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Diet, Nutrition, and Cancer Epigenetics.

The search for a connection between diet and human cancer has a long history in cancer research, as has interest in the mechanisms by which dietary factors might increase or decrease cancer risk. The realization that altering diet can alter the epigenetic state of genes and that these epigenetic alterations might increase or decrease cancer risk is a more modern notion, driven largely by studies in animal models. The connections between diet and epigenetic alterations, on the one hand, and between epigenetic alterations and cancer, on the other, are supported by both observational studies in h

Nutrients and bioactive compounds as modifiers of neurodegenerative trajectories: molecular mechanisms, translational barriers, and precision nutrition.

The Neurodegenerative diseases (NDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), Multiple sclerosis (MS), and Amyotrophic la … e stage. This review highlights emerging potential of precision nutrition frameworks that integrate nutrigenomics, metabolomics, and microbiome interactions, and individualized metabolic profiling to enable context-dependent and stage-specific interventions. Moreover, conceptualizing neurodegeneration as a nutrient-sensitive, systems level disorder, propose a m …

Nutraceuticals in breast cancer therapy: Mechanistic insights and therapeutic potential.

Breast cancer (BC) remains a major global health burden, ranking as the most diagnosed cancer and a leading cause of cancer-related deaths a … osomes and solid lipid nanoparticles, are recommended to address these issues and enhance efficacy. Nutrigenomics and metabolomics also provide a framework for personalized treatment strategies. Overall, this review highlights the therapeutic potential of these agents for breast cancer and advocates for their integration into the field of oncology. Further, con …

Expression of B. subtilis Phytase gene driven by fruit specific E8 promoter for enhanced minerals, metabolites and phytonutrient in cucumber fruit.

The fruit nutrigenomics is an interesting and important research area towards nutrition enhancement. The phytic acid is one of the major antinutrient compound, present in seeded fruits and crops. It hinders the absorption of iron (Fe), zinc (Zn), magnesium (Mg), potassium (K) and calcium (Ca), causing mineral deficiencies. In the present study, the BsPhy gene was overexpressed in the cucumber fruits using the tomato fruit specific E8 and constitutive CaMV 35S promoter. The E8 promoter imparted heterologous expression of GUS gene in cucumber fruits, furthermore, the fruit specific expression of…

The Alzheimer's Prevention Clinic at Weill Cornell Medical College / New York - Presbyterian Hospital: Risk Stratification and Personalized Early Intervention.

In July 2013, Weill Cornell Medical College founded the first Alzheimer's Prevention Clinic (APC) in the United States, providing direct cli … ng clinical and research technologies. The APC approach applies the principles of pharmacogenomics, nutrigenomics and clinical precision medicine, to tailor individualized therapies for patients. Longitudinal measures currently assessed in the clinic include anthropometrics, cognition, blood biomarkers (i.e., lipid, inflammatory, metabolic, nutritional) and gen …

Dietary, endocrine, and metabolic factors in the development of colorectal cancer.

INTRODUCTION: Colorectal cancer is the third cause of death in industrialized countries. Genetic susceptibility and diet are determinant of cancer risk and tumor behavior. Variation in cancer incidence among and within populations with similar dietary patterns suggests that an individual response may reflect interactions with genetic factors, which may modify gene, protein, and metabolite expression patterns. Nutrigenomics, defined as the interaction between nutrition and an individual genome, will likely provide important clues about responders and non-responders to nutritional intervention. …

Nutrigenetic Markers Related to Nutrient Metabolism, Recovery, and Performance in Athletes: a Review of Current Evidence.

PURPOSE OF REVIEW: This review aimed to evaluate current evidence regarding genetic markers associated with athletic performance, recovery, injury susceptibility, nutrient metabolism, responsiveness to ergogenic aids, and dietary behaviour in athletes. RECENT FINDINGS: Classical candidate-gene studies and contemporary genome-wide investigations have identified numerous genetic variants associated with power and endurance performance, skeletal muscle capillarization, cardiac adaptation, energy metabolism, and injury susceptibility. Variants related to carbohydrate, fat, and branched-chain amin

Postprandial lipemia: factoring in lipemic response for ranking foods for their healthiness.

