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Brain heterotopia in pharyngeal region. A morphological and immunohistochemical study.

Pharyngeal brain heterotopia is a congenital and generally biologically benign lesion. In contrast to brain heterotopia in the nose, the mos … s in the remaining areas (glial fibrillary acidic protein, neuron-specific enolase, neurofilaments, synaptophysin, and S-100 positive). This case report confirms that the presence of choroid plexus is not uncommon and that pharyngeal brain heterotopia is usually benign.

Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3.

Regulatory proteins have been identified in embryonic development of the endocrine pancreas. It is unknown whether these factors can also pl … ds Dll1 and Dll4 and neuroendocrine- and beta-cell-specific markers: it increased the percentage of synaptophysin- and insulin-positive cells 15-fold in ngn3-infected versus control cells. Infection with NeuroD/beta2 (a downstream target of ngn3) induced similar effects. These data indicate that the Delta-Notch pathway, which controls embryonic development of t …

Pigmented thymic carcinoids: a clinicopathological and immunohistochemical study of two cases.

Two cases of pigmented thymic carcinoids are presented. The patients were two men, 32 and 47 years of age. The two patients were asymptomati … formed in one case showed immunoreactivity of the tumor cells for chromogranin, Leu 7, and keratin. Synaptophysin and P53 immunostains were negative. Clinical follow-up was obtained in one patient who was alive and well 10 years after surgical resection. The presence of abundant melanin pigment in thymic carcinoids highlights an important pitfall for diagnosis …

A comparison of cell phenotypes in hemimegalencephaly and tuberous sclerosis.

Hemimegalencephaly, an uncommon sporadic nonfamilial congenital dysplastic abnormality of the central nervous system, constitutes a patholog … s. Microtubule-associated protein 1B and 2, phosphorylated and non-phosphorylated neurofilament and synaptophysin identify the large neurons and distinguish them from balloon cells in both entities. Balloon cells in hemimegalencephaly showed no immunoreactivity for TSC2 gene product, tuberin, and vimentin, but similar cells in tuber tissue showed consistent imm …

Mixed dysembryoplastic neuroepithelial tumor and ganglioglioma.

We report a case of a 15-year-old girl with new onset seizures, who had a mixed dysembryoplastic neuroepithelial tumor (DNT) and ganglioglio … nohistochemistry showed the neurons of the ganglioglioma to be positive for class III beta-tubulin, synaptophysin, and chromogranin A, whereas the astrocytic cells stained only for glial fibrillary acidic protein. Most OLCs in the DNT were positive for S-100 protein. This apparently mixed lesion suggests that a close histogenetic relationship exists between DNT …

Tumors of the endocrine/neuroendocrine system: an overview.

For the sake of discussion, the markedly diversified tumors of the endocrine/neuroendocrine system are classified as those originating in cl … neral endocrine/neuroendocrine cell markers such as neuron-specific enolase, the chromogranins, and synaptophysin are useful in identifying neuroendocrine differentiation in a neoplasm using routine immunohistochemical procedures. The current relevance of the APUD concept of Pearse as well as the biologic importance of endocrine/neuroendocrine secretory product …

Symptomatic lumbar spondylolysis. Neuroimmunologic studies.

OBJECTIVES: This study characterized the defect using neuroimmunologic and inflammatory cell analysis. SUMMARY OF BACKGROUND DATA: Spondylo … D2 lymphocytes and CD11b monocytes/macrophages. In a vascularized connective tissue stroma PGP 9.5, synaptophysin and neurofilament staining disclosed perivascular nerves, which did not extend to the synovial lining layer and which mainly represented postganglionic sympathetic nerve fibers but also calcitonin gene-related peptide and substance P containing sens …

Connectivity and phenotype of vasopressin 1a receptor cells in the lateral septum.

The neuropeptide arginine-vasopressin (AVP) regulates sexually-differentiated social behaviors, including sexual behavior, aggression, and s … outputs of V1aR+ cells in the LS, via a monosynaptic retrograde rabies virus as well as anterograde synaptophysin-mRuby AAV tracing approaches. Monosynaptic inputs to V1aR LS cells were observed from the medial preoptic area (MPA), lateral hypothalamus (LH), hippocampus (mostly ventral), medial septum, diagonal band of Broca (DBB), and the supramammillary nucle …

Aggressive hepatic carcinoma consistent with cholangioblastic cholangiocarcinoma treated with liver transplantation: a retrospectively reclassified case.

