consistently to simulated solar UV radiation with a continuous and strong tan. This mouse demonstrates a degree of protection from chronic UV-induced tumorigenesis when compared with the Skh:HRI hairless albino mouse, and has been used here to study the effect of induced melanogenesis on phototumorigenesis. Mice were irradiated for 10 weeks with incremental doses of simulated solar UV radiation (UVA + B) from a fluorescent tube source which induced …

Okay, so I need to translate this medical title into Russian. Let me start by understanding the source text. The title is "Lenalidomide-Associated Oral Pigmentation: A Case Report." First, I'll break down the components. "Lenalidomide" is a drug name. In Russian medical terminology, drug names are usually transliterated but sometimes have specific translations. Wait, but the instruction says to use international nonproprietary drug names. Lenalidomide is the nonproprietary name, so in Russian it's probably "Леналидомид" (I think that's the transliteration). Let me confirm. Yes, in Russian medical literature, lenalidomide is written as Леналидомид. Next, "Associated" here means that the pigmentation is associated with lenalidomide use. So the phrase "Lenalid. Associated Oral Pigmentation" would be "Связанная с леналидомидом оральная пигментация". Wait, but in medical terms, "associated" in this context is often translated as "связанная" or "ассоциированная". Hmm. Let me check. In Russian medical terminology,

Леннодомид является иммуномудулятором, широко используемым при лечении множественной миеломы, и, как правило, связан с благоприятной характеристикой безопасности. Несмотря на сообщения о таких изменениях пигментации, как резиновая гиперпигментация и перепигментация волос, оральная слизь по-прежнему плохо задокументирована. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: 80-year-old Черная самка с множественной миеломой, которая проходит курс лечения линалидомидом, имеет асимптомные коричневые макулы на языке, твердый вкус, двустороннюю буккультную слизь и ингиву. Гистопатологический анализ резной биопсии на языке пока

Совпадение в полном тексте источника
… Melanogenesis, the process of melanin production by melanocytes, is tightly regulated by a balance between stimulatory and inhibitory signals. … Experimental studies have demonstrated, for example, that TNF-α suppresses both the activity and expression of tyrosinase—a key enzyme in melanogenesis—through activation of the NF-κB signaling pathway [ 11 ]. …

Premature hair graying: a multifaceted phenomenon.

Premature hair graying (PHG) is the early loss of natural hair color, influenced by genetic, biological, and environmental factors. This review discusses the significant psychological impacts of PHG and explores its underlying mechanisms, related health conditions, and available treatments. The review examines the roles of genetics, oxidative stress, and lifestyle factors such as smoking and diet in premature graying. It also considers associated medical conditions and current and emerging treatment options. This overview aims to improve understanding of PHG and its broader implications.

Совпадение в полном тексте источника
… . 86 This was thought to occur via suppression of inhibitors of melanogenesis (IL‐17 and TNF‐a) that depend on IL‐23 upstream. … | Monoclonal antibody against IL‐17A | IL‐17 suppresses melanogenesis through ROS‐dependent melanocyte apoptosis and increased production of melanogenesis inhibitors Ustekinumab | Monoclonal antibody against IL‐12/23 p40 | Suppression of inhibitors of melanogenesis that depend on IL‐23 upstream, such …

Clinical and Histologic Analysis of the Efficacy of Topical Rapamycin Therapy Against Hypomelanotic Macules in Tuberous Sclerosis Complex.

IMPORTANCE: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder leading to the aberrant activation of the mammalian target of … from TSC. This efficacy of rapamycin was corroborated as stemming from the improvement of impaired melanogenesis in TSC melanocytes.

The progress of research on the herbology, geographical distribution, phytochemistry, pharmacological effects and gene regulation of snow lotus: A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Snow Lotus is a representative medicinal herb in the traditional medical systems of Tibetan, Mongolian, Uygh … x and blocking EGFR/AKT. Additional activities include ameliorating myocardial ischemia, inhibiting melanogenesis, and neuroprotection. Gene studies reveal that hypoxia/MeJA upregulates DNA repair, terpenoid synthesis, and cold/drought resistance genes (SiICE1, SikCOR413PM1), enhancing stress tolerance. CONCLUSION: This review systematically integrates the eth …

A Nude Mouse Model of Xenografted Hypertrophic Scar Cells to Test Therapeutics in the Skin.