One of the limitations for ranking foods and meals for healthiness on the basis of the glycaemic index (GI) is that the GI is subject to manipulation by addition of fat. Postprandial lipemia, defined as a rise in circulating triglyceride containing lipoproteins following consumption of a meal, has been recognised as a risk factor for the development of cardiovascular disease and other chronic diseases. Many non-modifiable factors (pathological conditions, genetic background, age, sex and menopausal status) and life-style factors (physical activity, smoking, alcohol and medication use, dietary

Nutri-epigenomic Studies Related to Neural Tube Defects: Does Folate Affect Neural Tube Closure Via Changes in DNA Methylation?

Neural tube defects (NTDs), affecting 1-2 per 1000 pregnancies, are severe congenital malformations that arise from the failure of neurulation during early embryonic development. The methylation hypothesis suggests that folate prevents NTDs by stimulating cellular methylation reactions. Folate is central to the one-carbon metabolism that produces pyrimidines and purines for DNA synthesis and for the generation of the methyldonor S-adenosyl-methionine. This review focuses on the relation between the folate-mediated one-carbon metabolism, DNA methylation and NTDs. Studies will be discussed that

Intersection of Precision Nutrition and Bladder Cancer: A Narrative State-of-the-Art Review of Potential Applications and Challenges.

Bladder cancer (BC) is a biologically heterogeneous tumor affected by genetic, metabolic, environmental, and lifestyle factors. Recent research indicates that nutrition can change the way urothelial cancer forms by affecting inflammation, oxidative stress, cellular energy, and the epigenome. It can also change the risk of BC and how well treatment works. Simultaneous progress in precision nutrition (PN) and nutriomic profiling-encompassing nutrigenomics, nutrigenetics, nutriepigenetics, metabolomics, and microbiome science-presents novel options to tailor dietary regimens beyond universal guid…

Artificial intelligence and sports genomics: advancing precision sports science and athletic performance.

The integration of artificial intelligence (AI) and genomics in sports science has immense potential in the field by enabling personalised, … ogical, biomechanical, and genomic datasets. The applications of AI-driven individualised training, nutrigenomics, biomarker-guided recovery, wearable sensor technologies, and injury prediction models are thoroughly reviewed. The integration of genomics with AI-driven predictive algorithms may support athlete classification, training optimisation, and assessmen …

Long-Term Health and Economic Impact of a Community-Based, Gene-Guided, Nutrition Program: The Sakado Folate Project in Japan.

BACKGROUND/OBJECTIVES: Precision nutrition informed by genetic profiling has been proposed to improve public health outcomes; however, long- … intervention may improve population health outcomes and reduce healthcare expenditures. Integrating nutrigenomics into public health strategies alongside community education and food environment improvements may contribute to sustainable healthcare systems in aging societies.

Personalising nutrition and lifestyle recommendations: Analysis of gene-test reports by individual and geographic differences.

Introduction: Advances in nutrigenomics have enabled exploration of how genetic variation may relate to nutrition and lifestyle traits. However, the extent to which demographic factors influence the distribution of such variants remains underexplored. Objective: This study examined gender- and region-specific variation in diet- and lifestyle-related genetic traits and described patterns of trait clustering within a cohort of direct-to-consumer gene-test clients. Methods: A cross-sectional analysis was conducted on 503 anonymised gene-test reports covering 41 nutrition- and lifestyle-linked gen…

Integrative Approaches to Prostate Disease Management: Nutrition, Exercise, and Lifestyle Modifications.

Prostate-related conditions, including benign prostatic hyperplasia, prostatitis, and prostate cancer, represent significant health concerns … ressing the physical, emotional, and social dimensions of prostate disease. Emerging fields such as nutrigenomics and natural products offer opportunities for personalized interventions, paving the way for innovative management strategies. This study underscores the potential of integrative methods to improve disease outcomes, prevent progression, and enhance t …

Точное питание и обезьяна кут-брэйна в профилактике нейродегенеративных заболеваний.

