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Вакцина ДНК оспы, поставляемая новым устройством электропорации кожи, защищает мышей от внутриназального оксивируса.

Ранее мы показали, что экспериментальная вакцина ДНК оспы, состоящая из четырех генов вируса Вакцинии (4покс), управляемых генным пистолетом, вызвала защитный иммунитет у мышей, сталкивающихся с вирусом Вакцинии, и у нечеловеческих приматов, сталкивающихся с вирусом обезьянопокса (Hooper JW, et al. Вакцина ДНК оспы защищает нечеловеческих приматов от смертельной обезьяноксики. J Virol 2004;78:4433-43). Здесь мы сообщаем, что эта 4поксовая вакцина ДНК может быть эффективно доставлена с помощью нового метода, предусматривающего электропорацию кожи с использованием плазмидных массивов микронуклей

Совпадение в аннотации оригинала
Previously, we demonstrated that an experimental smallpox DNA vaccine comprised of four vaccinia virus genes (4pox) administered by gene gun elicited protective immunity in mice challenged with vaccinia virus, and in nonhuman primates challenged with monkeypox virus (Hooper JW, et al. Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox. …

Impact of environmental pollutants Particulate Matter PM2.5, carbon monoxide, nitrogen dioxide and ozone on the incidence of Monkeypox cases. [corrected].

OBJECTIVE: The human monkeypox disease (MPXD), is an emerging zoonotic disease caused by the monkeypox virus. The rapid spread of human monkeypox cases has developed an alarming situation worldwide. This study evaluated the impact of day-to-day air pollutants, particulate matter PM2.5, Carbon monoxide (CO), Nitrogen dioxide (NO2), and Ozone (O3) on the daily incidence of monkeypox cases in New York City, United States of America. MATERIALS AND METHODS: The daily data on air pollutants and monkeypox cases were recorded from May 1, 2022, to August 16, 2022. The everyday concentrations of "PM2.5…

Mpox and the impact on people with HIV.

PURPOSE OF REVIEW: This review explores the intersection of Mpox and HIV, highlighting clinical manifestations, immune evasion mechanisms, epidemiological challenges, and prevention strategies. People with HIV (PWH), particularly those with low CD4 + cell count, face severe Mpox outcomes. Prevention relies on education, vaccination, and early detection. Integrating Mpox management into HIV care systems is vital. RECENT FINDINGS: Since May 2022, Mpox caused by Orthopoxvirus monkeypox (MPV) Clade IIb, has affected 126 countries. In 2024, Clade Ib emerged in the Democratic Republic of Congo, lea

GenomeBits Characterization of MPXV.

Genome sequences of the monkeypox virus (MPXV) causing the current outbreak are being reported from an increasing number of countries. We present a letter-to-numerical sequence study via GenomeBits signal mapping in order to characterize the evolution of the MPXV via simple statistical analysis. Histograms, empirical and theoretical cumulative distribution curves and the resulting scatter plots for the base nucleotides A and C versus their complementary base nucleotides T and G are discussed. GenomeBits may help the surveillance of emergent infectious diseases.

Monkeypox: A New Threat?

The global vaccination programme against smallpox led to its successful eradication and averted millions of deaths. Monkeypox virus (MPXV) is a close relative of the Variola (smallpox) virus. Due to antigenic similarity, smallpox vaccines cross-protect against MPXV. However, over 70% of people living today were never vaccinated against smallpox. Symptoms of monkeypox (MPX) include fever, head- and muscle ache, lymphadenopathy and a characteristic rash that develops into papules, vesicles and pustules which eventually scab over and heal. MPX is less often fatal (case fatality rates range from <…

Electron-microscopical observations on the development of vaccinia, cowpox and monkeypox viruses in pig skin.

Multiformal abnormal configurations of virus particles and virus factories were observed in pig skin inoculated with vaccinia, cowpox and monkeypox viruses. The discussion is based on the data of multiplication of the viruses and production of circulating antibody.

Assessment of the knowledge of healthcare workers on monkeypox in Nigeria.

BACKGROUND: Monkeypox, a re-emerging zoonotic disease caused by the monkeypox virus (MPXV), poses a public health challenge in Nigeria. To effectively combat this disease, it is essential to assess the knowledge of healthcare workers (HCWs) in Nigeria concerning monkeypox outbreak. METHODS: A cross-sectional web-based survey with 609 healthcare workers in Nigeria was conducted using a structured questionnaire to assess their knowledge of monkeypox. Data were coded and analyzed with Microsoft Excel and Python in Anaconda Jupyter Notebook. RESULTS: The majority of respondents (n=318, 52.2%) ha…