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Multidisciplinary Collaboration for the Optimization of Antibiotic Prescription: Analysis of Clinical Cases of Pneumonia between Emergency, Internal Medicine, and Pharmacy Services.

BACKGROUND: Pneumonia is a lung parenchyma acute infection usually treated with antibiotics. Increasing bacterial resistances force the revi … was made by the research team (professionals from the emergency department, internal medicine, and pharmacy services). RESULTS: Fifty-five medical records were reviewed. The adequacy of the treatments showed that antibiotic indication, time of administration of the first dose, and monitoring of efficacy and adverse effects were the items with the greates …

Impact of the Neck and/or Shoulder Pain on Self-reported Headache Treatment Responses - Results From a Pharmacy-Based Patient Survey.

Neck and/or shoulder pain (NSP) frequently occurs together with headache. Therefore, we explored how patients with and without concomitant NSP differ in their baseline characteristics and in perceived treatment responses to an analgesic. An anonymous survey was performed among 895 patients with headache (735 self-reported tension-type headache [TTH]) who used an analgesic fixed-dose combination containing 400 mg ibuprofen and 100 mg caffeine as a non-prescription treatment. NSP was abundant among patients in our survey (60%) and was associated with >1 additional day of headache per month. Pati

POSC374 Association of COVID-19 on Adherence to Oral Specialty Pharmacy Oncology Medications and Quality of Life of Multiple Myeloma Patients

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… There are two Objectives: that characterize how the P may be associated with changes in: 1. adherence to specialty pharmacy MM medications (O-SP-D) and 2. MM patient-reported quality of life (QoL). …

Survival implications of prescription opioid and benzodiazepine use in lung transplant recipients: Analysis of linked transplant registry and pharmacy fill records.

BACKGROUND: Prescription opioid and benzodiazepine use have been associated with morbidity and mortality among some groups of solid organ transplant recipients, but implications for outcomes among lung transplant patients are not well described. METHODS: We conducted a retrospective cohort study using linked national transplant registry and pharmaceutical records to characterize the associations between benzodiazepine and opioid prescription fills in the years before and after lung transplant (2006-2017), with risk-adjusted posttransplant survival (adjusted hazard ratio, LCLaHRUCL). RESULTS:

Factors influencing series completion rates of recombinant herpes zoster vaccine in the United States: A retrospective pharmacy and medical claims analysis.

BACKGROUND/OBJECTIVES: Vaccination against herpes zoster (HZ) is an effective strategy in protecting the population against consequences of … 50 years and to evaluate factors influencing completion rates. METHODS: Longitudinal, open-source pharmacy and medical claims databases were analyzed for adults aged at least 50 years with a first RZV prescription filled between October 2017 and September 2019. The data were linked to Experian Marketing Services Consumer View data to obtain information r …

Cancer, immune suppression and Coronavirus Disease-19 (COVID-19): Need to manage drug safety (French Society for Oncology Pharmacy [SFPO] guidelines).

The Coronavirus disease (COVID-19) pandemic is disrupting our health environment. As expected, studies highlighted the great susceptibility … n cancer patients, most of whom are immunocompromised. In addition cancer patients are prone to polypharmacy, enhancing the risk of drug-related problems as adverse events and drug-drug interactions. Due to increased risk in case of COVID-19, we reported a comprehensive review of all the drug-related problems between COVID-19 and antineoplastics. Moreover, …

Clinical outcomes associated with pathogenic genomic instability mutations in prostate cancer: a retrospective analysis of US pharmacy and medical claims data.

Background: Prostate cancer (PC) is a clinically heterogenous disease, and genetic mutations may be useful for patient risk stratification. This retrospective cohort study compared clinical outcomes, pharmacy use, and outpatient resource use in PC patients with and without pathogenic genomic instability mutations, including DNA repair deficiency (DRD) mutations and those in TP53, PTEN, and RB1. Methods: Patients ≥18 years newly-diagnosed with PC between June 2011-March 2016 were identified in medical and prescription claims databases linked to a genomic dataset. All-cause and PC-specific pharm…

Associations of obesity with antidiabetic medication use after living kidney donation: An analysis of linked national registry and pharmacy fill records.

