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Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science.

Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the present time is widely accepted as an alternative treatment for cancer. In this review, we sought to summarize the molecular and cellular mechanisms underlying the chemopreventive and therapeutic activity of TCM, especially that of the Chinese herbal medicine-derived phytochemicals curcumin, resveratrol, and berberine. Numerous genes have been reported to be involved when using TCM treatments and so we have selectively highlighted the role of a number of oncogene and tumor suppressor genes in TCM therapy. I

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… Berberine is reported to rescue Fusobacterium nucleatum ‐induced colorectal tumorigenesis by modulation of tumor microenvironment and interference in the activation of tumorigenesis‐related pathways. 218 As shown in Table 1 , there is evidence that all TCM compounds summarized differentially exert positive … Berberine may rescue Fusobacterium nucleatum‐induced colorectal tumorigenesis by modulating the tumor microenvironment . Oncotarget . 2015 ; 6 : 32013 ‐ 32026 . 26397137 10.18632/oncotarget.5166 PMC4741656 219 Hermawan A , Putri H . …

Neoplastic Disorders and Cardiovascular Comorbidities in Geriatric Patients: A Simple Association?

Cardiovascular disease (CVD) and cancer frequently coexist in older patients, posing significant challenges in clinical management due to overlapping risk factors and treatment-related complications. This narrative review summarizes current knowledge on the epidemiology, shared pathophysiological mechanisms and clinical impact of neoplastic comorbidities in older adults with cardiovascular diseases. It highlights the increased mortality, morbidity and diminished quality of life resulting from the coexistence of these conditions. The review also discusses personalized management strategies, emp

Public Omics Explorer (POE): Создание возможностей для комплексного семантического поиска по наборам данных GEO omics на основе публикаций PubMed.

Экспоненциальный рост общедоступных массивов данных об омиках и биомедицинской литературы создает как возможности, так и проблемы для открытия данных в области биологических наук. В то время как " Gene Express Omnibus " (GEO) содержит миллионы высокопроизводительных экспериментальных наборов данных, Европейский архив нуклеотидов (ENA) хранит соответствующие исходные данные о последовательности, а " PubMed " содержит большой объем соответствующих научных публикаций, комплексное исследование этих ресурсов по-прежнему носит ограниченный характер. Мы представляем "Public Omics

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… While the GEO keyword search retrieved directly annotated datasets such as GSE298584 ( “Fusobacterium nucleatum promotes metastasis of breast cancer via the miR-21–3p/FOXO3 axis” ), the POE semantic retrieval additionally surfaced functionally coherent studies including GSE109592 ( miR-21/DUSP8 axis …

Antibiotic lock therapy for the treatment of peripherally inserted central venous catheter-related bloodstream infection in patients with hematological malignancies: a single center retrospective study.

Catheter-related bloodstream infections represent one of the most prevalent complications in patients with peripherally inserted central venous catheters (PICCs). The application of antibiotic lock therapy (ALT), particularly in patients with hematological malignancies, has not been well documented. We aim to share our experience on ALT for these patients and to evaluate its effectiveness and safety. All cases of patients with hematological malignancies who had PICC from January 2018 to October 2024 were retrospectively reviewed. Microbiologic data of PICC-related bloodstream infections (PRBSI

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… Table 3 Microbiology of PRBSIs 1 Other GPC: Streptococcus viridans (1), Gemella haemolysans (1), Micrococcus luteus (1); 2 Other GNB: Alcaligenes xylosoxidans (1), Moraxella osloensis (1), Fusobacterium nucleatum (1); 3 Percentage among their species. …

Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy.

Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of

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… Nishi H Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke Clin. Exp. Immunol. 2020 200 302 309 32155293 10.1111/cei.13430 PMC7232001 26. …

Colorectal Cancer at the Crossroads: The Good, the Bad, and the Future of Platinum-Based Drugs.

Colorectal cancer (CRC) remains a significant global health challenge, ranking third in incidence and second in mortality among cancers worldwide. This review addresses the complex landscape of CRC, focusing on incidence, mortality trends, preventive strategies, and the evolving therapeutic approaches, particularly highlighting the role of platinum-based drugs like oxaliplatin (OXP). It also underscores the increasing burden of CRC, with factors such as westernized diets, aging populations, and genetic predispositions contributing to its prevalence. Therapeutically, early detection greatly enh

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… The Fusobacterium nucleatum ( F. nucleatum ) bacteria in tumor tissue, for instance, have been linked to increased chemoresistance, reduced T-cell infiltration, and poor patient survival. … Indeed, some microbial species and microbial metabolites, such as Enterotoxigenic Bacteroides fragilis , Escherichia coli , and Fusobacterium nucleatum have been implicated in promoting colorectal carcinogenesis and therapy resistance. − Immune cells, fibroblasts, and endothelial cells play pivotal …

Understanding the Mechanisms of Diet and Outcomes in Colon, Prostate, and Breast Cancer; Malignant Gliomas; and Cancer Patients on Immunotherapy.

