Результаты поиска

Pharmacological treatment options for mast cell activation disease.

Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated MCs due to MC proliferation (systemic mastocytosis [SM] and MC leukemia [MCL]) or morphologically ordinary MCs due to decreased apoptosis (MC activation syndrome [MCAS] and well-differentiated SM). Clinical signs and symptoms in MCAD vary depending on disease subtype and result from excessive mediator release by MC

Совпадение в полном тексте источника
… CRTH2 X Harvima et al. 2014 R Proteases inhibitors Tryptase, chymase, cathepsins, carboxypeptidase X Human and murine MCs Mice Caughey 2016 R Harvima et al. 2014 R Rapamycin mTOR pathway inhibitor X HMC-1 Chan et al. 2013 RNAi RNA interference against KIT RNA X HMC-1 Ruano et al. 2010 Rosiglitazone, pioglitazone … | Tryptase, chymase, cathepsins, carboxypeptidase | | | X | Human and murine MCs | Mice | Caughey 2016 R Harvima et al. 2014 R Rapamycin | mTOR pathway inhibitor | X | | | HMC-1 | | Chan et al. 2013 RNAi | RNA interference against KIT RNA | X | | | HMC-1 | | Ruano et al. 2010 Rosiglitazone, pioglitazone …

A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2021.

The second year of the COVID-19 pandemic had no adverse effect on the number of new drug approvals by the US Food and Drug Administration (FDA). Quite the contrary, with a total of 50 new drugs, 2021 belongs to the most successful FDA years. We assign these new drugs to one of three levels of innovation: (1) first drug against a condition ("first-in-indication"), (2) first drug using a novel molecular mechanism ("first-in-class"), and (3) "next-in-class", i.e., a drug using an already exploited molecular mechanism. We identify 21 first-in-class, 28 next-in-class, and only one first-in-indicati

Совпадение в полном тексте источника
… Comparative analysis of aducanumab, zagotenemab and pioglitazone as targeted treatment strategies for Alzheimer's disease. Aging Dis. 2021;12:1964–1976. doi: 10.14336/AD.2021.0719. Agarwal R, Kolkhof P, Bakris G, Bauersachs J, Haller H, Wada T, Zannad F. …

К лечению множественных склерозов

Множественный склероз (MS) является воспалительным и демиелинизирующим заболеванием центральной нервной системы (CNS). У большинства пациентов болезнь начинается с острого наступления, за которым следует этап ремиссии, последующие рецидивы и позднее переход к устойчивой хронической прогрессии. В меньшинстве пациентов эта постепенная фаза развивается с самого начала. Для рецидивов MS характерно в основном деновое образование побочного повреждения CNS и инфильтрация иммунных клеток, в то время как патологические особенности MS прогрессирования включают медленно расширяющиеся повреждения, глобаль

Совпадение в полном тексте источника
… Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis JAMA Neurol. 2016 73 520 528 10.1001/jamaneurol.2015.4807 26953870 67. Cho Y. Crichlow G.V. Vermeire J.J. Leng L. Du X. Hodsdon M.E. Bucala R. Cappello M. Gross M. Gaeta F. …

Targeting fibrosis, mechanisms and cilinical trials.

Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated wound and connective tissue repair response. Multiple organs can develop fibrosis, including the liver, kidney, heart, and lung. Fibrosis such as liver cirrhosis, idiopathic pulmonary fibrosis, and cystic fibrosis caused substantial disease burden. Persistent abnormal activation of myofibroblasts mediated by various signals, such as transforming growth factor, platelet-derived growth factor, and fibroblast growh factor, has been recongized as a major event in the occurrence and progression of fibrosi

