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Attribution of Meteorological Variability, Land-Cover/LAI Change, and O3-Induced Stomatal Regulation to Summer Biogenic VOC Emissions in China during 2013-2023.

Biogenic volatile organic compounds (BVOCs) strongly influence atmospheric oxidation capacity, ozone (O3) formation, and secondary organic aerosol production. In China, BVOC emissions are being reshaped by concurrent meteorological variability, land-cover changes, and increasing surface O3 pollution, yet their relative contributions remain unclear. Here, we developed an improved WRF-MCIP-BEIS modeling framework incorporating O3-induced stomatal regulation through the canopy energy-balance pathway, and integrated O3-on/O3-off experiments, factorial scenarios, and Shapley decomposition to attrib

Abscisic acid-triggered guard cell l-cysteine desulfhydrase function and in situ hydrogen sulfide production contributes to heme oxygenase-modulated stomatal closure.

Recent studies have demonstrated that hydrogen sulfide (H2 S) produced through the activity of l-cysteine desulfhydrase (DES1) is an important gaseous signaling molecule in plants that could participate in abscisic acid (ABA)-induced stomatal closure. However, the coupling of the DES1/H2 S signaling pathways to guard cell movement has not been thoroughly elucidated. The results presented here provide genetic evidence for a physiologically relevant signaling pathway that governs guard cell in situ DES1/H2 S function in stomatal closure. We discovered that ABA-activated DES1 produces H2 S in gua

Denture hygiene knowledge, cleaning practices, and denture stomatitis among primary care patients in Alkharj, Saudi Arabia: compliance predictors, barriers and educational preferences: a cross-sectional study.

BACKGROUND: Denture wearers must maintain good denture hygiene, as oral health significantly impacts systemic health; yet denture hygiene practices remain poorly addressed within dental primary care facilities. Saudi Arabia's dental primary care system serves a demographically diverse population, including a large proportion of non-Saudi patients, creating a setting in which sociodemographic, linguistic, and economic factors intersect to shape the oral health behaviors of individuals who wear dentures. OBJECTIVES: To assess denture hygiene knowledge, cleaning behaviors, and denture stomatitis…

Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights.

BACKGROUND: The emergence of different viral infections calls for the development of new, effective, and safe antiviral drugs. Glycyrrhiza glabra is a well-known herbal remedy possessing antiviral properties. OBJECTIVE: The objective of our research was to evaluate the effectiveness of a newly developed combination of the probiotics Lactobacillus acidophilus and G. glabra root extract against two viral models, namely the DNA virus Herpes simplex virus-1 (HSV-1) and the RNA virus Vesicular Stomatitis Virus (VSV), with regards to their antiviral properties. METHODOLOGY: To examine the antivira…

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis.

BACKGROUND: Oncolytic viruses reduce tumor burden in animal models and have generated promising results in clinical trials. However, it is l … natural killer T (NKT) cell-based immunotherapy in combination with recombinant oncolytic vesicular stomatitis virus (VSV) or reovirus. 4T1 mammary carcinoma cells or ID8 ovarian cancer cells were injected into syngeneic mice. Tumor-bearing mice were treated with VSV or reovirus followed by activation of NKT cells via the intravenous administration of autolo …

Воздействие гамма-излучения на реакцию антитела, измеренную в человеческой селюме от лиц, вакцинированных рекомбинантной вакциной от вируса везикулярного стоматита вируса-заирского вируса Эбола Энвелопе Гликпротеина.

rVSVΔG-ZEBOV-GP — это живой рекомбинант (r) вирус сосудистого стоматита (VSV), где протеин VSV G заменяется гликопротеином заирского вируса Эбола (ZEBOV). Для проверки иммуногенности вакцины сера клинических испытаний, собранная в ходе активной вспышки ЗЕБОВ, подверглась гамма-облучению (ГИ) перед испытанием в лабораториях уровня 2 по биобезопасности, с тем чтобы активировать возможный дикий тип ZEBOV. Перед облучением основных пробных образцов два независимых исследования провели оценку воздействия ГИ (50 кГГ) на связующие ЗЕБОВ-ГП (ЭЛИСА) антитела против rVSVΔG-ZEBOV-GP с использованием серы

Совпадение в аннотации оригинала
rVSVΔG-ZEBOV-GP vaccine is a live recombinant (r) vesicular stomatitis virus (VSV), where the VSV G protein is replaced with the Zaire Ebola virus (ZEBOV) glycoprotein (GP). For vaccine immunogenicity testing, clinical trial sera collected during an active ZEBOV outbreak underwent gamma irradiation (GI) before testing in biosafety level 2 laboratories to ina…

Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial.

