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Модуляторные эффекты традиционной китайской медицины и производные активных метаболитов на аутоиммунально-воспалительных путях сигнала при множестве склерозов: обзор повествования.

Множественный склероз (MS) — нервно-воспалительное заболевание с иммунной помощью, характеризующееся обезвоживанием, аксоновой травмой и обширным разрушением целостности центральной нервной системы. Экспериментальный аутоиммунный энцефаломиэлит (EAE) — наиболее часто применяемая модель для имитации патологических особенностей человека. В настоящее время еще многое предстоит сделать для совершенствования стратегии лечения MS. Все больше исследований показывают, что традиционная китайская медицина (TCM) и связанные с ней активные метаболиты полезны для лечения MS и умело регулируют уровни подстр

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… Mey or Panax notoginseng (Burkill) F.H.Chen | Ginseng radix Et rhizoma | Dry roots | ( Zhu et al., 2014 ) Ginsenoside Re | Panax ginseng C. A. Mey or Panax notoginseng (Burkill) F.H.Chen | Ginseng radix Et rhizoma | Dry rhizomes | ( Oh et al., 2024 ) Ginsenoside Rb3 | Panax ginseng C. A. … japonicus | Panax japonicus C. …

Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.

BACKGROUND: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (IFN) genes (STING) pathway is critical in the innate immune system and can be mobilized by cytosolic DNA. The various inflammatory and autoimmune diseases progression is highly correlated with aberrant cGAS-STING pathway activation. While some cGAS-STING pathway inhibitor were identified, there are no drugs that can be applied to the clinic. Compound Danshen Dripping Pill (CDDP) has been successfully used in clinic around the world, but the most common application is limited to cardiovascular disease. Therefore, the purpo

Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9.

Various colonic motor activities are thought to mediate propulsion and mixing/absorption of colonic content. The Japanese traditional medicine daikenchuto (TU-100), which is widely used for postoperative ileus in Japan, accelerates colonic emptying in healthy humans. Hydroxy-α sanshool (HAS), a readily absorbable active ingredient of TU-100 and a KCNK3/KCNK9/KCNK18 blocker as well as TRPV1/TRPA1 agonist, has been investigated for its effects on colonic motility. Motility was evaluated by intraluminal pressure and video imaging of rat proximal colons in an organ bath. Distribution of KCNKs was

Meta-Analysis of Pharmacological, Nutraceutical and Phytopharmaceutical Interventions for the Treatment of Cancer Related Fatigue.

Purpose: In this study we aimed to estimate the effectiveness of pharmacological, nutraceutical, and phytopharmaceutical treatments on CRF. Methods: Ovid MEDLINE, Ovid Embase, Ovid Psych info, CINHAHL and Cochrane Library databases were searched up to 30 September 2021. Randomized controlled trials of pharmacological, nutraceutical and phytopharmaceutical interventions for treatment of CRF for at least one week duration and have used valid tool to assess severity of CRF as a primary or secondary outcome were considered. Results: 32 eligible studies (4896 patients) were reviewed. For the overal

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… Ginseng is derived from processed plant root of ginseng species (Panax Ginseng, Panax quinquefolius L., Eleutherococcus senticosus (Rupr. & Maxim) [ 43 ]. Ginsenosides and saponins are the important pharmacological ingredients [ 44 ]. … Effects of Panax ginseng Root on the Vertical and Horizontal Motor Activities and on Brain Monoamine-Related Substances in Mice Planta Med. 1989 55 429 433 10.1055/s-2006-962058 2813579 49. Pannacci M. Lucini V. Colleoni F. Martucci C. Grosso S. Sacerdote P. Scaglione F. Panax ginseng C.A. …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis.

Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the presence of harmful microorganisms in blood which could cause mortality. Complications associated with sepsis involve multiple organ dysfunction. The pathogenesis of sepsis remains intricate, with limited treatment options and high mortality rates. Traditional Chinese medicine (TCM) has consistently demonstrated to have a potential on various disease management. Its complements include reduction of oxidative stress, inhibiting inflammatory pathways, regulating immune responses, and improving microcirculation. Tra

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… Jack | LPS-induced RAW 264.7 cells and female Balb/c mice | 10 mg/kg | ↓: iNOS, COX -2, NO, PGE2, TNF-α, IL-6, NF-κB | Liver, Lung, Kidney | Dexamethasone | Gupta et al. (2019) Ginsenoside Rg2 and Rh1 | Panax ginseng C.A.Mey. | LPS-induced RAW 264.7 cells and ICR mice | 20 mg/kg | ↓: TLR4, NF-κB, TNF-α … , IL-1β, IFN-β ↑: p38-STAT1 | Liver, Kidney | Dexamethasone | Huynh et al. (2020) Ginsenoside Rg1 and Re | Panax ginseng C.A.Mey. | LPS-induced RAW 264.7 and RAW-Blue cells LPS-induced male SD rats and BALB/c mice | 30, 5, 70 μg/mL Rg1 and 50, 70 μg/mL Re 10 mg/kg Rg1 and 20 mg/kg Re | ↓: TNF-α, IL-1β …

Chinese Herbal Medicine Is Helpful for Survival Improvement in Patients With Multiple Myeloma in Taiwan: A Nationwide Retrospective Matched-Cohort Study.

Aim of the studyThe purpose of this study is to demonstrate that Chinese herbal medicine is beneficial for survival improvement in patients with multiple myeloma.Materials and methodsWe performed a 1:1 propensity score-matched cohort study to analyze patients with multiple myeloma diagnosed between January 1, 2002, and December 31, 2012, through the Taiwanese National Health Insurance Research Database. Patients who received Chinese herbal medicine therapy from the initial date of diagnosis of multiple myeloma to December 31, 2012, were included in the Chinese herbal medicine group. Patients w

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… Schischk), Chuan-Qiong ( Ligusticum chuanxiong Hortorum), Ren-Shan ( Panax ginseng C.A.Mey.), Zhi-Gan-Cao ( Glycyrrhiza glabra L.), Dang-Gui ( Angelica sinensis (Oliv.) … Merr.), Ren-Shen ( Panax ginseng C.A.Mey.), Fu-Ling ( Poria cocos (Schw.) Wolff), Xuan-Shen ( Scrophularia ningpoensis Hemsl.), Dan-Shen ( Salvia miltiorrhiza Bunge), Yuan-Zhi ( Polygala tenuifolia Willd.), Jie-Geng ( Platycodon grandifloras (Jacq.) A.DC.), Dang-Gui ( Angelica sinensis (Oliv.) …

Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty.

Frailty and sarcopenia have recently gained considerable attention in terms of preventive care in Japan, which has an ever-increasing aging population. Sarcopenia is defined as atrophy of skeletal muscles caused by the age-related decrease in growth hormone/insulin-like growth factor and sex hormones. The Japanese Ministry of Health, Labor and Welfare reports that frailty can lead to impairment of both mental and physical functioning. Chronic diseases such as diabetes and dementia may underlie frailty. It is important to prevent progression of frailty and extend the healthy lifespan. In herbal

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… Panax ginseng was historically thought to promote immortality, which was sought by the first Qin Emperor. It was imported to Japan in the eighth century, in the era of Emperor Shomu, and has become one of the main components in Ninjin'yoeito. … AKT-targeted anti-inflammatory activity of Panax ginseng calyx ethanolic extract . J Ginseng Res . ( 2018 ) 42 : 496 – 503 . 10.1016/j.jgr.2017.06.003 30337810 PMC6187086 39. Yin L Guan E Zhang Y Shu Z Wang B Wu X . …

A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer.

Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substance

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… The main phytochemicals are withanolides, which are structurally similar to the ginsenosides of Panax ginseng (Asian ginseng), Panax notoginseng (Sanchi ginseng), and Panax quinquefolius (American ginseng). However, the ginsenoside contents within the Panax species vary significantly [ 5 ]. … Ginsenoside content and variation among and within American ginseng ( Panax quinquefolius L.) populations Phytochemistry 2006 67 14 1510 1519 10.1016/j.phytochem.2006.05.028 2-s2.0-33746253768 16839573 6 Elsakka M. Grigorescu E. Stanescu U. Stanescu U. Dorneanu V. …

In vivo anti-inflammatory, analgesic activities and phytochemical profile of Hu Lisan ethanol extract.

ETHNOPHARMACOLOGICAL RELEVANCE: Huli San (HLS) is a classic compound formulation long utilized by ethnic minorities such as the Yi and Miao peoples in Southwest China. Its composition blends traditional medicinal herbs including Aconitum vilmoriniannum Kom (AK), Panax notoginseng (Burk.) F. H. Che (PN), Cynanchum wallichii Wight (CW), and Campanumoea javanica BI (CJ), creating a formula deeply rooted in the rich tradition of ethnic pharmacology. This compound is renowned for its ability to dispel wind and dampness, invigorate blood, and alleviate pain. It is commonly used to treat rheumatic pa…

Shenhuang Granules regulate the NLRP3/Caspase-1/GSDMD pathway to alleviate pyroptosis of pulmonary microvascular endothelial cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Shenhuang Granules (SHG) is a traditional Chinese medicine (TCM) formula composed of six medicinal materials: Panax ginseng C.A. Mey. (Ginseng Radix et Rhizoma), Rheum palmatum L. (Rhei Radix et Rhizoma), Sargentodoxa cuneata (Oliv.) Rehder & E.H. Wilson (Sargentodoxae Caulis), Taraxacum mongolicum Hand. -Mazz. (Taraxaci Herba), Aconitum carmichaelii Debeaux (Aconiti Lateralis Radix Praeparata), and Whitmania pigra Whitman (Hirudo). According to TCM theory, this formula is designed to replenish Qi and strengthen the body's resistance, clear heat and remove toxin…

[Prediction of anti-gastric cancer effect of Panacis Quinquefolii Radix by network pharmacology and in vivo validation].

This study investigated the anti-gastric cancer activity and mechanism of Panacis Quinquefolii Radix(Panax quinquefolium L.), and preliminarily compared the in vivo anti-gastric cancer efficacy of American-imported(JK-AG) and domestically produced(Shandong) Panacis Quinquefolii Radix decoctions(SD-AG). Based on network pharmacology predictions, a LUC-MGC803 cell ectopic gastric cancer nude mouse model was established. Mice were administered JK-AG and SD-AG at 1 g·kg~(-1) via gavage for 21 consecutive days. The positive control group received intraperitoneal injections of 5-fluorouracil(5-FU) a…

Multifunctional Actions of Ninjinyoeito, a Japanese Kampo Medicine: Accumulated Scientific Evidence Based on Experiments With Cells and Animal Models, and Clinical Studies.

Herbal medicines are currently employed for the treatment of several types of diseases, and also employed for the improvement of Quality of Life (QOL) of patients over the world, in particular, in Asian countries. In Japan, a Japanese herbal medicine namely kampo medicine has been prescribed for the improvement of QOL of patients. Ninjinyoeito (NYT), composed of 12 herbal plants, is one of kampo medicines and used for helping recovery of diseases and improving several symptoms that suffer patients such as anemia, anorexia and fatigue. Recent scientific research approaches to kampo medicines wi

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… Also, ginsenoside-Rg 2 from Panax ginseng protected memory impairment through antiapoptosis with a rat model having vascular dementia ( 39 ). Cinnamon bark Cinnamon bark is widely used in food and traditional herbal medicine including NYT. … Pharmacological and medical applications of Panax ginseng and ginsenosides: a review for use in cardiovascular diseases. J Ginseng Res. (2018) 42:264–9. 10.1016/j.jgr.2017.10.004 42. Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S, et al. …

Soybean oil containing ginseng saponins as adjuvants promotes production of cytokines and enhances immune responses to foot-and-mouth disease vaccine.