Совпадение в полном тексте источника
… Terminated 1778 Galectin Galectin-3 Belapectin NASH III NCT04365868 Recruiting 1010 Galectin-3 GB1211 NASH II NCT04607655 withdrawn 0 Galectin-3 GB0139 IPF II NCT03832946 Active, not recruiting 426 MPC MPC Azemiglitazone potassium NASH III NCT03970031 Active, not recruiting 1800 MPC Deuterium-Stabilized (R)-Pioglitazone … NCT04365868 | Recruiting | 1010 | Galectin-3 | GB1211 | NASH | II | NCT04607655 | withdrawn | 0 | Galectin-3 | GB0139 | IPF | II | NCT03832946 | Active, not recruiting | 426 MPC | MPC | Azemiglitazone potassium | NASH | III | NCT03970031 | Active, not recruiting | 1800 | MPC | Deuterium-Stabilized (R)-Pioglitazone …

Metronomic Chemotherapy: A Systematic Review of the Literature and Clinical Experience.

Metronomic chemotherapy, continuous and dose-dense administration of chemotherapeutic drugs with lowered doses, is being evaluated for substituting, augmenting, or appending conventional maximum tolerated dose regimens, with preclinical and clinical studies for the past few decades. To date, the principle mechanisms of its action include impeding tumoral angiogenesis and modulation of hosts' immune system, affecting directly tumor cells, their progenitors, and neighboring stromal cells. Its better toxicity profile, lower cost, and easier use are main advantages over conventional therapies. The

Совпадение в полном тексте источника
… Another study used etoricoxib plus pioglitazone daily, with low-dose interferon three times a week and capecitabine twice daily orally for 4 days, every 3 weeks. Median OS and PFS for the total cohort were 26.9 and 7.2 months, respectively. Grade 4 toxicity was seen in 48.8% [ 173 ]. …

Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.

Rhabdomyolysis (RML), characterized by the breakdown of skeletal muscle fibers and the release of muscle contents into the bloodstream, has emerged as a notable complication associated with Coronavirus disease 2019 (COVID-19) infection and vaccination. Studies have reported an increased incidence of RML in individuals with severe COVID-19 infection. However, the exact mechanisms remain unclear and are believed to involve the host's immune response to the virus. Furthermore, RML has been documented as a rare adverse event following COVID-19 vaccination, particularly with mRNA vaccines. Proposed

Совпадение в полном тексте источника
… . | ( 50 ) Chetram et al. (2021) | A 62-year-old male with hypertension, morbid obesity (BMI of 39.6), and T2DM, on Aspirin, Glargine, Hydrochlorothiazide-Lisinopril, Pioglitazone, and Simvastatin, presented with malaise, poor appetite, oliguria, and hematuria. …

Immunotherapeutic approaches for systemic lupus erythematosus: early overview and future potential.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Current SLE therapies include immunosuppressants, antimalarial drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, but these treatments can cause substantial toxicities to organs and may not be effective for all patients. In recent years, significant progress has been made in the treatment of SLE using immunotherapy, including Benlysta and Saphnelo. These advances in immunotherapy hold promise for SLE patients, providing new therapeutic options that may offer better clinical benefit and effectiveness. S

Совпадение в полном тексте источника
… Mohammadi S Saghaeian-Jazi M Sedighi S Memarian A Immunomodulation in systemic lupus erythematosus: induction of M2 population in monocyte-derived macrophages by pioglitazone Lupus 2017 26 1318 27 10.1177/0961203317701842 28457196 9. …

Insulin Resistance at the Crossroads of Metabolic Inflammation, Cardiovascular Disease, Organ Failure and Cancer.

Insulin resistance (IR) describes impaired hormone signaling that triggers compensatory homeostatic responses resulting in hyperinsulinemia, increased accumulation of fatty substrates, lipotoxicity, oxidative stress, inflammation, cell death and fibrosis in target tissues. These processes ultimately lead to organ dysfunction and predispose certain individuals to various types of cancer. In this context, we will review the molecular pathogenesis and clinical significance of IR, its role in 'metaflammation', and the damage caused by IR in the pancreas, cardiovascular system, liver, and kidneys.

Совпадение в полном тексте источника
… One drug in this class, pioglitazone, has been shown to reduce cardiovascular events and slow the atherosclerotic process in high-risk patients with T2D [ 122 ]. …

Mechanisms of chemotherapy-induced behavioral toxicities.