BACKGROUND: Existing animal models for testing therapeutics in the skin are limited. Mouse and rat models lack similarity to human skin in s … . RNA was isolated and quantitative real-time polymerase chain reaction (qRT-PCR) was performed for melanogenesis-related genes TYR, TYRP1, and DCT. RESULTS: The seeding of HTSDFs formed a dermis that is similar in structure and cellularity to HTS dermis from the porcine model. When hyper-, hypo-, and normally-pigmented epidermal cells were seeded, a fully str …

PPAR-γ in Melanoma and Immune Cells: Insights into Disease Pathogenesis and Therapeutic Implications.

Changes in skin pigmentation, like hyperpigmentation or moles, can affect appearance and social life. Unlike locally containable moles, malignant melanomas are aggressive and can spread rapidly, disproportionately affecting younger individuals with a high potential for metastasis. Research has shown that the peroxisome proliferator-activated receptor gamma (PPAR-γ) and its ligands exhibit protective effects against melanoma. As a transcription factor, PPAR-γ is crucial in functions like fatty acid storage and glucose metabolism. Activation of PPAR-γ promotes lipid uptake and enhances sensitivi

Совпадение в полном тексте источника
… Targeting transcription factors capable of modulating melanogenesis could therefore serve as a potential molecular approach for anticancer therapy [ 227 ]. The contribution of PPAR-γ and its agonists to the regulation of melanogenesis is well documented. … Due to the changes in gene expression and cell metabolism, the outcomes of melanogenesis for melanoma cells treated with PPAR-γ agonists can be opposite. …

Multi-tissue multi-omics integration reveals tissue-specific pathways, gene networks and drug candidates for type 1 diabetes.

AIMS/HYPOTHESIS: Although genome-wide association studies (GWAS) have identified loci associated with type 1 diabetes, the specific pathways … RIG-I)/melanoma differentiation-associated protein 5 (MDA5) induction of interferons, together with melanogenesis, steroid hormone synthesis and iron transport. Network modelling highlighted the autoimmune basis of disease, with KDs such as FYN, TAP1, WAS and HLA-B/C/G, as well as additional immunomodulatory proteins such as LCK, LCP2 and genes such as EMR1 and …

The probable involvement of soluble and deposited melanins, their intermediates and the reactive oxygen side-products in human diseases and aging.

The plasma soluble melanins (PSM) form spontaneously in vitro and in vivo and their formation involves oxidative polymerization and copolyme … lso form from these precursors. Reactive oxygen side products (ROSP) are generated during and after melanogenesis. Melanins in vivo are generally associated with proteins or with proteins and lipids. The PSM-protein-lipid complexes are called plasma soluble lipofuscins (PSL), because they have histochemical and fluorescence properties similar to those of solid …

Lenalidomide Augments Differentiation of Cultured Hair Follicle Derived Melanocyte Stem Cells Into Functional Melanocytes.

IntroductionMelanocyte progenitors are embryonically derived from the neural crest and subsequently get localized in hair follicles and epidermis to provide hair and skin pigmentation. These progenitor cells in hair follicles repeatedly proliferate and differentiate to maintain pigmentation. Vitiligo, a pigmentary disorder, is associated with loss of melanocytes. Repigmentation of vitiligo lesions mainly depends upon the proliferation, migration and differentiation of melanocyte stem cells (MelSCs) into functional melanocytes. The current study is designed to check the efficacy of lenalidomide

Совпадение в полном тексте источника
… SOX10 is one of the key genes which play its role in coordinating melanocyte differentiation by upregulating expression of genes required for melanogenesis [ 30 ]. … TYR initiates the melanogenesis by oxidizing tyrosine to L-DOPA while DCT is required down the pathway in synthesis of melanin [ 31 , 32 ]. …

Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma.

