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[Retreatment with immunosuppression for 23 patients with refractory or relapsed severe aplastic anemia].

Objective: This study aims to evaluate the efficacy and safety of secondary immunosuppressive therapy (IST) in refractory or relapsed severe aplastic anemia. Methods: The hematologic response and safety of 23 patients with refractory or relapsed SAA treated with secondary IST (including ATG/ALG + cyclosporine or HD-CTX) in our hospital were retrospectively analyzed. Results: A total of 23 patients were involved, including 11 males and 12 females, with a median age of 21 (11-62) years. In the refractory group, the interval of IST was 7 (6-12) months. In the relapsed group, on the other hand, th

Retreatment with Bendamustine-Bortezomib-Dexamethasone in a Patient with Relapsed/Refractory Multiple Myeloma.

The clinical management of relapsed/refractory multiple myeloma and the correct choice of the most suitable therapy in heavily pretreated and fragile patients are tough clinical issues for clinicians. In advanced phases of disease, the choice of available therapies becomes very poor, and the retreatment with previously adopted and effective therapy, although unpredictable, could be an effective option. In this report, we describe the clinical history of a patient, previously treated with 9 lines of therapy, refractory to bortezomib and IMIDs, for whom the retreatment with bendamustine resulted…

Comparison of orange oil and chloroform as gutta- percha solvents in endodontic retreatment.

OBJECTIVE: To compare the efficacy of gutta-percha removal achieved with simple mechanical technique using two different solvents. MATERIALS AND METHODS: It was an in vitro experimental study conducted at the Aga Khan University Hospital, Karachi, Pakistan on 27 extracted human molars divided into two groups by alternate sampling technique. The teeth were prepared by manual filing and obturated with gutta-percha and calcium hydroxide sealer. Two drops of the assigned solvent were placed on the orifice of the obturated canal and Gates Glidden drills #1, 2 and 3 were used for removal of coronal

Alcon CustomCornea wavefront-guided retreatments after laser in situ keratomileusis.

PURPOSE: To evaluate the outcome of wavefront-guided ablations for the correction of residual myopia and astigmatism after standard laser in situ keratomileusis (LASIK). METHODS: Twenty nine eyes of 26 patients who underwent wavefront-guided LASIK retreatment with Alcon CustomCornea (Alcon Laboratories Inc, Fort Worth, Tex) were evaluated. Complete ophthalmologic examination, corneal topography, and wavefront measurements were performed. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refraction, and wavefront analysis were evaluated preoperatively, …

Two-Year Outcomes of Fractional CO₂ Laser for Vaginal Laxity: Effectiveness, Retreatment Need.

OBJECTIVE: The purpose of this study was to evaluate the long-term efficacy of fractional CO₂ laser in the treatment of vaginal laxity (VL) and to determine additional treatment requirements during two-year follow-up. METHODS: A total of 176 women who underwent fractional CO₂ laser therapy for vaginal laxity between January 2020 and January 2023 were retrospectively evaluated. Three sessions of laser therapy were applied at 4–6 week intervals in all cases. Primary outcome measures were additional laser therapy requirements, patient satisfaction with primary and secondary treatments, and the ge

PSMA-RECAP: [177Lu]Lu-PSMA-617 retreatment in metastatic castration-resistant prostate cancer.

PURPOSE: Radioligand therapy (RLT) with [177Lu] Lu-PSMA-617 has shown significant benefits in metastatic castration-resistant prostate cancer (mCRPC), including prolonged overall survival (OS) and progression-free survival (PFS), as well as improved quality of life. For patients previously treated with [177Lu]Lu-PSMA-617 who subsequently experience disease progression, retreatment with [177Lu] Lu-PSMA-617 has emerged as a potential approach, yet data on the outcomes of RLT retreatment remains limited. This study aimed to assess the efficacy and safety of retreatment RLT in mCRPC. METHODS: Cli…

TNFRSF17 - руководство по геномическому профилированию с использованием альтернативных иммунотерапий на базе BCMA в множестве миеломы.

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… UPN4 relapsed after idecabtagene vicleucel without a detectable BCMA alteration, supporting retreatment with a distinct BCMA-directed modality. … These observations argue that BCMA sequencing should be considered at relapse after BCMA-directed therapy to refine treatment selection, avoid ineffective retreatment, and extend clinical benefit in patients who were heavily pretreated. …

Adult orthodontic retreatment of severe root resorption by skeletal anchorage: A case report.

The presence of root resorption and its correlated factors are concerns that must be considered in orthodontic planning. This case report describes the orthodontic retreatment of a patient with a dental to facial midline discrepancy, a severe apical root resorption, and with maxillary and mandibular incisors presenting accentuated labial tipping and protrusion. The treatment included self-ligating brackets, maxillary unilateral distalization with skeletal anchorage and a mandibular extraction, followed by retraction. The orthodontic planning was based on simple and efficient mechanics and the …

Bortezomib retreatment for relapsed and refractory multiple myeloma in real-world clinical practice.

AimsStudies have shown that bortezomib retreatment is effective in relapsed/refractory multiple myeloma (MM). The observational, prospective electronic VELCADE® OBservational Study (eVOBS) study assessed bortezomib-based therapies for patients with MM in everyday practice. Here, we report on those patients receiving retreatment with bortezomib.MethodsConsenting adults scheduled to receive bortezomib for MM were enrolled at 162 sites across Europe, Canada, Brazil, Russia, and Turkey between 2006 and 2010. Retrospective data on prior therapies and prospective observational data after bortezomib …

Response to therapy following retreatment of serofast early syphilis patients with benzathine penicillin.

