Результаты поиска

Applications of synthetic biology in medical and pharmaceutical fields.

Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to develop various genomic/metabolic engineering tools and approaches. Medical and pharmaceutical demands have also pushed the development of synthetic biology, including integration of heterologous pathways into designer cells to efficiently produce medical agents, enhanced yields of natural products in cell growth media to equal or higher than that of the extract

Изучение механизма Shengmai San для лечения аденокарциномы легких на основе биоинформатики и моделирования молекулярной динамики.

Изучение механизма Shengmai San (SMS) в лечении аденокарциномы легких (LUAD) на основе комплексной стратегии, сочетающей «сетевую фармакологию, биоинформатику, стыковку молекулярной стыковки и моделирование молекулярной динамики», в целях разработки точной стратегии комбинированной терапии и выявления потенциальных биоактивных соединений. Дифференцированные гены в LUAD были выявлены в базе данных Gene Express Omnibus с использованием R (первоначально разработанные в Bell Laboratories и в настоящее время управляемые Lucent Technologies). Из энциклопедии традиционной китайской медицины были извл

Совпадение в полном тексте источника
… Ultimately, 54 active compounds from Panax ginseng, 30 from O japonicus , 50 from S chinensis , and 895 SMS-related targets were obtained ( Table S1 , Supplemental Digital Content 1). …

Effects of three flavonoids from an ancient traditional Chinese medicine Radix puerariae on geriatric diseases.

As the worldwide population ages, the morbidity of neurodegenerative, cardiovascular, cerebrovascular, and endocrine diseases, such as diabetes and osteoporosis, continues to increase. The etiology of geriatric diseases is complex, involving the interaction of genes and the environment, which makes effective treatment challenging. Traditional Chinese medicine, unlike Western medicine, uses diverse bioactive ingredients to target multiple signaling pathways in geriatric diseases. Radix puerariae is one of the most widely used ancient traditional Chinese medicines and is also consumed as food. T

Совпадение в полном тексте источника
… Q Yu N Yu K Wang S Rhizoma coptidis and berberine as a natural drug to combat aging and aging-related diseases via anti-oxidation and AMPK activation Aging Dis 2017 8 760 77 29344415 10.14336/AD.2016.0620 PMC5758350 8 Zhao H Han Z Li G Zhang S Luo Y Therapeutic potential and cellular mechanisms of panax …

Properties of Approved Antitumour Chinese Herbal Medicines: Integrating Evidence and Tradition.

The properties and meridian affinities of Chinese herbal medicine are closely associated with their therapeutic efficacy. This review focuses on approved antitumour Chinese medicines listed in the Pharmacopoeia of the People's Republic of China (2020 Edition, Volume I), highlighting their key components. Statistical methods were used to analyse the properties, flavours and channel tropisms of antitumour traditional Chinese medicine (TCM), including both proprietary formulations and commercially available individual herbs. Distinctive patterns were identified by comparing herb profiles with con

Совпадение в полном тексте источника
… Representative botanicals include Panax ginseng, Glycyrrhizae Radix et Rhizoma and Astragali Radix . …

Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

Совпадение в полном тексте источника
… A combination of essential fatty acids, Panax ginseng extract, and green tea catechins modifies brain fMRI signals in healthy older adults. J. Nutr. Health Aging. 2018;22:837–846. doi: 10.1007/s12603-018-1028-2. 42. Baba Y., Inagaki S., Nakagawa S., Kaneko T., Kobayashi M., Takihara T. …

Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation.

P-selectin is a membrane glycoprotein and a member of the selectin family of cell adhesion molecules. It is prestored in α-granules of platelets and Weibel-Palade bodies of endothelial cells and is rapidly expressed on their surfaces upon activation during the course of an inflammatory response. Although a critical component of the innate immune system, the interaction of P-selectin with its cognate ligand, P-selectin glycoprotein ligand 1 (PSGL-1) may mediate maladaptive events central to the pathophysiology of venous thromboembolism, cardiovascular disease, stroke, metabolic syndrome, and si

Совпадение в полном тексте источника
… reported to delay carotid artery occlusion and reduce stroke infarct area in several rodent models. 112 QSYQ is composed of Astragalus membranaceus (huangqi), which, as a component of yiqi qubai, has been traditionally associated with anti-inflammatory effects, as well as Salvia miltiorrhiza (danshen), Panax …

Mechanistic and Clinical Perspectives on Traditional Chinese Medicine in Thyroid Cancer Management.