In the present study, the adjuvant effect of soybean oil containing ginseng root saponins (SO-GS-R) on the immune response to foot-and-mouth disease vaccine (FMDV) in mice was investigated. When immunized with FMDV antigen emulsified in an SO-GS-R formulation, mice generated remarkably higher serum antibody and cytokine responses than mice immunized with FMDV antigen alone. To elucidate the mechanisms underlying the adjuvant effect of SO-GS-R, we measured cytokines in serum and muscle tissue after intramuscular injection of SO-GS-R. The results showed that injection of SO-GS-R significantly in

IL-6 and NFE2L2: A putative role for the hepatoprotective effect of N. Sativa, P. Ginseng and C. Sempervirens in AFB-1 induced hepatocellular carcinoma in rats.

In this study, we investigated possible hepato-protective effects of N. Sativa, P. Ginseng, and C. Sempervirens in Aflatoxin B1 (AFB-1) induced hepatocellular carcinoma rat model. Fifty-four male albino rats were randomly assigned to experimental groups. Alcoholic extracts of aforementioned herbs were administered orally for 28 days at different doses. IL-6, hs-CRP, MDA, SOD and NFE2L2 were determined using ELISA. Histopathological changes in treated groups were examined. Herbal treatment significantly reduced IL-6, hs-CRP, and MDA (P C. Sempervirens 600 and N. Sativa 1000 increased NFE2L2 lev

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… Panax Ginseng (P. Ginseng) is a Chinese herb that has been used commonly in medicine. Studies have shown Ginseng family members of herbs have potential roles as anticancer agents [ 18 , 19 ]. … Panax ginseng components and the pathogenesis of Alzheimer’s disease (Review) Mol Med Rep. 2019;19(4):2975–2998. doi: 10.3892/mmr.2019.9972. 23. Razgonova M.P. …

Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms.

Cancer is the leading cause of mortality worldwide. Various chemotherapeutic drugs have been extensively used for cancer treatment. However, current anticancer drugs cause severe side effects and induce resistance. Therefore, the development of novel and effective anticancer agents with minimal or no side effects is important. Notably, natural compounds have been highlighted as anticancer drugs. Among them, many researchers have focused on mushrooms that have biological activities, including antitumor activity. The aim of this review is to discuss the anticancer potential of different mushroom

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… Anti-proliferative properties of ethyl acetate extract of Phellinus linteus grown on ginseng (Panax ginseng) on HT-29 human colon carcinoma cells through inducing apoptosis. Food Sci. Biotechnol. 2012;21:683–690. doi: 10.1007/s10068-012-0089-y. 31. Choi C.W., Yoon J. … The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis. J. Ethnopharmacol. 2010;132:115–121. doi: 10.1016/j.jep.2010.07.052. 43. …

Синергистические механизмы традиционной китайской медицины и протеиновых ингибаторов в многократной терапии миеломы: всеобъемлющий обзор.

Множественная миелома (ММ) — клональная плазменная порча клеток, характеризующаяся инфильтрацией костного мозга, производством моноклонального иммуноглобулина и многосистемным повреждением. Протеозные ингибиторы (ИП), такие, как бортезомиб, карфилзомиб и иксазомиб, значительно улучшили без прогрессии и общее выживание пациентов с ОМ. Однако резистентность к лекарственным препаратам и неблагоприятные последствия, включая периферическую нейропатию и кардиотоксичность, по-прежнему являются основными ограничениями для долгосрочного контроля за заболеваниями. Цель настоящего обзора заключается в вс

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… resistance; inhibits proliferation Celastrol 14–16 Tripterygium wilfordii Bortezomib Inhibits NF-κB, IRAK4/ERK/p38 MAPK; induces ER stress/UPR; inhibits β5/β2/β1 proteasome subunits; increases Bax/Bcl-2 ratio Induces apoptosis; inhibits migration/invasion; enhances BTZ efficacy Ginsenoside Rg3 17 , 18 Panax … Ginsenoside Rg3 Ginsenoside Rg3, a bioactive saponin extracted from Panax ginseng, has demonstrated significant anti-myeloma activity through modulation of key survival, proliferation, and angiogenic pathways. …

Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns.

