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Механистические и переводческие данные о натуральных продуктах растительного происхождения в предклинических исследованиях по миеломе: текущие данные.

Множественная миелома (ММ) — гематологическая порча, характеризующаяся клональным распространением аномальных плазменных клеток с ярко выраженной гетерогенностью и терапевтической рефлексорностью. Несмотря на внедрение протеазонных ингибиторов (ИП), иммуноводных препаратов (ИМИД), моноклонных антител (mAbs) и химерика антигенного рецептора Т-клеток (CAR-T), рецидивы и резистентность к лекарствам по-прежнему остаются серьезными проблемами, требующими неотложного решения. В последние годы природные продукты растительного происхождения привлекают все большее внимание в связи с их многоцелевым син

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… Regarding the induction of apoptosis and regulation of the cell cycle, ginsenosides, the primary active constituents of Panax ginseng , exert anti-MM effects through various subtypes by modulating apoptosis-related pathways. … NF-κB,STAT3,Wnt/β-catenin Synergizing with carfilzomib, reducing transplant toxicity [ 71 , 70 ]; SUN, Hu, Guo, et al. 2006; Sun, Hu, Liu, et al. 2006; [ 77 , 76 , 74 ] Panax ginseng Ginsenosides In vitro (RPMI 8226, U266 etc. …

Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.

Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular mechanisms of how ginseng exerts its effects. Recently, we isolated a novel lysophosphatidic acid (LPA) receptor-activating ligand from ginseng, gintonin. AD is caused by amyloid-β protein (Aβ) accumulation. Aβ is derived from amyloid-β protein precursors (AβPPs) through the amyloidogenic pathway. In contrast, non-amyloidogenic pathways produce beneficial, soluble AβPPα (sAβPPα). Here, we describe our investigations of the effect of gintonin

The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer.

One of the most common malignant tumors worldwide is lung cancer, and it is associated with the highest death rate among all cancers. Traditional treatment options for lung cancer include radiation, chemotherapy, targeted therapy, and surgical resection. However, the survival rate is low, and the outlook is still dreadfully dire. The pursuit of a paradigm change in treatment approaches is, therefore, imperative. Tyrosine kinases (TKs), a subclass of protein kinases, regulate vital cellular function by phosphorylating tyrosine residues in proteins. Mutations, overexpression, and autocrine parac

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… . | [ 116 ] 20(S)-ginsenoside Rg3 | Triterpenoid saponins | Panax ginseng | Lung cancer | 20( S )-Rg3 may inhibit CDK2, Cyclin A2, and Cyclin E1 by blocking the cell cycle at the G0/G1 phase. | [ 117 ] Ginsenosides | Saponins | Panax ginseng | NSCLC | Decreased stemness marker expression and reduced … Panax ginseng , a member of the Araliaceous plant groups, has long been utilized in both medicine and cooking. In East Asian countries like China and Korea, Panax ginseng has been used for preventing as well as treating cancer and other diseases [ 217 , 218 ]. …

Apoptotic Pathway as the Therapeutic Target for Anticancer Traditional Chinese Medicines.

Cancer is a leading cause of morbidity and mortality worldwide. Apoptosis is a process of programmed cell death and it plays a vital role in human development and tissue homeostasis. Mounting evidence indicates that apoptosis is closely related to the survival of cancer and it has emerged as a key target for the discovery and development of novel anticancer drugs. Various studies indicate that targeting the apoptotic signaling pathway by anticancer drugs is an important mechanism in cancer therapy. Therefore, numerous novel anticancer agents have been discovered and developed from traditional

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… Panax ginseng C. A. Mey (Araliaceae) is a popular TCM for over 2,000 years and it has buzhongyiqi (补中益气) activity (supplementing the center and boosting energy) as described in Ben Cao Gang Mu (“Compendium of Materia Medica”). Pharmacological studies showed that the extracts of P. ginseng C. A. … Cusson (Osthole), Evodia rutaecarpa (Evodiamine), Panax ginseng C. A. Mey (Compound k, Ginsenoside Rh2, Ginsenoside Rk3), Brucea javanica (L). Merr ( Brucea javanica oil emulsion, (Yadanzi®), Coix lacryma-jobi L. …

Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials.