Thyroid cancer is one of the most prevalent malignancies of the endocrine system, comprising various subtypes such as papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), medullary thyroid carcinoma (MTC), and the aggressive anaplastic thyroid carcinoma (ATC). Despite a generally favorable prognosis for PTC, recurrence, metastasis, and resistance to conventional therapies continue to pose significant challenges. The pathogenesis of thyroid cancer involves genetic mutations in BRAF, RAS, and RET, as well as dysregulated molecular pathways such as MAPK, PI3K/Akt/mTOR, and NF-κB

Совпадение в полном тексте источника
… There are numerous TCM herbs, including Astragalus ( Astragalus membranaceus ) and Ginseng ( Panax ginseng ), which are known to boost immune cell activity, thereby increasing the body’s ability to identify and kill thyroid cancer cells ( Hu et al. , 2022 ). …

Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects.

Many naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots - decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological

Совпадение в полном тексте источника
… Three sesquiterpene hydrocarbons from the roots of Panax ginseng CA Meyer (Araliaceae). Phytochemistry, 66, 2708–2713. Ryu, K.‐S. , Hong, N.‐D. , Kim, N.‐J. , & Kong, Y.‐Y. (1990). …

Cancer Stem Cells: The Potential Targets of Chinese Medicines and Their Active Compounds.

The pivotal role of cancer stem cells (CSCs) in the initiation and progression of malignancies has been rigorously validated, and the specific methods for identifying and isolating the CSCs from the parental cancer population have also been rapidly developed in recent years. This review aims to provide an overview of recent research progress of Chinese medicines (CMs) and their active compounds in inhibiting tumor progression by targeting CSCs. A great deal of CMs and their active compounds, such as Antrodia camphorate, berberine, resveratrol, and curcumin have been shown to regress CSCs, in t

Совпадение в полном тексте источника
… To our knowledge, its main ingredients are musk, calculus bovis (gallstone of the ox), snake’s gall, and Radix Notoginseng (root of Panax Notoginseng, Tien chi/Tianqi/Sanqi in Chinese). …

The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy.

Cancer is a major disease with ever-increasing morbidity and mortality. The metabolites derived from traditional Chinese medicine (TCM) have played a significant role in combating cancers with curative efficacy and unique advantages. Ferroptosis, an iron-dependent programmed death characterized by the accumulation of lipid peroxide, stands out from the conventional forms of cell death, such as apoptosis, pyroptosis, necrosis, and autophagy. Recent evidence has demonstrated the potential of TCM metabolites targeting ferroptosis for cancer therapy. We collected and screened related articles publ

Совпадение в полном тексте источника
… Ginsenoside Rh4 is an active metabolite of triterpenoid saponins in Panax ginseng C.A.Mey . [Araliaceae ; P. ginseng root and rhizome ]. …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

Совпадение в полном тексте источника
… Nevertheless, as presented by Hosseini and Ghorbani, there is clinical evidence supporting the anticancer effects of camptothecin, curcumin, resveratrol, Allium sativum , Panax ginseng , Rhus verniciflua , Viscum album , and green tea [ 105 ]. …

Quantification of promoting efficiency and reducing toxicity of Traditional Chinese Medicine: A case study of the combination of Tripterygium wilfordii hook. f. and Lysimachia christinae hance in the treatment of lung cancer.

Traditional Chinese medicine (TCM) usually acts in the form of compound prescriptions in the treatment of complex diseases. The herbs contained in each prescription have the dual nature of efficiency and toxicity due to their complex chemical component, and the principle of prescription is usually to increase efficiency and reduce toxicity. At present, the studies on prescriptions have mainly focused on the consideration of the material basis and possible mechanism of the action mode, but the quantitative research on the compatibility rule of increasing efficiency and reducing toxicity is stil

Совпадение в полном тексте источника
… .; Aconitum carmichaelii Debeaux is mixed with Glycyrrhiza uralensis Fisch., Rheum officinale Baill., and Panax notoginseng (Burkill) F.H.Chen . Among them, Tripterygium wilfordii Hook. f. …

Sialyltransferase Inhibitors for the Treatment of Cancer Metastasis: Current Challenges and Future Perspectives.