These serial clinical and experimental studies were designed to clarify the pathogenesis of postburn MODS. Both animal and clinical studies were performed. In animal experiments, 46 male cross-bred dogs were cannulated with Swan-Ganz catheters and 39 of them were inflicted with 50% TBSA third degree burns (7 were used as controls). The burned dogs were randomly divided into 4 groups: immediate infusion, delayed infusion, delayed fast infusion and delayed fast infusion combined with ginsenosides. All dogs were kept under constant barbiturate sedation during the whole study period. Hemodynamics,

Ginsenoside-Mediated Ferroptosis Regulation: Bidirectional Effects and Therapeutic Potential in Diseases.

Notably, certain ginsenoside components exhibit distinct bidirectional and context-dependent regulatory effects on ferroptosis depending on the disease setting. In aberrantly proliferating or activated cells, ginsenosides function as ferroptosis inducers, whereas in damaged quiescent cells of normal tissues, they act as ferroptosis inhibitors. The pro-ferroptotic effect is predominantly observed in cells characterized by abnormal proliferation or activation, such as cancer cells and activated hepatic stellate cells in liver fibrosis. In this context, ginsenosides modulate key iron metabolism p

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… Panax ginseng: A candidate herbal medicine for autoimmune disease. J. Ginseng Res. 2019;43:342–348. doi: 10.1016/j.jgr.2018.10.002. 8. Im D.-S. Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng. Biomolecules. 2020;10:444. doi: 10.3390/biom10030444. 9. … Ginsenosides are active ingredients in Panax ginseng with immunomodulatory properties from cellular to organismal levels. J. Ginseng Res. 2021;46:711–721. doi: 10.1016/j.jgr.2021.12.007. 57. Wan Y., Liu D., Xia J., Xu J.-F., Zhang L., Yang Y., Wu J.-J., Ao H. …

Angioedema and Hemorrhage After 4.5-Hour tPA (Tissue-Type Plasminogen Activator) Thrombolysis Ameliorated by T541 via Restoring Brain Microvascular Integrity.

Background and Purpose- tPA (tissue-type plasminogen activator) is the only recommended intravenous thrombolytic agent for ischemic stroke. However, its application is limited because of increased risk of hemorrhagic transformation beyond the time window. T541 is a Chinese compound medicine with potential to attenuate ischemia and reperfusion injury. This study was to explore whether T541-benefited subjects underwent tPA thrombolysis extending the time window. Methods- Male C57BL/6 N mice were subjected to carotid artery thrombosis by stimulation with 10% FeCl3 followed by 10 mg/kg tPA with/wi

Acquired platelet disorders.

Platelets are essential to primary hemostasis, and defects in their number or function can lead to clinically significant bleeding or thrombosis. Acquired platelet disorders are far more common than the inherited forms and arise in a wide range of settings, including drug exposure, autoimmune, systemic, and critical illnesses. This review examines current understanding of the mechanisms driving acquired platelet dysfunction and outlines the diagnostic and therapeutic approaches that are shaping contemporary standards of care. Drug-related and immune-mediated platelet defects remain the most re

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… aggregation, thrombin-induced platelet activation, and TXB 2 * production ( 143 ) Feverfew ( Tanacetum parthenium ) | Reduced platelet aggregation and serotonin release ( 13 ) Turmeric ( Curcuma longa ) | Reduced GPVI-mediated platelet activation and dense granule secretion ( 144 ) ‡ Asian Ginseng ( Panax … ginseng ) | Reduced platelet aggregation, reduced granule secretion, calcium ion mobilization, and activation of integrin αIIbβ3, increase cAMP ( 96 , 145 ) ‡ American Ginseng ( Panax quinquefolius ) | Synergistic effect in platelet inhibition when combined with DAPT ( 146 ) ‡ Willow ( Salix alba ) …