Background and objective: Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provide an overview of the clinical application of Chinese herbal injections in cancer care based on randomized controlled trials, systematic reviews, and meta-analyses. Methods and results: Seven databases were systematically searched for eligible randomized controlled trials, systematic reviews, and met

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… Harms (Ciwujia), Ginseng: Panax ginseng C. A. Mey. … (Huangqi), Ginseng: Panax ginseng C. A. Mey. …

Допуск на засуху в хлопковых генотипах с помощью интегрированных морфофизиологических и биохимических маркеров на стадии цветения.

Засушливый стресс one из основных абиотических факторов, которые серьезно ограничивают глобальный урожай хлопка, нарушая основные морфофизиологические и биохимические функции. В этом исследовании forty В разделе, посвященном генетически разнообразным генотипам хлопка, была проведена оценка three ирригационные уровни: контроль100% мощность на местах), умеренная (60% FC) и сильная засуха40% FC) на стадии цветения в контролируемой стеклянной среде. Повышение интенсивности засухи привело к постепенному снижению темпов роста и физиологических характеристик. Острый стресс: уменьшение длины выстрела

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… One such example is the MYB2 protein identified in Panax ginseng that positively regulates genes involved in secondary metabolite synthesis under jasmonate signaling 57 . …

Bibliometric and visualization analyses of cancer-related fatigue research published worldwide from 2001 to 2023.

ObjectiveCancer seriously endangers human health and represents a global public health issue. Cancer-related fatigue (CRF) is a distressing and persistent sense of exhaustion caused by cancer or cancer treatment, widely prevalent among cancer patients. This study aims to summarize emerging trends and provide directions for future research of CRF through bibliometric and visualization analyses.MethodsA systematic search in the Web of Science Core Collection database from 2001-01-01 to 2023-05-18 were conducted. Only reviews and articles written in English were considered. CiteSpace and the R we

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… A randomized trial (N07C2) ( 46 ) provided evidence to support the effects of American ginseng (Panax quinquefolius) (2000 mg/day) on CRF, and no discernible treatment-related toxicities are reported. … Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. J Natl Cancer Inst. (2013) 105:1230–8. doi: 10.1093/jnci/djt181 47. Najafi TF, Bahri N, Tohidinik HR, Feyz S, Bloki F, Savarkar S, et al. …

Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review.

Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the production of prostaglandins (PGs). Two types of COXs have been identified as key biological targets for drug design: Constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflammatory drugs (NSAIDs) target COX-1, while selective COX-2 inhibitors are designed for COX-2. These COX isoforms are involved in multiple physiological and pathological pathways throughout the body. Overproduction of tumor necrosis factor-alpha (TNF-α) plays a role in COX-2's inflammatory activity. Tumor necrosis factor-alpha can c

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… Pyrimidine analogs 38, and 39 Ginsenosides are a class of bioactive compounds found in the roots, stems, and leaves of plants in the genus Panax, particularly Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng). …

Fatigue and Its Related Factors Among Iranian Cancer Survivors.

Introduction: Cancer-related fatigue (CRF) is one of the major problems experienced by cancer patients. Identifying the prevalence and factors associated with CRF may be effective in designing appropriate interventions to reduce this problem. This study aimed to examine the prevalence of CRF and its related factors among Iranian cancer survivors. Methods: The samples of this descriptive cross-sectional study included 131 cancer survivors referred to outpatient clinic of Shahid Gazi Hospital affiliated to Tabriz University of Medical Sciences. Brief fatigue inventory (BFI) questionnaire was use

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… J Lundqvist R Eliasson M Patients with type 1 diabetes in Sweden experience more fatigue than the general population J Clin Transl Endocrinol 2015 2 3 105 9 10.1016/j.jcte.2015.06.001 29204373 PMC5685038 35 Wang J Sun C Zheng Y Pan H Zhou Y Fan Y The effective mechanism of the polysaccharides from Panax …

Prospect of Gold Nanoparticles in Pancreatic Cancer

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… Several green biosynthesis approaches for synthesizing AuNPs in PC diagnosis and treatment employ plants such as Borassus flabellifer L., Scutellaria barbata , Panax notoginseng leaves, Acai berry, and Elderberry [ 46 , 47 , 48 , 49 ]. … Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines. Artif. Cells Nanomed. Biotechnol. 2019;47:1216–1223. doi: 10.1080/21691401.2019.1593852. 50. …

Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity.

Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two. The deficiency of Nrf2 elevates the expression of NF-κB, leading to increased production of inflammatory factors, while NF-κB can affect the expression of downstream target genes by regulating the transcription and activity of Nrf2. At the same time, many therapeutic drug-induced organ toxicities, including hepatotoxicity, nephrotoxicity, cardiotoxicity, pulmonary toxicity, dermal toxicity, and neurotoxi

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… Meanwhile, another agent panax notoginseng saponins (PNS) significantly increased Nrf2 phosphorylation for relieving the potential inhibition of TP-induced Nrf2/ARE binding activity. … Catalpol and Panax Notoginseng Saponins Synergistically Alleviate Triptolide-Induced Hepatotoxicity through Nrf2/ARE Pathway. Toxicol. Vitro 56, 141–149. 10.1016/j.tiv.2019.01.016 Finn W. F. (2006). The Clinical and Renal Consequences of Contrast-Induced Nephropathy. Nephrol. Dial. …

Understanding CAM Natural Health Products: Implications of Use Among Cancer Patients and Survivors.

Herbs, vitamins, and other natural health products are being used by cancer patients and survivors with increasing prevalence in the United States. These complementary and alternative medicine (CAM) products, which are also referred to as natural health products in Canada and abroad, are used during cancer treatment and the survivorship period to ease the burden of symptoms such as pain, fatigue, insomnia, anxiety, and depression and hence improve overall quality of life. Data indicate that while patients choose these products for self-treatment, they often do not inform their health-care prov

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… Phase III evaluation of American ginseng (panax quinquefolius) to improve cancer-related fatigue: NCCTG trial N07C2 [Abstract 9001] Journal of Clinical Oncology. 2012;30(suppl) 10. Bath-Hextall Fiona, Leonardi-Bee Jo, Smith Chris, Meal Andy, Hubbard Richard. … Panax ginseng: a role in cancer therapy? Integrative cancer therapies. 2003;2:13–33. doi: 10.1177/1534735403251167. 27. Charles C, Gafni A, Whelan T. Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango). …

Keyword Index for Volume 98

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… 1085, 1197, 1415, 1452, 1781, 1803, 1910 overall survival 489, 1641 oxaliplatin 120, 309, 542, 1034, 1204, 1959 oxidative stress 580, 1157 oxygen 294 p53 4, 1431, 1803 p70 S6k 443 PA2G4 1132 paclitaxel 316, 1068 paediatric brain tumour 474 paediatrics 1570 PAK1 1132 palliative care 294 Panax …

Negative Regulation of Cell Adhesion as a Driver of Brain Metastasis in NSCLC Patients with EGFR Amplification.

Brain metastases are strongly associated with a poor prognosis. Experimental animal models have provided valuable insights into the complex biology underlying brain metastasis, and translating these findings could pave the way for innovative management strategies for patients with brain metastases. Between May 2019 and June 2023, twenty-four lung cancer patients and thirty patients with brain metastases from lung cancer were enrolled at Guangdong Sanjiu Brain Hospital. Next-generation targeted panel sequencing (NGS) was performed on lung cancer tissue and surgical specimens from brain tumors f

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… Screening of active components in astragalus mongholicus bunge and Panax Notoginseng formula for anti-fibrosis in CKD: nobiletin inhibits Lgals1/PI3K/AKT signaling to improve renal fibrosis. Ren Fail. 2024;46(2):2375033. 19. Peters S, Camidge DR, Shaw AT, Gadgeel S, Ahn JS, Kim DW et al. …

Bioactivity of the Genus Turnera: A Review of the Last 10 Years.

Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Amo

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… Comparison study for the recovery of bioactive compounds from Tribulus terrestris , Panax ginseng , Gingko biloba , Lepidium meyenii , Turnera diffusa and Withania somnifera by using microwave-assisted, ultrasound-assisted and conventional extraction methods Ind. …

Exosomes-loaded with traditional Chinese medicine constituents: a novel therapeutic avenue for aplastic anemia.

