Результаты поиска

Gut Microbiota and Chronic Kidney Disease: A Complex Interplay with Implications for Diagnosis and Treatment.

Chronic kidney disease (CKD) progresses over the years with a steady loss of renal function, often culminating in renal failure. While diabe … tes and hypertension. Microbiome-targeted interventions, such as dietary interventions, probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT), are discussed with an emphasis on their therapeutic relevance in influencing renal health. Additionally, the potential of genetic engineering, particularly CRISPR-based systems, to develop 'sm …

Human gut microbiota-fermented asparagus powder protects human epithelial cells from injury and inflammation.

Dietary consumption of green asparagus has been associated with several health benefits. These beneficial properties are attributed to the presence of many bioactive compounds in asparagus, including saponins, phenolics, flavonoids, as well as dietary fiber mostly comprising fructans and inulins, which are prebiotics capable of supporting the growth of beneficial members of gut microbiota. In this study, we used the in vitro Human Gut Simulator system to assess the fermentation of oro-gastro-intestinally digested asparagus powder by the human gut microbiota. Microbial community composition dif…

Effect of dietary supplementation with Saccharomyces cerevisiae on reproductive parameters of rabbit bucks.

The objective of the present study was to evaluate the effect of dietary supplementation with the prebiotic Saccharomyces cerevisiae yeast on testicular width and semen quality in rabbit bucks. Twenty-four male rabbits were randomly assigned to three groups and their semen was sampled for 8 weeks: a control group (C) fed with a conventional diet without S. cerevisiae, a group supplemented with 0.3 g of S. cerevisiae/kg of feed (T1) and a group supplemented with 1 g of S. cerevisiae/kg of feed (T2). Testicular width was determined using a caliper. Semen was collected from each buck and evaluate

Modulatory effects of in ovo delivery of galactooligosaccharide and Lactiplantibacillus plantarum on antioxidant capacity, gene expression, and selected plasma metabolite parameters of broiler chickens.

A stable gut microbiota promotes a healthy gut and enhances immune function, antioxidant status, and metabolic activities in chickens. The present research work aimed to investigate the modulatory impacts of in ovo delivery of prebiotic and probiotic on oxidative stress, the intestinal transcriptome, and various plasma metabolites in chickens. Fertilized Ross 308 eggs were administered in ovo either with galactooligosaccharide (GOS) (3.5 mg/egg or Lactiplantibacillus plantarum (LP) 1 × 106/egg on the 12th day of egg incubation. Three hundred viable Ross 308 broiler hatching eggs in total were

Gut Microbiome in Alzheimer's Disease: from Mice to Humans.

Alzheimer's disease (AD) is the most prevalent type of dementia, but its etiopathogenesis is not yet fully understood. Recent preclinical st … oduced by the gut microbiome in AD are also highlighted. Furthermore, the potential of antibiotics, prebiotics, probiotics, fecal microbiota transplantation, and dietary interventions as complementary therapies for the management of AD is summarized. This review provides valuable insights into potential therapeutic strategies to modulate the gut microbiome i …

Synergistic effects of Ligilactobacillus salivarius Li01 and psyllium husk prevent mice from developing loperamide-induced constipation.

Constipation is a gastrointestinal (GI) condition marked by difficulty in defecation, abdominal pain and distension, significantly impacting both physical and mental health. Ligilactobacillus salivarius Li01 (Li01) is a probiotic known to prevent constipation in mice, while psyllium husk (PSH) is a dietary fiber with high water retention, acting as an intestinal lubricant. This study investigates the effects of a combined treatment of Li01 and PSH on mice with loperamide-induced constipation. The combination treatment improved GI transit rates, increased the water content of feces, and regulat

Unravelling the Role of Gut and Oral Microbiota in the Pediatric Population with Type 1 Diabetes Mellitus.