В последние годы ускорение глобального демографического перехода к старению населения сопровождалось заметным увеличением распространенности нейродегенеративных расстройств, в частности болезни Альцгеймера, болезни Паркинсона, амиотропического бокового склероза и множественного склероза. Среди новых подходов значительное внимание привлекло диетическое вмешательство, направленное на ось кишечника, в силу их потенциала модуляции ключевых патогенных путей, лежащих в основе нейродегенеративных процессов. В этом обзоре обобщены современные концепции точного питания и разъяснены нейрохуморальные, им

Совпадение в аннотации оригинала
In the recent years, the accelerating global demographic shift toward population aging has been accompanied by a marked increase in the prev … iple sclerosis is systematically summarized. The review further discusses the prospects of applying nutrigenomics, chrononutrition, and metagenomic analysis to the development of personalized dietary strategies. The presented findings underscore the potential of integrating precision nutrition with targeted modulation of the gut-brain axis as a multifaceted app …

Effects of gene-lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis.

BACKGROUND: The relationship between lifestyle and obesity is a major focus of research. Personalized nutrition, which utilizes evidence from nutrigenomics, such as gene-environment interactions, has been attracting attention in recent years. However, evidence for gene-environment interactions that can inform treatment strategies is lacking, despite some reported interactions involving dietary intake or physical activity. Utilizing gene-lifestyle interactions in practice could aid in optimizing interventions according to genetic risk. METHODS: This study aimed to elucidate the effects of gene…

Novel effects of hormonal contraceptive use on the plasma proteome.

BACKGROUND: Hormonal contraceptive (HC) use may increase cardiometabolic risk; however, the effect of HC on emerging cardiometabolic and other disease risk factors is not clear. OBJECTIVES: To determine the association between HC use and plasma proteins involved in established and emerging disease risk pathways. METHOD: Concentrations of 54 high-abundance plasma proteins were measured simultaneously by LC-MRM/MS in 783 women from the Toronto Nutrigenomics and Health Study. C-reactive protein (CRP) was measured separately. ANCOVA was used to test differences in protein concentrations between …

Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens.

BACKGROUND: The present study was conducted to investigate the effects of dietary plant-derived phytonutrients, carvacrol, cinnamaldehyde and Capsicum oleoresin, on the translational regulation of genes associated with immunology, physiology and metabolism using high-throughput microarray analysis and in vivo disease challenge model of avian coccidiosis. METHODS: In this study, we used nutrigenomics technology to investigate the molecular and genetic mechanisms of dietary modulation of host innate immunity and metabolism by three phytonutrients. To validate their immunomodulatory effects in a…

Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency.

BACKGROUND: Haptoglobin (which is encoded by the Hp gene) is a hemoglobin-binding protein that has antioxidant properties and a common polym … DESIGN: Nonsmoking men and women (n = 1046) between 20 and 29 y of age participated in the Toronto Nutrigenomics and Health Study. Blood samples were collected after the subjects had fasted overnight to determine serum ascorbic acid concentrations by HPLC and for genotyping. A 196-item food-frequency questionnaire was used to estimate vitamin C intake. RESULT …

Heat stress in riverine buffaloes: regulatory mechanism, physiological changes, production and reproductive performance, and mitigation strategies.

Buffalo is playing a leading role in the national economy by producing milk, meat and draught power in Pakistan. According to the Economic Survey of Pakistan (2023-24), buffalo contributes about 59.6%, followed by cattle (37.4%) and sheep/goat/camel (3%). The climatic conditions of tropical areas are primarily characterized as hot and humid. High ambient temperatures, mainly, are a significant factor affecting animals in tropical and subtropical regions. Due to high temperatures and moisture, heat stress is the main force hindering buffalo productivity in tropical regions. High ambient tempera