Melanoma is an aggressive form of skin cancer, being one of the deadliest cancers in the world. The current treatment options involve surgery, radiotherapy, targeted therapy, immunotherapy and the use of chemotherapeutic agents. Although the last approach is the most used, the high toxicity and the lack of efficacy in advanced stages of the disease have demanded the search for novel bioactive molecules and/or efficient drug delivery systems. The current review aims to discuss the most recent advances on the elucidation of potential targets for melanoma treatment, such as aquaporin-3 and tyrosi

Совпадение в полном тексте источника
… Tyrosinase as Potential Therapeutic Target in Melanoma Several years ago, researchers began studying a putative connection between melanin biosynthesis and melanoma progression and resistance, as well as the modulation of melanogenesis as antimelanoma therapy [ 49 , 129 ]. … In turn, this excess of pigment (a) protects melanoma cells from radiotherapy; (b) produces melanogenesis intermediates that are selectively toxic towards immune cells; and (c) functions as an antioxidant, counteracting chemotherapy effects [ 49 , 130 ]. …

Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects.

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots - decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological

Совпадение в полном тексте источника
… Lv et al. ( 2007 ) showed that AGN extract acts as hypopigmenting agent in B16 melanoma cells by reducing isobutylmethylxanthine‐induced melanogenesis. … D2, tested at 1–100 μM concentrations, strongly inhibited melanogenesis without any cytotoxicity. …

Vitamin C Transporters and Their Implications in Carcinogenesis.

Vitamin C is implicated in various bodily functions due to its unique properties in redox homeostasis. Moreover, vitamin C also plays a great role in restoring the activity of 2-oxoglutarate and Fe2+ dependent dioxygenases (2-OGDD), which are involved in active DNA demethylation (TET proteins), the demethylation of histones, and hypoxia processes. Therefore, vitamin C may be engaged in the regulation of gene expression or in a hypoxic state. Hence, vitamin C has acquired great interest for its plausible effects on cancer treatment. Since its conceptualization, the role of vitamin C in cancer t

Совпадение в полном тексте источника
… Moreover, in vitro studies indicated that the melanogenesis process induced in melanoma cells may, in fact, be a trigger for an increase in HIF1-α expression [ 122 ]. … The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch. Biochem. Biophys. 2014;563:79–93. doi: 10.1016/j.abb.2014.06.030. 123. Fischer A.P., Miles S.L. …

Мельфаланский змеиный надвенный гиперпигментация с сопутствующим венозным тромбозом.

Serpentin suprevenus гиперпигментация (SSH) — редкая резиновая негативная реакция, характеризующаяся линейной гиперпигментацией вдоль поверхностных вен после внутривенной наркотерапии, чаще всего химиотерапией. Мы сообщаем о редком случае SSH, вызванном мелфаланом, который осложняется поверхностным венозным тромбозом. A 54-year-old человек, лечившийся от светоцепных миэломы, разработал асимптомные серпигинозные гиперпигированные повреждения вдоль поверхностной венозной сети one Через день после внутривенного инъекции мелфала до аутологической трансплантации стволовых клеток. Ten Через нескольк

Совпадение в полном тексте источника
… Discussion Anticancer chemotherapeutic agents can be responsible for skin pigmentation disorders through stimulation of melanogenesis or toxic mechanisms [ 2 ]. Pigmentation may also affect mucous membranes and skin appendages [ 3 ]. …

Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer.

Cancer is one of the most dreadful diseases in the world with a mortality of 9.6 million annually. Despite the advances in diagnosis and treatment during the last couple of decades, it still remains a serious concern due to the limitations associated with currently available cancer management strategies. Therefore, alternative strategies are highly required to overcome these glitches. The importance of medicinal plants as primary healthcare has been well-known from time immemorial against various human diseases, including cancer. Commiphora wightii that belongs to Burseraceae family is one suc

Совпадение в полном тексте источника
… In addition, treatment with GS was shown to inhibit melanogenesis in B16 murine melanoma cells through the reduction of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related protein (TRP-1 and TRP-2). … This compound was also found to suppress melanogenesis induced by α-melanocyte-stimulating hormone and forskolin [ 219 ]. …

The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy.