While chemotherapeutic agents have yielded relative success in the treatment of cancer, patients are often plagued with unwanted and even debilitating side-effects from the treatment which can lead to dose reduction or even cessation of treatment. Common side effects (symptoms) of chemotherapy include (i) cognitive deficiencies such as problems with attention, memory and executive functioning; (ii) fatigue and motivational deficit; and (iii) neuropathy. These symptoms often develop during treatment but can remain even after cessation of chemotherapy, severely impacting long-term quality of lif

АКНП 60th Ежегодное совещание: выдержки из плакатов P276 - P550.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Mesenchymal stem cells: A new therapeutic tool for chronic kidney disease.

Chronic kidney disease (CKD) has a major impact on public health, which could progress to end-stage kidney disease (ESRD) and consume many medical resources. Currently, the treatment for CKD has many flaws, so more effective treatment tools are urgently required for CKD. Mesenchymal stem cells (MSCs) are primitive cells with self-renewal and proliferation capacity and differentiation potential. Extensive preclinical and clinical data has shown that cell-based therapies using MSCs can modulate immunity, inhibit inflammatory factors, and improve renal function in CKD, suggesting that MSCs have t

Совпадение в полном тексте источника
… Potential treatments for ADPKD include tolvaptan, octreotide, cystic fibrosis transmembrane conductance regulator protein (CFTR) inhibitors, pioglitazone, etanercept, and triptolide ( Patel et al., 2009 ). …

Pharmaceutical Prevention and Management of Cardiotoxicity in Hematological Malignancies.

Modern treatment modalities in hematology have improved clinical outcomes of patients with hematological malignancies. Nevertheless, many new or conventional anticancer drugs affect the cardiovascular system, resulting in various cardiac disorders, including left ventricular dysfunction, heart failure, arterial hypertension, myocardial ischemia, cardiac rhythm disturbances, and QTc prolongation on electrocardiograms. As these complications may jeopardize the significantly improved outcome of modern anticancer therapies, it is crucial to become familiar with all aspects of cardiotoxicity and pr

Совпадение в полном тексте источника
… Anti-Inflammatory and Antioxidants Agents Anti-inflammatory agents, such as colchicine, dexamethasone, pioglitazone, and non-steroidal inflammatory drugs, as well as antioxidants agents such as pentoxifylline combined with α-tocopherol, melatonin and amifostine, decrease myocardial fibrosis and exert …

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

Совпадение в полном тексте источника
… months), gonadotropin releasing hormone agonists and antagonists, Depot medroxyprogesterone acetate (Depo-provera), Methotrexate, parenteral nutrition, proton pump inhibitors, selective serotonin reuptake inhibitors, Tamoxifen (premenopausal use for breast cancer treatment), thiazolidinediones (such as pioglitazone …

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity.

Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two. The deficiency of Nrf2 elevates the expression of NF-κB, leading to increased production of inflammatory factors, while NF-κB can affect the expression of downstream target genes by regulating the transcription and activity of Nrf2. At the same time, many therapeutic drug-induced organ toxicities, including hepatotoxicity, nephrotoxicity, cardiotoxicity, pulmonary toxicity, dermal toxicity, and neurotoxi

Совпадение в полном тексте источника
… et al. (2020) , Li et al. (2014b) , Hou et al. (2018) Panax notoginseng saponins | • Inducing phase I/II detoxification enzyme via Nrf2 pathway to increasing metabolic conversion Sulforaphane; Catalpol | • Restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway Polygonum multiflorum | Pioglitazone …

Фитогормонная абсциозная кислота усиливает ремиелионацию в мышиных моделях множественного склероза.