We examined a novel linkage of national US donor registry data with records from a pharmacy claims warehouse (2007-2016) to examine associations (adjusted hazard ratio, LCL aHRUCL ) of post-donation fills of antidiabetic medications (ADM, insulin or non-insulin agents) with body mass index (BMI) at donation and other demographic and clinical factors. In 28 515 living kidney donors (LKDs), incidence of ADM use at 9 years rose in a graded manner with higher baseline BMI: underweight, 0.9%; normal weight, 2.1%; overweight, 3.5%; obese, 8.5%. Obesity was associated with higher risk of ADM use comp…

Pharmacy workers in Nepal can provide the correct information about using mifepristone and misoprostol to women seeking medication to induce abortion.

In Nepal, despite policy restrictions, both registered and unregistered brands of mifepristone and misoprostol can easily be obtained at pharmacies. Since many women visit pharmacies for abortion information, ensuring that they receive effective care from pharmacy workers remains an important challenge. We conducted an operations research study to examine whether trained pharmacy workers can correctly provide information on safe use of mifepristone and misoprostol for early first trimester medical abortion. Pharmacy workers in one district were given orientation and training using a harm-reduc…

Nature and frequency of drug-related problems in self-medication (over-the-counter drugs) in daily community pharmacy practice in Germany.

PURPOSE: To quantify drug-related problems (DRPs) in self-medication (over-the-counter [OTC] drug use) identified by community pharmacists (CPs) in Germany at the time the drug is dispensed. METHODS: One hundred CPs were asked to document 100 consecutive customers presenting symptoms or requesting OTC drugs using a standardized documentation form. The number of 10,000 encounters seemed reasonable to evaluate the set objective. For each encounter, data such as age, sex, and first or repeated request and the availability of a patient file in the pharmacy including drug history were documented. …

In defence of the drug, two hearts, one profession: Reintegrating medicines expertise and patient-centred care in pharmacy's professional identity.

For more than three decades, pharmacy has narrated its evolution as a movement away from the product and toward the patient. The pharmaceutical care era ushered in by Hepler and Strand in 1990 framed dispensing and product expertise as a chrysalis the profession needed to shed in order to mature. That framing has been useful, but it has also been misread, and the misreading has now been institutionalised. Some accreditation councils, regulatory and licensing bodies, and advocacy bodies have positioned the profession as one moving away from a so-called "product centric" past. The thesis of this…

Tiered diagnosis and value-based healthcare: can the outpatient reimbursement policy for medical costs in retail pharmacies promote both?

BACKGROUND: Amid growing health demands and tight welfare budgets, guiding rational healthcare-seeking behavior to improve health while controlling costs has become a global challenge. This study aims to examine whether the reform of medical insurance on the cost-sharing of pharmacy can promote tiered diagnosis and value-based healthcare. METHODS: Using 2011-2018 China Health and Retirement Longitudinal Study data and the Staggered DID method, this paper estimates the effects of the Retail Pharmacies Outpatient Reimbursement (RPOR) reform in the Urban Employee Basic Medical Insurance (UEBMI).…

[Development of an Innovative Training Tool for Inhalers - Inhalation training for patients in practices, hospitals and pharmacies during times of climate change].

BACKGROUND: Cornerstones of inhalation therapy are training in the correct use of inhalers and selecting the most suitable method of administration. At the same time, guidelines call for participatory therapy decisions and, increasingly, consideration of ecological impacts. METHODS: As part of a 12-month pilot study a practical training tool was developed at the Hospital Havelhöhe in Germany. The tool uses a visual traffic-light system to integrate technique, equipment suitability, sustainability, and climate impacts. The material was iteratively revised in 49 group training sessions (n = 145

Antimicrobial stewardship: coming to a community pharmacy near you? A cross-sectional study to understand the perspectives of pharmacists, prescribers and the public.