Aplastic anemia (AA) is a life-threatening blood disorder characterized by bone marrow failure and pancytopenia. Treatments such as immunosuppressive therapy (IST) and allogeneic hematopoietic stem cell transplantation (allo-HSCT) have limitations, including poor long-term remission and donor shortages. Exosomes, nanosized extracellular vesicles, are promising drug delivery systems (DDS) due to their biocompatibility, targeted delivery, and capacity to penetrate biological barriers. Traditional Chinese medicine (TCM) regulates hematopoiesis and immunity but faces challenges with delivery. This

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… TCM constituents with potential in AA treatment Active components of TCM and their mechanisms Ginsenoside Rg1 Ginsenoside Rg1 (Table 1 ), derived from Panax ginseng , exhibits hematopoietic protection in AA models. … Ginsenoside Rg1 | Panax ginseng | Promotes proliferation and inhibits apoptosis of HSPCs; reduces pro-inflammatory cytokines | MAPK signaling pathway; ROS↓, TNF- α ↓, IL-6↓ | Cyclophosphamide-induced myelosuppression in mice | [ 126 , 127 ] APS | Astragalus membranaceus | Enhances HSPCs self-renewal …

Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products.

In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences in efficacy have been observed in clinical practice. There is increasing evidence that gut microbial metabolites influence the efficacy of distal tumor immunotherapy via the gut-liver axis, the gut-brain axis and the gut-breast axis, a process that may involve modulating the expression of immune cells and cytokines in the tumor microenvironment (TME). In this review, we systematically explore the relationship between gut microbial metabolites and tumor i

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… . | ( 182 ) Panax ginseng | Ginseng glucosyl oleanolate | SCFAs | Regulation of the MAPK signaling pathway inhibits Hep G2 cell proliferation, rebalances the intestinal flora, increases the level of total SCFAs improves intestinal inflammation and inhibits tumor growth. | ( 183 ) Gynostemma pentaphyllum … Among these, Panax ginseng C. A. Mey. has been widely used as a functional food and medicine. Ginseng glucosyl oleanolate (GGO) was enzymatically prepared from ginsenoside Ro. …

MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.

In recent decades Chinese medicine has been used worldwide as a complementary and alternative medicine to treat cancer. Plenty of studies have shown that microRNAs (miRNAs) play fundamental roles in many pathological processes, including cancer, while the anti-cancer mechanisms of Chinese medicinal herbs targeting miRNAs also have been extensively explored. Our previous studies and those of others on Chinese medicinal herbs and miRNAs in various cancer models have provided a possibility of new cancer therapies, for example, up-regulating the expression of miR-23a may activate the positive regu

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… Panax Notoginseng Saponins (PNS) is the major class of bioactive ingredients of notoginseng, a herb extensively utilized in TCM for cancer treatment. …

Causal Relationship Between Gut Microbiota and Leukemia: Future Perspectives.

The gut microbiota plays a crucial role in maintaining homeostasis in the human gastrointestinal tract. Numerous studies have shown a strong association between the gut microbiota and the emergence and progression of various diseases. Leukemia is one of the most common hematologic malignancies. Although standardized protocols and expert consensus have been developed for routine diagnosis and treatment, limitations remain due to individual differences. Nevertheless, a large number of studies have established a link between the gut microbiota and leukemia, with disturbances in the gut microbiota

Potential of Lycii Radicis Cortex as an Ameliorative Agent for Skeletal Muscle Atrophy.

Lycii Radicis Cortex (LRC) is a traditional medicine in East Asia with various beneficial effects, including antioxidant, anti-inflammatory, anti-tumor, anti-diabetic, and anti-depressant properties. However, its potential effects on skeletal muscle atrophy have not been studied. In this study, the protective effects of LRC extract (LRCE) on dexamethasone (DEX)-induced muscle atrophy were investigated in C2C12 myotubes and mice. We evaluated the effect of LRCE on improving muscle atrophy using a variety of methods, including immunofluorescence staining, quantitative polymerase chain reaction (

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… Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growth J. Ginseng Res. 2017 41 608 614 10.1016/j.jgr.2017.05.006 29021711 PMC5628345 18. Kim J.W. Ku S.K. Han M.H. Kim K.Y. Kim S.G. Kim G.Y. Hwang H.J. Kim B.W. Kim C.M. Choi Y.H. …