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Pediatric Psoriasis: A Peek into the Comorbidity Profile.

BACKGROUND: Psoriasis is a multifactorial immune-mediated inflammatory disorder in which the involvement of the skin is merely the tip of the iceberg. It poses a significant global problem affecting both children and adults, with childhood onset occurring in almost one-third of the cases. Early diagnosis of pediatric psoriasis is crucial to address, identify, and manage the growing list of established extracutaneous manifestations and comorbidities. AIMS AND OBJECTIVES: To study the clinico-epidemiological profile of pediatric psoriasis and determine the prevalence of various comorbidities as…

Ocular Manifestations of Psoriasis: A Systematic Review.

PURPOSE: Psoriasis, a chronic inflammatory skin disease, manifests itself by an array of immunological and inflammatory alterations. Ocular involvement can occur through a variety of pathways, notably direct interaction with psoriatic plaques or psoriasis-associated inflammatory responses. The present systematic review was intended to more effectively comprehend and describe the prevalent nature of psoriasis ocular symptoms by tracking all relevant studies published over the last decade and carefully synthesizing their findings. METHODS: This systematic review was performed by the Preferred R…

Is erectile dysfunction genetically associated with psoriasis?

BACKGROUND: The association between psoriasis and erectile dysfunction (ED) is currently inconsistent in epidemiological and observational studies and the causal relationship between them has not been established. The aim of our study is to explore the potential genetic association between ED and psoriasis. METHODS: We explored the putative causality between psoriasis and ED by bidirectional Mendelian randomization (MR). The single nucleotide polymorphisms (SNPs) associated with psoriasis were retrieved from a large-scale public genome-wide association study (GWAS). The summary statistics of …

The Role of Epigenetic Factors in the Pathogenesis of Psoriasis.

Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histocompatibility complex. Genome-wide association studies have made it possible to link psoriasis to genes and therefore to epigenetics. The acquired knowledge may in the future …

Managing the Patient with Psoriasis and Metabolic Comorbidities.

Epidemiological data demonstrate strong associations between psoriasis and metabolic comorbidities, including obesity, hypertension, diabetes mellitus, dyslipidemia, and non-alcoholic fatty liver disease. The presence of metabolic comorbidities significantly influences the selection and effectiveness of pharmacological treatments. Some drugs should be prescribed with caution in patients with metabolic comorbidities because of an increased risk of adverse events, while others could have a reduced effectiveness. The aim of this narrative review is to highlight the challenges that healthcare prof…

Preclinical techniques for drug discovery in psoriasis.

Psoriasis is a chronic, inflammatory, papulosquamous, noncontagious disease characterized by scaly, demarcated erythematous plaque, affecting skin, nails, and scalp. The IL-23/Th17 axis is the main operator in the development of psoriasis. Psoriasis is affecting worldwide, and new treatment options are urgently needed. Various local and systemic treatments are available for psoriasis but they only provide symptomatic relief because of numerous unknown mechanisms. Clinical trials demand overwhelming resources; therefore, drug development predominantly depends on the in-vivo, in-vitro, and ex-vi…

Electrostimulation: A Promising New Treatment for Psoriasis.

Psoriasis is a chronic inflammatory skin disease caused by abnormal activation and immune system disorder. Despite the availability of several treatments, they only provide temporary relief, and there is a critical need for more effective therapies to manage this condition. Electrostimulation has been widely used as a physical stimulus in treating various diseases, and recent studies have shown its potential in psoriasis treatment. In this review, we explore the direct and indirect effects of electrostimulation in treating psoriasis and their underlying mechanisms (the decreased secretion of i…

Evaluation of Audiovestibular Involvement in Patients with Psoriasis.

BACKGROUND: Little is known about audiovestibular function in psoriasis, a chronic systemic inflammatory disease that affects 2% of the world's population. OBJECTIVES: To investigate audiovestibular function in patients with psoriasis. METHODS: In this prospective case-control trial, we enrolled 33 patients with psoriasis and 30 healthy controls. Audiologic testing included audiometry, tympanometry, and otoacoustic emissions recording. The vestibular investigation consisted of a dizziness handicap inventory questionnaire, a complete clinical vestibular examination, and video head impulse tes…

Predictors of initiating biologics in the treatment of psoriasis.