Persistent nontreponemal titers after treatment are common among patients with early syphilis. We retreated 82 human immunodeficiency virus-negative early syphilis participants who were serofast at 6 months using benzathine penicillin. Only 27% exhibited serological response after retreatment and after an additional 6 months of follow-up.

Outcomes of Retreatment after Aborted Laser In Situ Keratomileusis due to Flap Complications.

PURPOSE: To determine the refractive outcomes and complications of retreatment after aborted primary laser in situ keratomileusis (LASIK) due to flap complications. MATERIALS AND METHODS: This retrospective study evaluated 50 retreated eyes that had flap complications during primary LASIK at the Eye Consultants Center in Riyadh, Saudi Arabia. Data were analyzed for patients with at least 3 months follow-up post retreatment. RESULTS: Thirty-three eyes of 31 consecutive patients with 3 months follow-up or later post retreatment were included. The primary LASIK was aborted due to incomplete fla…

[Retreatment of chronic hepatitis C patients non responder to a previous antiviral treatment].

Treatment of chronic hepatitis C during the past years has shown a significant increase of the percentage of therapeutic response, mostly due to the availability of pegylated interferons. Nevertheless a proportion of patients, ranging from 15% to 60%, do not achieve the virus eradication after treatment, largely depending on viral genotype. Retreatment of non responders is recommended in those patients who have been treated with non-pegylated interferon. In these patients, the rate of antiviral response to retreatment depends on genotype, viral load, degree of histological damage, ethnicity an…

Retreatment with nafarelin for recurrent endometriosis symptoms: efficacy, safety, and bone mineral density.

OBJECTIVE: To assess the efficacy, safety, and effect on bone mineral density of a 3-month course of retreatment with intranasal nafarelin acetate for recurrent symptoms of endometriosis. DESIGN: Multicenter, open-label, nonrandomized clinical trial. SETTING: Eleven hospital-based and private practices. PATIENT(S): Thirty-six women with endometriosis symptoms recurring after 3 or 6 months of treatment with nafarelin. INTERVENTION(S): Nasal nafarelin 200 micrograms twice daily for 3 months. MAIN OUTCOME MEASURE(S): Assessments for dysmenorrhea, dyspareunia, pelvic pain, tenderness, and ind…

Health-related quality of life with pertuzumab retreatment: Secondary analysis of the PRECIOUS trial.

BACKGROUND: Retreatment with pertuzumab has demonstrated survival benefit in previously treated human epidermal growth factor receptor 2 (HER2)-positive locally advanced or metastatic breast cancer, but its effect on health-related quality of life (HRQoL) is not well established. METHODS: This secondary analysis of the randomized, open-label phase III PRECIOUS trial evaluated HRQoL in women previously treated with pertuzumab, trastuzumab, and chemotherapy. Patients were randomized 1:1 to pertuzumab plus trastuzumab plus chemotherapy (PTC) or trastuzumab plus chemotherapy (TC). HRQoL was asses…

Retreatment of persistent pulmonary arteriovenous malformations: factors associated with technical success and durable occlusion.

AIM: To evaluate factors that contribute to successful retreatment of persistent Pulmonary Arteriovenous Malformations (PAVMs) after initial embolization, focusing on long-term occlusion outcomes. MATERIALS AND METHODS: This study reviewed consecutive treatments for persistent PAVMs re-treated at a single institution. The success of repeat treatment was assessed on follow-up imaging. RESULTS: Twenty-four retreatment procedures in 19 patients were included (median age 59, range 9-71). Most PAVMs were simple (71%) rather than complex (29%), and saccular (71%) rather than non-saccular (29%). PA…

Reactivation of retinopathy of prematurity after intravitreal bevacizumab: incidence, risk factors, and retreatment requirements.

BACKGROUND: This study aimed to evaluate the incidence and risk factors of reactivation following intravitreal bevacizumab (IVB) treatment f … stage, duration of oxygen therapy, and timing of IVB administration were analyzed. Reactivation and retreatment rates were compared to identify potential risk factors. RESULTS: Reactivation occurred in 36 eyes (30.3%), and 31 of these eyes (86.1%) required additional treatment. The mean gestational age and birth weight in reactivated eyes were 24.4 ± 1.2 wee …

CBCT assessment of mandibular molar furcation following root canal retreatment using engine-driven instruments.

This study employed e-Vol DXS cone beam computed tomography (CBCT) software to assess dentin remnants in the furcation area of mesial canals in mandibular molars during root canal retreatment (RCR). Four groups (Reciproc®, ProTaper Next®, Race Evo®, Protaper Gold®) were subjected to RCR, and CBCT images were captured before (T1) and after (T2) treatment. Measurements of remaining dentin thickness at 1 mm and 3 mm below the furcation were scrutinized. Results revealed no significant differences in mean thicknesses of mesiobuccal (MB) and mesiolingual (ML) canals at 1 mm and 3 mm from the furcat…

Prevalence of Enterococcus faecalis and Candida albicans in endodontic retreatment Cases: A comprehensive study.

INTRODUCTION: Endodontic treatment failures often stem from the presence of microbial pathogens, particularly Enterococcus faecalis and Candida albicans. This study systematically assesses the prevalence of E. faecalis and C. albicans in endodontic retreatment cases, aiming to explore their impact on treatment outcomes. METHODS: Employing a systematic sampling approach, 30 patients with a history of previous endodontic treatment were selected. Rigorous clinical and radiographic assessments were conducted, following standardized protocols for root canal sample collection. Microbiological analy…