Type 1 Diabetes Mellitus (T1DM) is a chronic autoimmune disease that results in the destruction of pancreatic β cells, leading to hyperglyca … athogenesis of T1DM and examines the potential of microbiome-based therapies, including probiotics, prebiotics, synbiotics, and faecal microbiota transplantation (FMT). This complex relationship highlights the need for longitudinal studies to monitor microbiome changes over time, investigate causal relationships between specific microbial species and T1DM, a …

Role of maternal milk in providing a healthy intestinal microbiome for the preterm neonate.

The immature gastrointestinal tract of preterm neonates leads to a delayed and distinctive establishment of the gut microbiome, making them susceptible to potentially pathogenic bacteria and increasing the risk of infections. Maternal milk, recognized as the optimal source of nutrition, plays a multifaceted role in modulating the gut microbiome of premature newborns. Human milk oligosaccharides, acting as prebiotics, provide essential nourishment for key bacteria such as Bifidobacterium, contributing to the proliferation of beneficial bacterial populations. Additionally, maternal milk is rich …

Effect of polysaccharides from Tibetan turnip (Brassica rapa L.) on the gut microbiome after in vitro fermentation and in vivo metabolism.

Tibetan turnip (Brassica rapa L.) polysaccharide (TTP) is an active ingredient and has been studied for many years due to its biological effect. There are a few studies on its digestion properties and the regulation of the intestinal microbiota. In this study, the regulation of intestinal health by TTP was investigated in vitro and in vivo. The results showed that TTP was not degraded after simulated gastrointestinal digestion. When TTP was fermented by the gut microbiota, the content of short-chain fatty acids (SCFAs) and the relative abundance of Bifidobacterium, Catenibacterium increased; t

Does Dysbiosis Increase the Risk of Developing Schizophrenia? - A Comprehensive Narrative Review.

BACKGROUND: There is increasing evidence regarding the influence of the intestinal microbiota on the disease processes of various organs and … othesis and the inflammatory hypothesis. We explored the evidence concerning the use of probiotics, prebiotics, and fecal transplants. CONCLUSION: Although there is no consensus regarding the alterations that could constitute a risk factor for schizophrenia, some of the species appear to be more frequently altered, and their relationship with the host is dy …

Intervention with inulin prior to and during sanative therapy to further support periodontal health: study protocol for a randomized controlled trial.

BACKGROUND: Periodontal disease is a chronic state of inflammation that can destroy the supporting tissues around the teeth, leading to the … agement of periodontal disease. The results of the study will provide guidance regarding the use of prebiotics prior to and as a supportive adjunct to ST for periodontal health. TRIAL REGISTRATION: ClinicalTrials.gov NCT04670133 . Registered on 17 December 2020.

High animal protein diet and gut microbiota in human health.

The role of the intestinal flora in health and disease has become a research hotspot. Compared with carbohydrates and fats, proteins are met … l. Natural compounds (plant extracts, whose main constituents are polysaccharides and polyphenols), prebiotics, probiotics, and regular physical exercise improve gut dysbiosis and reduce disease risk.

Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice.

Polysaccharides isolated from mushrooms have been identified as potential prebiotics that could impact gut microbiota. In this study, a water-soluble polysaccharide (MP) extracted from wild morels was evaluated for its effects on the gut microbiota of non-treated and cyclophosphamide (CP)-treated mice. The results showed that MP restored the spleen weight and increased the counts of white blood cells and lymphocytes in the peripheral blood and spleen of the CP-treated mice. Mice treated with MP exhibited increased levels of short-chain fatty acid (SCFA)-producing bacteria, especially Lachnospi…

The gut microbiome in anorexia nervosa: relevance for nutritional rehabilitation.

Rapidly accumulating evidence supports the important role of gut microbiome in the regulation of mood, behaviour, appetite, gastrointestinal symptomology, and nutrient metabolism. These are all core features frequently altered in individuals with anorexia nervosa (AN). Current treatment recommendations for AN support the use of high-calorie diets as an essential part of nutritional rehabilitation, commonly achieved by elevating the fat content of the diet. However, in contrast to this approach, there is accumulating evidence suggesting the importance of balanced, high-fibre diets on the gut mi

Gut microbiota in chronic kidney disease.