ВВЕДЕНИЕ: За последние несколько десятилетий в западных странах произошел внезапный рост числа случаев множественного склероза (МС). Однако нынешние методы лечения часто демонстрируют ограниченную эффективность у некоторых пациентов и связаны с неблагоприятными последствиями, что подчеркивает необходимость более безопасных и эффективных терапевтических подходов. Было отмечено, что важную роль в развитии НР играют экологические факторы, в частности привычки питания. В этом исследовании мы первыми исследуем потенциальное защитное воздействие гибридной кислоты (ABA) в MS. АБА, которая изобилие вс

Совпадение в полном тексте источника
… Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice. Cell Death Dis. (2012) 3:e448. doi: 10.1038/cddis.2012.189 92. Loix M, Wouters E, Vanherle S, Dehairs J, McManaman JL, Kemps H, et al. …

Role of mitochondria in physiological activities, diseases, and therapy.

Mitochondria are generally considered essential for life in eukaryotic organisms because they produce most of the energy or adenosine triphosphate (ATP) needed by the cell. Beyond energy production, it is now widely accepted that mitochondria also play a pivotal role in maintaining cellular homeostasis and signaling. The two core processes of mitochondrial dynamics, fission and fusion, serve as crucial foundations for maintaining mitochondrial morphology, distribution, and quantity, thereby ensuring cellular homeostasis. Mitochondrial autophagy (mitophagy) ensures the selective degradation of

The Multifaceted Nature of GLP-1: Molecular Mechanisms and Signaling Pathways in Metabolic and Neurodegenerative Diseases.

The aim of this article is to present the current state of knowledge regarding the use of GLP-1 agonists in the treatment of type 2 diabetes, obesity, and other potential clinical indications, including neurodegenerative conditions. The article describes the characteristics of the diseases discussed, with particular emphasis on the pathophysiological mechanisms and the impact of metabolic disorders on the course of the diseases. In addition, the specific role of GLP-1 receptor agonists and their mechanisms of action leading to improved clinical outcomes were discussed, including their impact o

Совпадение в полном тексте источника
… should be considered in patients with type 2 diabetes and metabolic syndrome-associated steatohepatitis (MASLD), especially in those who are overweight or obese, as well as in patients with confirmed or high risk of metabolic-associated hepatitis (MASH), both as monotherapy and in combination with pioglitazone …

The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a

Mechanisms, Mediators, and Moderators of the Effects of Exercise on Chemotherapy-Induced Peripheral Neuropathy.

Chemotherapy-induced peripheral neuropathy (CIPN) is an adverse effect of neurotoxic antineoplastic agents commonly used to treat cancer. Patients with CIPN experience debilitating signs and symptoms, such as combinations of tingling, numbness, pain, and cramping in the hands and feet that inhibit their daily function. Among the limited prevention and treatment options for CIPN, exercise has emerged as a promising new intervention that has been investigated in approximately two dozen clinical trials to date. As additional studies test and suggest the efficacy of exercise in treating CIPN, it i

Совпадение в полном тексте источника
… Pioglitazone, a PPARgamma agonist, reduces cisplatin-evoked neuropathic pain by protecting against oxidative stress. Pain. 2019;160:688–701. doi: 10.1097/j.pain.0000000000001448. 95. Zheng H., Xiao W.H., Bennett G.J. Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy. Exp. …

Unraveling Obesity and Multiple Myeloma: Insights from Epidemiology and Molecular Mechanisms.

Purpose of reviewThe global incidence of obesity has risen dramatically in recent decades, with consequent detrimental health effects. Extensive studies have demonstrated that obesity significantly affects the risk, prognosis, and progression of various cancers, including multiple myeloma (MM). As an established modifiable risk factor for both MM and its precursor stages -monoclonal gammopathy of unknown significance (MGUS) and smoldering MM (SMM)- the association between obesity and disease onset has become a compelling area of research. This review presents a comprehensive overview of the cu

Совпадение в полном тексте источника
… Among them, PPARγ agonists—specifically thiazolidinediones such as pioglitazone, rosiglitazone, and troglitazone—are commonly utilized to improve insulin sensitivity and control blood glucose levels in affected patients [ 214 ]. …