Cholangioblastic cholangiocarcinoma, also known as NIPBL::NACC1 fusion hepatic carcinoma, is an extremely rare and diagnostically challengin … illary growth patterns. Initial immunohistochemistry showed focal positivity for chromogranin A and synaptophysin and absence of hepatocellular markers. Pathologic review 25 years later demonstrated patchy but strong positivity for cytokeratin 19 and inhibin, and the tumor was considered most consistent with cholangioblastic cholangiocarcinoma. Metastatic recur …

Ectopic ACTH Syndrome Caused by Pheochromocytoma: A Case Report and Systematic Review.

INTRODUCTION: Ectopic adrenocorticotropic hormone (ACTH) syndrome caused by pheochromocytoma is extremely rare, and its highly variable clin … revealed features of a pheochromocytoma. Immunohistochemistry showed positivity for chromogranin A, synaptophysin, neuron-specific enolase, and ACTH, with a Ki67 labeling index of approximately 1%. Post-operatively, the patient's electrolyte, serum cortisol, and ACTH levels returned to normal rapidly, and the symptoms of edema resolved. The diagnosis was ectopi …

Ectopic Olfactory Neuroblastoma of the Maxillary Sinus: A Case Report.

Olfactory neuroblastoma is a rare neuroendocrine tumor typically arising from the superior nasal cavity, and primary occurrence in the maxil … histopathology demonstrated small round blue cells in lobular architecture, strong chromogranin and synaptophysin positivity, absence of mitoses or necrosis, and a low Ki-67 index, confirming Hyams grade I olfactory neuroblastoma. Adjuvant intensity-modulated radiotherapy was administered. The postoperative course was uneventful, and at 12-month follow-up there …

Interleukin-1β - Информация о воспламенении и связанные с миелином изменения в Олигодендроглиа и Шванн Клетках в многоразовом склерозе: модуляторное воздействие ибупрофена и флюрбипрофена.

Нейроинфламмация, рассматриваемая как повышенный уровень Интерлейкина-1β (IL-1β) и его каскада вниз по течению, была продемонстрирована нейропатогенная роль в многочисленных нейродегенеративных болезнях, включая болезнь Альцгеймера и Паркинсона. Западные пятна использовались для определения воздействия IL-1β и его сигнального каскада на клетки человека Олигодендроглиома (HOG) и Шванн, а также для оценки потенциального терапевтического воздействия ибупрофена и флюрбипрофена на патогенез MS in vitro. IL-1β увеличила нейро-воспалительные маркеры, такие, как TNFα, MyD88, βAPP, COX-2 и IL-6, а такж

Совпадение в аннотации оригинала
Neuroinflammation, read as elevated levels of Interleukin-1β (IL-1β) and of its downstream signaling cascade, has been shown to play a neuro … The IL-1β treatment of HOG and Schwann cells decreased the levels of myelin Basic Protein (MBP) and synaptophysin while at the same time increasing βAPP. Autophagy markers like LAMP-2 and LC3B were downregulated. In contrast, treatment with Ibuprofen and Flurbiprofen effectively countered the harmful effects of IL-1β in MS. These in vitro studies show that IL-1 …

Tympany in a cow secondary to a follicular-compact thyroid carcinoma with metastases.

A 12-y-old, 654-kg, Santa Gertrudis cow was presented to the veterinary hospital with acute abdominal distension and a large mass on the lef … r thyroid transcription factor 1 (TTF1), and none of the neoplastic cells showed immunolabeling for synaptophysin. Although the cytological features were typical of neuroendocrine neoplasia, immunohistochemistry excluded a thyroid medullary neoplasm. Unlike C-cell and ultimobranchial neoplasms, thyroid follicular carcinomas are rarely reported in cattle. The th …

Olfactory neuroblastoma in a goat.