The intestinal microflora maintains a symbiotic relationship with the host under normal conditions, but its imbalance has recently been asso … cardiovascular disease, anaemia, mineral metabolism disorders or the progression of CKD. The use of prebiotics, probiotics or synbiotics, among other approaches, could improve the dysbiosis and/or the increased permeability of the intestinal barrier in CKD. This article describes the situation of the intestinal microflora in CKD, the alteration of the intest …

Двунаправленная связь между кишечной микробиотой и центральной нервной системой.

В последние годы все большее число исследователей заинтересовалось двунаправленной связью между кишечной микробиотой и центральной нервной системой. Это общение происходит через ось микробиота-гут-мозгов. По мере старения людей состав кишечного микробиота претерпевает значительные изменения, которые, как известно, играют важную роль в развитии многих нейродегенеративных заболеваний. Целью этого обзора является изучение сложных путей двунаправленного сигнала между кишечником и мозгом. В нем резюмируются последние результаты исследований о том, как кишечная микробиота и ее метаболиты играют важн

Совпадение в аннотации оригинала
In recent years, an increasing number of researchers have become interested in the bidirectional communication between the gut microbiota an … treatments for neurological disorders, including fecal microbiota transplantation, probiotics, and prebiotics. Many studies show that the gut microbiota affects the brain in several ways. For example, it can produce substances such as short-chain fatty acids and activate inflammatory pathways. Studies involving animals and laboratory models have demonstrate …

From Meteorite to Life's Building Blocks: A possible Electrochemical Pathway to Amino Acids and Peptide Bonds.

This study explores the electrochemical properties of the carbonaceous Allende CV3 meteorite, focusing on its potential as a Fe-based catalyst derived from Mackinawite iron sulfide for electrocatalytic reactions facilitating nitrogen (N2) fixation into ammonia. Through comprehensive analysis, we not only monitored the evolution of key compounds such as CN-, sulfur/H2S, H2 and carbonyl compounds, but also identified potential reagent carriers, indicating significant implications for the Strecker synthesis of amino acids in space environments. Initial examination revealed the presence of polypep

Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic Inflammation with Special Reference to Periodontitis: Current Knowledge and Perspectives.

Under steady-state circumstances, the oral microbiota is in equilibrium with host tissues, thus contributing to local and systemic health. A … iabetes and cardiovascular disease will be elucidated. Some natural compounds, such as polyphenols, prebiotics, and probiotics, will be discussed for their ability to exert anti-inflammatory and anti-oxidant activities in the context of the inflamed buccal cavity and systemically, as well as for their modulation of the altered gum-gut microbiota.

A cyanosulfidic origin of the Krebs cycle.

The centrality of the Krebs cycle in metabolism has long been interpreted as evidence of its antiquity, and consequently, questions regarding its provenance, and whether it initially functioned as a cycle or not, have received much attention. The present report shows that prebiotic oxidation of α-hydroxy carboxylates can be achieved by UV photolysis of a simple geochemical species (HS-), which leads to α-oxo carboxylates that feature in the Krebs cycle and glyoxylate shunt. Further reaction of these products leads to almost all intermediates of the Krebs cycle proper, succinate semialdehyde by

Localized aliphatic organic material on the surface of Ceres.

Organic compounds occur in some chondritic meteorites, and their signatures on solar system bodies have been sought for decades. Spectral signatures of organics have not been unambiguously identified on the surfaces of asteroids, whereas they have been detected on cometary nuclei. Data returned by the Visible and InfraRed Mapping Spectrometer on board the Dawn spacecraft show a clear detection of an organic absorption feature at 3.4 micrometers on dwarf planet Ceres. This signature is characteristic of aliphatic organic matter and is mainly localized on a broad region of ~1000 square kilometer