BACKGROUND: Stomatitis is a class effect associated with the inhibition of mTOR and is associated with everolimus therapy for breast cancer. Topical steroids might reduce stomatitis incidence and severity, and the need for dose reductions and interruptions of everolimus. Anecdotal use of topical steroid oral prophylaxis has been reported in patients with breast cancer. We aimed to assess dexamethasone-based mouthwash for prevention of stomatitis in patients with breast cancer. METHODS: This US-based, multicentre, single-arm, phase 2 prevention study enrolled women aged 18 years and older with…

Mechanism of interferon action: inhibition of vesicular stomatitis virus replication in human amnion U cells by cloned human gamma-interferon. II. Effect on viral macromolecular synthesis.

The effects of recombinant human gamma-interferon (IFN-gamma) on vesicular stomatitis virus (VSV) macromolecular synthesis in human amnion U cells were examined. Saturating concentrations of IFN-gamma caused only a 3 to 5-fold reduction of viral protein synthesis in wild-type VSV-infected cells, an extent insufficient to account for the 100-fold inhibition of viral infectivity. By use of the VSV mutant tsG41, which is competent in RNA transcription but defective in RNA replication at 40 degrees C, it was shown that the apparent IFN-induced inhibition of viral protein synthesis was likely due t…

Effectiveness of 0.1% triamcinolone acetonide compared with those of other therapies for minor recurrent aphthous stomatitis: a systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral mucosal condition affecting over 2.5 billion people worldwide. Although 0.1% triamcinolone acetonide is a standard treatment, its comparative efficacy remains uncertain. OBJECTIVE: To evaluate and compare systematically the efficacy of 0.1% triamcinolone acetonide with those of alternative therapies for RAS management. METHODS: A systematic review and meta-analysis were conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. From December 2024 to April 2025, PubMed …

A Brighton Collaboration standardized template with key considerations for a benefit/risk assessment for the emergent vesicular stomatitis virus (VSV) viral vector vaccine for Lassa fever.

There are currently no prophylactic vaccines licensed to protect against Lassa fever caused by Lassa virus (LASV) infection. The Emergent BioSolutions (EBS) vaccine candidate, EBS-LASV, is being developed for the prevention of Lassa fever. EBS-LASV is a live-attenuated recombinant Vesicular Stomatitis Virus (rVSV)-vectored vaccine encoding the surface glycoprotein complex (GPC) from LASV and has two attenuating vector modifications: a gene shuffle of the VSV N gene and a deletion of the VSV G gene. Several preclinical safety studies demonstrate that EBS-LASV is safe when administered to animal…

Analysis of the Risk of Oral Squamous Cell Carcinoma in Patients with and without Recurrent Aphthous Stomatitis: A Retrospective Evaluation of Real-World Data of about 150,000 Patients.

Background: Recurrent aphthous stomatitis (RAS) is found among the most frequent diseases of the oral cavity. It is characterized by repeated formation of painful ulcers. The question has risen if due to potential tumor-promoting inflammation and sustaining proliferative signaling RAS may contribute to oral cancer. Accordingly, the aim of the study was to assess if an association of RAS and the development oral squamous cell carcinoma (OSCC) could be found in a larger cohort. As recurrent aphthous stomatitis is not classified as an oral potentially malignant disorder, it was assumed that the r…

Periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy syndrome is associated with activation of GM-CSF and burst-like expression of IL-8 in peripheral blood.

INTRODUCTION: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy (PFAPA) is an autoinflammatory syndrome characterized by periodic fever with aphthous stomatitis, cervical lymphadenopathy, myalgia, and abdominal pain. Peripheral blood concentrations of selected cytokines of PFAPA patients during and between febrile episodes were analyzed in a search for PFAPA-specific molecular signature. METHODS: 23 children with PFAPA (age 6.07 ± 2.94 years, range 5-9 years) and three control children with severe oropharyngeal infections (age 6.2 ± 7.95 years, range 1-17 years) partici…

Nitric oxide production occurs downstream of reactive oxygen species in guard cells during stomatal closure induced by chitosan in abaxial epidermis of Pisum sativum.