In this review, we carefully describe the composition and operation of cryptochrome-1 (CRY1). We introduce four related signaling pathways, namely cAMP/PKA/CREB signaling way, HIFα signaling way, NF-κB signaling way, STAT3 signaling way, FOXO signaling pathway and Hedgehog (HH) signaling pathway. We also emphasize the current understanding of the complex roles CRY1 plays in the progression of various solid tumors. We propose that its function represents a novel therapeutic target that could pave the way for new cancer treatments. Additionally, we summarize three emerging therapeutic strategies

Совпадение в полном тексте источника
… By facilitating the temporal modulation of glucagon signaling, this relationship seems to eventually cause the classical cAMP/PKA pathway to phosphorylate CREB, which in turn inhibits melanogenesis (Fig. 2 ) [ 106 , 107 ]. Fig. 2 Mechanism of related signaling pathway . … Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. Front Pharmacol. 2023;14:1081030. 108. Ke Q, Costa M. Hypoxia-Inducible Factor-1 (HIF-1). Mol Pharmacol. 2006;70(5):1469–80. 109. Peng G, Liu Y. …

:: разработка системы запретов на использование кинжалов на основе капсаицина для модуляции взаимодействия киназы A/PHB2 и митофагии в раковых клетках.

A/AURKA — киназа серена/трионина, часто перевоплощающаяся в рак. Недавние открытия указывают на подклеточные пулы АУРКА, в том числе в митохондрии. Там AURKA вызывает расчистку органеллой митофагией вместе с автоматическим посредником LC3 и его рецептором PHB2. Здесь мы показываем, что натуральный продукт капсаицин изменяет взаимодействие AURKA/PHB2. Мы синтезируем 16 Аналоговые аналоги капсаицина и передача энергии/флюоресценция Förster's Energy Transport/Fluorescence Life Time Imageing Microscope (FRET/FLIM) в клетках рака груди показывают, что соединения 12 и 13 :: расширение взаимодействия

Совпадение в полном тексте источника
… Development of fluorizoline analogues as prohibitin ligands that modulate C-RAF signaling, p21 expression and melanogenesis. Eur. J. Med. Chem. 242 , 114635 (2022). 13. Tabti, R. et al. Development of prohibitin ligands against osteoporosis. Eur. J. Med. Chem. 210 , 112961 (2021). 14. … Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. Eur. J. Med. Chem. 155 , 880–888 (2018). 17. Padilla-Parra, S., Audugé, N., Coppey-Moisan, M. & Tramier, M. …

Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer.

Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulati

Совпадение в полном тексте источника
… resveratrol neutralized its effect | [ 129 ] Resveratrol caused proliferative activity in a dose- and time-dependent manner | [ 130 ] Resveratrol inhibited proliferation of myeloma cells in a dose- and time-dependent manner | [ 131 ] Melanoma | Resveratrol treatment inhibited proliferation and promoted melanogenesis … Altogether, the data show that resveratrol suppresses melanoma cell growth while promoting melanogenesis [ 178 ]. …

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-s

Совпадение в полном тексте источника
… Increased tyrosinase activity was observed in hyperpigmentation disorders; conversely downregulation of tyrosinase activity led to melanogenesis inhibition [ 10 , 11 ]. Therefore, inhibition of elastase and tyrosinase is one of the most prominent strategies used to fight skin aging. … Poly-γ-glutamate from Bacillus subtilis inhibits tyrosinase activity and melanogenesis. Appl. Microbiol. Biotechnol. 2013;97:9801–9809. doi: 10.1007/s00253-013-5254-6. 94. Kim K., Leutou A.S., Jeong H., Kim D., Seong C.N., Nam S.-J., Lim K.-M. …

Revealing the pharmacological effects of Remodelin against osteosarcoma based on network pharmacology, acRIP-seq and experimental validation.

Osteosarcoma (OS) is the most common primary malignant tumor of bone. Remodelin, an inhibitor of the N (4)-Acetylcytidine (ac4C) acetylation modifying enzyme N-acetyltransferase 10 (NAT10), has been shown to have therapeutic effects on cancer in several studies, and our previous studies have confirmed the inhibitory effect of Remodelin on OS cells, however, the mechanism of action has not yet been elucidated. We used network pharmacological analysis to quantify the therapeutic targets of Remodelin against OS. acRIP-seq and RNA-seq were performed to investigate the inhibitory activity of Remode

Совпадение в полном тексте источника
… Oh TI Lee YM Lim BO Lim JH Inhibition of NAT10 suppresses melanogenesis and melanoma growth by attenuating microphthalmia-associated transcription factor (MITF) expression Int. J. Mol. Sci. 2017 10.3390/ijms18091924 28880216 PMC5618573 28. …