This survey of the public, pharmacists, and other healthcare professionals identified factors affecting implementation of antibiotic stewardship in Canadian community pharmacies. Lack of support from non-pharmacist healthcare providers and pharmacy leadership were common barriers. Facilitators included providers' perceived importance of antibiotic stewardship, pharmacists' role as educators, and potential for healthcare cost savings.

Optimizing drug delivery in smart pharmacies: a novel framework of multi-stage grasping network combined with adaptive robotics mechanism.

Robotic drug grasping in complex smart pharmacy environments requires accurate detection and efficient execution, yet existing methods struggle with clutter, overlapping, and small target objects. To improve robotic grasping of chaotic and variably shaped drugs, we propose a novel multi-stage framework that integrates enhanced perception, grasp detection, and trajectory planning. First, images are preprocessed with an improved Super-Resolution Convolutional Neural Network (SRCNN) to enhance input quality. Next, drug segmentation is performed using our YOLO-EASB instance segmentation algorithm …

Trends and Contributing Factors in Medication Home Delivery Incidents in Community Pharmacies Before and After COVID-19: A Retrospective Analysis.

This study examines medication home delivery incidents reported in community pharmacies before and after the onset of the COVID-19 pandemic. Medication home delivery incidents are defined as medication errors that occur during the transportation of medication to patients outside the pharmacy through shipping, courier, or pharmacy delivery services. The objective was to analyze trends over time and identify contributing factors to inform patient safety improvements. A retrospective analysis was conducted on medication home delivery incidents reported to a national Community Pharmacy Incident Re…

Experiences of people who inject drugs with hepatitis C testing and their perceptions of a pharmacy-based testing option: a qualitative study.

BACKGROUND: People who inject drugs (PWID) are at high risk of acquiring hepatitis C virus (HCV) infection, yet many remain undiagnosed due to testing barriers. Pharmacy-based point-of-care testing could improve access; however, little is known about its acceptability among PWID. AIM: To explore the experiences of PWID with HCV testing and their perceptions of a pharmacy-based HCV testing option. METHOD: A qualitative study involving interviews with eleven PWID between June and August 2022. Participants were asked about their perceptions and experiences about HCV testing as well as their vie…

Barriers and facilitators to implementing a brief tobacco cessation intervention during vaccine administration in community pharmacies: A mixed-methods study.

OBJECTIVE: This study describes the implementation of a brief tobacco cessation intervention (Ask, Advise, Refer: AAR) into routine vaccination workflows. METHODS: Using a convergent mixed methods approach, data were collected from 10 community pharmacies in (independent, hospital outpatient, and chain locations) via electronic documentation during vaccine administration and semi-structured interviews with pharmacy staff. The Consolidated Framework for Implementation Research served as a framework to guide qualitative interview coding and analyses, and quantitative data were analyzed descript…

Implementation of Medication Disposal Programs and Availability of Same-Day Naloxone at Community Pharmacies: Protocol for a Secret Shopper Caller Approach.

BACKGROUND: Pharmacies can implement multiple strategies, including medication disposal programs (eg, disposal boxes, deactivation products, … racteristics are associated with nonmedical opioid use and overdose. It is essential to ensure that pharmacy-based overdose prevention practices are widely available to all individuals. OBJECTIVE: : This study aims to assess the extent to which disposal programs and same-day naloxone have been implemented in pharmacies across the United States and examine …

Best practices to reduce microbial contamination during media-fill testing process in hospital pharmacies: a scoping review of literature.

UNLABELLED: The Media-Fill Test is a crucial procedure in the pharmaceutical industry, especially for the production of sterile drugs that do not undergo terminal sterilization (meaning they are prepared directly under aseptic conditions).The primary goal of the Media-Fill Test is to evaluate the overall effectiveness of the aseptic process in preventing microbial contamination. It doesn't serve to test the sterility of an individual production batch, but rather to: Validate the aseptic process, Qualify personnel, Identify critical points and Verify the environment. The aim of this scoping rev