Nasal tumours are uncommon in goats, with lymphoma, enzootic intranasal tumours and polyps being the most commonly reported. Nasal neuroecto … tokeratin AE1/AE3, cytokeratin 8, beta III tubulin, vimentin, COX-2, E-cadherin, chromogranin A and synaptophysin. The immunoprofile confirmed the diagnosis of an ONB, with neoplastic cells being only positive for cytokeratin AE1/AE3 and beta-III tubulin. To the best of the authors' knowledge this is the first description of ONB in goats.

Primary Intrarenal Neuroblastoma in a Four-Month-Old Infant: A Rare Diagnostic Challenge Mimicking Wilms Tumor.

Primary intrarenal neuroblastoma is an exceedingly rare entity that often mimics Wilms tumor in clinical and radiologic presentation, making … gland. Pathologic examination revealed sheets of small round blue cells positive for chromogranin, synaptophysin, and cluster of differentiation 56, establishing the diagnosis of neuroblastoma. Four lymph nodes were positive for metastatic involvement, but there was no amplification of the MYCN oncogene. Postoperative urinary catecholamine metabolite levels no …

SMARCB1-deficient sinonasal carcinoma with oral involvement: A potential mimicker of salivary-type carcinomas.

SMARCB1-deficient sinonasal carcinoma is a rare sinonasal malignancy characterized by loss if INI1 expression on immunohistochemistry due to … sis showed neoplastic cells positive to AE1/AE3 and p63, but negative to 34βE12, p16, chromogranin, synaptophysin, NUT, CD99, myogenin, smooth muscle actin, HMB45, S100 protein, androgen receptor, and TTF1. INI1 was also negative in neoplastic cells, but its expression was retained in stromal cells. The final diagnosis of SMARCB1-deficient sinonasal carcinoma w …

Coping with the experience of frustration throughout life: Sex- and age-specific effects of early life stress on the susceptibility to reward devaluation.

Early life stress may lead to lifelong impairments in psychophysiological functions, including emotional and reward systems. Unpredicted dec … lateral amygdala (BLA) were evaluated for protein levels of NMDA receptor subunits (GluN2A/GluN2B), synaptophysin, PSD95, SNAP-25 and CRF1. We found that adult MS males had greater vulnerability to reward reduction, together with decreased GluN2A and increased GluN2B immunocontent in the dHC. MS females and adolescents did not differ from controls. We concluded …

Early adenocarcinoma mixed with a neuroendocrine carcinoma component arising in the gastroesophageal junction: A case report.

BACKGROUND: Early adenocarcinoma mixed with a neuroendocrine carcinoma (NEC) component arising in the gastroesophageal junctional (GEJ) regi … nocarcinoma and NEC components were positive for P53 with a Ki67 index of 90%; NEC was positive for synaptophysin and chromogranin. Next-generation sequencing of 196 genes demonstrated a novel germline mutation of the ERCC3 gene in the DNA repair pathway and a germline mutation of the RNF43 gene, a common gastric cancer driver gene, in addition to pathogenic so …

[Clinical and pathological characteristics of gastric adenocarcinoma of fundic gland type].

To analyze the clinical, endoscopic and pathological feature of gastric adenocarcinoma of fundic gland type (GA-FG) (18 cases) collected fro … ells were positive for the expression of mucin-6 (MUC6) and Pepsinogen 1, and partial expression of synaptophysin (Syn). GA-FG is a rare type of gastric adenocarcinoma with good differentiation, and currently only a few cases have been reported, and often easily been misdiagnosed or missed. Therefore, to master the characteristics of clinic and pathology is hel …

Intracranial embryonal neoplasm in an alpaca.

An 11-y-old hembra alpaca was admitted because of cerebellar and vestibular signs, dysphagia, and aspiration pneumonia; without clinical imp … lasmic immunolabeling for vimentin, microtubule-associated protein-2, protein gene product 9.5, and synaptophysin; ~50% immunolabeling for cytokeratin AE1/3; sporadic OLIG2 and S100 immunolabeling; and absent glial fibrillary acidic protein immunolabeling. Based on the histologic pattern and the IHC results, our diagnosis was a poorly differentiated embryonal t …