Cancer patients often ask which foods would be best to consume to improve outcomes. This is a difficult question to answer as there are no case-controlled, prospective studies that control for confounding factors. Therefore, a literature review utilizing PubMed was conducted with the goal to find evidence-based support for certain diets in specific cancer patients-specifically, we reviewed data for colon cancer, prostate cancer, breast cancer, malignant gliomas, and cancer patients on immunotherapy. Improved outcomes in colon cancer and patients on immunotherapy were found with high-fiber diet

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… Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J. Gastroenterol. 2016;22:557–566. doi: 10.3748/wjg.v22.i2.557. 4. O’Keefe S.J., Li J.V., Lahti L., Ou J., Carbonero F., Mohammed K., Posma J.M., Kinross J., Wahl E., Ruder E., et al. …

Contribution of immune cells to bone metastasis pathogenesis.

Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a variety of immune cells, including T cells, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, participate in the process of bone metastasis. In this review, we will introduce the interactions between immune cells and cancer cells in the bone microenvironment,

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… Fusobacterium nucleatum facilitates M2 macrophage polarization and colorectal carcinoma progression by activating Tlr4/Nf-Kappab/S100a9 cascade . Front Immunol ( 2021 ) 12 : 658681 . doi: 10.3389/fimmu.2021.658681 34093546 PMC8176789 77 Williams R Cooley S Bachanova V Waldmann TA Verneris MR . …

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

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… This formulation effectively targeted and eradicated tumor-associated Fusobacterium nucleatum bacteria in breast cancer models, suggesting its potential in microbiota-related oncogenesis [ 127 ]. 9. …

Фармакомикробиомика: От взаимодействия хост-микробиома-наркотики к клиническому переводу в докторскую медицину.

Заметная межиндивидуальная изменчивость реакции на наркотики по-прежнему является серьезной проблемой в области клинической фармакологии и не может быть в полной мере объяснена только генетикой принимающей страны. Растущие данные свидетельствуют о том, что кишечная микробиота является дополнительным фактором, определяющим эффективность и токсичность наркотиков посредством двустороннего взаимодействия с фармакологической терапией. Это признание привело к появлению фармакомикробиомики - области, которая изучает, как микробные сообщества влияют на утилизацию наркотиков и реагирование на них, и ка

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… Fusobacterium nucleatum , frequently found in colorectal cancer contexts, may instead induce chemoresistance to oxaliplatin by activating the TLR4/MYD88 pathway and diverting tumour cells from apoptosis towards autophagy [ 74 , 79 ]. …

No patient left behind: The promise of immune priming with epigenetic agents.

Checkpoint inhibitors, monoclonal antibodies that inhibit PD-1 or CTLA-4, have revolutionized the treatment of multiple cancers. Despite the enthusiasm for the clinical successes of checkpoint inhibitors, and immunotherapy, in general, only a minority of patients with specific tumor types actually benefit from treatment. Emerging evidence implicates epigenetic alterations as a mechanism of clinical resistance to immunotherapy. This review presents evidence for that association, summarizes the epi-based mechanisms by which tumors evade immunogenic cell death, discusses epigenetic modulation as

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… Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 2013; 14:207-15; PMID:23954159; https://doi.org/ 10.1016/j.chom.2013.07.007 63. Corso CD, Ali AN, Diaz R. …

Роль микробиотики в гематологических заболеваниях: описательный обзор механизмов и терапевтического потенциала.

Микробиота человека, в частности кишечный микробиом, играет центральную роль в поддержании иммунного гомеостаза, регулировании гематопоисиса и модуляции хост-метаболизма с помощью биоактивных метаболитов, таких, как короткоцепные жирные кислоты (СКФА), желчные кислоты и соединения триптофана. Разрушение этой микробной экосистемы (дисбиоз) стало одним из ключевых факторов развития и развития гематологических магнатов (ГМ), включая острые и хронические лейкемии, лимфомы и множественные миеломы. В настоящем обзоре описательной части обобщаются последние данные (см.2022-2025) о сложных двухнаправл

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… A good example of this link is that some types of vaginal community state type (CST) related to cervical cancer or the presence of Fusobacterium nucleatum are often found in cases of CRC [ 147 ]. It seems that chemotherapy is affected by efficacy mechanisms and toxicity. …

Refining the relationship between gut microbiota and common hematologic malignancies: insights from a bidirectional Mendelian randomization study.