Potent, cell-permeable, and subtype-selective sialyltransferase inhibitors represent an attractive family of substances that can potentially be used for the clinical treatment of cancer metastasis. These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, which then blocks the sialic acid recognition pathway and leads to deterioration of cell motility and invasion. A vast amount of evidence for the in vitro and in vivo effects of sialyltransferase inhibition or knockdown on tumor progression and tumor cell meta

Совпадение в полном тексте источника
… ) | K m (μM) 0 | 0.66 | 4.77 | | | | | | 30 | 0.66 | 5.21 | 25 | 0.66 | 3.39 | 2.0 | 0.73 | 3.02 50 | 0.59 | 11.6 | 50 | 0.52 | 7.56 | 4.0 | 0.72 | 8.39 80 | 0.35 | 25.6 | 75 | 0.24 | 12.3 | 6.0 | 0.53 | 15.9 Recently, ginsenosides 80 – 83 ( Figure 15 ) isolated from the ethanolic extract of Panax …

Research progress on the anti-cancer mechanisms of edible salty-flavored Chinese materia medica.

Edible salty-flavored Chinese materia medica (ESCM) refers to a category of traditional Chinese medicine (TCM) that also serve as food, characterized by their salty flavor. According to the TCM theory, ESCM can soften and disperse knots, thus potentially offering benefits for cancer prevention and treatment. With cancer remaining a major global health challenge, its primary prevention strategies, especially through dietary modification, are crucial. ESCM have recently garnered substantial attention, due to their remarkable clinical efficacy and low side-effect profile. Researches on ESCM demon

Совпадение в полном тексте источника
… Astragali Radix, Mori Folium, Natrii Sulfas Exsiccatus, Chromium Picolinate | G20130058 Auxiliary protection from chemical liver injury | Haizao | Blue Key Brand Sodium Alginate Taurine Capsules | Sodium alginate (irradiated), Taurine (irradiated) | G20070380 Juemingzi | Herbalife Brand Cassia Seed Panax …

Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications.

HHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was condu

A review of chemotherapeutic drugs-induced arrhythmia and potential intervention with traditional Chinese medicines.

Significant advances in chemotherapy drugs have reduced mortality in patients with malignant tumors. However, chemotherapy-related cardiotoxicity increases the morbidity and mortality of patients, and has become the second leading cause of death after tumor recurrence, which has received more and more attention in recent years. Arrhythmia is one of the common types of chemotherapy-induced cardiotoxicity, and has become a new risk related to chemotherapy treatment, which seriously affects the therapeutic outcome in patients. Traditional Chinese medicine has experienced thousands of years of cli

Совпадение в полном тексте источника
… The three herbal ingredients include Danshen (Salvia miltiorrhiza), Sanqi (Panax notoginseng), and Bingpian (Borneol) ( Guo et al., 2016 ; Hu et al., 2022 ), and it was found that its main active ingredients are danshenolic acids (e.g., danshenolic, etc.), saponins (e.g., ginsenoside Re), flavonoids …

Biosynthesis of anticancer phytochemical compounds and their chemistry.

Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived phytochemical compounds target different oncogenes, tumor suppressor genes, protein channels, immune cells, protein channels, and pumps, which have attracted much attention for treating cancer in preclinical studies. Despite the anticancer capabilities of these phytochemical compounds, systemic toxicity, medication resistance, and limited absorption re

Совпадение в полном тексте источника
… . • Inhibits transcription in tumor cells by targeting genes like RPB1 , MYC , SP1 and FOS . 14 | Protopanaxadiol | Panax ginseng | - | • Induces caspase dependent apoptosis | C.-Z. Wang et al. (2013), Z. …

2026 Приложение к резюме Международного конгресса

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Natural anti-cancer products: insights from herbal medicine.

Herbal medicine exhibits a broad spectrum of potent anti-cancer properties, including the enhancement of tumor immune responses, reversal of multidrug resistance, regulation of autophagy and ferroptosis, as well as anti-proliferative, pro-apoptotic, and anti-metastatic effects. This review systematically explores recent advances (primarily documented since 2019) in research on key anti-cancer compounds derived from herbal medicine, such as apigenin, artemisinin, berberine, curcumin, emodin, epigallocatechin gallate (EGCG), ginsenosides, icariin, resveratrol, silibinin, triptolide, and ursolic

Совпадение в полном тексте источника
… Fluorouracil, Celecoxib, Cilantro, Cisplatin, Daunorubici, Doxorubicin, Gefitinib, Oxaliplatin, Paclitaxel, Resveratrol, Sorafenib, Vitamin D | [ 519 , 527 , 528 , 532 – 543 , 546 – 554 , 558 – 560 , 563 – 572 , 578 , 579 , 581 , 586 , 592 – 594 , 598 , 599 , 1118 – 1125 ] Ginsenosides(Rg3, Rh2, Compound K) | Panax …

Targeting Members of the Chemokine Family as a Novel Approach to Treating Neuropathic Pain.

Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients' quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and ma