BACKGROUND: Biologics are among the most effective therapies for psoriasis. However, many patients are only introduced to them at advanced stages of the disease course. OBJECTIVES: Our aim was to identify predictors of initiating biologic therapy in patients with psoriasis and compare patients initiating biologics early versus late in their disease course. METHODS: Kaplan-Meier curves visualized time to biologic initiation, while Cox regression models further explored variables as predictors of biologic initiation. Mann-Whitney U and chi-squared tests compared patients who started biologics …

mTORC1 and mTORC2 Levels in Patients with Psoriasis.

INTRODUCTION: In recent years, there has been a growing emphasis on the role of the mammalian target of rapamycin (mTOR) pathway in the pathogenesis of psoriasis. This intracellular signaling pathway is known as the main control pathway of metabolism and is of particular interest in this context. OBJECTIVES: To investigate the importance of the mTOR pathway in the pathogenesis of plaque psoriasis. METHODS: A total of forty patients with plaque psoriasis and 40 non-psoriatic volunteers were included in this case-control study. The fasting serum levels of mTORC1 and mTORC2 in the study groups …

The Immunology of Psoriasis-Current Concepts in Pathogenesis.

Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-remitting course. The last decades of intense research uncovered a pathological network of interactions between immune cells and other types of cells in the pathogenesis of psoriasis. Emerging evidence indicates that dendritic cells, TH17 cells, and keratinocytes constitute a pathogenic triad in psoriasis. Dendritic cells produce TNF-α and IL-23 to promote T cell differentiation toward TH17 cells that produce key psoriatic cytokines IL-17, IFN-γ, and IL-22. Their activity results in skin inflammation and a…

Subclinical Enthesopathy in Psoriasis-An Ultrasonographic Study.

The present study is aimed at assessing the presence and prevalence of subclinical entheseal changes in Psoriasis (PsO) patients using musculoskeletal ultrasonography (US), conjoined with the analysis of possible differences in terms of demographic, clinical, or biological features. We carried out an observational study on 54 patients with PsO and 40 controls. Subclinical enthesopathy, according to OMERACT definitions, was identified in 20 of the psoriasis patients (37.03%), a significantly difference compared to the controls (5 patients; 10.20%). A comparison between US examinations for psori…

Umbilical psoriasis is not relevant to psoriatic arthritis.

Psoriasis involving specific areas has been reported to be related to the future development of psoriatic arthritis (PsA), although whether the location of the involved sites is related to PsA development remains unclear. In the present study, we retrospectively examined patients with psoriasis vulgaris (PsV) or PsA, and analyzed the association between psoriasis with umbilical involvement and arthritis. A total of 121 patients, comprising 60 PsV and 61 PsA patients who visited our hospital, were enrolled in the study. We compared the prevalence of umbilical lesions between the PsV and PsA gro…

Множественность в псориазисе вульгарис: ретроспективный анализ.

Частота комбинаций у пациентов с псориазом была сопоставлена с частотой, характерной для населения в целом, во многих исследованиях. Кроме того, в ряде исследований были изучены факторы риска, влияющие на количество коморбидов у пациентов с псориазом. Однако в нескольких исследованиях были изучены группы пациентов с псориазом в зависимости от их соперничества. В этом исследовании мы стремились изучить многосопоставимость псориазиса вульгариса с точки зрения факторов риска и кластеров. МЕТОДЫ: Все диагнозы 452 Пациенты с псориазным вульгарисом были извлечены из электронных медицинских записей т

Совпадение в аннотации оригинала
BACKGROUND: The frequencies of comorbidities in patients with psoriasis have been compared to that in the general population in many studies. Moreover, several studies have investigated the risk factors influencing the number of comorbidities in patients with psoriasis. However, a few studies have examined clusters of patients with psoriasis according to the…