BackgroundThe relationship between gut microbiota and hematologic malignancies has attracted considerable attention. As research progresses, it has become increasingly clear that the composition of gut microbiota may influence the onset and progression of hematologic malignancies. However, our understanding of this association remains limited.MethodsIn our study, we classified gut microbiota into five groups based on information at the phylum, class, order, family, and genus levels. Subsequently, we obtained data related to common hematologic malignancies from the IEU Open GWAS project. We the

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… Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment . Cell Host Microbe 14 , 207 – 215 . doi: 10.1016/j.chom.2013.07.007 23954159 PMC3772512 Kurilshikov A. Medina-Gomez C. Bacigalupe R. Radjabzadeh D. Wang J. Demirkan A. . ( 2021 ). …

Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement.

Medication-related osteonecrosis of the jaw (MRONJ) in cancer patients presents a considerable challenge in management. Current management is primarily based on interventions in a limited number of cases assessing a single approach. Medical management typically is reported to include antimicrobial therapy with or without surgery. Advances in the understanding of pathogenesis have led to the investigation of additional medical interventions for early-stage necrosis. We present 3 patients with advanced-stage MRONJ of the maxilla using combined medical modalities including antimicrobial therapy,

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… Efficacy of antimicrobial photodynamic and photobiomodulation therapy against Treponema denticola, fusobacterium nucleatum and human beta defensin-2 levels in patients with gingivitis undergoing fixed orthodontic treatment: a clinic-laboratory study. …

Oxidative Stress Linking Obesity and Cancer: Is Obesity a 'Radical Trigger' to Cancer?

Obesity is on the rise worldwide, and consequently, obesity-related non-communicable diseases are as well. Nutritional overload induces metabolic adaptations in an attempt to restore the disturbed balance, and the byproducts of the mechanisms at hand include an increased generation of reactive species. Obesity-related oxidative stress causes damage to vulnerable systems and ultimately contributes to neoplastic transformation. Dysfunctional obese adipose tissue releases cytokines and induces changes in the cell microenvironment, promoting cell survival and progression of the transformed cancer

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… Some of the species identified as contributors to CRC carcinogenesis are Fusobacterium nucleatum , Bacteroides fragilis , and Escherichia coli [ 138 ]. In addition to oxidative stress being the consequence of inflammation, the microbiota can be a direct source of reactive species. …

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and inva

Ось Гут-Брэйна в нейродегенерации: механистические связи между дисбиозом и нейроатологией.

& ЦЕЛЬ: Ось кишечника по сути представляет собой two- система связи, которая физически соединяет мозг с кишечным трактом. Связь поддерживается через ряд путей, включая нейронные, эндокринные и иммунные пути. Гут дисбиоз, который объясняется как дисбаланс в микробном сообществе, связан с причинно-следственной связью различных нейродегенеративных расстройств, таких, как болезнь Альцгеймера, болезнь Паркинсона и множественный склероз. Однако патологические механизмы в мозге известны лишь частично. В настоящем обзоре описывается процесс кишечного дисбиоза и нейродегенерации с подробным описанием ф

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… Additionally, other microorganisms linked to neurodegenerative diseases include Treponema denticola, which produces dentilisin that may damage neural tissue, and Fusobacterium nucleatum, which is associated with colorectal cancer and Alzheimer's disease and promotes neuroinflammation. …

An overview of cancer health disparities: new approaches and insights and why they matter.

Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies greatly reduced cancer mortality among women and men and underserved communities in this country. Yet, disparities in cancer outcomes remain. Underserved populations continue to experience an excessive cancer burden. This burden is largely explained by health care disparities, lif

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… Kostic, A.D. et al. (2013) Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe, 14, 207–215. 188. Greathouse, K.L. et al. (2018) Interaction between the microbiome and TP53 in human lung cancer. …

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

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… A study found oral bacteria called Fusobacterium nucleatum was the likely culprit in infecting a 35-year-old woman’s fetus through her bloodstream (Carroll 2010 ). The doctors determined that the same strain of oral bacteria found in the woman’s mouth was in the deceased baby’s stomach and lungs. …

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets.

Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and elucidating its molecular crosstalk with tumors is crucial for developing effective clinical therapies. Internal drivers of inflammation-tumor transformation include genomic disorder, epigenetic memory, mitochondrial stress, and metabolic reprogramming, which synergistically initiate carcinogenesis. External factors amplifying tumor progression cover immune dysfunction, stromal fibrosis, microbial dysbiosis, vascular neoplasia, and neurotoxicity, collectively accelerating tumor

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… Fusobacterium nucleatum is enriched in colorectal cancer; by disrupting communication between TAMs and IgA plasma cells, it inhibits the production of secretory IgA, leading to impaired mucosal immunity and increased bacterial infiltration. …