The effects of chitosan (beta-1,4 linked glucosamine, a fungal elicitor), on the patterns of stomatal movement and signaling components were studied. cPTIO (NO scavenger), sodium tungstate (nitrate reductase inhibitor) or L: -NAME (NO synthase inhibitor) restricted the chitosan induced stomatal closure, demonstrating that NO is an essential factor. Similarly, catalase (H(2)O(2) scavenger) or DPI [NAD(P)H oxidase inhibitor] and BAPTA-AM or BAPTA (calcium chelators) prevented chitosan induced stomatal closure, suggesting that reactive oxygen species (ROS) and calcium were involved during such re

Effects of Antimicrobial Photodynamic Therapy Mediated by Free Curcumin and Curcumin-Associated Superparamagnetic Iron Oxide Nanoparticles on Candida spp. and Microcosm Biofilms Associated with Denture Stomatitis.

Antimicrobial photodynamic therapy (aPDT) has emerged as a promising strategy for managing infections associated withCandidaspp. In this con … lected from the prosthesis surfaces and oral mucosa of 5 patients clinically diagnosed with denture stomatitis.Candidaisolates were identified using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS). CUR-SPION were synthesized via the coprecipitation method, allowing the incorporation and association of CUR with the …

Differentiating Periodic Fever, Aphthous Stomatitis, Pharyngitis, Cervical Adenitis (PFAPA) and Syndrome of Undifferentiated Recurrent Fever (SURF): A Comparative Study of Clinical Features, Treatment Response, and Remission.

OBJECTIVE: To apply proposed classification criteria for periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis (PFAPA) and syndrome of undifferentiated recurrent fever (SURF) to a heterogeneous cohort of children with recurrent fever syndromes and to evaluate the differences in phenotype, treatment response, and disease outcomes. METHODS: We conducted a retrospective cohort study of 235 children referred to the Autoinflammatory Clinic at The Hospital for Sick Children between 2016 and 2024. Patients were classified as PFAPA or SURF using validated Eurofever/Paediatric Rheumatolo…

A single amino acid substitution in the Borna disease virus glycoprotein enhances the infectivity titer of vesicular stomatitis virus pseudotyped virus by altering membrane fusion activity.

Borna disease virus 1 (BoDV-1) causes acute fatal encephalitis in mammals, including humans. Despite its importance, research on BoDV-1 cell entry has been hindered by low infectious viral particle production in cells and the lack of cytopathic effects, which are typically useful for screening. To address these issues, we developed a method to efficiently produce vesicular stomatitis virus (VSV) pseudotyped with glycoprotein (G) of members of the genus Orthobornavirus, including BoDV-1. We discovered that optimal G expression is required to obtain a high infectivity titer of the VSV pseudotype…

Tonsillectomy reduces the family impact of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome and improves health-related quality of life in affected children.

BACKGROUND: Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome is an autoinflammatory disorder that primarily affects young children, and typically gives rise to fever episodes that recur monthly for several years. This study investigated the impact of PFAPA syndrome on the families of affected children, the health-related quality of life (HRQOL) of children with the syndrome, and how these factors were influenced by tonsillectomy. METHODS: This prospective cohort study included 24 children with typical PFAPA syndrome that were referred for tonsillectomy, …

Root coverage of a maxillary lateral incisor with gingival recession, gingival stillman's cleft, bony exostosis, and denture stomatitis: a case report with 3-year follow-up.

BACKGROUND: Coronally advanced flap combined with connective tissue graft is considered as the golden standard of root coverage. Although Miller class I recession is considered to get complete root coverage, there are some uncommon conditions in different cases. This case reported a maxillary lateral incisor with a gingival recession, a stillman's cleft, a bony exostosis and a denture stomatitis. CASE PRESENTATION: A 27-year-old female with a gingival recession, a stillman's cleft and a bony exostosis was treated by coronally advanced flap combined with connective tissue graft technique, and …