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Alterations in the gastric and small intestinal microbiota of mice exposed to short-term and long-term hypoxia.

Tens of millions of people worldwide travel to high-altitude regions (> 2500 m) every year for short-term work, tourism and pilgrimage. Hypo … the phyla Gemmatimonadetes and Acidobacteria and genera Gemmatimonas, Kocuria, Parasutterella, and Saccharopolyspora declined steadily, while Staphylococcus increased consistently in the stomach. In the small intestine, the relative abundance of the genus Stomatobaculum consistently increased in response to prolonged hypoxia. This study provided a time-resolved ov …

Initial evaluations of the effectiveness of spinetoram as a long-acting, oral systemic pulicide for controlling cat flea (Ctenocephalides felis) infestations on dogs.

Spinetoram is a semi-synthetic, spinosyn class natural product derived from fermentation by the actinomycete, Saccharopolyspora spinosa. Based on LD50 (50% lethal dose) values against adult cat fleas (Ctenocephalides felis) using an in vitro contact assay, spinetoram was approximately 4-fold more potent than spinosad. Subsequently, two parallel-arm, randomized block design laboratory studies were conducted to evaluate the effectiveness of orally administered spinetoram against experimental C. felis infestations on dogs, when administered as a single dose or multiple doses over a 6-12h interval…

[Weidiao-3 Mixture Improves the Clinical Efficacy of Immunotherapy for Advanced Gastric Cancer by Regulating Intestinal Flora].

Objective To investigate the effects of Weidiao-3(WD-3)Mixture on the clinical efficacy of immunotherapy for advanced gastric cancer and the … abundance of 6 intestinal bacterial taxa between the WD-3 group and the GC group.At the genus level,Saccharopolyspora had higher relative abundance in the WD-3 group than in the healthy control group and only existed in the WD-3 group.The content of isobutyric acid and isovaleric acid in the WD-3 group was higher than that in the healthy control group(P=0.037,P=0.0 …

Microbiome and pancreatic cancer: time to think about chemotherapy.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and a high mortality rate. Its complex biology, characterized by a dense, stromal tumor environment with an immunosuppressive milieu, contributes to resistance against standard treatments like chemotherapy and radiation. This comprehensive review explores the dynamic role of the microbiome in modulating chemotherapy efficacy and outcomes in PDAC. It delves into the microbiome's impact on drug metabolism and resistance, and the interaction between microbial elements, drugs,

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… Further research by Riquelme et al. (2019) indicated that the tumor microbiome in long-term survivors of pancreatic cancer aids T-cell activation. 99 This is associated with the presence of specific bacterial genera such as Saccharopolyspora, Pseudoxanthomonas, and Streptomyces within the tumor ( Figure … prognosis. 90 Riquelme et al. (2019) analyzed the tumor microbiome in PDAC patients with varying survival rates, discovering that long-term survivors exhibited higher alpha-diversity in their tumor microbiome. 99 They identified a distinct microbiome signature, including Pseudoxanthomonas , Streptomyces , Saccharopolyspora …

Microorganisms Associated with the Marine Sponge Scopalina hapalia: A Reservoir of Bioactive Molecules to Slow Down the Aging Process.

Aging research aims at developing therapies that delay normal aging processes and some related pathologies. Recently, many compounds and extracts from natural products have been shown to slow aging and/or extend lifespan. Marine sponges and their associated microorganisms have been found to produce a wide variety of bioactive secondary metabolites; however, those from the Southwest of the Indian Ocean are much less studied, especially regarding anti-aging activities. In this study, the microbial diversity of the marine sponge Scopalina hapalia was investigated by metagenomic analysis. Twenty-s

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… Saccharopolyspora spongiae sp. nov., a novel actinomycete isolated from the marine sponge Scopalina ruetzleri (Wiedenmayer, 1977) Int. J. Syst. Evol. Microbiol. 2017;67:2019–2025. doi: 10.1099/ijsem.0.001912. 73. Vicente J., Stewart A., Song B., Hill R.T., Wright J.L. …

Микробиота человека в области здравоохранения и отдельные раковые заболевания.

Большинство эпителиальных поверхностей нашего тела, пищеварительный тракт, дыхательные и врожденные системы, колонизируются большим количеством бактерий, археи, грибов, протозоанов и вирусов. Эти микробиота, особенно кишки, играют важную и полезную роль в пищеварении, метаболизме и синтезе витаминов. Их метаболиты стимулируют производство цитокина человеком, которое используется против потенциальных патогенов. На состав микробиоты влияет ряд внутренних и внешних факторов, включая питание, возраст, болезни и образ жизни. Такие изменения, называемые дисбиозом, могут быть связаны с развитием разл

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… In addition, the patients with long-term survival demonstrated significantly higher levels of Pseudoxanthoma , Saccharopolyspora , and Streptomyces than those with short-term survival, suggesting that these three genera, and additional Bacillus clausii may predict long-term survival in PDAC patients …

Targeting Autophagy with Natural Products as a Potential Therapeutic Approach for Cancer.

Macro-autophagy (autophagy) is a highly conserved eukaryotic intracellular process of self-digestion caused by lysosomes on demand, which is upregulated as a survival strategy upon exposure to various stressors, such as metabolic insults, cytotoxic drugs, and alcohol abuse. Paradoxically, autophagy dysfunction also contributes to cancer and aging. It is well known that regulating autophagy by targeting specific regulatory molecules in its machinery can modulate multiple disease processes. Therefore, autophagy represents a significant pharmacological target for drug development and therapeutic

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… of human cancers | Guttiferone K is another active component of the plant causes autophagy induction [ 82 , 83 , 84 , 85 , 86 ] Autolysosomal acidification stage inhibitors Fusion and degradation | Azithromycin | | Macrolide antibiotic erythromycin analogue | Actinomycete, Streptomyces erythreus (Saccharopolyspora … | Many pharmacological actions including COVID-19 | A wide range of human cancers | Failure to kill intracellular mycobacteria in NTM, Mycobacterium abscessus in CF patients [ 87 ] Fusion and degradation | Clarithromycin | | Macrolide erythromycin analogue | Actinomycete, Streptomyces erythreus ( Saccharopolyspora …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… The etiological agents are thermophilic actinomycetes (e.g., Saccharopolyspora rectivirgula , Thermoactinomyces vulgaris , Thermoactinomyces viridis , and Thermoactinomyces sacchari ) and fungi (e.g., Alternaria spp., A. fumigatus , Botrytis spp., Penicillium brevicompactum , and Penicillium olivicolo …

ECC-4 Abstracts

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Е-постеры.

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